Glycolysis selectively shapes the presynaptic action potential waveform

Ultrasensitive fluorescent proteins for imaging neuronal activity

Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works

Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity

Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796 · see citing works

Synaptic Energy Use and Supply

Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747 · see citing works

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243 · see citing works

The NEURON Book

Carnevale, N. T., & Hines, M. L. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541612 · Cited by 1,199 · see citing works

Glutamate release in severe brain ischaemia is mainly by reversed uptake

Rossi, D. J., Oshima, T., & Attwell, D. (2000) · Nature · doi:10.1038/35002090 · Cited by 1,128 · see citing works

The NEURON Book

Carnevale, N. T., & Hines, M. L. (2006) · Cited by 885 · see citing works

Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions

Verstreken, P., Ly, C. V., Venken, K. J. T., Koh, T.-W., Zhou, Y., & Bellen, H. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.018 · Cited by 841 · see citing works

Activity-driven local ATP synthesis is required for synaptic function

Rangaraju, V., Calloway, N., & Ryan, T. A. (2014) · Cell · doi:10.1016/j.cell.2013.12.042 · Cited by 836 · see citing works

Rates of diffusional exchange between small cells and a measuring patch pipette

Pusch, M., & Neher, E. (1988) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582316 · Cited by 709 · see citing works

Released Fraction and Total Size of a Pool of Immediately Available Transmitter Quanta at a Calyx Synapse

Schneggenburger, R., Meyer, A. C., & Neher, E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80789-8 · Cited by 621 · see citing works

The GTPase dMiro Is Required for Axonal Transport of Mitochondria to Drosophila Synapses

Guo, X., Macleod, G. T., Wellington, A. J., Hu, F., Panchumarthi, S., Schoenfield, M., Marin, L., Charlton, M. P., Atwood, H. L., & Zinsmaier, K. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.027 · Cited by 619 · see citing works

Dynamic Control of Presynaptic Ca2+ Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons

Geiger, J. R. P., & Jónás, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00164-1 · Cited by 605 · see citing works

Lactate-supported synaptic function in the rat hippocampal slice preparation.

Schurr, A., West, C. A., & Rigor, B. (1988) · Science · doi:10.1126/science.3375817 · Cited by 594 · see citing works

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

Zala, D., Hinckelmann, M.-V., Yu, H., da Cunha, M. M. L., Liot, G., Cordelières, F. P., Marco, S., & Saudou, F. (2013) · Cell · doi:10.1016/j.cell.2012.12.029 · Cited by 459 · see citing works

Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing

Hall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451 · see citing works

Mitochondria, Calcium Regulation, and Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

Budd, S. L., & Nicholls, D. G. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67062282.x · Cited by 435 · see citing works

Energy-Efficient Action Potentials in Hippocampal Mossy Fibers

Alle, H., Roth, A., & Geiger, J. R. P. (2009) · Science · doi:10.1126/science.1174331 · Cited by 429 · see citing works

Presynaptic Mitochondrial Calcium Sequestration Influences Transmission at Mammalian Central Synapses

Billups, B., & Forsythe, I. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05840.2002 · Cited by 414 · see citing works

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7807 · Cited by 381 · see citing works

Inactivation of Presynaptic Calcium Current Contributes to Synaptic Depression at a Fast Central Synapse

Forsythe, I. D., Tsujimoto, T., Barnes‐Davies, M., Cuttle, M. F., & Takahashi, T. (1998) · Neuron · doi:10.1016/s0896-6273(00)81017-x · Cited by 356 · see citing works

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

Duchen, M. R. (1992) · Biochemical Journal · doi:10.1042/bj2830041 · Cited by 338 · see citing works

Lactate is a Preferential Oxidative Energy Substrate over Glucose for Neurons in Culture

Bouzier-Sore, A.-K., Voisin, P., Canioni, P., Magistretti, P. J., & Pellerin, L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000091761.61714.25 · Cited by 328 · see citing works

The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

Pathak, D., Shields, L. Y., Mendelsohn, B. A., Haddad, D., Lin, W., Gerencser, A. A., Kim, H., Brand, M. D., Edwards, R. H., & Nakamura, K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656405 · Cited by 311 · see citing works

Calcium dynamics associated with a single action potential in a CNS presynaptic terminal

Helmchen, F., Borst, J. G. G., & Sakmann, B. J. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78792-7 · Cited by 306 · see citing works

Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion

Lou, X., Scheuß, V., & Schneggenburger, R. (2005) · Nature · doi:10.1038/nature03568 · Cited by 289 · see citing works

Modulation of transmitter release by presynaptic resting potential and background calcium levels.

