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Cited by 1,894Neural and Behavioral Psychology StudiesPsychopathy, Forensic Psychiatry, Sexual OffendingNeurotransmitter Receptor Influence on Behavior

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Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence

Davidson, Richard J., Putnam, Katherine M., Larson, Christine L.·2000·Science
DOI 10.1126/science.289.5479.591
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Abstract

Emotion is normally regulated in the human brain by a complex circuit consisting of the orbital frontal cortex, amygdala, anterior cingulate cortex, and several other interconnected regions. There are both genetic and environmental contributions to the structure and function of this circuitry. We posit that impulsive aggression and violence arise as a consequence of faulty emotion regulation. Indeed, the prefrontal cortex receives a major serotonergic projection, which is dysfunctional in individuals who show impulsive violence. Individuals vulnerable to faulty regulation of negative emotion are at risk for violence and aggression. Research on the neural circuitry of emotion regulation suggests new avenues of intervention for such at-risk populations.

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Research works printed but not linked: 65

  1. R. J. Davidson in The Cognitive Neurosciences M. S. Gazzaniga Ed. (MIT Press Cambridge MA 2000) pp.1149–1159.
  2. L. Berkowitz in Handbook of Cognition and Emotion T. Dagleish and M. Power Eds. (Wiley Chichester UK 1999) pp. 411–428.
  3. ___ in Handbook of Affective Sciences R. J. Davidson K. Scherer H. H. Goldsmith Eds. (Oxford Univ. Press New York in press).
  4. M. Linnoila D. S. Charney in The Neurobiology of Mental Illness D. S. Charney E. J. Nestler B. S. Bunney Eds. (Oxford Univ. Press New York 1999) pp. 855–871.
  5. Barratt E. S., et al., Psychiatry Res. 86, 163 (1999). · DOI
  6. Davidson R. J., Irwin W., Trends Cognit. Sci. 3, 11 (1999). · DOI · Paper page
  7. R. J. Davidson D. C. Jackson N. H. Kalin Psychol. Bull. in press.
  8. 10.1016/S1364-6613(00)01483-2 · DOI · Paper page
  9. S. J. DeArrnond M. M. Fusco M. M. Dewey Structure of the Human Brain: A Photographic Atlas (Oxford Univ. Press New York 3rd ed. 1989).
  10. E. T. Rolls The Brain and Emotion (Oxford Univ. Press New York 1999). · DOI
  11. Holland P. C., Gallagher M., Trends Cognit. Sci. 3, 65 (1999). · DOI
  12. Whalen P. J., et al., J. Neurosci. 18, 411 (1998). · DOI · Paper page
  13. Buchel C., Morris J. S., Dolan R. J., Friston K. J., Neuron 20, 947 (1998). · DOI · Paper page
  14. 10.1016/S0896-6273(00)80475-4 · DOI · Paper page
  15. W. Irwin et al. Neuroreport 7 1765 (1996). · DOI
  16. Blair R. J., et al., Brain 122, 883 (1999). · DOI · Paper page
  17. D. D. Dougherty et al. Biol. Psychiatry 46 466 (1999). · DOI
  18. Kimbrell T. A., et al., Biol. Psychiatry 46, 454 (1999). · DOI
  19. M. Davis in The Amygdala J. P. Aggleton Ed. (Wiley-Liss New York 1992) pp. 255–306.
  20. Sutton S. K., et al., Psychophysiology 34, 217 (1997). · DOI
  21. Larson C. L., Ruffalo D., Nietert J. Y., Davidson R. J., Psychophysiology 37, 92 (2000). · DOI
  22. D. C. Jackson J. R. Malmstadt C. L. Larson R. J. Davidson Psychophysiology in press.
  23. Davis M., J. Neuropsychiatry Clin. Neurosci. 9, 382 (1997). · DOI
  24. Vrana S. R., Spence E. L., Lang P. J., J. Abnorm. Psychol. 97, 487 (1988). · DOI
  25. Lang P. J., Am. Psychol. 50, 372 (1995). · DOI
  26. ___ D. C. Jackson C. L. Larson in Handbook of Psychophysiology J. T. Cacioppo L. Tassinary G. Bernston Eds. (Cambridge Univ. Press New York 2000) pp. 27–52.
  27. 10.1126/science.275.5304.1293 · DOI · Paper page
  28. Gewirtz J. C., Falls W. A., Davis M., Behav. Neurosci. 111, 712 (1997). · DOI
  29. S. M. Schaefer et al. Neurosci. Abstr. in press.
  30. E. F. Coccaro Br. J. Psychiatry Suppl. 52 (1989). · DOI
