Cited by 1,316Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology Research

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Regressive Events in Neurogenesis

Cowan, W. Maxwell, Fawcett, James W., O'Leary, Dennis D. M., Stanfield, Brent B.·1984·Science

DOI 10.1126/science.6474175

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Abstract

The development of most regions of the vertebrate nervous system includes a distinct phase of neuronal degeneration during which a substantial proportion of the neurons initially generated die. This degeneration primarily adjusts the magnitude of each neuronal population to the size or functional needs of its projection field, but in the process it seems also to eliminate many neurons whose axons have grown to either the wrong target or an inappropriate region within the target area. In addition, many connections that are initially formed are later eliminated without the death of the parent cell. In most cases such process elimination results in the removal of terminal axonal branches and hence serves as a mechanism to "fine-tune" neuronal wiring. However, there are now also several examples of the large-scale elimination of early-formed pathways as a result of the selective degeneration of long axon collaterals. Thus, far from being relatively minor aspects of neural development, these regressive phenomena are now recognized as playing a major role in determining the form of the mature nervous system.

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Authors: Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., & Stanfield, B. B.
Affiliations: Salk Institute for Biological Studies (US)
Weingart Laboratory for Developmental Neurobiology and the Clayton Foundation for Research-California Division, at the Salk Institute for Biological Studies, San Diego, California 92138.
ORCID: Fawcett, James W.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1984-09-21
Volume: 225
Issue: 4668
Pages: 1258-1265
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.6474175
OpenAlex: W1993902481
Cited by: 1,316
References: 108
Citations by year: 2026: 4 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 12 · 2013: 17 · 2012: 19
FWCI: 23.60
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurodegeneration, neuronal cell death, neurogenesis, axon elimination, axon collaterals, synaptic pruning, neuronal wiring, neural development, vertebrate nervous system
MeSH terms: Aging, Animals, Brain, Cricetinae, Nerve Degeneration, Nerve Growth Factors, Nervous System, Purkinje Cells, Retina, Superior Colliculi, Synapses, Visual Pathways, Rats

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