Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans

Mushiake, Hajime; Saito, Naohiro; Sakamoto, Kazuhiro; Itoyama, Yasuto; Tanji, Jun

doi:10.1016/j.neuron.2006.03.045

Cited by 249Neural and Behavioral Psychology StudiesMotor Control and AdaptationNeural dynamics and brain function

Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans

Open access

Mushiake, Hajime, Saito, Naohiro, Sakamoto, Kazuhiro, Itoyama, Yasuto, Tanji, Jun·2006·Neuron

DOI 10.1016/j.neuron.2006.03.045

Open this paper in CoChat — free account Open PDF

Abstract

To achieve a behavioral goal in a complex environment, we must plan multiple steps of motor behavior. On planning a series of actions, we anticipate future events that will occur as a result of each action and mentally organize the temporal sequence of events. To investigate the involvement of the lateral prefrontal cortex (PFC) in such multistep planning, we examined neuronal activity in the PFC of monkeys performing a maze task that required the planning of stepwise cursor movements to reach a goal. During the preparatory period, PFC neurons reflected each of all forthcoming cursor movements, rather than arm movements. In contrast, in the primary motor cortex, most neuronal activity reflected arm movements but little of cursor movements during the preparatory period, as well as during movement execution. Our data suggest that the PFC is involved primarily in planning multiple future events that occur as a consequence of behavioral actions.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2006.03.045

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hippocampal-prefrontal interaction has been suggested to allow rapid, subconscious evaluation of potential action sequences during decision-making, with the hippocampus simulating expected outcomes of potential actions generated and evaluated in the prefrontal.
“Hippocampal-prefrontal interaction has been suggested to allow rapid, subconscious evaluation of potential action sequences during decision-making, with the hippocampus in effect simulating the expected outcomes of potential actions that are generated and evaluated in the prefrontal (Mushiake et al., 2006; Wang et al., 2015).”
From Toward an integration of deep learning and neuroscience (2016) · cites this paper as Mushiake et al., 2006

