Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Mitochondria and Apoptosis

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Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

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Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson’s disease

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Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter

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Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1–dependent apoptotic pathway

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p53 Is a Key Molecular Target of Ursodeoxycholic Acid in Regulating Apoptosis

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Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA

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Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.

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Apoptosis commitment – translating survival signals into decisions on mitochondria

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Identification of a Novel Phosphorylation Site, Ser-170, as a Regulator of Bad Pro-apoptotic Activity

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An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs

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Mitochondria-mediated and p53-associated apoptosis induced in human cancer cells by a novel selenophene derivative, D-501036

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Apoptosis in inner ear sensory hair cells

Morrill, S., & He, D. Z. Z. (2017) · Journal of Otology · doi:10.1016/j.joto.2017.08.001 · Cited by 78

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types

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Oscillations of the p53-Akt Network: Implications on Cell Survival and Death

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A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells

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Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

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Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis

Kütük, Ö., & Başağa, H. (2006) · APOPTOSIS · doi:10.1007/s10495-006-9402-7 · Cited by 76

What have animal models taught us about the p53 pathway?

Lozano, G., & Zambetti, G. P. (2005) · The Journal of Pathology · doi:10.1002/path.1704 · Cited by 78

Androgen and Its Receptor Promote Bax-Mediated Apoptosis

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Apoptotic Signaling Pathways Induced by Nitric Oxide in Human Lymphoblastoid Cells Expressing Wild-Type or Mutant p53

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Genealogy, expression, and molecular mechanisms in apoptosis

Dlamini, Z., Mbita, Z., & Zungu, M. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.08.005 · Cited by 74

MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells

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Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+T cells

Sung, T.-L., & Rice, A. P. (2006) · Retrovirology · doi:10.1186/1742-4690-3-66 · Cited by 74

Targeting Activating Transcription Factor 3 by Galectin-9 Induces Apoptosis and Overcomes Various Types of Treatment Resistance in Chronic Myelogenous Leukemia

Kuroda, J., Yamamoto, M., Nagoshi, H., Kobayashi, T., Sasaki, N., Shimura, Y., Horiike, S., Kimura, S. H., Yamauchi, A., Hirashima, M., et al. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0040 · Cited by 75

WT1 Induces Apoptosis through Transcriptional Regulation of the Proapoptotic Bcl-2 Family Member Bak

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Therapeutic Inducers of Apoptosis in Ovarian Cancer

Binju, M., Amaya-Padilla, M. A., Wan, G., Gunosewoyo, H., Rahmanto, Y. S., & Yu, Y. (2019) · Cancers · doi:10.3390/cancers11111786 · Cited by 78

Mitochondrial Liaisons of p53

Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Pinti, M., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3504 · Cited by 83

Multiple actions of pifithrin-α on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells

Chua, C. C., Liu, X., Gao, J., Hamdy, R. C., & Chua, B. H. L. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01138.2005 · Cited by 74

p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

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Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?

Elkholi, R., Renault, T. T., Serasinghe, M. N., & Chipuk, J. E. (2014) · Cancer & Metabolism · doi:10.1186/2049-3002-2-16 · Cited by 77

Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo

Talos, F., Petrenko, O., Mena, P., & Moll, U. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1084 · Cited by 74

Noxa Is a Critical Mediator of p53-Dependent Motor Neuron Death after Nerve Injury in Adult Mouse

Kiryu‐Seo, S., Hirayama, T., Kato, R., & Kiyama, H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4041-04.2005 · Cited by 74

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasisPreprint

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Regulation of Caenorhabditis elegans p53/CEP-1–Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

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Research Resource: The Pdx1 Cistrome of Pancreatic Islets

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New insights into the functions and localization of nuclear transglutaminase 2

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In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit

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BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

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Stem cells: balancing resistance and sensitivity to DNA damage

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Divergence from a Dedicated Cellular Suicide Mechanism: Exploring the Evolution of Cell Death

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Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.

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Puma and p53 Play Required Roles in Death Evoked in a Cellular Model of Parkinson Disease

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Apoptosis and its clinical impact

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The molecular control of DNA damage-induced cell death

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A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

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Redox-Dependent Translocation of p53 to Mitochondria or Nucleus in Human Melanocytes after UVA- and UVB-Induced Apoptosis

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Reactive Oxygen Species Across Death Pathways: Gatekeepers of Apoptosis, Ferroptosis, Pyroptosis, Paraptosis, and Beyond

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Identification of SCN3B as a novel p53-inducible proapoptotic gene

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Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish

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Regulation of the DNA damage response by ubiquitin conjugation

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p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome

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Regulation of Apoptosis by HER2 in Breast Cancer

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Cell death and cancer therapy

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HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage

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Proteotoxic Stress and Cell Death in Cancer Cells

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SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer

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Redox Stress and the Contributions of BH3-Only Proteins to Infarction

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Autoregulatory control of the p53 response by caspase‐mediated processing of HIPK2

