Cited by 1,316Neurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

Regressive Events in Neurogenesis

Cowan, W. Maxwell, Fawcett, James W., O'Leary, Dennis D. M., Stanfield, Brent B.·1984·Science

DOI 10.1126/science.6474175

Open this paper in CoChat — free account

Abstract

The development of most regions of the vertebrate nervous system includes a distinct phase of neuronal degeneration during which a substantial proportion of the neurons initially generated die. This degeneration primarily adjusts the magnitude of each neuronal population to the size or functional needs of its projection field, but in the process it seems also to eliminate many neurons whose axons have grown to either the wrong target or an inappropriate region within the target area. In addition, many connections that are initially formed are later eliminated without the death of the parent cell. In most cases such process elimination results in the removal of terminal axonal branches and hence serves as a mechanism to "fine-tune" neuronal wiring. However, there are now also several examples of the large-scale elimination of early-formed pathways as a result of the selective degeneration of long axon collaterals. Thus, far from being relatively minor aspects of neural development, these regressive phenomena are now recognized as playing a major role in determining the form of the mature nervous system.

Integrity signals

Registry

Crossref · 10.1126/science.6474175

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Plasticity of ocular dominance columns in monkey striate cortex
Hubel, D. H., Wiesel, T. N., LeVay, S., Barlow, H. B., & Gaze, R. M. (1977) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1977.0050 · Cited by 1,629
Physiology of nerve growth factor.
Thoenen, H., & Barde, Y. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,573
CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY
Glucksmann, A. (1951) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1951.tb00774.x · Cited by 1,208
The development of ocular dominance columns in normal and visually deprived monkeys
Le Vay, S., Wiesel, T. N., & Hubel, D. H. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901910102 · Cited by 1,123
Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions
Hamburger, V., & Levi‐Montalcini, R. (1949) · Journal of Experimental Zoology · doi:10.1002/jez.1401110308 · Cited by 985
Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo
Levi‐Montalcini, R., & Hamburger, V. (1951) · Journal of Experimental Zoology · doi:10.1002/jez.1401160206 · Cited by 958
Elimination of synapses in the developing nervous system
Purves, D., & Lichtman, J. W. (1980) · Science · doi:10.1126/science.7414326 · Cited by 808
Local control of neurite development by nerve growth factor
Campenot, R. B. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4516 · Cited by 747
Prenatal development of the visual system in rhesus monkey
RAKIC, P. T., Barlow, H. B., & Gaze, R. M. (1977) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1977.0040 · Cited by 739
The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action
Greene, L. A., & Shooter, E. M. (1980) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.03.030180.002033 · Cited by 734

Flagged first, then by citations

Show all 108 references

Research works printed but not linked: 24

BLAKEMORE, C, RECOVERY FROM MONOCULAR DEPRIVATION IN THE MONKEY .1. REVERSAL OF PHYSIOLOGICAL-EFFECTS IN THE VISUAL-CORTEX, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 213: 399 (1981).
CARR, V.M., DEV BRAIN RES 2: 157 (1982).
COLLIN, R, NEVRAXE 8: 181 (1906).
CONSTANTINEPATO.M, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 9: 760 (1983).
COWAN, W.M., DEV AGING NERVOUS SY: 19 (1973).
COWAN, W.M., INT REV PHYSL NEUROP 17: 149 (1978).
Crespo D. Society for Neuroscience Abstracts in press.
DELHAYEBOUCHAUD, N, EVIDENCE OF A TRANSIENT MULTI-INNERVATION OF CEREBELLAR PURKINJE-CELLS BY CLIMBING FIBERS DURING DEVELOPMENT OF RAT, COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D 281: 909 (1975).
Fawcett, J. W., Proceedings of the National Academy of Sciences of the United States of America 81: 5589 (1984).
HAMBURGER, V, AM J ANAT 102: 265 (1958).
HAMBURGER, V, NEUROSCIENCE COMMENTARIES 1: 39 (1982).
HOLLYDAY, M, LIMB DEV REGENERAT A: 183 (1983).
HORVITZ, H.R., NEUROSCIENCE COMMENTARIES 1: 56 (1982).
NARAYANAN, C.H., J EMBRYOL EXP MORPH 44: 57 (1978).
O'LEARY, D. D. M., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 25 : 126 (1984).
O'LEARY, D. D. M., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 9: 856 (1983).
O'LEARY, D. D. M., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 10: 464 (1984).
STANFIELD, B.B., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 8: 438 (1982).
STANFIELD, B.B., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 9: 375 (1983).
STENT, G.S., PHYSIOLOGICAL MECHANISM FOR HEBBS POSTULATE OF LEARNING, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 997 (1973).
STRYKER, M.P., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 7: 842 (1981).
TRUMAN, J.W., NEUROSCIENCE COMMENTARIES 1: 66 (1982).
TURLEJSKI, K, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 10: 464 (1984).
Van Essen, D. C., Neuronal Development: 333 (1982).