Applied Regression Analysis
Gunst, R. F., Draper, N. R., & Smith, H. C. (1999) · Technometrics · doi:10.2307/1270576 · Cited by 3,795 · see citing works
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
Fuster, J. M. (1980) · Cited by 2,367 · see citing works
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960 · see citing works
Primate frontal eye fields. I. Single neurons discharging before saccades.
Bruce, C. J., & Goldberg, M. E. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.53.3.603 · Cited by 1,584 · see citing works
The prefrontal cortex: Anatomy, physiology, and neuropsychology of the frontal lobe
Holmes, G. L. (1989) · Journal of Epilepsy · doi:10.1016/0896-6974(89)90035-2 · Cited by 1,210 · see citing works
The Frontal Lobes and Voluntary Action
Passingham, R. (1993) · doi:10.1093/oso/9780198521853.001.0001 · Cited by 970 · see citing works
Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque
Kim, J.-N., & Shadlen, M. N. (1999) · Nature Neuroscience · doi:10.1038/5739 · Cited by 950 · see citing works
The Prefrontal Cortex: Response Selection or Maintenance Within Working Memory?
Rowe, J. B., Toni, I., Josephs, O., Frackowiak, R. S. J., & Passingham, R. E. (2000) · Science · doi:10.1126/science.288.5471.1656 · Cited by 856 · see citing works
Neuronal correlates of parametric working memory in the prefrontal cortex
Romo, R., Brody, C. D., Hernández, A., & Lemus, L. (1999) · Nature · doi:10.1038/20939 · Cited by 822 · see citing works
Self-initiated versus externally triggered movements
Jenkins, I. H., Jahanshahi, M., Jueptner, M., Passingham, R. E., & Brooks, D. J. (2000) · Brain · doi:10.1093/brain/123.6.1216 · Cited by 746 · see citing works
Representation of the Quantity of Visual Items in the Primate Prefrontal Cortex
Nieder, A., Freedman, D. J., & Miller, E. K. (2002) · Science · doi:10.1126/science.1072493 · Cited by 703 · see citing works
Reward expectancy in primate prefrental neurons
Watanabe, M. (1996) · Nature · doi:10.1038/382629a0 · Cited by 684 · cited 3× · see citing works
“, 2000; Wallis and Miller, 2003), as do reward conditions (Watanabe, 1996; Leon and Shadlen, 1999).”
Background
Neuronal activity in the primate premotor, supplementary, and precentral motor cortex during visually guided and internally determined sequential movements
Mushiake, H., Inase, M., & Tanji, J. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.3.705 · Cited by 680 · see citing works
Self-citation
Cross-modal and cross-temporal association in neurons of frontal cortex
Fuster, J. M., Bodner, M., & Kroger, J. K. (2000) · Nature · doi:10.1038/35012613 · Cited by 528 · see citing works
Task-Specific Neural Activity in the Primate Prefrontal Cortex
Asaad, W. F., Rainer, G., & Miller, E. K. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.451 · Cited by 524 · see citing works
Effect of Expected Reward Magnitude on the Response of Neurons in the Dorsolateral Prefrontal Cortex of the Macaque
Leon, M. I., & Shadlen, M. N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80854-5 · Cited by 449 · see citing works
The Frontal Cortex-Basal Ganglia System in Primates
Wise, S. P., Murray, E. A., & Gerfen, C. R. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.30 · Cited by 443 · see citing works
Specialized systems for the processing of mnemonic information within the primate frontal cortex
Petrides, M. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0130 · Cited by 443 · see citing works
Rule-dependent neuronal activity in the prefrontal cortex
White, I. M., & Wise, S. P. (1999) · Experimental Brain Research · doi:10.1007/s002210050740 · Cited by 429 · see citing works
Cerebellar complex spikes encode both destinations and errors in arm movements
Kitazawa, S., Kimura, T., & Yin, P.-B. (1998) · Nature · doi:10.1038/33141 · Cited by 401 · see citing works
From Rule to Response: Neuronal Processes in the Premotor and Prefrontal Cortex
Wallis, J. D., & Miller, E. K. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00086.2003 · Cited by 352 · see citing works
Prefrontal unit activity and delayed response: Relation to cue location versus direction of response
Niki, H., & Watanabe, M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90924-0 · Cited by 325 · see citing works
Serial Position Curve in Rats: Role of the Dorsal Hippocampus
Kesner, R. P., & Novak, J. M. (1982) · Science · doi:10.1126/science.7123228 · Cited by 310 · see citing works
Parallel processing of serial movements in prefrontal cortex
Averbeck, B. B., Chafee, M. V., Crowe, D. A., & Georgopoulos, A. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162485599 · Cited by 287 · see citing works
The Prefrontal Cortex
Miller, E. K. (1999) · Neuron · doi:10.1016/s0896-6273(00)80673-x · Cited by 283 · see citing works
The sensory nature of mnemonic representation in the primate prefrontal cortex
Constantinidis, C., Franowicz, M. N., & Goldman-Rakic, P. S. (2001) · Nature Neuroscience · doi:10.1038/85179 · Cited by 233 · see citing works
Behavioral planning in the prefrontal cortex
Tanji, J., & Hoshi, E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00192-6 · Cited by 224 · see citing works
Self-citation
Neuronal Activity in the Primate Prefrontal Cortex in the Process of Motor Selection Based on Two Behavioral Rules
Hoshi, E., Shima, K., & Tanji, J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.2355 · Cited by 204 · see citing works
Self-citation
Prefrontal Task-Related Activity Representing Visual Cue Location or Saccade Direction in Spatial Working Memory Tasks
Takeda, K., & Funahashi, S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00249.2001 · Cited by 201 · see citing works
Representation of Action Sequence Boundaries by Macaque Prefrontal Cortical Neurons
Fujii, N., & Graybiel, A. M. (2003) · Science · doi:10.1126/science.1086872 · Cited by 193 · see citing works
Primate frontal cortex: neuronal activity following attentional versus intentional cues
Boussaoud, D., & Wise, S. P. (1993) · Experimental Brain Research · doi:10.1007/bf00229650 · Cited by 179 · see citing works
Task-Dependent Selectivity of Movement-Related Neuronal Activity in the Primate Prefrontal Cortex
Hoshi, E., Shima, K., & Tanji, J. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3392 · Cited by 154 · see citing works
Self-citation
Prefrontal Cortex and the Bridging of Temporal Gaps in the Perception‐Action Cycle
Fuster, J. M. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48901.x · Cited by 140 · see citing works
Representation of Immediate and Final Behavioral Goals in the Monkey Prefrontal Cortex during an Instructed Delay Period
Saito, N., Mushiake, H., Sakamoto, K., Itoyama, Y., & Tanji, J. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi032 · Cited by 121 · see citing works
Self-citation
Representation of the Temporal Order of Visual Objects in the Primate Lateral Prefrontal Cortex
Ninokura, Y., Mushiake, H., & Tanji, J. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00647.2002 · Cited by 117 · see citing works
Self-citation
Area-Selective Neuronal Activity in the Dorsolateral Prefrontal Cortex for Information Retrieval and Action Planning
Hoshi, E., & Tanji, J. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00904.2003 · Cited by 115 · see citing works
Self-citation
Digit-muscle responses evoked from multiple intracortical foci in monkey precentral motor cortex
Sato, K., & Tanji, J. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.4.959 · Cited by 111 · see citing works
Self-citation
Monkey Prefrontal Neuronal Activity Coding the Forthcoming Saccade in an Oculomotor Delayed Matching-to-Sample Task
Hasegawa, R., Sawaguchi, T., & Kubota, K. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.322 · Cited by 88 · see citing works
Neurons in Monkey Prefrontal Cortex That Track Past or Predict Future Performance
Hasegawa, R. P., Blitz, A. M., Geller, N. L., & Goldberg, M. E. (2000) · Science · doi:10.1126/science.290.5497.1786 · Cited by 71 · see citing works
Visually based path-planning by Japanese monkeys
Mushiake, H., Saito, N., Sakamoto, K., Sato, Y., & Tanji, J. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00067-7 · Cited by 47 · see citing works
Self-citation
Circuitry of primate prefrontal cortex and regulation of behavior by representational memory
Goldman-Rakic (1987) · Medical Entomology and Zoology · Cited by 37 · see citing works
Prefrontal Neuronal Activity Encodes Spatial Target Representations Sequentially Updated After Nonspatial Target-Shift Cues
Fukushima, T., Hasegawa, I., & Miyashita, Y. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00306.2003 · Cited by 32 · see citing works

