The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor
Abstract
Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining tolerance to self antigens. These apparently contradictory roles have been suggested to depend on different subsets of DCs that arise from either myeloid or lymphoid hematopoietic origins, respectively. Although DC expression of CD8α is attributed to a lymphoid origin, here we show that both CD8α + and CD8α − DCs can arise from clonogenic common myeloid progenitors in both thymus and spleen. Thus, expression of CD8α is not indicative of a lymphoid origin, and phenotypic and functional differences among DC subsets are likely to reflect maturation status rather than ontogeny.
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Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,336
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Self-citationIdentification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
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Self-citationReciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Rissoan, M.-C., Soumelis, V., Kadowaki, N., Grouard, G., Briere, F., Malefyt, R. D. W., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.283.5405.1183 · Cited by 1,846
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
Hart, D. N. J. (1997) · Blood · doi:10.1182/blood.v90.9.3245 · Cited by 1,483
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Dendritic cells in the T‐cell areas of lymphoid organs
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CD8 is needed for development of cytotoxic T but not helper T cells
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Cited by
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
Weissman, I. L., Anderson, D. J., & Gage, F. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.387 · Cited by 948
Self-citationHematopoietic stem cell: self‐renewal versus differentiation
Seita, J., & Weissman, I. L. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.86 · Cited by 932
Self-citationPassegué, E., Jamieson, C. H. M., Ailles, L. E., & Weissman, I. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2034201100 · Cited by 686
Self-citationHepatic T cells and liver tolerance
Crispe, I. N. (2003) · Nature Reviews Immunology · doi:10.1038/nri981 · Cited by 661
Metadata
- Authors
- Traver, D., Akashi, K., Manz, M., Merad, M., Miyamoto, T., Engleman, E. G., & Weissman, I. L.
- Venue
- Science
- Published
- 2000-12-15
- Volume
- 290
- Issue
- 5499
- Pages
- 2152-2154
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975463463
- Cited by
- 393
- References
- 25
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Traver, D., Akashi, K., Manz, M., Merad, M., Miyamoto, T., Engleman, E. G., & Weissman, I. L. (2000). Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor. Science. https://doi.org/10.1126/science.290.5499.2152
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
