Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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Genome Stability Requires p53

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High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

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Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA

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Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

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Transcription, apoptosis and p53: catch-22

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BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis

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Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation

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Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis

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Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

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Increased ROS generation and p53 activation in α-lipoic acid-induced apoptosis of hepatoma cells

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Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

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The rise of apoptosis: targeting apoptosis in hematologic malignancies

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Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells

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Sp1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p21 Gene by the p53 Tumor Suppressor Protein

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Bcl-2 Family Member Bfl-1/A1 Sequesters Truncated Bid to Inhibit Its Collaboration with Pro-apoptotic Bak or Bax

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Analysing differential gene expression in cancer

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CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death

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Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis

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Apoptotic Cell Death Under Hypoxia

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Granzyme B Induces BID-mediated Cytochrome c Release and Mitochondrial Permeability Transition

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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

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Bim and the Pro-Survival Bcl-2 Proteins: Opposites Attract, ERK Repels

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Dysregulation of apoptosis genes in hematopoietic malignancies

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The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose

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Should mutant TP53 be targeted for cancer therapy?

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Downregulation of miR-23a and miR-27a following Experimental Traumatic Brain Injury Induces Neuronal Cell Death through Activation of Proapoptotic Bcl-2 Proteins

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Transglutaminase 2 has opposing roles in the regulation of cellular functions as well as cell growth and death

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BH-3-only BIK Functions at the Endoplasmic Reticulum to Stimulate Cytochrome c Release from Mitochondria

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WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase

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Dying a Thousand Deaths: Redundant Pathways From Different Organelles to Apoptosis and Necrosis

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Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells

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Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria

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c-Myc Functionally Cooperates with Bax To Induce Apoptosis

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Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53

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Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy

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A Novel Sirtuin 2 (SIRT2) Inhibitor with p53-dependent Pro-apoptotic Activity in Non-small Cell Lung Cancer*

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Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen‐2) demonstrate excessive p53‐dependent apoptosis and neuronal loss

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Review: Mitochondrial apoptotic pathways

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Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

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HIV-1 Vpr Causes Neuronal Apoptosis andIn VivoNeurodegeneration

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BAX and BAK mediate p53-independent suppression of tumorigenesis

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Death and more: DNA damage response pathways in the nematode C. elegans

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The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

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Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53Preprint

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Bim and Noxa Are Candidates to Mediate the Deleterious Effect of the NF-κB Subunit RelA in Cerebral Ischemia

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Celecoxib activates a novel mitochondrial apoptosis signaling pathway

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Expression of the Bcl-3 proto-oncogene suppresses p53 activationPreprint

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In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

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Mitochondria and Endoplasmic Reticulum: The Lethal Interorganelle Cross-Talk

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Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival

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p53 induction of heparin‐binding EGF‐like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades

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p53: The Attractive Tumor Suppressor in the Cancer Research Field

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Overexpression of OATP1B3 Confers Apoptotic Resistance in Colon Cancer

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The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

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BCL-2 family deregulation in colorectal cancer: potential for BH3 mimetics in therapy

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Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent Pathways

Yamaguchi, H., Chen, J., Bhalla, K. N., & Wang, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401530200 · Cited by 128

The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis

Takimoto, R., Wang, W., Dicker, D. T., Rastinejad, F., Lyssikatos, J. P., & El‐Deiry, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.1.41 · Cited by 130

p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas

Qin, J., Stennett, L. S., Bacon, P. E., Bodner, B. K., Hendrix, M. J. C., Seftor, R. E. B., Seftor, E. A., Margaryan, N. V., Pollock, P. M., Curtis, A. V., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.895.3.8 · Cited by 128

Homozygous deletions and point mutations of the Rit1/Bcl11b gene in γ-ray induced mouse thymic lymphomas

Wakabayashi, Y., Inoue, J., Takahashi, Y., Matsuki, A., Kosugi-Okano, H., Shinbo, T., Mishima, Y., Niwa, O., & Kominami, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03069-3 · Cited by 130

Antitumor Effects of the Proteasome Inhibitor Bortezomib in Medullary and Anaplastic Thyroid Carcinoma Cells in Vitro

Mitsiades, C. S., McMillin, D. W., Kotoula, V., Poulaki, V., McMullan, C. J., Negri, J. M., Fanourakis, G., Tseleni‐Balafouta, S., Ain, K. B., & Mitsiades, N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2472 · Cited by 128

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X L

Maclean, K. H., Keller, U. B., Galindo, C. R., Nilsson, J. A., & Cleveland, J. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7256-7270.2003 · Cited by 128

Apoptosis-promoted tumorigenesis: γ-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte deathPreprint

Michalak, E. M., Vandenberg, C. J., Delbridge, A. R. D., Wu, L., Scott, C. L., Adams, J. M., & Strasser, A. (2010) · Genes & Development · doi:10.1101/gad.1940110 · Cited by 129

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Palanikumar, L., Karpauskaite, L., Al‐Sayegh, M., Chehade, I., Alam, M., Hassan, S., Maity, D., Ali, L., Kalmouni, M., Hunashal, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23985-1 · Cited by 126

Classic and novel roles of p53: prospects for anticancer therapy

Fuster, J. J., Sanz-Gonzalez, S. M., Moll, U. M., & Andrés, V. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.03.002 · Cited by 128

PARP‐2 deficiency affects the survival of CD4+CD8+ double‐positive thymocytes

Yélamos, J., Monreal, Y., Saenz, L., Aguado, E., Schreiber, V., Mota, R., Fuente, T., Minguela, A., Parrilla, P., de MURCIA, G., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601301 · Cited by 133

Apoptosis-modulating agents in combination with radiotherapy—current status and outlook

Belka, C., Jendrossek, V., Pruschy, M. N., Vink, S. R., Verheij, M., & Budach, W. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.09.067 · Cited by 127

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

Fielder, E., von Zglinicki, T., & Jurk, D. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161221 · Cited by 126

PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21

Hu, F., Gartenhaus, R. B., Eichberg, D. G., Liu, Z., Fang, H.-B., & Rapoport, A. P. (2010) · Oncogene · doi:10.1038/onc.2010.275 · Cited by 125

Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells

Ostrakhovitch, E. A., & Cherian, M. G. (2005) · APOPTOSIS · doi:10.1007/s10495-005-6066-7 · Cited by 127

In Harm's Pathway

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Progress on Pro-Apoptotic Effect of Noxa on Tumor

Yon, D. (2010) · Medical Recapitulate

Synergistic Induction of Apoptosis by p53-inducible Bcl-2 Family Proteins Noxa and Puma

Nakajima, W., & Tanaka, N. (2007) · Journal of Nippon Medical School · doi:10.1272/jnms.74.148 · Cited by 23

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327

Involvement of Bcl-2 Family Proteins in p53-induced Apoptosis

Tobiume, K. (2005) · Journal of Nippon Medical School · doi:10.1272/jnms.72.192 · Cited by 14