Cited by 152Genomics and Chromatin DynamicsT-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Research

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Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus

Mercola, Mark, Wang, Xiao-Fan, Olsen, Jory, Calame, Kathryn·1983·Science

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Abstract

Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (J h ) and the constant region of the μ chain (Cμ) can enhance transcription when it is cloned either 5′ or 3′ to the SV40 early promoter. The region between Cα and the alpha switch site, which occurs 5′ to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.

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Authors: Mercola, M., Wang, X.-F., Olsen, J., & Calame, K.
Affiliations: University of California, Los Angeles (US)
ORCID: Mercola, Mark
Wang, Xiao-Fan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1983-08-12
Volume: 221
Issue: 4611
Pages: 663-665
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.6306772
OpenAlex: W2002397775
Cited by: 152
References: 31
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 4 · 2019: 4 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 1
FWCI: 8.82
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Keywords: enhancers, immunoglobulin heavy chain locus, SV40 early promoter, c-myc oncogene, plasmacytoma, immunoglobulin gene rearrangement, mice
MeSH terms: Animals, Cloning, Molecular, Gene Expression Regulation, Genetic Vectors, Immunoglobulin Heavy Chains, Operon, Simian virus 40, Transcription, Genetic, Transfection, Mice

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Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus

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