Flagged first, then by citations

Sorted by citations

States versus Rewards: Dissociable Neural Prediction Error Signals Underlying Model-Based and Model-Free Reinforcement Learning
Gläscher, J., Daw, N., Dayan, P., & O'Doherty, J. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.016 · Cited by 1,166 · see citing works
Active inference: a process theory
Friston, K., FitzGerald, T., Rigoli, F., Schwartenbeck, P., & Pezzulo, G. (2017) · Neural Computation · doi:10.1162/neco_a_00912 · Cited by 1,156 · see citing works
Beyond the comparator model: A multifactorial two-step account of agency
Synofzik, M., Vosgerau, G., & Newen, A. (2007) · Consciousness and Cognition · doi:10.1016/j.concog.2007.03.010 · Cited by 1,066 · see citing works
Choice, uncertainty and value in prefrontal and cingulate cortex
Rushworth, M. F. S., & Behrens, T. E. J. (2008) · Nature Neuroscience · doi:10.1038/nn2066 · Cited by 866 · see citing works
Active inference and epistemic value
Friston, K., Rigoli, F., Ognibene, D., Mathys, C., Fitzgerald, T., & Pezzulo, G. (2015) · Cognitive Neuroscience · doi:10.1080/17588928.2015.1020053 · Cited by 731 · see citing works
Intention, Action Planning, and Decision Making in Parietal-Frontal Circuits
Andersen, R. A., & Cui, H. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.028 · Cited by 707 · see citing works
Reading Hidden Intentions in the Human Brain
Haynes, J., Sakai, K., Rees, G. E., Gilbert, S. J., Frith, C., & Passingham, R. E. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.072 · Cited by 695 · see citing works
Active inference and learning
Friston, K., FitzGerald, T., Rigoli, F., Schwartenbeck, P., O⿿Doherty, J., & Pezzulo, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.022 · Cited by 674 · see citing works
Motor Learning
Krakauer, J. W., Hadjiosif, A. M., Xu, J., Wong, A. L., & Haith, A. M. (2019) · Comprehensive physiology · doi:10.1002/cphy.c170043 · Cited by 832 · see citing works
Emotion, Cognition, and Mental State Representation in Amygdala and Prefrontal Cortex
Salzman, C., & Fusi, S. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135256 · Cited by 581 · see citing works
The proactive brain: memory for predictions
Bar, M. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0310 · Cited by 583 · see citing works
Evidence for a distributed hierarchy of action representation in the brain
Grafton, S. T., & de C. Hamilton, A. F. (2007) · Human Movement Science · doi:10.1016/j.humov.2007.05.009 · Cited by 503 · see citing works
A unified framework for addiction: Vulnerabilities in the decision process
Redish, A. D., Jensen, S., & Johnson, A. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0800472x · Cited by 501 · see citing works
The ecology of human fear: survival optimization and the nervous system
Mobbs, D., Hagan, C. C., Dalgleish, T., Silston, B., & PrÃ©vost, C. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00055 · Cited by 498 · see citing works
Role of the lateral prefrontal cortex in executive behavioral control.
Tanji, J., & Hoshi, E. (2008) · Physiological Reviews · doi:10.1152/physrev.00014.2007 · Cited by 495 · see citing works
Self-citation
Task-Based Core-Periphery Organization of Human Brain Dynamics
Bassett, D. S., Wymbs, N. F., Rombach, M. P., Porter, M. A., Mucha, P. J., & Grafton, S. T. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003171 · Cited by 356 · see citing works
Managing competing goals — a key role for the frontopolar cortex
Mansouri, F. A., Koechlin, É., Rosa, M. G. P., & Buckley, M. J. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.111 · Cited by 330 · see citing works
Decoding a Perceptual Decision Process across Cortex
Hernández, A., Nácher, V., Luna, R., Zainos, A., Lemus, L., Álvarez, M., Vázquez, Y., Camarillo, L., & Romo, R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.031 · Cited by 269 · see citing works
Motor Planning
Wong, A. L., Haith, A. M., & Krakauer, J. W. (2014) · The Neuroscientist · doi:10.1177/1073858414541484 · Cited by 257 · see citing works
Prefrontal Cortex Fails to Learn from Reward Prediction Errors in Alcohol Dependence
Park, S. Q., Kahnt, T., Beck, A., Cohen, M. X., Dolan, R. J., Wrase, J., & Heinz, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5587-09.2010 · Cited by 257 · see citing works
Cognitive Neural Prosthetics
Andersen, R. A., Hwang, E. J., & Mulliken, G. H. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100503 · Cited by 238 · see citing works
A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila
Seeds, A. M., Ravbar, P., Chung, P., Hampel, S., Midgley, F. M., Mensh, B. D., & Simpson, J. H. (2014) · eLife · doi:10.7554/elife.02951 · Cited by 200 · see citing works
Synchronous activity of two people's prefrontal cortices during a cooperative task measured by simultaneous near-infrared spectroscopy
Funane, T., Kiguchi, M., Atsumori, H., Sato, H. R., Kubota, K., & Koizumi, H. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3602853 · Cited by 200 · see citing works
Cortical connections of the anterior (F5a) subdivision of the macaque ventral premotor area F5
Gerbella, M., Belmalih, A., Borra, E., Rozzi, S., & Luppino, G. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0293-6 · Cited by 198 · see citing works
Action semantics: A unifying conceptual framework for the selective use of multimodal and modality-specific object knowledge
van Elk, M., van Schie, H. T., & Harold Bekkering, A. (2013) · Physics of Life Reviews · doi:10.1016/j.plrev.2013.11.005 · Cited by 189 · see citing works
Motor Learning
Krakauer, J. W., Hadjiosif, A. M., Xu, J., Wong, A. L., & Haith, A. M. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00069.x · Cited by 189 · see citing works
Goal-directed decision making as probabilistic inference: A computational framework and potential neural correlates.
Solway, A., & Botvinick, M. (2012) · Psychological Review · doi:10.1037/a0026435 · Cited by 180 · see citing works
Conversion of sensory signals into perceptual decisions
Romo, R., & de Lafuente, V. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.03.007 · Cited by 181 · see citing works
Neural Correlates of Forward Planning in a Spatial Decision Task in Humans
Simon, D. A., & Daw, N. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4647-10.2011 · Cited by 181 · see citing works
The nucleus accumbens as a nexus between values and goals in goal-directed behavior: a review and a new hypothesis
Mannella, F., Gurney, K., & Baldassarre, G. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00135 · Cited by 166 · see citing works
Executive Functioning Component Mechanisms and Schizophrenia
Kerns, J. G., Nuechterlein, K. H., Braver, T. S., & Barch, D. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.027 · Cited by 163 · see citing works
Integrated Intelligence from Distributed Brain Activity
Duncan, J., Assem, M., & Shashidhara, S. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.06.012 · Cited by 170 · see citing works
The motor hierarchy: from kinematics to goals and intentions
Hamilton, A. F. D. C., & Grafton, S. T. (1993) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199231447.003.0018 · Cited by 161 · see citing works
Properties of attentional selection during the preparation of sequential saccades
Baldauf, D., & Deubel, H. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-1114-x · Cited by 150 · see citing works
Dual Neural Network Model for the Evolution of Speech and Language
Hage, S. R., & Nieder, A. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.10.006 · Cited by 148 · see citing works
Single neurons in monkey prefrontal cortex encode volitional initiation of vocalizations
Hage, S. R., & Nieder, A. (2013) · Nature Communications · doi:10.1038/ncomms3409 · Cited by 142 · see citing works
The macaque lateral grasping network: A neural substrate for generating purposeful hand actions
Borra, E., Gerbella, M., Rozzi, S., & Luppino, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.017 · Cited by 143 · see citing works
Prefrontal cortex and the evolution of symbolic reference
Nieder, A. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.04.008 · Cited by 137 · see citing works
The Versatile Wayfinder: Prefrontal Contributions to Spatial Navigation
Patai, E. Z., & Spiers, H. J. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2021.02.010 · Cited by 129 · see citing works
Intention, Choice, and the Medial Frontal Cortex
Rushworth, M. F. S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.014 · Cited by 132 · see citing works
Laminar cortical dynamics of cognitive and motor working memory, sequence learning and performance: Toward a unified theory of how the cerebral cortex works.
Grossberg, S., & Pearson, L. R. (2008) · Psychological Review · doi:10.1037/a0012618 · Cited by 131 · see citing works
Connectional Heterogeneity of the Ventral Part of the Macaque Area 46
Gerbella, M., Borra, E., Tonelli, S., Rozzi, S., & Luppino, G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs096 · Cited by 127 · see citing works
Directionality in hyperbrain networks discriminates between leaders and followers in guitar duets
