Cited by 1,796Advanced MRI Techniques and ApplicationsNeuroscience and Neuropharmacology ResearchMedical Imaging Techniques and Applications

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Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity

Fox, Peter T., Raichle, Marcus E., Mintun, Mark A., Dence, Carmen·1988·Science

DOI 10.1126/science.3260686

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Abstract

Brain glucose uptake, oxygen metabolism, and blood flow in humans were measured with positron emission tomography, and a resting-state molar ratio of oxygen to glucose consumption of 4.1:1 was obtained. Physiological neural activity, however, increased glucose uptake and blood flow much more (51 and 50 percent, respectively) than oxygen consumption (5 percent) and produced a molar ratio for the increases of 0.4:1. Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.

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Self-citation

Authors: Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C.
Affiliations: Washington University in St. Louis (US)
ORCID: Fox, Peter T.
Raichle, Marcus E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1988-07-22
Volume: 241
Issue: 4864
Pages: 462-464
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.3260686
OpenAlex: W1993303421
Cited by: 1,796
References: 27
Citations by year: 2026: 24 · 2025: 32 · 2024: 34 · 2023: 30 · 2022: 29 · 2021: 69 · 2020: 29 · 2019: 37 · 2018: 58 · 2017: 50 · 2016: 46 · 2015: 46 · 2014: 59 · 2013: 56 · 2012: 56
FWCI: 19.19
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 13851)
National Institute of Neurological Disorders and Stroke (NS-07025, NS 06833)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: brain glucose uptake, oxygen consumption, cerebral blood flow, neuronal activity, brain energy metabolism, local blood flow regulation
MeSH terms: Brain, Cerebrovascular Circulation, Energy Metabolism, Glucose, Humans, Neurons, Oxygen, Tomography, Emission-Computed, Visual Cortex, Visual Perception

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Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity

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