Sorted by citations

Items 101–200 of 1,000

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro
Milligan, C. E., Prevette, D. M., Yaginuma, H., Homma, S., Cardwellt, C., Fritz, L. C., Tomaselli, K. J., Oppenheim, R. W., & Schwartz, L. M. (1995) · Neuron · doi:10.1016/0896-6273(95)90042-x · Cited by 313
Role of Mechanical Factors in the Morphology of the Primate Cerebral Cortex
Hilgetag, C. C., & Barbas, H. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020022 · Cited by 311
Quantitative Genetic Modeling of Variation in Human Brain Morphology
Baaré, W. F. C. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.9.816 · Cited by 313
Naturally occurring cell death during neural development
Oppenheim, R. W. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90175-4 · Cited by 309
Rat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus
Whittemore, S. R., Friedman, P. L., Larhammar, D., Persson, H., Gonzalez-Carvajal, M., & Holets, V. R. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200402 · Cited by 308
Expression and possible function of nerve growth factor receptors on Schwann cells
Johnson, E. M., Taniuchi, M., & DiStefano, P. S. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90090-2 · Cited by 302
INFLUENCES ON INFANT SPEECH PROCESSING: Toward a New Synthesis
Werker, J. F., & Tees, R. C. (1999) · Annual Review of Psychology · doi:10.1146/annurev.psych.50.1.509 · Cited by 312
Energy metabolism in mammalian brain during development
Erecińska, M., Cherian, S., & Silver, I. A. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.003 · Cited by 308
The emergence of multisensory systems through perceptual narrowing
Lewkowicz, D. J., & Ghazanfar, A. A. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.08.004 · Cited by 299
Does oligodendrocyte survival depend on axons?
Barres, B. A., Jacobson, M. D., Schmid, R., Sendtner, M., & RAFF, M. C. (1993) · Current Biology · doi:10.1016/0960-9822(93)90039-q · Cited by 310
Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors
Weskamp, G., & Reichardt, L. F. (1991) · Neuron · doi:10.1016/0896-6273(91)90067-a · Cited by 292
Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system
Albers, K. M., Wright, D., & Davis, B. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01422.1994 · Cited by 292
A three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing
Murakami, T. C., Mano, T., Saikawa, S., Horiguchi, S. A., Shigeta, D., Baba, K., Sekiya, H., Shimizu, Y., Tanaka, K. F., Kiyonari, H., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0109-1 · Cited by 292
Axonogenesis in the brain of zebrafish embryos
Chitnis, A. B., & Kuwada, J. Y. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-06-01892.1990 · Cited by 288
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.Preprint
Lee, E. Y., Hu, N., Yuan, S. F., Cox, L. A., Bradley, A., Lee, W., & Herrup, K. (1994) · Genes & Development · doi:10.1101/gad.8.17.2008 · Cited by 285
Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons
Sofroniew, M. V., Galletly, N. P., Ole Isacson, A., & Svendsen, C. N. (1990) · Science · doi:10.1126/science.1688664 · Cited by 284
Neurotransmitters as developmental signals
Meier, E., Hertz, L., & Schousboe, A. (1991) · Neurochemistry International · doi:10.1016/0197-0186(91)90113-r · Cited by 278
Design and evolution of modular neural network architectures
Happel, B. L. M., & Murre, J. M. J. (1994) · Neural Networks · doi:10.1016/s0893-6080(05)80155-8 · Cited by 273
Sympathetic neuroblasts undergo a developmental switch in trophic dependence
Birren, S. J., Lo, L., & Anderson, D. J. (1993) · Development · doi:10.1242/dev.119.3.597 · Cited by 275
Electrophysiological changes during adolescence: A review
Segalowitz, S. J., Santesso, D. L., & Jetha, M. K. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.10.003 · Cited by 282
Foundations of cognitive science
Sejnowski, T. J., & Smith, P. (1990) · Choice Reviews Online · doi:10.5860/choice.28-0601 · Cited by 271
The cytomechanics of axonal elongation and retraction.
Dennerll, T. J., Lamoureux, P., Buxbaum, R. E., & Heidemann, S. R. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3073 · Cited by 264
Operational principles of neurocognitive networks
Bressler, S. L., & Tognoli, E. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.12.008 · Cited by 268
Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neuronsPreprint
Tasdemir-Yilmaz, O. E., & Freeman, M. R. (2013) · Genes & Development · doi:10.1101/gad.229518.113 · Cited by 260
Axon pruning: An essential step underlying the developmental plasticity of neuronal connections
Low, L. K., & Cheng, H.-J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1883 · Cited by 258
Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells.
Snipes, G. J., McGuire, C. B., Norden, J. J., & Freeman, J. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1130 · Cited by 258
Adrenal steroids regulate postnatal development of the rat dentate gyrus: I. Effects of glucocorticoids on cell death
Gould, E., Woolley, C. S., & McEwen, B. S. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130308 · Cited by 254
Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life
Zecevic, N., Bourgeois, J.-P., & Rakic, P. (1989) · Developmental Brain Research · doi:10.1016/0165-3806(89)90124-7 · Cited by 253
bcl-2 transgene expression can protect neurons against developmental and induced cell death.
Farlie, P. G., Dringen, R., Rees, S. M., Kannourakis, G., & Bernard, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4397 · Cited by 253
Differential immunochemical markers reveal the normal distribution of brain macrophages and microglia in the developing rat brain
Milligan, C. E., Cunningham, T. J., & Levitt, P. R. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903140112 · Cited by 252
Topographic targeting errors in the retinocollicular projection and their elimination by selective ganglion cell death
O'Leary, D., Fawcett, J. W., & Cowan, W. M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-12-03692.1986 · Cited by 251
Self-citation
Calcium as sculptor and destroyer of neural circuitry
Mattson, M. P. (1992) · Experimental Gerontology · doi:10.1016/0531-5565(92)90027-w · Cited by 250
Prenatal development of neurons in the human prefrontal cortex: I. A qualitative Golgi study
Mrzljak, L., Uylings, H. B. M., Kostović, I., & van Eden, C. G. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902710306 · Cited by 249
Direct Evidence for Wake-Related Increases and Sleep-Related Decreases in Synaptic Strength in Rodent Cortex
Liu, Z.-W., Faraguna, U., Cirelli, C., Tononi, G., & Gao, X.-B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1409-10.2010 · Cited by 248
Chapter 9 Neuronal development in human prefrontal cortex in prenatal and postnatal stages
Mrzljak, L., Uylings, H. B. M., Van Eden, G. G., & Judáš, M. (1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62681-3 · Cited by 247
The response of chick sensory neurons to brain-derived neurotrophic factor
Davies, A. M., Thoenen, H., & Barde, Y. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-07-01897.1986 · Cited by 247
NEUROTROPHINS AND THEIR RECEPTORS IN NERVE INJURY AND REPAIR
Ebadi, M., BASHIR, R. M., Heidrick, M. L., HAMADA, F. M., REFAEY, E. E., HAMED, A., HELAL, G., Baxi, M. D., CERUTIS, D. R., & Lassi, N. K. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(96)00071-x · Cited by 245
Apoptotic cell death in retinal degenerations
Remé, C. E., Grimm, C., Hafezi, F., Marti, A., & Wenzel, A. (1998) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(98)00009-3 · Cited by 246
Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus
Gould, E., Cameron, H. A., & McEwen, B. S. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903400408 · Cited by 244
Evidence That Wallerian Degeneration and Localized Axon Degeneration Induced by Local Neurotrophin Deprivation Do Not Involve Caspases
Finn, J. T., Weil, M., Archer, F., Siman, R., Srinivasan, A. N., & RAFF, M. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01333.2000 · Cited by 241
Protection of Retinal Ganglion Cells from Natural and Axotomy-Induced Cell Death in Neonatal Transgenic Mice Overexpressing bcl-2
Bonfanti, L., Strettoi, E., Chierzi, S., Cenni, M. C., Liu, X.-H., Martinou, J., Maffei, L., & Rabacchi, S. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04186.1996 · Cited by 238
Predictors of Brain Morphology for the Men of the NHLBI Twin Study
DeCarli, C. S., Miller, B. L., Swan, G. E., Reed, T., Wolf, P. A., Garner, J. R., Jack, L. M., & Carmelli, D. (1999) · Stroke · doi:10.1161/01.str.30.3.529 · Cited by 238
