Cited by 2,112Cell death mechanisms and regulationCancer-related Molecular PathwaysHeat shock proteins research

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, Eri, Ohki, Rieko, Murasawa, Hideki, Nemoto, Jiro, Shibue, Tsukasa, Yamashita, Toshiharu, Tokino, Takashi, Taniguchi, Tadatsugu, Tanaka, † Nobuyuki·2000·Science

DOI 10.1126/science.288.5468.1053

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Abstract

A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, Noxa . Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation was dependent on p53. Noxa encodes a Bcl-2 homology 3 (BH3)–only member of the Bcl-2 family of proteins; this member contains the BH3 region but not other BH domains. When ectopically expressed, Noxa underwent BH3 motif–dependent localization to mitochondria and interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. We also demonstrate that blocking the endogenous Noxa induction results in the suppression of apoptosis. Noxa may thus represent a mediator of p53-dependent apoptosis.

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Mitochondria and Apoptosis
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
The Bcl-2 Protein Family: Arbiters of Cell Survival
Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
Liang, P., & Pardee, A. B. (1992) · Science · doi:10.1126/science.1354393 · Cited by 4,964
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
BCL-2 family members and the mitochondria in apoptosisPreprint
Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,642
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Thymocyte apoptosis induced by p53-dependent and independent pathways
Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985

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Marcellus R. C., Teodoro J. G., Charbonneau R., Shore G. C., Branton P. E., Cell Growth Differ. 7, 1643 (1996).

