The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells
Abstract
During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells produce various kinds of specified precursors that divide a limited number of times before they terminally differentiate into either neurons or glial cells. We show here that certain extracellular signals can induce oligodendrocyte precursor cells to revert to multipotential neural stem cells, which can self-renew and give rise to neurons and astrocytes, as well as to oligodendrocytes. Thus, these precursor cells have greater developmental potential than previously thought.
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Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Self-citationMabie, P. C., Mehler, M. F., Marmur, R., Papavasiliou, A., Song, Q., & Kessler, J. A. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04112.1997 · Cited by 294
Cited by
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
Visvader, J. E., & Lindeman, G. J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2499 · Cited by 3,429
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Astroglia induce neurogenesis from adult neural stem cells
Song, H., Stevens, C. F., & Gage, F. H. (2002) · Nature · doi:10.1038/417039a · Cited by 1,452
Metadata
- Authors
- Kondo, T., & Raff, M.
- Venue
- Science
- Published
- 2000-09-08
- Volume
- 289
- Issue
- 5485
- Pages
- 1754-1757
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2113964043
- Cited by
- 878
- References
- 3
- FWCI
- 14.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kondo, T., & Raff, M. (2000). Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells. Science. https://doi.org/10.1126/science.289.5485.1754
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
