The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function
Abstract
This article reviews the electroresponsive properties of single neurons in the mammalian central nervous system (CNS). In some of these cells the ionic conductances responsible for their excitability also endow them with autorhythmic electrical oscillatory properties. Chemical or electrical synaptic contacts between these neurons often result in network oscillations. In such networks, autorhythmic neurons may act as true oscillators (as pacemakers) or as resonators (responding preferentially to certain firing frequencies). Oscillations and resonance in the CNS are proposed to have diverse functional roles, such as (i) determining global functional states (for example, sleep-wakefulness or attention), (ii) timing in motor coordination, and (iii) specifying connectivity during development. Also, oscillation, especially in the thalamo-cortical circuits, may be related to certain neurological and psychiatric disorders. This review proposes that the autorhythmic electrical properties of central neurons and their connectivity form the basis for an intrinsic functional coordinate system that provides internal context to sensory input.
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“This alternative perspective suggests that the brain is active even in the absence of task, primarily driven by internal dynamics, with external events modulating rather than determining the activity of the system (24)(25)(26)(27)(28).”
From Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems (2006) · cites this paper as [24]
Citations
Cites
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Cited by
Sorted by citations
Items 1,001–1,004 of 1,004
Polarised localisation of the voltage-gated sodium channel NaV1. 2 in cerebellar granule cells
Martínez-Hernández, J., Ballesteros-Merino, C., Fernández-Alacid, L., Nicolau, J. C., Aguado, C., & Luján, R. (2013) · The Cerebellum · doi:10.1007/s12311-012-0387-1 · Cited by 27
Soldado-Magraner, S., Brandalise, F., Honnuraiah, S., Pfeiffer, M., Moulinier, M., Gerber, U., & Douglas, R. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00506.2019 · Cited by 25
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Metadata
- Authors
- Llinás, R. R.
- Affiliations
- Department of Physiology and Biophysics, New York University Medical Center, New York, NY 10016.
- Venue
- Science
- Published
- 1988-12-23
- Volume
- 242
- Issue
- 4886
- Pages
- 1654-1664
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079173805
- Cited by
- 2,285
- References
- 110
- Citations by year
- 2026: 20 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 45 · 2021: 49 · 2020: 31 · 2019: 60 · 2018: 42 · 2017: 35 · 2016: 38 · 2015: 41 · 2014: 47 · 2013: 54 · 2012: 62
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- neuronal excitability, ionic conductance, electrical oscillations, cardiac pacemaker, neuronal resonance, network oscillations, chemical synapses, electrical synapses, sleep-wake states, attention, motor coordination, thalamocortical circuits, neuropsychiatric disorders, central nervous system
- MeSH terms
- Animals, Brain, Cell Membrane, Central Nervous System, Electric Conductivity, Electrophysiology, Ions, Neurons
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