Awatramani, G., Price, G., & Trussell, L. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.038 · Cited by 285 · see citing works

Glycolytic enzymes localize to synapses under energy stress to support synaptic function

Jang, S., Nelson, J. C., Bend, E. G., Rodríguez-Laureano, L., Tueros, F. G., Cartagenova, L., Underwood, K., Jorgensen, E. M., & Colón-Ramos, D. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.011 · Cited by 270 · see citing works

Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain

Pellerin, L., Halestrap, A. P., & Pierre, K. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20307 · Cited by 269 · see citing works

Motile axonal mitochondria contribute to the variability of presynaptic strength

Sun, T., Qiao, H., Pan, P.-Y., Chen, Y., & Sheng, Z.-H. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.040 · Cited by 263 · see citing works

Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons

Trussell, L., & Jackson, M. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03306.1987 · Cited by 252 · see citing works

Pre‐ and postsynaptic glutamate receptors at a giant excitatory synapse in rat auditory brainstem slices.

Barnes‐Davies, M., & Forsythe, I. D. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020974 · Cited by 249 · see citing works

The calyx of Held

Schneggenburger, R., & Forsythe, I. D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0272-7 · Cited by 239 · see citing works

Calcium current during a single action potential in a large presynaptic terminal of the rat brainstem

Borst, J. G. G., & Sakmann, B. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.143bx.x · Cited by 227 · see citing works

The Calyx of Held Synapse: From Model Synapse to Auditory Relay

Borst, J. G. G., & van Hoeve, J. S. S. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153236 · Cited by 225 · see citing works

Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity

Tekkök, S. B., Brown, A. M., Westenbroek, R., Pellerin, L., & Ransom, B. R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20573 · Cited by 224 · see citing works

Functional Activation of Cerebral Blood Flow and Metabolism before and after Global Ischemia of Rat Brain

Ueki, M., Linn, F., & Hossmann, K. A. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.89 · Cited by 215 · see citing works

Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones

Zhou, Q., Petersen, C. C. H., & Nicoll, R. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00195.x · Cited by 214 · see citing works

Membrane-bound ATP fuels the Na/K pump. Studies on membrane-bound glycolytic enzymes on inside-out vesicles from human red cell membranes.

Mercer, R. W., & Dunham, P. B. (1981) · The Journal of General Physiology · doi:10.1085/jgp.78.5.547 · Cited by 208 · see citing works

Glycolysis and Glutamate Accumulation into Synaptic Vesicles

Ikemoto, A., Bole, D. G., & Ueda, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211617200 · Cited by 193 · see citing works

Distinct Roles of Kv1 and Kv3 Potassium Channels at the Calyx of Held Presynaptic Terminal

Ishikawa, T., Nakamura, Y., Saitoh, N., Li, W., Iwasaki, S., & Takahashi, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10445.2003 · Cited by 181 · see citing works

Glucose is Necessary to Maintain Neurotransmitter Homeostasis during Synaptic Activity in Cultured Glutamatergic Neurons

Bak, L. K., Schousboe, A., Sonnewald, U., & Waagepetersen, H. S. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600281 · Cited by 170 · see citing works

Synaptosomal bioenergetics

Kauppinen, R. A., & Nicholls, D. G. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09733.x · Cited by 150 · see citing works

Optogenetic acidification of synaptic vesicles and lysosomes

Rost, B. R., Schneider, F., Grauel, M. K., Wozny, C., Bentz, C. G., Blessing, A., Rosenmund, T., Jentsch, T. J., Schmitz, D., Hegemann, P., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4161 · Cited by 141 · see citing works

IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

Gazit, N., Vertkin, I., Shapira, I., Helm, M. S., Slomowitz, E., Sheiba, M., Mor, Y., Rizzoli, S. O., & Slutsky, I. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.034 · Cited by 138 · see citing works