Sorted by citations

Items 401–500 of 1,003

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Schüler, M., Maurer, U., Goldstein, J. C., Breitenbücher, F., Hoffarth, S., Waterhouse, N. J., & Green, D. R. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401180 · Cited by 127
Cytokine control of developmental programs in normal hematopoiesis and leukemia
Lotem, J., & Sachs, L. (2002) · Oncogene · doi:10.1038/sj.onc.1205319 · Cited by 125
Manumycin polyketides act as molecular glues between UBR7 and P53
Isobe, Y., Okumura, M., McGregor, L. M., Brittain, S. M., Jones, M. D., Liang, X., White, R., Forrester, W., McKenna, J. M., Tallarico, J. A., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0557-2 · Cited by 124
Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa
Inoue, S., Riley, J., Gant, T. W., Dyer, M. J. S., & Cohen, G. M. (2007) · Leukemia · doi:10.1038/sj.leu.2404760 · Cited by 124
Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53
Charvet, C., Wissler, M., Brauns‐Schubert, P., Wang, S.-J., Tang, Y., Sigloch, F. C., Mellert, H. S., Brandenburg, M., Lindner, S. E., Breit, B., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.033 · Cited by 125
Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53
Mathai, J. P., Germain, M., Marcellus, R. C., & Shore, G. C. (2002) · Oncogene · doi:10.1038/sj.onc.1205340 · Cited by 123
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane
Bourdon, J., Renzing, J., Robertson, P., Fernandes, K., & Lane, D. P. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203006 · Cited by 126
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
LeBron, C., Chen, L., Gilkes, D. M., & Chen, J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601032 · Cited by 122
Crosstalk between Apoptosis and Autophagy: Molecular Mechanisms and Therapeutic Strategies in Cancer
El‐Khattouti, A., Selimović, D., Haïkel, Y., & Hassan, M. (2013) · Journal of Cell Death · doi:10.4137/jcd.s11034 · Cited by 125
The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD
Song, Q., Chen, P., & Liu, X. (2021) · Respiratory Research · doi:10.1186/s12931-021-01630-1 · Cited by 129
Death to flies: Drosophila as a model system to study programmed cell death
Richardson, H. E., & Kumar, S. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00068-6 · Cited by 122
p53 downstream targets and chemosensitivity
Sax, J. K., & El‐Deiry, W. S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401227 · Cited by 122
Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389
Bruins, W., Zwart, E., Attardi, L. D., Iwakuma, T., Hoogervorst, E. M., Beems, R. B., Miranda, B., van Oostrom, C. T. M., van den Berg, J., van den Aardweg, G. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8884-8894.2004 · Cited by 121
Targeting mitochondria for cancer therapy
Hockenbery, D. M. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20552 · Cited by 124
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
Naik, E., Michalak, E. M., Villunger, A., Adams, J. M., & Strasser, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608070 · Cited by 123
Mitochondria: regulating the inevitable
Parone, P. A., James, D. I., & Martinou, J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01380-9 · Cited by 118
PUMA Overexpression Induces Reactive Oxygen Species Generation and Proteasome-Mediated Stathmin Degradation in Colorectal Cancer Cells
Liu, Z., Lu, H., Shi, H., Du, Y., Yu, J., Gu, S., Chen, X., Liu, K. J., & Hu, C. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1754 · Cited by 127
Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Antitumor Activity
Matthews, G. M., Newbold, A., & Johnstone, R. W. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-394387-3.00005-7 · Cited by 120
Lead-induced apoptosis in PC 12 cells: Involvement of p53, Bcl-2 family and caspase-3
Xu, J., Ji, L., & Xu, L. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.06.643 · Cited by 120
p53AIP1 regulates the mitochondrial apoptotic pathway.
Matsuda, K., Yoshida, K., Taya, Y., Nakamura, K., Nakamura, Y., & Arakawa, H. (2002) · PubMed · Cited by 120
Ribosomal Stress Couples the Unfolded Protein Response to p53-dependent Cell Cycle Arrest
Zhang, F., Hamanaka, R. B., Bobrovnikova-Marjon, E. V., Gordan, J. D., Dai, M., Lu, H., Simon, M. C., & Diehl, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604674200 · Cited by 120
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
Bechmann, L. P., Gieseler, R. K. H., Sowa, J., Kahraman, A., ERHARD, J., Wedemeyer, I., Emons, B., Jochum, C., Feldkamp, T., Gerken, G., et al. (2009) · Liver International · doi:10.1111/j.1478-3231.2010.02248.x · Cited by 120
Intracellular signal transduction of cells in response to carcinogenic metals
Chen, F., & Shi, X. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00211-6 · Cited by 121
Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1
Pan, F., Zhu, L., Lv, H., & Pei, C. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2755 · Cited by 119
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Gao, R., Chakraborty, A., Smith-Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., et al. (2019) · eLife · doi:10.7554/elife.42988 · Cited by 120
A novel p53‐inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis‐inducing factor (AIF)
Ohiro, Y., Garkavtsev, I., Kobayashi, S., Sreekumar, K. R., Nantz, R., Higashikubo, B. T., Duffy, S., Higashikubo, R., Usheva, A., Gius, D. R., et al. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03049-1 · Cited by 117
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Williams, M. M., & Cook, R. S. (2015) · Oncotarget · doi:10.18632/oncotarget.2792 · Cited by 125
Proteasome Inhibitor PS-341 Induces Apoptosis in Cisplatin-resistant Squamous Cell Carcinoma Cells by Induction of Noxa
Fribley, A. M., Evenchik, B., Zeng, Q., Park, B.-K., Guan, J. Y., Zhang, H., Hale, T. J., Soengas, M. S., Kaufman, R. J., & Wang, C. Y. (2006) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84056-5 · Cited by 117
