The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Impaired Cued and Contextual Memory in NPAS2-Deficient Mice
Abstract
Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a β-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory.
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Cites
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The mesolimbic dopamine reward circuit in depression
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New approaches to antidepressant drug discovery: beyond monoamines
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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
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Self-citation
Metadata
- Authors
- Garcia, J. A., Zhang, D., Estill, S. J., Michnoff, C., Rutter, J., Reick, M., Scott, K., Diaz-Arrastia, R., & McKnight, S. L.
- Venue
- Science
- Published
- 2000-06-23
- Volume
- 288
- Issue
- 5474
- Pages
- 2226-2230
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040804871
- Cited by
- 244
- References
- 9
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
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