Depletion of calcium in the synaptic cleft of a calyx‐type synapse in the rat brainstem

Borst, J. G. G., & Sakmann, B. J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00123.x · Cited by 132 · see citing works

Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices

Izumi, Y., Benz, A. M., Zorumski, C. F., & Olney, J. W. (1994) · Neuroreport · doi:10.1097/00001756-199401000-00021 · Cited by 132 · see citing works

EFFECTS OF GLUCOSE AND OXYGEN DEPRIVATION ON FUNCTION OF ISOLATED MAMMALIAN RETINA

Ames, A., & Gurian, B. S. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.4.617 · Cited by 122 · see citing works

Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones

Duchen, M. R. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018073 · Cited by 121 · see citing works

Beyond the mitochondrion: cytosolic PINK 1 remodels dendrites through Protein Kinase A

Dagda, R. K., Pien, I., Wang, R., Zhu, J., Wang, K. Z. Q., Callio, J., Banerjee, T. D., Dagda, R. Y., & Chu, C. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12494 · Cited by 120 · see citing works

Synaptic Vesicle Endocytosis at a CNS Nerve Terminal: Faster Kinetics at Physiological Temperatures and Increased Endocytotic Capacity During Maturation

Renden, R., & von Gersdorff, H. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00898.2007 · Cited by 118 · see citing works

Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus

Fleck, M. W., Henze, D. A., Barrionuevo, G., & Palmer, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03944.1993 · Cited by 117 · see citing works

Direct measurement of oxidative metabolism in the living brain by microdialysis: a review

Zielke, H. R., Zielke, C. L., & Baab, P. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05941.x · Cited by 116 · see citing works

The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide

Wu, K. M., Aoki, C. J., Elste, A. M., Rogalski, A. A., & Siekevitz, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13273 · Cited by 116 · see citing works

Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem

Balfour, R. H., Hansen, A. M. K., & Trapp, S. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098822 · Cited by 115 · see citing works

Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices

Ivanov, A. I., Malkov, A. E., Waseem, T., Mukhtarov, M., Buldakova, S., Gubkina, O., Zilberter, M., & Zilberter, Y. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.222 · Cited by 113 · see citing works

Neuronal glucose but not lactate utilization is positively correlated with NMDA‐induced neurotransmission and fluctuations in cytosolic Ca²⁺levels

Bak, L. K., Walls, A. B., Schousboe, A., Ring, A., Sonnewald, U., & Waagepetersen, H. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05943.x · Cited by 107 · see citing works

Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolarization mediated by the α3 Na+/K+-ATPase

Kim, J. H., Sizov, I., Dobretsov, M. G., & von Gersdorff, H. (2007) · Nature Neuroscience · doi:10.1038/nn1839 · Cited by 104 · see citing works

Mitochondrial Clearance of Cytosolic Ca2+in Stimulated Lizard Motor Nerve Terminals Proceeds without Progressive Elevation of Mitochondrial Matrix [Ca2+]

David, G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07495.1999 · Cited by 104 · see citing works

Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia

Sun, H., & Feng, Z. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.138 · Cited by 103 · see citing works

Preferential support of Ca 2+ uptake in smooth muscle plasma membrane vesicles by an endogenous glycolytic cascade

Paul, R. J., Hardin, C. D., Raeymaekers, L., Wuytack, F., & Casteels, R. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.11.2528493 · Cited by 99 · see citing works

Glycolysis and brain function: [K+]o stimulation of protein synthesis and K+ uptake require glycolysis.