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
Tian, C., Xing, G., Xie, P., Lu, K., Nie, J., Wang, J., Li, L., Gao, M., Zhang, L., & He, F. (2009) · Nature Cell Biology · doi:10.1038/ncb1864 · Cited by 120
Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage
Bowen, J. M., Gibson, R. J., Cummins, A. G., & Keefe, D. M. K. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-005-0004-7 · Cited by 119
Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells
Zhao, X., Liu, X., & Su, L. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-33-3 · Cited by 116
Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277
Buzek, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2340 · Cited by 118
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Gao, C. F., Ren, S., Zhang, L., Nakajima, T., Ichinose, S., Hara, T., Koike, K., & Tsuchida, N. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5171 · Cited by 117
BAX and BH3-domain-only proteins in p53-mediated apoptosis
Wu, X. (2002) · Frontiers in bioscience · doi:10.2741/a772 · Cited by 117
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Liang, P. (2002) · BioTechniques · doi:10.2144/02332rv01 · Cited by 117
Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages
Lee, S. M.-Y., Gardy, J. L., Cheung, C. Y., Cheung, T., Hui, K. P. Y., Ip, N. Y., Guan, Y., Hancock, R. E. W., & Peiris, M. J. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008072 · Cited by 116
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Bush, J., & Li, G. (2002) · International Journal of Cancer · doi:10.1002/ijc.10226 · Cited by 117
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Yuan, Z., Villagra, A., Peng, L., Coppola, D., Glozak, M. A., Sotomayor, E. M., Chen, J., Lane, W. S., & Seto, E. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01023-09 · Cited by 116
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Finnberg, N. K., Gruber, J. J., Fei, P., Rudolph, D., Bric, A., Kim, S., Burns, T. F., Ajuha, H., Page, R., Wu, G. S., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.2000-2013.2005 · Cited by 114
The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
Tundo, G. R., Sbardella, D., Santoro, A. M., Coletta, A., Oddone, F., Grasso, G., Milardi, D., Lacal, P. M., Marini, S., Purrello, R., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107579 · Cited by 120
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis
Schmitt, E., Paquet, C., Beauchemin, M., & Bertrand, R. (2007) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.2007.b0377 · Cited by 117
Viral and bacterial proteins regulating apoptosis at the mitochondrial level
Boya, P., Roques, B. P., & Kroemer, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4325 · Cited by 115
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Sogbein, O., Paul, P., Umar, M., Châari, A., Batuman, V., & Upadhyay, R. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123125 · Cited by 123
Death squads enlisted by the tumour suppressor p53
Michalak, E. M., Villunger, A., Erlacher, M., & Strasser, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.183 · Cited by 116
The Snail-like CES-1 protein of C. elegans can block the expression of theBH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins
Thellmann, M., Hatzold, J., & Conradt, B. (2003) · Development · doi:10.1242/dev.00597 · Cited by 114
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Tsuchiya, N., Izumiya, M., Ogata‐Kawata, H., Okamoto, K., Fujiwara, Y., Nakai, M., Okabe, A., Schetter, A. J., Bowman, E. D., Midorikawa, Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2475 · Cited by 120
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Takeyama, N., Miki, S., Hirakawa, A., & Tanaka, T. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5447 · Cited by 113
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Mrass, P., Rendl, M., Mildner, M., Gruber, F., Lengauer, B., Ballaun, C., Eckhart, L., & Tschachler, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1129 · Cited by 112
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Ryan, K. M. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.10.020 · Cited by 114
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Su, Y., Wu, H., Pavlosky, A., Zou, L., Deng, X., Zhang, Z., & Jevnikar, A. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.210 · Cited by 116
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Elston, R., & Inman, G. J. (2012) · Journal of Signal Transduction · doi:10.1155/2012/294097 · Cited by 113
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Bacon, A., & Harris, A. L. (2004) · Annals of Medicine · doi:10.1080/07853890410018231 · Cited by 113
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Elkholi, R., Floros, K. V., & Chipuk, J. E. (2011) · Genes & Cancer · doi:10.1177/1947601911417177 · Cited by 114
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Kawaguchi, T., Kato, S., Otsuka, K., Watanabe, G., Kumabe, T., Tominaga, T., Yoshimoto, T., & Ishioka, C. (2005) · Oncogene · doi:10.1038/sj.onc.1208839 · Cited by 111
p53 directly suppresses BNIP3 expression to protect against hypoxia‐induced cell death
Feng, X., Liu, X., Zhang, W., & Xiao, W. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.248 · Cited by 112
Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy
Liu, Y., & Ye, Y. (2011) · Cell Research · doi:10.1038/cr.2011.75 · Cited by 111
Therapeutic potential of antisense Bcl‐2 as a chemosensitizer for cancer therapy
Kim, R., Emi, M., Tanabe, K., & Toge, T. (2004) · Cancer · doi:10.1002/cncr.20696 · Cited by 109
Role of Transglutaminase 2 in Cell Death, Survival, and Fibrosis
Tatsukawa, H., & Hitomi, K. (2021) · Cells · doi:10.3390/cells10071842 · Cited by 109
Mitochondrial regulation of apoptotic cell death
Gogvadze, V. G., & Orrenius, S. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.04.010 · Cited by 113
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