Sänger, J., Müller, V., & Lindenberger, U. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00234 · Cited by 129 · see citing works
Multiple Representations of Belief States and Action Values in Corticobasal Ganglia Loops
Samejima, K., & Doya, K. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.024 · Cited by 124 · see citing works
Prefrontal Cortex Predicts State Switches during Reversal Learning
Bartolo, R., & Averbeck, B. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.024 · Cited by 123 · see citing works
From Numerosity to Ordinal Rank: A Gain-Field Model of Serial Order Representation in Cortical Working Memory
Botvinick, M., & Watanabe, T. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2110-07.2007 · Cited by 122 · see citing works
The amygdalo-motor pathways and the control of facial expressions
Gothard, K. M. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00043 · Cited by 120 · see citing works
Toward an integration of deep learning and neuroscience
Marblestone, A. H., Wayne, G., & Kording, K. P. (2016) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2016.00094 · Cited by 119 · see citing works
Is the Prefrontal Cortex Especially Enlarged in the Human Brain? Allometric Relations and Remapping Factors
Passingham, R., & Smaers, J. (2014) · Brain, Behavior and Evolution · doi:10.1159/000365183 · Cited by 101 · see citing works
Representation of Future and Previous Spatial Goals by Separate Neural Populations in Prefrontal Cortex
Genovesio, A., Brasted, P. J., & Wise, S. P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0699-06.2006 · Cited by 115 · see citing works
Planning in the brain
Mattar, M. G., & Lengyel, M. (2022) · Neuron · doi:10.1016/j.neuron.2021.12.018 · Cited by 113 · see citing works
Dopamine Modulation of Hippocampal-Prefrontal Cortical Interaction Drives Memory-Guided Behavior
Goto, Y., & Grace, A. A. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm172 · Cited by 104 · see citing works
Grasping Neurons of Monkey Parietal and Premotor Cortices Encode Action Goals at Distinct Levels of Abstraction during Complex Action Sequences
Bonini, L., Serventi, F. U., Simone, L., Rozzi, S., Ferrari, P. F., & Fogassi, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5186-10.2011 · Cited by 97 · see citing works
Neural population partitioning and a concurrent brain-machine interface for sequential motor function
Shanechi, M. M., Hu, R. C., Powers, M., Wornell, G. W., Brown, E. N., & Williams, Z. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3250 · Cited by 96 · see citing works
The Posterior Parietal Cortex Encodes in Parallel Both Goals for Double-Reach Sequences
Baldauf, D., Cui, H., & Andersen, R. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3423-08.2008 · Cited by 92 · see citing works
Distinct Information Representation and Processing for Goal-Directed Behavior in the Dorsolateral and Ventrolateral Prefrontal Cortex and the Dorsal Premotor Cortex
Yamagata, T., Nakayama, Y., Tanji, J., & Hoshi, E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2398-12.2012 · Cited by 90 · see citing works
Self-citation
Spatial Learning and Action Planning in a Prefrontal Cortical Network Model
Martinet, L., Sheynikhovich, D., Benchenane, K., & Arleo, A. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002045 · Cited by 79 · see citing works
Prefrontal Neural Correlates of Memory for Sequences
Averbeck, B. B., & Lee, D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4483-06.2007 · Cited by 76 · see citing works
Covert rapid action-memory simulation (CRAMS): a hypothesis of hippocampal-prefrontal interactions for adaptive behavior
Wang, J. X., Cohen, N. J., & Voss, J. L. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.04.003 · Cited by 75 · see citing works
Attentional Selection of Multiple Goal Positions Before Rapid Hand Movement Sequences: An Event-related Potential Study
Baldauf, D., & Deubel, H. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21021 · Cited by 75 · see citing works
Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective
Hanganu‐Opatz, I. L., Klausberger, T., Sigurdsson, T., Nieder, A., Jacob, S. N., Bartos, M., Sauer, J., Durstewitz, D., Leibold, C., & Diester, I. (2023) · Neuron · doi:10.1016/j.neuron.2023.03.017 · Cited by 73 · see citing works
Action simulation in the human brain: Twelve questions
Pezzulo, G., Candidi, M., Dindo, H., & Barca, L. (2013) · New Ideas in Psychology · doi:10.1016/j.newideapsych.2013.01.004 · Cited by 73 · see citing works