Lipton, P., & Robacker, K. M. (1983) · PubMed · Cited by 98 · see citing works

NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function

Brennan, A. M., Connor, J. A., & Shuttleworth, C. W. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600292 · Cited by 97 · see citing works

Association of glycolytic enzymes with particulate fractions from nerve endings

Knull, H. R. (1978) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(78)90316-9 · Cited by 92 · see citing works

Amplitude and Kinetics of Action Potential-Evoked Ca2+Current and Its Efficacy in Triggering Transmitter Release at the Developing Calyx of Held Synapse

Yang, Y., & Wang, L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4889-05.2006 · Cited by 91 · see citing works

Software-based correction of single compartment series resistance errors

Traynelis, S. F. (1998) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(98)00140-x · Cited by 84 · see citing works

Diffusion coefficients of atp and creatine phosphate in isolated muscle: pulsed gradient 31p nmr of small biological samples

Hubley, M. J., Moerland, T. S., & Rosanske, R. C. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080205 · Cited by 77 · see citing works

Infrared-Guided Laser Stimulation of Neurons in Brain Slices

Dodt, H., Eder, M., Schierloh, A., & Zieglgänsberger, W. (2002) · Science s STKE · doi:10.1126/stke.2002.120.pl2 · Cited by 75 · see citing works

Neurone‐Specific Enolase and Creatine Phosphokinase Are Protein Components of Rat Brain Synaptic Plasma Membranes

Lim, L., Hall, C., LEUNG, T. K. C., Mahadevan, L. C., & Whatley, S. A. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb09069.x · Cited by 74 · see citing works

Adenosine A1 receptor‐mediated presynaptic inhibition at the calyx of Held of immature rats

Kimura, M., Saitoh, N., & Takahashi, T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.048371 · Cited by 67 · see citing works

Calcium clearance and its energy requirements in cerebellar neurons

Ivannikov, M. V., Sugimori, M., & Llinás, R. R. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.04.004 · Cited by 65 · see citing works

ADrosophilaTemperature-Sensitive Seizure Mutant in Phosphoglycerate Kinase Disrupts ATP Generation and Alters Synaptic Function

Wang, P., Saraswati, S., Guan, Z., Watkins, C. J., Wurtman, R. J., & Littleton, J. T. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0542-04.2004 · Cited by 59 · see citing works

Cerebral Lactate Elevation by Electroshock: A 1H Magnetic Resonance Studya

Prichard, J. W., Petroff, O. A. C., Ogino, T., & Shulman, R. G. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb32894.x · Cited by 55 · see citing works

Electrophysiology of energy metabolism and neuronal function in the hippocampal slice preparation

Schurr, A., West, C. A., & Rigor, B. M. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90004-6 · Cited by 52 · see citing works

Anaerobic glycolysis is crucial for the maintenance of neural activity in guinea pig hippocampal slices

Yamane, K., Yokono, K., & Okada, Y. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00312-5 · Cited by 46 · see citing works

Glucose depletion hyperpolarizes guinea pig hippocampal neurons by an increase in potassium conductance

Spuler, A., Endres, W., & Grafe, P. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90217-8 · Cited by 44 · see citing works

Glucose regulation of synaptic transmission in the dorsolateral septal nucleus of the rat

Shoji, S. (1992) · Synapse · doi:10.1002/syn.890120409 · Cited by 44 · see citing works

Effects of deprivation of oxygen or glucose on the neural activity in the guinea pig hippocampal slice—intracellular recording study of pyramidal neurons

Takata, T., & Okada, Y. (1995) · Brain Research · doi:10.1016/0006-8993(95)00318-k · Cited by 41 · see citing works

�ber die Erholung des Gehirns nach kompletter Isch�mie bei Hypothermie

HIRSCH, H. J., Euler, K. H., & Schneider, M. (1957) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00364181 · Cited by 39 · see citing works

Stimulation‐induced changes in NADH fluorescence and mitochondrial membrane potential in lizard motor nerve terminals

Talbot, J. D., Barrett, J. N., Barrett, E. F., & David, G. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.126383 · Cited by 37 · see citing works

Changes in FAD and NADH Fluorescence in Neurosecretory Terminals Are Triggered by Calcium Entry and by ADP Production

KOSTERIN, P. V., Kim, G. H., Muschol, M., Obaid, A. L., & Salzberg, B. M. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0824-x · Cited by 36 · see citing works

Synaptic Vesicle-bound Pyruvate Kinase can Support Vesicular Glutamate Uptake

Ishida, A., Noda, Y., & Ueda, T. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9833-3 · Cited by 35 · see citing works

2-Deoxy- D -glucose-induced changes in membrane potential, input resistance, and excitatory postsynaptic potentials of CA1 hippocampal neurons