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Identification of a Mouse Thiamine Transporter Gene as a Direct Transcriptional Target for p53

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Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

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Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells

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DDB2 (damaged-DNA binding protein 2) in nucleotide excision repair and DNA damage response

Stoyanova, T., Roy, N., Kopanja, D., Raychaudhuri, P., & Bagchi, S. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10109 · Cited by 70

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

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Apoptosis and Tumor Cell Death in Response to HAMLET (Human α-Lactalbumin Made Lethal to Tumor Cells)

Hällgren, O., Aits, S., Brest, P., Gustafsson, L., Mossberg, A., Wullt, B., & Svanborg, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-74087-4_8 · Cited by 71

The Anti-apoptotic Protein BCL2L1/Bcl-xL Is Neutralized by Pro-apoptotic PMAIP1/Noxa in Neuroblastoma, Thereby Determining Bortezomib Sensitivity Independent of Prosurvival MCL1 Expression

Hagenbuchner, J., Ausserlechner, M. J., Porto, V., David, R., Meister, B., Bodner, M., Villunger, A., Geiger, K., & Obexer, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.038331 · Cited by 73

FL118 Induces p53-Dependent Senescence in Colorectal Cancer Cells by Promoting Degradation of MdmX

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Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain

Cross, B. L., Chen, L., Cheng, Q., Li, B., Yuan, Z.-M., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.228981 · Cited by 72

How do viruses control mitochondria-mediated apoptosis?

Neumann, S., Maadidi, S. E., Faletti, L. E., Haun, F., Labib, S., Schejtman, A., Maurer, U., & Borner, C. (2015) · Virus Research · doi:10.1016/j.virusres.2015.02.026 · Cited by 74

egl-1: a key activator of apoptotic cell death in C. elegans

Nehme, R., & Conradt, B. (2008) · Oncogene · doi:10.1038/onc.2009.41 · Cited by 71

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells

Ichwan, S. J. A., Yamada, S., Sumrejkanchanakij, P., Auerkari, E. I., Eto, K., & Ikeda, M.-A. (2005) · Oncogene · doi:10.1038/sj.onc.1209158 · Cited by 68

BAD/BCL-xL heterodimerization leads to bypass of G0/G1 arrest

Chattopadhyay, A., Chiang, C.-W., & Yang, E. (2001) · Oncogene · doi:10.1038/sj.onc.1204584 · Cited by 70

Transcriptional control of the core cell-death machinery

Kumar, S., & Cakouros, D. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.02.001 · Cited by 72

Requirement of clathrin heavy chain for p53-mediated transcriptionPreprint

Enari, M., Ohmori, K., Kitabayashi, I., & Taya, Y. (2006) · Genes & Development · doi:10.1101/gad.1381906 · Cited by 71

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation

Panjarian, S., Kozhaya, L., Arayssi, S., Yehia, M., Bielawski, J., Bielawska, A., Usta, J., Hannun, Y. A., Obeid, L. M., & Dbaibo, G. S. (2008) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2008.02.004 · Cited by 69

Involvement of Noxa in Cellular Apoptotic Responses to Interferon, Double-stranded RNA, and Virus Infection

Sun, Y., & Leaman, D. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412630200 · Cited by 70

Structure and apoptotic function of p73

Yoon, M.-K., Ha, J., Lee, M.-S., & Chi, S. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.2.255 · Cited by 69

Alantolactone induces activation of apoptosis in human hepatoma cells

Lei, J., Yu, J. J., Yin, Y., Yan-wen, L., & Zou, G. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.06.014 · Cited by 70

MDM2 Is Required for Suppression of Apoptosis by Activated Akt1 in Salivary Acinar Cells

Limesand, K. H., Schwertfeger, K. L., & Anderson, S. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01846-05 · Cited by 73

PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein

Hyder (2009) · International Journal of Oncology · doi:10.3892/ijo_00000416 · Cited by 69

Leukocyte Elastase Induces Lung Epithelial Apoptosis via a PAR-1–, NF-κB–, and p53-Dependent Pathway

Suzuki, T., Yamashita, C. M., Zemans, R. L., Briones, N. J., Linden, A. V., & Downey, G. P. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0157oc · Cited by 71

p53 mediates DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in SH-SY5Y neuroblastoma cells.

Cui, H., Schroering, A. G., & Ding, H. (2002) · PubMed · Cited by 69

Ionizing radiation manifesting DNA damage response in plants: An overview of DNA damage signaling and repair mechanisms in plants

Kim, J., Ryu, T. H., Lee, S. S., Lee, S., & Chung, B. Y. (2018) · Plant Science · doi:10.1016/j.plantsci.2018.10.013 · Cited by 73

MYC levels govern hematopoietic tumor type and latency in transgenic mice

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Role of Bcl-2 family members in immunity and disease

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Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

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Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell Fate

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Elimination of Hepatic Metastases of Colon Cancer Cells via p53-Independent Cross-Talk between Irinotecan and Apo2 Ligand/TRAIL

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