The role of immediate and final goals in action planning: An fMRI study
Majdandžić, J., Grol, M. J., van Schie, H. V., Verhagen, L., Toni, I., & Bekkering, H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.071 · Cited by 81 · see citing works
Planning Ahead: Object-Directed Sequential Actions Decoded from Human Frontoparietal and Occipitotemporal Networks
Gallivan, J. P., Johnsrude, I. S., & Flanagan, J. R. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu302 · Cited by 65 · see citing works
Model-based action planning involves cortico-cerebellar and basal ganglia networks
Fermin, A. S. R., Yoshida, T., Yoshimoto, J., Ito, M., Tanaka, S., & Doya, K. (2016) · Scientific Reports · doi:10.1038/srep31378 · Cited by 65 · see citing works
Hidden neural states underlie canary song syntax
Cohen, Y., Shen, J., Semu, D., Leman, D. P., Liberti, W. A., Perkins, L. N., Liberti, D. C., Kotton, D. N., & Gardner, T. J. (2020) · Nature · doi:10.1038/s41586-020-2397-3 · Cited by 65 · see citing works
Neural correlates of a postponed decision report
Lemus, L., Hernández, A., Luna, R., Zainos, A., Nácher, V., & Romo, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707961104 · Cited by 62 · see citing works
Tracking Progress toward a Goal in Corticostriatal Ensembles
Ma, L., Hyman, J. M., Phillips, A. G., & Seamans, J. K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3834-13.2014 · Cited by 61 · see citing works
Problem Solving as Probabilistic Inference with Subgoaling: Explaining Human Successes and Pitfalls in the Tower of Hanoi
Donnarumma, F., Maisto, D., & Pezzulo, G. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004864 · Cited by 58 · see citing works
<i>Divide et impera</i> : subgoaling reduces the complexity of probabilistic inference and problem solving
Maisto, D., Donnarumma, F., & Pezzulo, G. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.1335 · Cited by 59 · see citing works
Goal-Directed Decision Making with Spiking Neurons
Friedrich, J. H., & Lengyel, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2854-15.2016 · Cited by 57 · see citing works
Distributed Representations of Rule Identity and Rule Order in Human Frontal Cortex and Striatum
Reverberi, C., Görgen, K., & Haynes, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2344-12.2012 · Cited by 53 · see citing works
Abnormal Functional Connectivity in Cognitive Control Network, Default Mode Network, and Visual Attention Network in Internet Addiction: A Resting-State fMRI Study
Wang, Y., Qin, Y. F., Li, H., Yao, D., Sun, B., Li, Z., Li, X., Dai, Y., Wen, C., Zhang, L., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01006 · Cited by 52 · see citing works
Movement‐related activity during goal‐directed hand actions in the monkey ventrolateral prefrontal cortex
Simone, L., Rozzi, S., Bimbi, M., & Fogassi, L. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13040 · Cited by 52 · see citing works
Temporal Production Signals in Parietal Cortex
Schneider, B. A., & Ghose, G. M. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001413 · Cited by 46 · see citing works
Transient Neuronal Correlations Underlying Goal Selection and Maintenance in Prefrontal Cortex
Tsujimoto, S., Genovesio, A., & Wise, S. P. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn033 · Cited by 49 · see citing works
Planning at decision time and in the background during spatial navigation
Pezzulo, G., Donnarumma, F., Maisto, D., & Stoianov, I. P. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.04.009 · Cited by 44 · see citing works
Planning activity for internally generated reward goals in monkey amygdala neurons
Hernádi, I., Fabian Grabenhorst, B., & Schultz, W. (2015) · Nature Neuroscience · doi:10.1038/nn.3925 · Cited by 46 · see citing works
Why we may not find intentions in the brain
Uithol, S., Burnston, D. C., & Haselager, P. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.01.010 · Cited by 47 · see citing works
The Monitoring and Control of Task Sequences in Human and Non-Human Primates
Desrochers, T. M., Burk, D. C., Badre, D., & Sheinberg, D. L. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00185 · Cited by 47 · see citing works
Space representation in the prefrontal cortex
Funahashi, S. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.04.002 · Cited by 45 · see citing works
A neural model of sequential movement planning and control of eye movements: Item-Order-Rank working memory and saccade selection by the supplementary eye fields