Zhao, Y.-T., Tekkök, S. B., & Krnjević, K. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-75-5-368 · Cited by 32 · see citing works

Monomethylarsonous acid, but not inorganic arsenic, is a mitochondria-specific toxicant in vascular smooth muscle cells

Pace, C. E., Banerjee, T. D., Welch, B. M., Khalili, R., Dagda, R. K., & Angermann, J. E. (2016) · Toxicology in Vitro · doi:10.1016/j.tiv.2016.06.006 · Cited by 32 · see citing works

Inhibition of Glycolysis Alters Potassium Ion Transport and Mitochondrial Redox Activity in Rat Brain

Raffin, C. N., Sick, T. J., & Rosenthal, M. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.143 · Cited by 29 · see citing works

Distinct Pools of Non-Glycolytic Substrates Differentiate Brain Regions and Prime Region-Specific Responses of Mitochondria

Lee, D. Y., Xun, Z.-Y., Platt, V. M., Budworth, H., Canaria, C., & McMurray, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068831 · Cited by 25 · see citing works

Mechanisms underlying presynaptic Ca2+ transient and vesicular glutamate release at a CNS nerve terminal during in vitro ischaemia

Lee, S. Y., & Kim, J. H. (2015) · The Journal of Physiology · doi:10.1113/jp270060 · Cited by 24 · see citing works

The Effects of Blood Glucose Levels on Cognitive Performance: A Review of the Literature

Feldman, J., & Barshi, I. (2013) · NASA STI Repository (National Aeronautics and Space Administration) · Cited by 22 · see citing works

Effect of glucose concentration on peripheral nerve and its response to anoxia

Stecker, M. M., & Stevenson, M. (2013) · Muscle & Nerve · doi:10.1002/mus.23917 · Cited by 21 · see citing works

Direct demonstration of sulphonylurea‐sensitive KATP channels on nerve terminals of the rat motor cortex

Lee, K., Dixon, A. K., Rowe, I. C. M., Ashford, M. L. J., & Richardson, P. J. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16344.x · Cited by 21 · see citing works

Functional Expression of Rat Nav1.6 Voltage-Gated Sodium Channels in HEK293 Cells: Modulation by the Auxiliary β1 Subunit

He, B., & Soderlund, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085188 · Cited by 18 · see citing works

Influence of Glucose Deprivation on Membrane Potentials of Plasma Membranes, Mitochondria and Synaptic Vesicles in Rat Brain Synaptosomes

Hrynevich, S. V., Pekun, T. G., Waseem, T. V., & Fedorovich, S. V. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1579-0 · Cited by 18 · see citing works

ATP Hydrolysis Is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca2+Clearance

Weiler, S., Krinner, S., Wong, A. B., Moser, T., & Pangršič, T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4990-13.2014 · Cited by 13 · see citing works

Brain Glucose Metabolism: Integration of Energetics with Function.

Dienel, G. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 806 · see citing works

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

Yellen, G. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803152 · Cited by 371 · see citing works

Energy matters: presynaptic metabolism and the maintenance of synaptic transmission

Li, S., & Sheng, Z. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00535-8 · Cited by 273 · see citing works

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

Dienel, G. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24015 · Cited by 168 · see citing works

Synapses: The Brain’s Energy-Demanding Sites

Faria‐Pereira, A., & Morais, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073627 · Cited by 145 · see citing works

Brain energetics during the sleep-wake cycle

DiNuzzo, M., & Nedergaard, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.010 · Cited by 130 · see citing works

Powerhouse of the mind: mitochondrial plasticity at the synapse

Rossi, M., & Pekkurnaz, G. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.02.001 · Cited by 110 · see citing works

Brain energy metabolism: A roadmap for future research

Rae, C. D., Baur, J. A., Borges, K., Dienel, G. A., Díaz‐García, C. M., Douglass, S. R., Drew, K. L., Duarte, J. M. N., Durán, J., Kann, O., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16032 · Cited by 109 · see citing works

Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

Yang, S., Park, J. H., & Lu, H.-C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00634-3 · Cited by 94 · see citing works

Differential presynaptic ATP supply for basal and high-demand transmission

Sobieski, C., Fitzpatrick, M. J., & Mennerick, S. J. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2712-16.2017 · Cited by 74 · see citing works

Energy metabolic pathways in neuronal development and function

Rumpf, S., Sanal, N., & Marzano, M. (2023) · Oxford Open Neuroscience · doi:10.1093/oons/kvad004 · Cited by 75 · see citing works

Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla

Boillat, Y., Xin, L., van der Zwaag, W., & Gruetter, R. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19831022 · Cited by 58 · see citing works

Presynaptic Mitochondrial Volume and Packing Density Scale with Presynaptic Power Demand

Justs, K. A., Lu, Z., Chouhan, A. K., Borycz, J. A., Lu, Z., Meinertzhagen, I. A., & Macleod, G. T. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1236-21.2021 · Cited by 52 · see citing works

Chronic inhibition of brain glycolysis initiates epileptogenesis

Samokhina, E., Popova, I. Y., Malkov, A., Ivanov, A., Papadia, D., Osypov, A. A., Molchanov, M. V., Paskevich, S. I., Fisahn, A., Zilberter, M. Y., et al. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24019 · Cited by 50 · see citing works

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Koenig, J. B., Cantu, D., Low, C., Sommer, M., Noubary, F., Croker, D., Whalen, M. J., Kong, D., & Dulla, C. G. (2019) · JCI Insight · doi:10.1172/jci.insight.126506 · Cited by 50 · see citing works

Presynaptic loss of dynamin‐related protein 1 impairs synaptic vesicle release and recycling at the mouse calyx of Held

Singh, M., Denny, H., Smith, C. R., Granados, J. Z., & Renden, R. (2018) · The Journal of Physiology · doi:10.1113/jp276424 · Cited by 46 · see citing works

Lactate as a supplemental fuel for synaptic transmission and neuronal network oscillations: Potentials and limitations

Kann, O. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15867 · Cited by 44 · see citing works

Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

Lucas, S. J., Michel, C. B., Marra, V., Smalley, J. L., Hennig, M. H., Graham, B. P., & Forsythe, I. D. (2018) · The Journal of Physiology · doi:10.1113/jp275107 · Cited by 39 · see citing works

Glycolysis regulates neuronal excitability via lactate receptor, HCA1R

Skwarzyńska, D., Sun, H., Williamson, J., Kasprzak, I., & Kapur, J. (2022) · Brain · doi:10.1093/brain/awac419 · Cited by 38 · see citing works

Brain‐derived neurotrophic factor protects neurons by stimulating mitochondrial function through protein kinase A

Swain, M., Soman, S. K., Tapia, K., Dagda, R. Y., & Dagda, R. K. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15945 · Cited by 39 · see citing works

Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy

Koenig, J. B., & Dulla, C. G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00350 · Cited by 31 · see citing works

Presynaptic Diversity Revealed by Ca 2+ -Permeable AMPA Receptors at the Calyx of Held Synapse

Lujan, B., Dagostin, A., & von Gersdorff, H. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2565-18.2019 · Cited by 30 · see citing works

How Energy Supports Our Brain to Yield Consciousness: Insights From Neuroimaging Based on the Neuroenergetics Hypothesis

Chen, Y., & Zhang, J. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.648860 · Cited by 27 · see citing works

Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission

Stawarski, M., Hernandez, R. X., Feghhi, T., Borycz, J. A., Lu, Z., Agarwal, A. B., Reihl, K. D., Tavora, R., Lau, A. W. C., Meinertzhagen, I. A., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1774-19.2020 · Cited by 27 · see citing works

Developmental shift to mitochondrial respiration for energetic support of sustained transmission during maturation at the calyx of Held

Lujan, B., Singh, M., Singh, A., & Renden, R. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00333.2021 · Cited by 21 · see citing works

Mitochondrial protein synthesis and the bioenergetic cost of neurodevelopment

Bülow, P., Patgiri, A., & Faúndez, V. (2022) · iScience · doi:10.1016/j.isci.2022.104920 · Cited by 20 · see citing works

2-Deoxy- d -glucose reduces epileptiform activity by presynaptic mechanisms

Pan, Y.-Z., Sutula, T. P., & Rutecki, P. A. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00723.2018 · Cited by 20 · see citing works