Drawing Abilities in Williams Syndrome: A Case Study
Stiles, J. (2000) · Developmental Neuropsychology · doi:10.1207/s15326942dn1802_5 · Cited by 236
The pedunculopontine nucleus—Auditory input, arousal and pathophysiology
Reese, N. B., García‐Rill, E., & Skinner, R. D. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00023-o · Cited by 239
Birth of projection neurons in the higher vocal center of the canary forebrain before, during, and after song learning.
Álvarez-Buylla, A., Theelen, M., & Nottebohm, F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8722 · Cited by 234
The deferred imitation task as a nonverbal measure of declarative memory.
McDonough, L., Mandler, J. M., McKee, R. D., & Squire, L. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7580 · Cited by 232
Left out axoms make men right: A hypothesis for the origin of handedness and functional asymmetry
Witelson, S. F., & Nowakowski, R. S. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90046-b · Cited by 232
Cell Loss in Isolated Human Islets Occurs by Apoptosis
Paraskevas, S., Maysinger, D., Wang, R., Duguid, W. P., & Rosenberg, L. (2000) · Pancreas · doi:10.1097/00006676-200004000-00008 · Cited by 229
Cellular mechanisms of dendrite pruning in Drosophila : insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons
Williams, D. W., & Truman, J. W. (2005) · Development · doi:10.1242/dev.01928 · Cited by 228
Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt
Bonthius, D. J., & West, J. R. (1991) · Teratology · doi:10.1002/tera.1420440203 · Cited by 225
Postnatal development of GABA-mediated synaptic inhibition in rat hippocampus
Swann, J. W., Brady, R. J., & Martin, D. L. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90004-3 · Cited by 226
Development of Human Brain Structural Networks Through Infancy and Childhood
Huang, H., Shu, N., Mishra, V., Jeon, T., Chalak, L., Wang, Z. J., Rollins, N., Gong, G., Cheng, H., Peng, Y., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht335 · Cited by 223
Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence
Lewis, J., Wesselingh, S. L., Griffin, D. E., & Hardwick, J. M. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.1828-1835.1996 · Cited by 223
Neuronal models of cognitive functions
Changeux, J., & Dehaene, S. (1989) · Cognition · doi:10.1016/0010-0277(89)90006-1 · Cited by 222
Cell death in early neural development: beyond the neurotrophic theory
de la Rosa, E. J., & de Pablo, F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01628-3 · Cited by 221
Anatomy, Development, and Function of Sexually Dimorphic Neural Circuits in the Mammalian Brain
Vries, G. J. D., & Simerly, R. B. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50066-4 · Cited by 221
An automated colorimetric microassay for neuronotrophic factors
Manthorpe, M., Fagnani, R., Skaper, S. D., & Varon, S. S. (1986) · Developmental Brain Research · doi:10.1016/0165-3806(86)90208-7 · Cited by 219
The Genetics of Schizophrenia is the Genetics of Neurodevelopment
Jones, P. B., & Murray, R. M. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.5.615 · Cited by 217
The ontogeny of excitatory amino acid receptors in the rat forebrain—II. Kainic acid receptors
Miller, L. P., Johnson, A. E., Gelhard, R. E., & Insel, T. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90118-n · Cited by 219
The perinatal reorganization of the innervation of skeletal muscle in mammals
JANSEN, J., & Fladby, T. (1990) · Progress in Neurobiology · doi:10.1016/0301-0082(90)90025-c · Cited by 212
Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit
Knapp, P. E., Skoff, R. P., & Redstone, D. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02813.1986 · Cited by 212
Functional organization of forebrain pathways for song production and perception
Margoliash, D. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19971105)33:5 · Cited by 206
Glia protect hippocampal neurons against excitatory amino acid‐induced degeneration: Involvement of fibroblast growth factor
Mattson, M. P., & Rychlik, B. (1990) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(90)90073-b · Cited by 209
Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities
Petten, C. K. V., Plante, E., Davidson, P. S. R., Kuo, T. Y., Bajuscak, L., & Glisky, E. L. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.02.009 · Cited by 215
The transient corticospinal projection from the occipital cortex during the postnatal development of the rat
Stanfield, B. B., & O’Leary, D. D. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902380210 · Cited by 206
Self-citation
Cell death and removal in the cerebral cortex during development
Ferrer, I., Soriano, E., del Rı́o, J. A., Alcántara, S., & Auladell, C. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90029-e · Cited by 207
An In Vivo Study of the Prefrontal Cortex of Schizophrenic Patients at Different Stages of Illness via Phosphorus Magnetic Resonance Spectroscopy
Stanley, J. A. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950170073010 · Cited by 204
Altered corpus callosum morphology associated with autism over the first 2 years of life
Wolff, J. J., Gerig, G., Lewis, J. D., Soda, T., Styner, M. A., Vachet, C., Botteron, K. N., Elison, J. T., Dager, S. R., Estes, A. M., et al. (2015) · Brain · doi:10.1093/brain/awv118 · Cited by 207
Advancing a Neurodevelopmental Origin for Schizophrenia
Bloom, F. E. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820150074008 · Cited by 202
Programmed cell death in the developing human telencephalon
Rakić, S., & Zečević, N. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00153.x · Cited by 209
Programmed Cell Death in Development
Sanders, E. J., & Wride, M. A. (1995) · International review of cytology · doi:10.1016/s0074-7696(08)62210-x · Cited by 193
p53 Plays a Regulatory Role in Differentiation and Apoptosis of Central Nervous System-Associated Cells
Eizenberg, O., Faber‐Elman, A., Gottlieb, E., Oren, M., Rotter, V., & Schwartz, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.5178 · Cited by 200
The fraction of cortical GABAergic neurons is constant from near the start of cortical neurogenesis to adulthood
Sahara, S., Yanagawa, Y., O'Leary, D. D. M., & Stevens, C. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6412-11.2012 · Cited by 198
Self-citation
Adrenal steroids regulate postnatal development of the rat dentate gyrus: II. Effects of glucocorticoids and mineralocorticoids on cell birth
Gould, E., Woolley, C. S., Cameron, H. A., Daniels, D. C., & McEwen, B. S. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903130309 · Cited by 194
Genesis and death of vocal control neurons during sexual differentiation in the zebra finch
Kirn, J., & Devoogd, T. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03176.1989 · Cited by 192
Neural sexual mosaicism: Sexual differentiation of the human temporo-parietal region for functional asymmetry
Witelson, S. F. (1991) · Psychoneuroendocrinology · doi:10.1016/0306-4530(91)90075-5 · Cited by 192
Molecular probes for the development and plasticity of neural crest derivatives
Anderson, D. J., & Axel, R. (1985) · Cell · doi:10.1016/0092-8674(85)90122-9 · Cited by 191
Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy
Springer, J. E., Koh, S., Tayrien, M. W., & Loy, R. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170204 · Cited by 191
Mechanisms of developmental neurite pruning
Schuldiner, O., & Yaron, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1729-6 · Cited by 190
Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism
Hill, S. Y., Bellis, M. D. D., Keshavan, M. S., Lowers, L., Shen, S., Hall, J., & Pitts, T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01088-5 · Cited by 194
Cytotoxic Effect of Brain Macrophages on Developing Neurons
Théry, C., Chamak, B., & Mallat, M. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00050.x · Cited by 190
Neuronal stem cells in the brain of adult vertebrates
Álvarez-Buylla, A., & Lois, C. (1995) · Stem Cells · doi:10.1002/stem.5530130307 · Cited by 190
Autobiographical memory and the self in time: brain lesion effects, functional neuroanatomy, and lifespan development
Levine, B. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00280-x · Cited by 189
The organization and development of the hippocampal mossy fiber system
Gaarskjaer, F. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90004-4 · Cited by 186
Neural development is regulated by classical neurotransmitters: Dopamine D2 receptor stimulation enhances neurite outgrowth
Todd, R. D. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90311-m · Cited by 187