Silver, M. R., Grossberg, S., Bullock, D. H., Histed, M. H., & Miller, E. K. (2011) · Neural Networks · doi:10.1016/j.neunet.2011.10.004 · Cited by 45 · see citing works
Discharge Synchrony during the Transition of Behavioral Goal Representations Encoded by Discharge Rates of Prefrontal Neurons
Sakamoto, K., Mushiake, H., Saito, N., Aihara, K., Yano, M., & Tanji, J. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm234 · Cited by 45 · see citing works
Self-citation
Processing and Integration of Contextual Information in Monkey Ventrolateral Prefrontal Neurons during Selection and Execution of Goal-Directed Manipulative Actions
Bruni, S., Giorgetti, V., Bonini, L., & Fogassi, L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1938-15.2015 · Cited by 46 · see citing works
Representational Switching by Dynamical Reorganization of Attractor Structure in a Network Model of the Prefrontal Cortex
Katori, Y., Sakamoto, K., Saito, N., Tanji, J., Mushiake, H., & Aihara, K. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002266 · Cited by 43 · see citing works
Self-citation
Cortico-basal ganglia networks subserving goal-directed behavior mediated by conditional visuo-goal association
Hoshi, E. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00158 · Cited by 42 · see citing works
Reactivation of behavioral activity during sharp waves: A computational model for two stage hippocampal dynamics
Molter, C., Sato, N., & Yamaguchi, Y. (2007) · Hippocampus · doi:10.1002/hipo.20258 · Cited by 42 · see citing works
Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum
Barnes, T. D., Mao, J.-B., Hu, D., Kubota, Y., Dreyer, A. A., Stamoulis, C., Brown, E. N., & Graybiel, A. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00871.2010 · Cited by 40 · see citing works
Japanese Macaques as Laboratory Animals
Isa, T., Yamane, I., Hamai, M., & Inagaki, H. (2009) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.58.451 · Cited by 39 · see citing works
Comparative Overview of Visuospatial Working Memory in Monkeys and Rats
Tsutsui, K., Oyama, K., Nakamura, S., & Iijima, T. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00099 · Cited by 39 · see citing works
Navigating complex decision spaces: Problems and paradigms in sequential choice.
Walsh, M. M., & Anderson, J. R. (2013) · Psychological Bulletin · doi:10.1037/a0033455 · Cited by 39 · see citing works
How do keas (Nestor notabilis) solve artificial-fruit problems with multiple locks?
Miyata, H., Gajdon, G. K., Huber, L., & Fujita, K. (2010) · Animal Cognition · doi:10.1007/s10071-010-0342-9 · Cited by 38 · see citing works
Interrelations between cognitive dysfunction and motor symptoms of Parkinson’s disease: behavioral and neural studies
Moustafa, A. A., Chakravarthy, V. S., Phillips, J. R., Crouse, J. J., Gupta, A., Frank, M. J., Hall, J. M., & Jahanshahi, M. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0070 · Cited by 36 · see citing works
Expectation mismatch: Differences between self-generated and cue-induced expectations
Gaschler, R., Schwager, S., Umbach, V. J., Frensch, P. A., & Schubert, T. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.009 · Cited by 34 · see citing works
Akinetic rigid symptoms are associated with decline in a cortical motor network in Parkinson’s disease
Kann, S. J., Chang, C., Manza, P., & Leung, H. (2020) · npj Parkinson s Disease · doi:10.1038/s41531-020-00120-3 · Cited by 33 · see citing works
Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics
Matsuzaka, Y., Akiyama, T., Tanji, J., & Mushiake, H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119971109 · Cited by 32 · see citing works
Self-citation
Covert Representation of Second-Next Movement in the Pre-Supplementary Motor Area of Monkeys
Nakajima, T., Hosaka, R., Mushiake, H., & Tanji, J. (2009) · Journal of Neurophysiology · doi:10.1152/jn.90636.2008 · Cited by 32 · see citing works
Self-citation
Syntactic sequencing in Hebbian cell assemblies
Wennekers, T., & Palm, G. (2009) · Cognitive Neurodynamics · doi:10.1007/s11571-009-9095-z · Cited by 29 · see citing works
Common excitatory synaptic inputs to electrically connected cortical fast-spiking cell networks
Otsuka, T., & Kawaguchi, Y. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00071.2013 · Cited by 29 · see citing works
Increased Firing Irregularity as an Emergent Property of Neural-State Transition in Monkey Prefrontal Cortex
Sakamoto, K., Katori, Y., Saito, N., Yoshida, S., Aihara, K., & Mushiake, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080906 · Cited by 13 · see citing works
Self-citation

Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans. Neuron. 50:631--641
Mushiake, H., Saito, N., Sakamoto, K., Itoyama, Y., & Tanji, J. (2006)
Self-citation
Chapter 1 Involvement of the Prefrontal Cortex in Problem Solving
Mushiake, H., Sakamoto, K., Saito, N., Inui, T., Aihara, K., & Tanji, J. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85001-0 · Cited by 27 · see citing works
Self-citation
Neuronal Synchrony During the Planning and Execution Period in the Prefrontal Cortex
Sakamoto, K., Yamamoto, K., Saito, N., Aihara, K., Tanji, J., & Mushiake, H. (2013) · Springer eBooks · doi:10.1007/978-94-007-4792-0_45 · Cited by 1 · see citing works
Self-citation
Representation of Immediate and Final Behavioral Goals in the Monkey Prefrontal Cortex during an Instructed Delay Period
Saito, N., Mushiake, H., Sakamoto, K., Itoyama, Y., & Tanji, J. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi032 · Cited by 121 · see citing works
Self-citation
Diversity of set-related neuronal activity in the dorsal premotor cortex of monkeys during a path-planning taskPreprint
Sakamoto, K., Saito, N., & Mushiake, H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.30.630724
Self-citation

Authors: Mushiake, H., Saito, N., Sakamoto, K., Itoyama, Y., & Tanji, J.
Affiliations: Tohoku University (JP)
Tamagawa University (JP)
Corresponding author: Mushiake, Hajime
ORCID: Mushiake, Hajime
Sakamoto, Kazuhiro
Venue: Neuron
Publisher: Elsevier BV
Published: 2006-05
Volume: 50
Issue: 4
Pages: 631-641
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2006.03.045
OpenAlex: W2169035993
Cited by: 249
References: 42
Citations by year: 2026: 10 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 8 · 2021: 16 · 2020: 9 · 2019: 10 · 2018: 2 · 2017: 7 · 2016: 17 · 2015: 11 · 2014: 19 · 2013: 19 · 2012: 14
FWCI: 8.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2634 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: Exploratory Research for Advanced Technology
Ministry of Education, Culture, Sports, Science and Technology
Japan Science and Technology Agency
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: lateral prefrontal cortex, action planning, primary motor cortex, neuronal activity, cursor movement, goal-directed behavior, preparatory period
MeSH terms: Animals, Behavior, Animal, Electrodes, Implanted, Eye Movements, Learning, Macaca, Motor Skills, Neurons, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks