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Cited by 770Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Bright Light Resets the Human Circadian Pacemaker Independent of the Timing of the Sleep-Wake Cycle

Czeisler, Charles A., Allan, James S., Strogatz, Steven H., Ronda, Joseph M., Sánchez, Ramiro, Ríos, C. David, Freitag, Walter O., Richardson, Gary S., Kronauer, Richard E.·1986·Science
DOI 10.1126/science.3726555
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Abstract

Human circadian rhythms were once thought to be insensitive to light, with synchronization to the 24-hour day accomplished either through social contacts or the sleep-wake schedule. Yet the demonstration of an intensity-dependent neuroendocrine response to bright light has led to renewed consideration of light as a possible synchronizer of the human circadian pacemaker. In a laboratory study, the output of the circadian pacemaker of an elderly woman was monitored before and after exposure to 4 hours of bright light for seven consecutive evenings, and before and after a control study in ordinary room light while her sleep-wake schedule and social contacts remained unchanged. The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion. The unexpected magnitude, rapidity, and stability of the shift challenge existing concepts regarding circadian phase-resetting capacity in man and suggest that exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function.

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Crossref · 10.1126/science.3726555

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29 of 29 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 18

  1. ASCHOFF, J, HUMAN CIRCADIAN-RHYTHMS - MULTI-OSCILLATORY SYSTEM, FEDERATION PROCEEDINGS 35: 2326 (1976).
  2. BROWN, E.N., SLEEP RESEARCH 14: 290 (1985).
  3. CZEISLER, C.A., SLEEP RESEARCH 14: 295 (1985).
  4. CZEISLER, C.A., SLEEP RESEARCH 15: 266 (1986).
  5. CZEISLER C.A. THESIS STANFORD U (1978).
  6. DAAN, S, TIMING OF HUMAN SLEEP - RECOVERY PROCESS GATED BY A CIRCADIAN PACEMAKER, AMERICAN JOURNAL OF PHYSIOLOGY 246: R161 (1984).
  7. GANDER, P.H., SIMULATING THE ACTION OF ZEITGEBERS ON A COUPLED 2-OSCILLATOR MODEL OF THE HUMAN CIRCADIAN SYSTEM, AMERICAN JOURNAL OF PHYSIOLOGY 247: R418 (1984).
  8. GANDER, P.H., PHASE-SHIFTING 2-COUPLED CIRCADIAN PACEMAKERS - IMPLICATIONS FOR JET-LAG, AMERICAN JOURNAL OF PHYSIOLOGY 249: R704 (1985).
  9. Klein, K. E., Chronobiology: 564 (1974).
  10. KRONAUER, R.E., MATHEMATICAL-MODEL OF THE HUMAN CIRCADIAN SYSTEM WITH 2 INTERACTING OSCILLATORS, AMERICAN JOURNAL OF PHYSIOLOGY 242: R3 (1982).
  11. KRONAUER, R.E., SLEEP RESEARCH 12: 368 (1983).
  12. Lewy, A. J., The Pineal Gland and Its Endocrine Role 65: 535 (1983).
  13. LEWY, A.J., SLEEP RESEARCH 14: 304 (1985).
  14. MCFARLAND, R.A., INFLUENCE OF CHANGING TIME ZONES ON AIR CREWS AND PASSENGERS, AEROSPACE MEDICINE 45: 648 (1974).
  15. MINORS, D.S., CHRONOBIOLOGY INTERNATIONAL 1: 205 (1985).
  16. Pittendrigh, C. S., Handbook of Behavioral Biology: Biological Rhythms 4: 95 (1981).
  17. STROGATZ, S.H., SLEEP RESEARCH 14: 219 (1985).
  18. Tepas, D. I., The Twenty-Four Hour Workday: 419 (1981).

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Metadata

Authors
Czeisler, C. A., Allan, J. S., Strogatz, S. H., Ronda, J. M., Sánchez, R., Ríos, C. D., Freitag, W. O., Richardson, G. S., & Kronauer, R. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
  • Neuroendocrinology Laboratory, Division of Endocrinology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1986-08-08
Volume
233
Issue
4764
Pages
667-671
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.3726555
OpenAlex
W2003623977
Cited by
770
References
28
Citations by year
2026: 12 · 2025: 17 · 2024: 15 · 2023: 24 · 2022: 25 · 2021: 14 · 2020: 25 · 2019: 23 · 2018: 19 · 2017: 23 · 2016: 27 · 2015: 17 · 2014: 27 · 2013: 19 · 2012: 27
FWCI
12.02
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd020174-03)
  • U.S. Public Health Service (AFOSR-83-0309)
  • National Institute on Aging (1 R01-AG-04912-02)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (1 R01-HD-20174-01)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords
circadian pacemaker, phase resetting, bright light exposure, circadian synchronization, circadian phase shift, body temperature, cortisol secretion, sleep-wake cycle, older women
MeSH terms
Aged, Body Temperature, Circadian Rhythm, Female, Humans, Hydrocortisone, Light, Sleep

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