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Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence

Davidson, Richard J., Putnam, Katherine M., Larson, Christine L.·2000·Science

DOI 10.1126/science.289.5479.591

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Abstract

Emotion is normally regulated in the human brain by a complex circuit consisting of the orbital frontal cortex, amygdala, anterior cingulate cortex, and several other interconnected regions. There are both genetic and environmental contributions to the structure and function of this circuitry. We posit that impulsive aggression and violence arise as a consequence of faulty emotion regulation. Indeed, the prefrontal cortex receives a major serotonergic projection, which is dysfunctional in individuals who show impulsive violence. Individuals vulnerable to faulty regulation of negative emotion are at risk for violence and aggression. Research on the neural circuitry of emotion regulation suggests new avenues of intervention for such at-risk populations.

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Authors: Davidson, R. J., Putnam, K. M., & Larson, C. L.
Affiliations: University of Wisconsin System (US)
Corresponding author: Davidson, Richard J.
ORCID: Davidson, Richard J.
Larson, Christine L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-07-28
Volume: 289
Issue: 5479
Pages: 591-594
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.289.5479.591
OpenAlex: W1984030600
Cited by: 1,894
References: 6
Citations by year: 2026: 26 · 2025: 35 · 2024: 41 · 2023: 45 · 2022: 52 · 2021: 66 · 2020: 61 · 2019: 79 · 2018: 96 · 2017: 95 · 2016: 87 · 2015: 95 · 2014: 106 · 2013: 104 · 2012: 84
FWCI: 4.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01mh040747-14)
National Institute of Mental Health (P50-MH 52354, P50MH052354, MH40747, MH 43454)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: emotion regulation, neural circuits, impulsive aggression, violence, orbitofrontal cortex, amygdala, anterior cingulate cortex, serotonergic system, prefrontal cortex, negative emotions, genetic and environmental contributions, vulnerable populations, intervention
MeSH terms: Affect, Aggression, Amygdala, Anger, Animals, Brain, Cues, Emotions, Humans, Impulsive Behavior, Neural Pathways, Serotonin, Violence, Prefrontal Cortex

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Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence

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