Neuronal death in the development of the vertebrate nervous system
Clarke, R. C. (1985) · Trends in Neurosciences · doi:10.1016/0166-2236(85)90120-1 · Cited by 185
Arsenite-Induced Apoptosis in Cortical Neurons Is Mediated by c-Jun N-Terminal Protein Kinase 3 and p38 Mitogen-Activated Protein Kinase
Namgung, U., & Xia, Z. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06442.2000 · Cited by 182
Alterations of cerebral metabolism in probable Alzheimer's disease: A preliminary study
Pettegrew, J. W., Panchalingam, K., Klunk, W. E., McClure, R. J., & Muenz, L. R. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90152-x · Cited by 183
The survival of developing neurons: A review of afferent control
Linden, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90447-2 · Cited by 180
A role for action-potential activity in the development of neuronal connections in the kitten retinogeniculate pathway
Dubin, M. W., Stark, L. A., & Archer, S. M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-04-01021.1986 · Cited by 179
Neurobiological Aspects of Language in Children
Witelson, S. F. (1987) · Child Development · doi:10.1111/j.1467-8624.1987.tb01408.x · Cited by 178
The absence of significant postnatal motoneuron death in the brachial and lumbar spinal cord of the rat
Oppenheim, R. W. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902460211 · Cited by 176
Dendritic growth and remodeling of cat retinal ganglion cells during fetal and postnatal development
Ramoa, A., Campbell, G., & Shatz, C. J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04239.1988 · Cited by 175
Hippocampal Structure Predicts Statistical Learning and Associative Inference Abilities during Development
Schlichting, M. L., Guarino, K. F., Schapiro, A. C., Turk-Browne, N. B., & Preston, A. R. (2017) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01028 · Cited by 173
Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations
Peng, Y., Hao, Y., Petters, R. M., & Wong, F. (2000) · Nature Neuroscience · doi:10.1038/80639 · Cited by 173
Neuronal replacement in adult brain
Nottebohm, F. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00750-5 · Cited by 172
Calcium-activated RAF/MEK/ERK Signaling Pathway Mediates p53-dependent Apoptosis and Is Abrogated by αB-Crystallin through Inhibition of RAS Activation
Li, D. W.-C., Liu, J.-P., Mao, Y., Xiang, H., Wang, J., Ma, W.-Y., Dong, Z., Pike, H. M., Brown, R. E., & Reed, J. C. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0010 · Cited by 172
Two C. elegans genes control the programmed deaths of specific cells in the pharynx
Ellis, R. E., & Horvitz, H. R. (1991) · Development · doi:10.1242/dev.112.2.591 · Cited by 171
The early commitment of fetal neurons to the limbic cortex
Barbe, M., & Levitt, P. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00519.1991 · Cited by 169
Dynamics of microglia in the developing rat brain
Dalmau, I., Vela, J. M., González, B., Finsen, B. R., & Castellano, B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10572 · Cited by 167

Authors: Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M., & Stanfield, B. B.
Affiliations: Salk Institute for Biological Studies (US)
Weingart Laboratory for Developmental Neurobiology and the Clayton Foundation for Research-California Division, at the Salk Institute for Biological Studies, San Diego, California 92138.
ORCID: Fawcett, James W.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1984-09-21
Volume: 225
Issue: 4668
Pages: 1258-1265
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.6474175
OpenAlex: W1993902481
Cited by: 1,316
References: 108
Citations by year: 2026: 4 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 10 · 2014: 12 · 2013: 17 · 2012: 19
FWCI: 23.60
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neurodegeneration, neuronal cell death, neurogenesis, axon elimination, axon collaterals, synaptic pruning, neuronal wiring, neural development, vertebrate nervous system
MeSH terms: Aging, Animals, Brain, Cricetinae, Nerve Degeneration, Nerve Growth Factors, Nervous System, Purkinje Cells, Retina, Superior Colliculi, Synapses, Visual Pathways, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regressive Events in Neurogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks