The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation
Abstract
Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the number of M1 receptors. These results are in keeping with evidence that M2 receptors function in cholinergic nerve terminals to regulate the release of acetylcholine, whereas M1 receptors are located on postsynaptic cells and facilitate cellular excitation. New M1-selective agonists and M2-selective antagonists directed at post- or presynaptic sites deserve consideration as potential agents for the treatment of the disease.
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Citations
Cites
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,052
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M.-M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,328
NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA
Perry, E., Perry, R., Blessed, G., & Tomlinson, B. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91780-9 · Cited by 1,069
Fonnum, F. (1969) · Biochemical Journal · doi:10.1042/bj1150465 · Cited by 1,035
The organization and some projections of cholinergic neurons of the mammalian forebrain
Fibiger, H. C. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90011-x · Cited by 818
Neurotransmitter-related enzymes in senile dementia of the alzheimer type
Davies, P. (1979) · Brain Research · doi:10.1016/0006-8993(79)90336-6 · Cited by 634
The distribution of septal projections to the hippocampus of the rat
Mosko, S., Lynch, G., & Cotman, C. W. (1973) · Journal of Comparative Neurology · doi:10.1002/cne.901520204 · Cited by 370
Pre- and postsynaptic neurochemical alterations in Alzheimer's disease
Reisine, T. D., Yamamura, H. I., Bird, E. D., Spokes, E., & Enna, S. J. (1978) · Brain Research · doi:10.1016/0006-8993(78)90562-0 · Cited by 342
Raiteri, M., Leardi, R., & Marchi, M. (1984) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21528-2 · Cited by 314
Davies, P., & Verth, A. H. (1977) · Brain Research · doi:10.1016/0006-8993(77)90758-2 · Cited by 313
Cited by
The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
Hampel, H., Mesulam, M.-M., Cuello, A. C., Farlow, M. R., Giacobini, E., Grossberg, G. T., Khachaturian, A. S., Vergallo, A., Cavedo, E., Snyder, P. J., et al. (2018) · Brain · doi:10.1093/brain/awy132 · Cited by 1,918
Katzman, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604103141506 · Cited by 801
The Cholinergic Lesion of Alzheimer's Disease: Pivotal Factor or Side Show?
Mesulam, M. (2004) · Learning & Memory · doi:10.1101/lm.69204 · Cited by 467
Aubert, I., Araujo, D. M., Cécyre, D., Robitaille, Y., Gauthier, S., & Quirion, R. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09752.x · Cited by 320
Flynn, D. D., & Mash, D. C. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13113.x · Cited by 285
Self-citation
Metadata
- Authors
- Mash, D. C., Flynn, D. D., & Potter, L. T.
- Venue
- Science
- Published
- 1985-05-31
- Volume
- 228
- Issue
- 4703
- Pages
- 1115-1117
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080781505
- Cited by
- 698
- References
- 20
- FWCI
- 45.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mash, D. C., Flynn, D. D., & Potter, L. T. (1985). Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation. Science. https://doi.org/10.1126/science.3992249
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
