Cell Sensitivity to Gravity
Abstract
Cultures of human lymphocytes exposed in microgravity to the mitogen concanavalin A showed less than 3 percent of the activation of ground controls. This result supports the hypothesis, based on simulations at low g and experiments at high g , that microgravity depresses whereas high gravity enhances cell proliferation rates. The effects of gravity are particularly strong in cells undergoing differentiation.
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The immune system is already affected by spaceflight per se, and vigorous exercise induces a marked impairment of the immune system.
“While the immune system is already affected by spaceflight per se39–41, vigorous exercise induces a marked impairment of the immune system39.”
From Increased core body temperature in astronauts during long-duration space missions (2017) · cites this paper as [40]
Cites
Human cellular immune responsiveness following space flight.
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Effect of hypogravity on human lymphocyte activation.
Cogoli, A., Morf-Valluchi, M., Mueller, M., & Briegleb, W. (1980) · PubMed · Cited by 62 · see citing works
Self-citationHypergravity promotes cell proliferation
Tschopp, A., & Cogoli, A. (1983) · Cellular and Molecular Life Sciences · doi:10.1007/bf01990088 · Cited by 49 · see citing works
Self-citationHematological and immunological changes during space flight
Cogoli, A. (1981) · Acta Astronautica · doi:10.1016/0094-5765(81)90070-9 · Cited by 45 · see citing works
Self-citationTálas, M., Bátkai, L., Stöger, I., et al. (1983) · PubMed · Cited by 28 · see citing works
Biotechnology in space laboratories
Cogoli, A., & Tschopp, A. (1982) · Advances in biochemical engineering, biotechnology · doi:10.1007/3540114645_1 · Cited by 19 · see citing works
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How does spaceflight affect the acquired immune system?
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Gravity, Microgravity and Artificial Gravity: Physiological Effects, Implementation and Applications
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- Authors
- Cogoli, A., Tschopp, A., & Fuchs-Bislin, P.
- Affiliations
- ETH Zurich (CH)
- Venue
- Science
- Published
- 1984-07-13
- Volume
- 225
- Issue
- 4658
- Pages
- 228-230
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059193195
- Cited by
- 314
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 11 · 2014: 6 · 2013: 9 · 2012: 6
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- microgravity, lymphocyte activation, concanavalin A, cell proliferation, high gravity, cell differentiation
- MeSH terms
- Cell Differentiation, Cell Physiological Phenomena, Concanavalin A, Humans, Lymphocyte Activation, Lymphocytes, Space Flight, Weightlessness
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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