Opposing effects of 2-deoxy- d -glucose on interictal- and ictal-like activity when K+currents and GABAAreceptors are blocked in rat hippocampus in vitro

Nedergaard, S., & Andreasen, M. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00732.2017 · Cited by 19 · see citing works

Presynaptic GCaMP expression decreases vesicle release probability at the calyx of Held

Singh, M., Lujan, B., & Renden, R. (2018) · Synapse · doi:10.1002/syn.22040 · Cited by 18 · see citing works

Na+-K+-ATPase functions in the developing hippocampus: regional differences in CA1 and CA3 neuronal excitability and role in epileptiform network bursting

Shao, L., Janicot, R., & Stafstrom, C. E. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00453.2020 · Cited by 18 · see citing works

Energetic substrate availability regulates synchronous activity in an excitatory neural network

Tourigny, D. S., Karim, M. K. A., Echeveste, R., Kotter, M., & O'Neill, J. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220937 · Cited by 15 · see citing works

How glycogen sustains brain function: A plausible allosteric signaling pathway mediated by glucose phosphates

DiNuzzo, M. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19856713 · Cited by 15 · see citing works

Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner

Frame, A. K., Sinka, J. L., Courchesne, M. C. J., Muhammad, R. A., Grahovac-Nemeth, S., Bernards, M. A., Bartha, R., & Cumming, R. C. (2024) · iScience · doi:10.1016/j.isci.2024.110342 · Cited by 14 · see citing works

An auditory brainstem nucleus as a model system for neuronal metabolic demands

Brosel, S., Grothe, B., & Kunz, L. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13789 · Cited by 14 · see citing works

The mitochondrial calcium uniporter inhibitor Ru265 increases neuronal excitability and reduces neurotransmission via off‐target effects

Xu, P., Swain, S., Novorolsky, R. J., Garcı́a, E., Huang, Z., Snutch, T. P., Wilson, J. J., Robertson, G. S., & Renden, R. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16425 · Cited by 14 · see citing works

Assembly and Characterization of Biocompatible Coenzyme Q10‐Enriched Lipid Nanoparticles

Moschetti, A., Vine, L. N., Lethcoe, K., Dagda, R. K., Ellison, P. A., & Ryan, R. O. (2020) · Lipids · doi:10.1002/lipd.12218 · Cited by 13 · see citing works

Changes in Metabolism and Proteostasis Drive Aging Phenotype in Aplysia californica Sensory Neurons

Kron, N. S., Schmale, M. C., & Fieber, L. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.573764 · Cited by 12 · see citing works

Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation

Sobieski, C. A., Warikoo, N., Shu, H., & Mennerick, S. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195520 · Cited by 11 · see citing works

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

Constantino, N. J., Carroll, C. M., Williams, H. C., Vekaria, H. J., Yuede, C. M., Saito, K., Sheehan, P. W., Snipes, J. A., Raichle, M. E., Musiek, E. S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2416578122 · Cited by 11 · see citing works

Age-related defects in short-term plasticity are reversed by acetyl-L-carnitine at the mouse calyx of Held

Singh, M., Miura, P., & Renden, R. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.03.015 · Cited by 9 · see citing works

D- ꞵ-hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance

Kula, B., Antal, B. B., Weistuch, C., Gackière, F., Barre, A., Velado, V., Hubbard, J. M., Kukley, M., Mujica-Parodi, L. R., & Smith, N. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae196 · Cited by 7 · see citing works

AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins

Shi, G., Scott, H. L., Azhar, N. I. F. M., Gialeli, A., Clennell, B., Lee, K. S., Hurcombe, J., Whitcomb, D. J., Coward, R. J., Wong, L., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35480-2 · Cited by 7 · see citing works

A subset of synaptic transmission events is coupled to acetyl coenzyme A production

Jakkamsetti, V., Ma, Q., & Pascual, J. M. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00200.2021 · Cited by 7 · see citing works

Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes

Moschetti, A., Dagda, R. K., & Ryan, R. O. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102439 · Cited by 5 · see citing works

Metabolic response of auditory brainstem neurons to their broad physiological activity range

