The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling
Open accessAbstract
In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day.
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“These peripheral clocks are synchronized to the SCN by a multitude of signals, including glucocorticoids, which are able to “reset” some peripheral clocks in the brain and body (eg, liver), but not others.24”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [24]
In the citing paper
“Moreover, glucocorticoids are able to reset and synchronize the circadian clocks of peripheral tissues, including the liver, although the central pacemaker clock of the SCN does not respond to glucocorticoid.24”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [24]
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Metadata
- Authors
- Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U.
- Affiliations
- Département de Biologie Moléculaire, Sciences II, Université de Genève, 30 Quai Ernest Ansermet, CH-1211 Genève, Switzerland.
- University of Geneva (CH)
- Molecular Biology of the Cell, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Federal Republic of Germany.
- German Cancer Research Center (DE)
- Corresponding author
- Kellendonk, Christoph
- Schibler, Ueli
- Venue
- Science
- Published
- 2000-09-29
- Volume
- 289
- Issue
- 5488
- Pages
- 2344-2347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060925737
- Cited by
- 1,859
- References
- 20
- Citations by year
- 2026: 65 · 2025: 62 · 2024: 87 · 2023: 76 · 2022: 89 · 2021: 90 · 2020: 91 · 2019: 79 · 2018: 79 · 2017: 87 · 2016: 86 · 2015: 83 · 2014: 79 · 2013: 89 · 2012: 71
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- circadian clock, peripheral circadian oscillators, glucocorticoid signaling, dexamethasone, phase resetting, suprachiasmatic nucleus, circadian gene expression, liver, kidney, heart, fibroblasts
- MeSH terms
- Animals, Biological Clocks, Cell Line, Circadian Rhythm, Dexamethasone, DNA-Binding Proteins, Female, Gene Expression Regulation, Kidney, Liver, Male, Mice, Inbred Strains, Mutation, Myocardium, Neurons, Nuclear Proteins, Receptors, Glucocorticoid, Suprachiasmatic Nucleus, Transcription Factors, Signal Transduction, Cell Cycle Proteins, Mice, Rats, Period Circadian Proteins
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