Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Mitochondria and Apoptosis

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Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance

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Venetoclax: Targeting BCL2 in Hematological Cancers

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Short-term developmental toxicity and potential mechanisms of the herbicide metamifop to zebrafish (Danio rerio) embryos

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2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells

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Adaptive response of the skin to UVB damage: role of the p53 protein

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Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33ING1 in T.Tn human esophageal carcinoma cells

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Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporine

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p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53

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TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells

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p53 and Bad: remote strangers become close friends

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In Vivo Application of Histone Deacetylase Inhibitor Trichostatin‐A Impairs Murine Male Meiosis

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Induction of apoptosis in cancer: new therapeutic opportunities

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Scanning Protein Surfaces with DNA‐Encoded Libraries

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The switch from survival responses to apoptosis after chromosomal breaks

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Early gene response in lithium chloride induced apoptosis

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Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene

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Proapoptotic activity of ITM2Bs, a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2

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Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation

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INVOLVEMENT OF MITOCHONDRIA IN APOPTOSIS

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Noxa and cancer therapy

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MYC Degradation under Low O 2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death

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An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells

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Novel chemotherapeutic agents for the treatment of glioblastoma multiforme

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HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

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Requirement for Aspartate-cleaved Bid in Apoptosis Signaling by DNA-damaging Anti-cancer Regimens

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Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo

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Apoptosis Timeline

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Host-Cell Survival and Death During Chlamydia Infection

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A p53-Pax2 Pathway in Kidney Development: Implications for Nephrogenesis

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The Prosurvival Activity of p53 Protects Cells from UV-Induced Apoptosis by Inhibiting c-Jun NH2-terminal Kinase Activity and Mitochondrial Death Signaling

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Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt( ii )(salicylaldiminato)(DMSO or Picolino)Cl complexes

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Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway

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Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

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The Proteasome Inhibitor Bortezomib Induces Apoptosis in Human Retinoblastoma Cell Lines In Vitro

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Role of p38 MAPK and JNK in enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation

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Pharmacogenomic Identification of Targets for Adjuvant Therapy with the Topoisomerase Poison Camptothecin

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The pro-apoptotic protein, Bik, exhibits potent antitumor activity that is dependent on its BH3 domain.

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p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs

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Tetrandrine inhibits hepatocellular carcinoma cell growth through the caspase pathway and G2/M phase

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Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus

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DUSP6 is a novel transcriptional target of p53 and regulates p53‐mediated apoptosis by modulating expression levels of Bcl‐2 family proteins

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Uncovering Gene Regulatory Networks During Mouse Fetal Germ Cell Development

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Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA

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Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

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miR-30 functions as an oncomiR in gastric cancer cells through regulation of P53-mediated mitochondrial apoptotic pathway

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Bacterial Carriers for Glioblastoma Therapy

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Regulation of stressed-induced cell death by the Bcl-2 family of apoptotic proteins

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A p38-dependent pathway regulates ΔNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes

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The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax

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Protein kinase Cɛ confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53

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Apoptosis and Autophagy Induction in Mammalian Cells by Small Interfering RNA Knockdown of mRNA Capping Enzymes

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Apoptosis in Carcinogenesis and Chemotherapy

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Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand.

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Death receptor‐induced cell death in prostate cancer

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Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype

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Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells

Liu, Y. L., Lai, F., Wilmott, J. S., Yan, X. G., Liu, X. Y., Luan, Q., Guo, S. T., Jiang, C. C., Tseng, H.-Y., Scolyer, R. A., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2616 · Cited by 40

Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins

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Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein

Chen, Y., Fujita, T., Zhang, D., Doan, H. Q., Pinkaew, D., Liu, Z., Wu, J., Koide, Y., Chiu, A., Lin, C. C.-J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217836 · Cited by 40

Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells

Janus, P., Toma-Jonik, A., Vydra, N., Mrowiec, K., Korfanty, J., Chadalski, M., Widłak, P., Dudek, K., Paszek, A., Rusin, M., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0501-8 · Cited by 40

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

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p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl2): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells

Höti, N., Zhu, D.-E., Song, Z., Wu, Z., Tabassum, S., & Wu, M. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.069104 · Cited by 40

Diphenyleneiodonium induces ROS‐independent p53 expression and apoptosis in human RPE cells

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Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

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Chromosome instability and deregulated proliferation: an unavoidable duo

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Arsenic sulfide, the main component of realgar, a traditional Chinese medicine, induces apoptosis of gastric cancer cells in vitro and in vivo

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Bim and Bmf Synergize To Induce Apoptosis in Neisseria Gonorrhoeae Infection

Kepp, O., Gottschalk, K., Churin, Y., Rajalingam, K., Brinkmann, V., Machuy, N., Kroemer, G., & Rudel, T. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000348 · Cited by 39

Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression

Sachweh, M. C. C., Drummond, C. J., Higgins, M., Campbell, J., & Laı́n, S. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.61 · Cited by 38

SNF5 Reexpression in Malignant Rhabdoid Tumors Regulates Transcription of Target Genes by Recruitment of SWI/SNF Complexes and RNAPII to the Transcription Start Site of Their Promoters

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Bcl‐2 proteins in development, health, and disease of the hematopoietic system

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Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

Pen, J. L., Laurent, M., Sarosiek, K. A., Vuillier, C., Gautier, F., Montessuit, S., Martinou, J., Letai, A. G., Braun, F., & Juin, P. P. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.400 · Cited by 40

Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway

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Potential therapeutic targets ofTP53gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer

Tanaka, T., Watanabe, M., & Yamashita, K. (2018) · Oncotarget · doi:10.18632/oncotarget.24611 · Cited by 46

Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells

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Candesartan could ameliorate the COVID-19 cytokine storm

ELKAHLOUN, A. G., & Saavedra, J. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110653 · Cited by 40

Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer

Jeong, S. H., Kim, H. H., Ha, S. E., Park, M. Y., Bhosale, P. B., Abusaliya, A., Park, K., Heo, J., Kim, H. W., & Kim, G. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810965 · Cited by 40

p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress

Jõers, A., Jaks, V., Kase, J., & Maimets, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207864 · Cited by 39

p53 and ΔNp63α differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis

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Interferon-γ Induces X-linked Inhibitor of Apoptosis-associated Factor-1 and Noxa Expression and Potentiates Human Vascular Smooth Muscle Cell Apoptosis by STAT3 Activation

Bai, Y., Ahmad, U., Wang, Y., Li, J. H., Choy, J. C., Kim, R. W., Kirkiles-Smith, N. C., Maher, S. E., Karras, J. G., Bennett, C. F., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706021200 · Cited by 39

Ultraviolet Irradiation Induces Apoptosis in Human Immature, But Not in Skin Mast Cells

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Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges

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Granzyme B-induced Cell Death Involves Induction of p53 Tumor Suppressor Gene and Its Activation in Tumor Target Cells

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Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K/Akt and MAPK pathways

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Quantitative analysis of p53 targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo

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Targeting the Bcl-2 Family in Cancer Therapy

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Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms

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Progress on Pro-Apoptotic Effect of Noxa on Tumor

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Synergistic Induction of Apoptosis by p53-inducible Bcl-2 Family Proteins Noxa and Puma

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p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

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Involvement of Bcl-2 Family Proteins in p53-induced Apoptosis

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