Palandt, N., Resch, C., Unterlechner, P., Voshagen, L., Winhart, V. R., & Kunz, L. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16091 · Cited by 5 · see citing works

Dopamine Release Neuroenergetics in Mouse Striatal Slices

Msackyi, M., Chen, Y., Tsering, W., Wang, N., Zhao, J., & Zhang, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094580 · Cited by 5 · see citing works

Presynaptic ATP Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission

Straub, I., Kunstmann, L., Baeza‐Lehnert, F., Chowdhry, S., Renden, R., Gonzalez‐Aragón, G., Groschup, B., Hofmann, T. F., Jovanović, S., Sonntag, M., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70212 · Cited by 5 · see citing works

Harnessing metabolic control for synaptic stability: REST/NRSF links glycolytic inhibition to excitatory neurotransmission

Ferrante, D., Parisi, B., Marte, A., Marianna, D., Prestigio, C., Benzi, A., Bruzzone, S., Benfenati, F., Onofri, F., Valente, P., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288763 · Cited by 4 · see citing works

Sex-specific loss of mitochondrial membrane integrity in the auditory brainstem of a mouse model of Fragile X Syndrome

Caron, C., McCullagh, E. A., & Bertolin, G. (2025) · Open Biology · doi:10.1098/rsob.240384 · Cited by 4 · see citing works

Interdependence of cellular and network properties in respiratory rhythmogenesisPreprint

Phillips, R. S., & Baertsch, N. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.30.564834 · Cited by 2 · see citing works

Mitochondrial Health and Critical Neurotransmitters in Neurodegeneration

Sharma, N., Jain, M., & Navik, U. (2026) · Springer eBooks · doi:10.1007/978-981-95-5088-3_11 · Cited by 1 · see citing works

Bioenergetic signature of Synaptic mitochondriaPreprint

Faria‐Pereira, A., & Morais, V. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.28.625855 · Cited by 1 · see citing works

Mitochondrial membrane junction-mediated ATP channeling drives activity-dependent glucose metabolismPreprint

Yang, D., Molinaro, G., Nijem, N., Zhang, C., Penny, D., Bai, M., Lin, M.-J., Wen, X., Peña, S., Wansapura, J. P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.18.695286

The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer’s DiseasePreprint

Shao, B., Kula, B., Le, H., Venkhatesh, P., Katti, P., Marshall, A. G., Chittaranjan, S., Thapilyal, S., Kalpana, N. H., Nivedya, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.13.693635

ATP-sensitive potassium channels in neurons: Roles in and beyond metabolic control

Leão, R. M., Migliaccio, M. M., de Siqueira, D. F., & Barbosa, P. S. Z. (2026) · Current topics in membranes · doi:10.1016/bs.ctm.2026.01.001

Mitochondria-centered metabolic microdomains: Regulatory roles in synaptic plasticity and circuit homeostasis

Mohammad, S. I., Kareem, A. K., Rekha, M. M., Vasudevan, A., Jabir, M. S., Nayak, P. P., Abosaoda, M. K., Arora, V., Nanda, A., & Hsu, C. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106264

Developmental shift to mitochondrial respiration for energetic support of sustained transmission during maturation at the calyx of Held

Lujan, B., Singh, M., Singh, A., & Renden, R. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00333.2021 · Cited by 21 · see citing works

Differential presynaptic ATP supply for basal and high-demand transmission

Sobieski, C., Fitzpatrick, M. J., & Mennerick, S. J. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2712-16.2017 · Cited by 74 · see citing works

Glycolysis and Glutamate Accumulation into Synaptic Vesicles

Ikemoto, A., Bole, D. G., & Ueda, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211617200 · Cited by 193 · see citing works

Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

Lucas, S. J., Michel, C. B., Marra, V., Smalley, J. L., Hennig, M. H., Graham, B. P., & Forsythe, I. D. (2018) · The Journal of Physiology · doi:10.1113/jp275107 · Cited by 39 · see citing works

Synaptosomal Bioenergetics and the Mechanism of Amino Acid Transmitter Release

Nicholls, D. G., & Sánchez‐Prieto, J. (1988) · Springer eBooks · doi:10.1007/978-3-642-73172-3_11 · Cited by 2 · see citing works