Happo, L., Cragg, M. S., Phipson, B., Haga, J. M., Jansen, E. S., Herold, M. J., Dewson, G., Michalak, E. M., Vandenberg, C. J., Smyth, G. K., et al. (2010) · Blood · doi:10.1182/blood-2010-04-280818 · Cited by 112
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Elco, C. P., Guenther-Johnson, J. M., Williams, B. R. G., & Sen, G. C. (2005) · Journal of Virology · doi:10.1128/jvi.79.7.3920-3929.2005 · Cited by 108
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DePina, A., Iser, W. B., Park, S. S., Maudsley, S. R., Wilson, M. A., & Wolkow, C. A. (2011) · BMC Physiology · doi:10.1186/1472-6793-11-11 · Cited by 109
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Liu, Y., Wang, J., Guo, J., Wu, J., Lieberman, H. B., & Yin, Y. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2019 · Cited by 109
Apoptotic Pathways and Therapy Resistance in Human Malignancies
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Harnessing apoptosis for improved anticancer gene therapy.
Waxman, D. J., & Schwartz, P. S. (2003) · PubMed · Cited by 106
Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA Damage
Aleyasin, H., Cregan, S. P., Iyirhiaro, G. O., O'Hare, M. J., Callaghan, S. M., Slack, R. S., & Park, D. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0155-04.2004 · Cited by 108
Cell death decision by p53 via control of the mitochondrial membrane
Dashzeveg, N. K., & Yoshida, K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.019 · Cited by 108
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Sun, R., Zhang, Y., Lv, Q., Liu, B., Jin, M., Zhang, W., He, Q., Deng, M., Liu, X., Li, G., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178798 · Cited by 109
Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis
Rudner, J., Lepple‐Wienhues, A., Budach, W., Berschauer, J. E., Friedrich, B., Wesselborg, S., Schulze‐Osthoff, K., & Belka, C. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4161 · Cited by 107
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Cui, D., Qu, R., Liu, D., Xiong, X., Liang, T., & Zhao, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.775507 · Cited by 112
Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F
Hershko, T., Chaussepied, M., Oren, M., & Ginsberg, D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401575 · Cited by 107
Dral Is a P53-Responsive Gene Whose Four and a Half Lim Domain Protein Product Induces Apoptosis
Scholl, F. A., McLoughlin, P., Ehler, E., Giovanni, C. D., & Schäfer, B. W. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.495 · Cited by 107
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Kawase, T., Ichikawa, H., Ohta, T., Nozaki, N., Tashiro, F., Ohki, R., & Taya, Y. (2008) · Oncogene · doi:10.1038/onc.2008.32 · Cited by 105
Self-citation
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Santidrián, A. F., González‐Gironès, D. M., Iglesias‐Serret, D., Coll-Mulet, L., Cosialls, A. M., de Frías, M., Campàs, C., González-Barca, E. M., Alonso, E., Labi, V., et al. (2010) · Blood · doi:10.1182/blood-2010-05-283960 · Cited by 110
DNA Polymerase η, the Product of the Xeroderma Pigmentosum Variant Gene and a Target of p53, Modulates the DNA Damage Checkpoint and p53 Activation
Liu, G., & Chen, X. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1398-1413.2006 · Cited by 104
Cell death at the intestinal epithelial front line
Delgado, M. E., Grabinger, T., & Brunner, T. (2015) · FEBS Journal · doi:10.1111/febs.13575 · Cited by 107
Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells
Zhou, M., Tu, W.-W., & Xu, J. (2015) · Toxicon · doi:10.1016/j.toxicon.2015.05.005 · Cited by 107
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Terui, T., Murakami, K., Takimoto, R., Takahashi, M., Takada, K., Murakami, T., Minami, S., Matsunaga, T., Takayama, T., Kato, J., et al. (2003) · PubMed · Cited by 104
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Jordan, J. J., Menendez, D., Inga, A., Nourredine, M., Bell, D., & Resnick, M. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000104 · Cited by 103
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Belka, C., & Budach, W. (2002) · International Journal of Radiation Biology · doi:10.1080/09553000210137680 · Cited by 105
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Shibue, T., Suzuki, S., Okamoto, H., Yoshida, H., Ohba, Y., Takaoka, A., & Taniguchi, T. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601359 · Cited by 104
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Authors: Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N.
Affiliations: The University of Tokyo (JP)
Sapporo Medical University (JP)
Corresponding author: Oda, Eri
Ohki, Rieko
ORCID: Ohki, Rieko
Murasawa, Hideki
Shibue, Tsukasa
Tokino, Takashi
Taniguchi, Tadatsugu
Tanaka, † Nobuyuki
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-05-12
Volume: 288
Issue: 5468
Pages: 1053-1058
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.288.5468.1053
OpenAlex: W2024996523
Cited by: 2,112
References: 43
Citations by year: 2026: 21 · 2025: 36 · 2024: 51 · 2023: 56 · 2022: 44 · 2021: 62 · 2020: 65 · 2019: 71 · 2018: 59 · 2017: 67 · 2016: 76 · 2015: 77 · 2014: 73 · 2013: 83 · 2012: 89
FWCI: 39.09
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords: Noxa, BH3-only proteins, Bcl-2 family proteins, p53, X-ray irradiation, mitochondrial localization, caspase-9 activation, tumor suppressor
MeSH terms: Amino Acid Sequence, Animals, Cell Line, Cells, Cultured, DNA Damage, Enzyme Activation, Gene Expression Regulation, Humans, Mitochondria, Molecular Sequence Data, Promoter Regions, Genetic, Proto-Oncogene Proteins, RNA, Messenger, T-Lymphocytes, Tumor Suppressor Protein p53, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Amino Acid Substitution, Caspases, Amino Acid Motifs, Gene Expression Profiling, bcl-2-Associated X Protein, Mice, Caspase 9

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Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

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