  31. M. Virkkunen et al. Arch. Gen. Psychiatry 51 20 (1994). · DOI
  32. Linnoila M., DeJong J., Virkkunen M., Psychopharmacol. Bull. 25, 404 (1989).
  33. Roy A., Adinoff B., Linnoila M., Psychiatry Res. 24, 187 (1988). · DOI
  34. Mann J. J., Nature Med. 4, 25 (1998). · DOI
  35. M. J. Kruesi et al. Arch. Gen. Psychiatry 49 429 (1992). · DOI
  36. Virkkunen M., et al., Arch. Gen. Psychiatry 46, 600 (1989). · DOI
  37. Linnoila M., et al., Life Sci. 33, 2609 (1983). · DOI · Paper page
  38. Virkkunen M., Nuutila A., Goodwin F. K., Linnoila M., Arch. Gen. Psychiatry 44, 241 (1987). · DOI
  39. Moss H. B., Yao J. K., Panzak G. L., Biol. Psychiatry 28, 325 (1990). · DOI
  40. Manuck S. B., et al., Neuropsychopharmacology 19, 287 (1998). · DOI
  41. Wurtman R. J., Hefti F., Melamed E., Pharmacol. Rev. 32, 315 (1980).
  42. Bjork J. M., et al., Psychopharmacology 142, 24 (1999). · DOI
  43. Cleare A. J., Bond A. J., Psychopharmacology 118, 72 (1995). · DOI
  44. Chamberlain B., Ervin F. R., Pihl R. O., Young S. N., Pharmacol. Biochem. Behav. 28, 503 (1987). · DOI
  45. D. A. Nielsen et al. Arch. Gen. Psychiatry 51 34 (1994). · DOI
  46. Manuck S. B., et al., Biol. Psychiatry 45, 603 (1999). · DOI
  47. Biver F., et al., Neurosci. Lett. 204, 25 (1996). · DOI
  48. Mann J. J., et al., J. Cereb. Blood Flow Metab. 16, 418 (1996). · DOI
  49. Siever L. J., et al., Neuropsychopharmacology 20, 413 (1999). · DOI
  50. Soloff P. H., et al., Biol. Psychiatry 47, 540 (2000). · DOI
  51. Volkow N. D., et al., Psychiatry Res. 61, 243 (1995). · DOI
  52. Goyer P. F., et al., Neuropsychopharmacology 10, 21 (1994). · DOI
  53. A. Raine et al. Biol. Psychiatry 36 365 (1994). · DOI
  54. Raine A., Buchsbaum M., LaCasse L., Biol. Psychiatry 42, 495 (1997). · DOI
  55. A. Raine et al. Behav. Sci. Law 16 319 (1998). · DOI
  56. Anderson S. W., et al., Nature Neurosci. 2, 1032 (1999). · DOI · Paper page
  57. Blair R. J., Cipolotti L., Brain 123, 1122 (2000). · DOI
  58. Raine A., et al., Arch. Gen. Psychiatry 57, 119 (2000). · DOI
  59. F. G. Woermann et al. J. Neurol. Neurosurg. Psychiatry 68 162 (2000). · DOI
  60. J. D. Higley et al. Biol. Psychiatry 40 1067 (1996). · DOI
  61. Kaplan J. R., et al., Psychosoma. Med. 56, 479 (1994). · DOI
  62. N. J. Emery and D. G. Amaral in The Cognitive Neuroscience of Emotion R. D. Lane and L. Nadal Eds. (Oxford Univ. Press New York 2000) pp. 156–191. · DOI
  63. Öngür D., Price J. L., Cereb. Cortex 10, 206 (2000). · DOI · Paper page
  64. 10.1093/cercor/10.3.220 · DOI · Paper page
  65. Coccaro E. F., Kavoussi R. J., Arch. Gen. Psychiatry 54, 1081 (1997). · DOI

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Metadata

Authors
Davidson, R. J., Putnam, K. M., & Larson, C. L.
Affiliations
University of Wisconsin System (US)
Corresponding author
Davidson, Richard J.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2000-07-28
Volume
289
Issue
5479
Pages
591-594
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.289.5479.591
OpenAlex
W1984030600
Cited by
1,894
References
6
Citations by year
2026: 26 · 2025: 35 · 2024: 41 · 2023: 45 · 2022: 52 · 2021: 66 · 2020: 61 · 2019: 79 · 2018: 96 · 2017: 95 · 2016: 87 · 2015: 95 · 2014: 106 · 2013: 104 · 2012: 84
FWCI
4.70
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh040747-14)
  • National Institute of Mental Health (P50-MH 52354, P50MH052354, MH40747, MH 43454)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
emotion regulation, neural circuits, impulsive aggression, violence, orbitofrontal cortex, amygdala, anterior cingulate cortex, serotonergic system, prefrontal cortex, negative emotions, genetic and environmental contributions, vulnerable populations, intervention
MeSH terms
Affect, Aggression, Amygdala, Anger, Animals, Brain, Cues, Emotions, Humans, Impulsive Behavior, Neural Pathways, Serotonin, Violence, Prefrontal Cortex

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