Neurons in Monkey Prefrontal Cortex That Track Past or Predict Future Performance
Abstract
Although frontal cortex is thought to be important in controlling behavior across long periods of time, most studies of this area concentrate on neuronal responses instantaneously relevant to the current task. In order to investigate the relationship of frontal activity to behavior over longer time periods, we trained rhesus monkeys on a difficult oculomotor task. Their performance fluctuated during the day, and the activity of prefrontal neurons, even measured while the monkeys waited for the targets to appear at the beginning of each set of trials, correlated with performance in a probabilistic rather than a determinist manner: neurons reflected past or predicted future performance, much more than they reflected current performance. We suggest that this activity is related to processes such as arousal or motivation that set the tone for behavior rather than controlling it on a millisecond basis, and could result from ascending pathways that utilize slow, second-messenger synaptic processes.
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During arousal, there is a significant temporary boost in the capacity to respond to stimuli, indicative of phasic alertness, which is manifested by improved performance on a number of visual and memory tasks.
“Previous findings demonstrated that during arousal, there is a significant temporary boost in the capacity to respond to stimuli, indicative of phasic alertness, which is manifested by improved performance on a number of visual and memory tasks [59–61].”
From The Influence of Buddhist Meditation Traditions on the Autonomic System and Attention (2015) · cites this paper as [61]
Cites
Fuster, J. M. (1997) · Cited by 2,095 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Primate frontal eye fields. I. Single neurons discharging before saccades.
Bruce, C. J., & Goldberg, M. E. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.53.3.603 · Cited by 1,584 · see citing works
Self-citationDeficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man
Petrides, M., & Milner, B. A. (1982) · Neuropsychologia · doi:10.1016/0028-3932(82)90100-2 · Cited by 1,272 · see citing works
The role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715 · see citing works
Sawaguchi, T., & Goldman‐Rakic, P. S. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.2.515 · Cited by 649 · see citing works
Visual, presaccadic, and cognitive activation of single neurons in monkey lateral intraparietal area
Colby, C. L., Duhamel, J. R., & Goldberg, M. E. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.5.2841 · Cited by 631 · see citing works
Self-citationTask-Specific Neural Activity in the Primate Prefrontal Cortex
Asaad, W. F., Rainer, G., & Miller, E. K. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.451 · Cited by 524 · see citing works
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1984) · Brain Research · doi:10.1016/0006-8993(84)90351-2 · Cited by 333 · see citing works
Increase of Extracellular Dopamine in Primate Prefrontal Cortex During a Working Memory Task
Watanabe, M., Kodama, T., & Hikosaka, K. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.5.2795 · Cited by 236 · see citing works
Collins, P., Roberts, A., Dias, R. S., Everitt, B. J., & Robbins, T. W. (1998) · Journal of Cognitive Neuroscience · doi:10.1162/089892998562771 · Cited by 229 · see citing works
t Immediate Neural Plasticity Shapes Motor Performance
Dorris, T. C., Paré, M., & Munoz, D. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-j0005.2000 · Cited by 121 · see citing works
Powell, K. D., & Goldberg, M. E. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.301 · Cited by 111 · see citing works
Self-citationSawaguchi, T. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.4.2200 · Cited by 55 · see citing works
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Mushiake, H., Saito, N., Sakamoto, K., Itoyama, Y., & Tanji, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.045 · Cited by 249 · see citing works
Is a bird in the hand worth two in the future? The neuroeconomics of intertemporal decision-making
Tobias Kalenscher, A., & Pennartz, C. M. A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.11.004 · Cited by 222 · see citing works
Hamker, F. H. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh146 · Cited by 217 · see citing works
Mansouri, F. A., Matsumoto, K., & Tanaka, K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5238-05.2006 · Cited by 196 · see citing works
Amihai, I., & Kozhevnikov, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102990 · Cited by 173 · see citing works
Electrophysiological correlates of default-mode processing in macaque posterior cingulate cortex
Hayden, B. Y., Smith, D. V., & Platt, M. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812035106 · Cited by 169 · see citing works
Coding and Monitoring of Motivational Context in the Primate Prefrontal Cortex
Watanabe, M., Hikosaka, K., Sakagami, M., & Shirakawa, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02391.2002 · Cited by 159 · see citing works
Influence of history on saccade countermanding performance in humans and macaque monkeys
Emeric, E. E., Brown, J. W., Boucher, L., Carpenter, R. H. S., Hanes, D. P., Harris, R., Logan, G. D., Mashru, R. N., Paré, M., Pouget, P., et al. (2007) · Vision Research · doi:10.1016/j.visres.2006.08.032 · Cited by 151 · see citing works
Hörzer, G. M., Legenstein, R. A., & Maass, W. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs348 · Cited by 135 · see citing works
Integration of Cognitive and Motivational Context Information in the Primate Prefrontal Cortex
Watanabe, M., & Sakagami, M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm067 · Cited by 107 · see citing works
Spatial Navigation and Hippocampal Place Cell Firing: The Problem of Goal Encoding
Poucet, B., Lenck‐Santini, P., Hok, V., Save, É., Banquet, J. P., Gaussier, P., & Muller, R. U. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.2.89 · Cited by 102 · see citing works
Prefrontal Neurons Coding Suppression of Specific Saccades
Hasegawa, R. P., Peterson, B. W., & Goldberg, M. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.013 · Cited by 100 · see citing works
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Opriș, I. C., & Bruce, C. J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.11.001 · Cited by 79 · see citing works
Touzani, K., Puthanveettil, S. V., & Kandel, E. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611554104 · Cited by 78 · see citing works
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Wyder, M. T., Massoglia, D. P., & Stanford, T. R. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01221.2003 · Cited by 64 · see citing works
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Chermak, G. D. (2002) · Otolaryngologic Clinics of North America · doi:10.1016/s0030-6665(02)00056-7 · Cited by 50 · see citing works
Bompas, A., Sumner, P., Muthumumaraswamy, S. D., Singh, K. D., & Gilchrist, I. D. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.11.057 · Cited by 49 · see citing works
A Model of Prefrontal Cortex Dopaminergic Modulation during the Delayed Alternation Task
Dreher, J., Guigon, E., & Burnod, Y. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760191081 · Cited by 45 · see citing works
Ceci, S. J., Fitneva, S. A., & Williams, W. M. (2010) · Psychological Review · doi:10.1037/a0019067 · Cited by 41 · see citing works
Hasegawa, R. P., Blitz, A. M., & Goldberg, M. E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01110.2003 · Cited by 40 · see citing works
Self-citationBrain Activity During the Encoding, Retention, and Retrieval of Stimulus RepresentationsPreprint
de Zubicaray, G. I., McMahon, K. L., Wilson, S. J., & Muthiah, S. (2001) · Learning & Memory · doi:10.1101/lm.40301 · Cited by 39 · see citing works
THE MOTOR CORTEX: Anatomic Substrates of Function
Naidich, T. P., Hof, P. R., Yousry, T. A., & Yousry, I. (2001) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00699-9 · Cited by 36 · see citing works
Distributed functions of prefrontal and parietal cortices during sequential categorical decisions
Zhou, Y., Rosen, M. C., Swaminathan, S. K., Masse, N. Y., Zhu, O., & Freedman, D. J. (2021) · eLife · doi:10.7554/elife.58782 · Cited by 34 · see citing works
Chermak, G. D. (2001) · The Hearing Journal · doi:10.1097/01.hj.0000294109.14504.d8 · Cited by 31 · see citing works
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Bach‐y‐Rita, P. (2001) · Neurochemical Research · doi:10.1023/a:1012300914150 · Cited by 23 · see citing works
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Sharika, K. M., Ramakrishnan, A., & Murthy, A. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90238.2008 · Cited by 23 · see citing works
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Hasegawa, R. P., Hasegawa, Y. T., & Segraves, M. A. (2006) · Neural Networks · doi:10.1016/j.neunet.2006.05.035 · Cited by 22 · see citing works
Self-citationZhang, M., Wang, X., & Goldberg, M. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407540111 · Cited by 21 · see citing works
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Yang, C., & Naya, Y. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000876 · Cited by 17 · see citing works
Graham, K., Spruston, N., & Bloss, E. B. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109837 · Cited by 15 · see citing works
Berdyyeva, T. K., & Olson, C. R. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00903.2010 · Cited by 15 · see citing works
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Zhou, Y., Liu, Y., Wu, S., & Zhang, M. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx166 · Cited by 12 · see citing works
Naidich, T. P., & Yousry, T. A. (2007) · Medical radiology · doi:10.1007/978-3-540-49976-3_3 · Cited by 12 · see citing works
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Sharika, K. M., Ray, S., & Murthy, A. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17613-6 · Cited by 10 · see citing works
Menzer, D. L., Bokil, H., Ryou, J. W., Schiff, N. D., Purpura, K. P., & Mitra, P. P. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.11.012 · Cited by 9 · see citing works
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Sailer, U., Eggert, T., Strassnig, M., Riedel, M. J., & Straube, A. M. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0749-8 · Cited by 9 · see citing works
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Nishimura, M., Yoshii, Y., Watanabe, J., & Ishiuchi, S. (2009) · Neuroreport · doi:10.1097/wnr.0b013e328330a883 · Cited by 6 · see citing works
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- Authors
- Hasegawa, R. P., Blitz, A. M., Geller, N. L., & Goldberg, M. E.
- Affiliations
- National Institutes of Health (US)
- National Heart, Lung, and Blood Institute (US)
- Corresponding author
- Hasegawa, Ryohei P.
- Venue
- Science
- Published
- 2000-12
- Volume
- 290
- Issue
- 5497
- Pages
- 1786-1789
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014187604
- Cited by
- 71
- References
- 14
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 6 · 2020: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 4 · 2012: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prefrontal cortex, oculomotor tasks, rhesus monkeys, neuronal activity, performance prediction, probabilistic forecasting, arousal, motivation, ascending pathways
- MeSH terms
- Afferent Pathways, Animals, Behavior, Animal, Cues, Forecasting, Learning, Macaca mulatta, Neurons, Neuropsychological Tests, Probability, Psychomotor Performance, Second Messenger Systems, Prefrontal Cortex
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