Cited by 2,285Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchIon channel regulation and function

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The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function

Llinás, Rodolfo R.·1988·Science

DOI 10.1126/science.3059497

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Abstract

This article reviews the electroresponsive properties of single neurons in the mammalian central nervous system (CNS). In some of these cells the ionic conductances responsible for their excitability also endow them with autorhythmic electrical oscillatory properties. Chemical or electrical synaptic contacts between these neurons often result in network oscillations. In such networks, autorhythmic neurons may act as true oscillators (as pacemakers) or as resonators (responding preferentially to certain firing frequencies). Oscillations and resonance in the CNS are proposed to have diverse functional roles, such as (i) determining global functional states (for example, sleep-wakefulness or attention), (ii) timing in motor coordination, and (iii) specifying connectivity during development. Also, oscillation, especially in the thalamo-cortical circuits, may be related to certain neurological and psychiatric disorders. This review proposes that the autorhythmic electrical properties of central neurons and their connectivity form the basis for an intrinsic functional coordinate system that provides internal context to sensory input.

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Authors: Llinás, R. R.
Affiliations: Department of Physiology and Biophysics, New York University Medical Center, New York, NY 10016.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1988-12-23
Volume: 242
Issue: 4886
Pages: 1654-1664
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.3059497
OpenAlex: W2079173805
Cited by: 2,285
References: 110
Citations by year: 2026: 20 · 2025: 27 · 2024: 26 · 2023: 31 · 2022: 45 · 2021: 49 · 2020: 31 · 2019: 60 · 2018: 42 · 2017: 35 · 2016: 38 · 2015: 41 · 2014: 47 · 2013: 54 · 2012: 62
FWCI: 6.95
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: neuronal excitability, ionic conductance, electrical oscillations, cardiac pacemaker, neuronal resonance, network oscillations, chemical synapses, electrical synapses, sleep-wake states, attention, motor coordination, thalamocortical circuits, neuropsychiatric disorders, central nervous system
MeSH terms: Animals, Brain, Cell Membrane, Central Nervous System, Electric Conductivity, Electrophysiology, Ions, Neurons

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The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function

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