The DOI matches its Crossref record.
Early Signals in the Mitogenic Response
Abstract
Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
G-protein-coupled receptors and signaling networks: emerging paradigms
Marinissen, M. J., & Gutkind, J. S. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01678-3 · Cited by 1,049
Lau, L. F., & Nathans, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1182 · Cited by 856
Gutkind, J. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1839 · Cited by 812
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
Angel, P., & Karin, M. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90011-9 · Cited by 450
Mast cell tryptase is a mitogen for cultured fibroblasts
Ruoss, S. J., Hartmann, T., & Caughey, G. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115330 · Cited by 390
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310
Rozengurt, E., Sinnett-Smith, J., & Kisfalvi, K. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2229 · Cited by 247
“At the cellular level, insulin dramatically synergizes with GPCR agonists in inducing mitogenic signaling (3), and many GPCRs and their cognate agonists are implicated as autocrine-paracrine growth factors for multiple solid tumors, including pancreas, colon, prostate, and breast (1, 4).”
BackgroundSelf-citationDual activation by thyrotropin of the phospholipase c and cyclic AMP cascades in human thyroid
Laurent, E., Mockel, J., Van Sande, J., Graff, I., & Dumont, J. E. (1987) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(87)90055-4 · Cited by 174
Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts.
Dike, L. E., & Farmer, S. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6792 · Cited by 171
Miki, H., & Takagi, M. (2015) · Cytotechnology · doi:10.1007/s10616-014-9778-0 · Cited by 43
Metadata
- Authors
- Rozengurt, E.
- Venue
- Science
- Published
- 1986-10-10
- Volume
- 234
- Issue
- 4773
- Pages
- 161-166
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992472345
- Cited by
- 1,455
- References
- 0
- FWCI
- 58.02
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
