The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Oxytocin Induces Maternal Behavior in Virgin Female Rats
Abstract
Intracerebroventricular administration of oxytocin to virgin female rats that had been ovariectomized and primed with estrogen 48 hours previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin F2 alpha induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and prostaglandin E2 were no more effective than saline. These findings suggest that the release of oxytocin and prostaglandin F2 alpha during labor may promote maternal behavior in rats.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Pedersen et al. (1982) showed that oxytocin injection into the lateral cerebral ventricles of nulliparous/virgin rats rapidly induced maternal behaviors.”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Pedersen et al. 1982
In the citing paper
“In lactating rats, suckling evokes bursts of action potentials in oxytocin cells that result in pulsatile oxytocin secretion, and this bursting is facilitated by 1-2ng oxytocin i.c.v.(26).Effects on maternal behavior in the rat need much higher doses (~400ng) (4).Partner preference effects in voles require infusions of oxytocin at 10-100ng/h (5), and, to stimulate maternal behavior in sheep, it”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [4]
In the citing paper
“the OT system undergoes dramatic changes during pregnancy and lactation to facilitate maternal behaviors (Jirikowski, Caldwell, Pilgrim, Stumpf, & Pendersen, 1989; Meddle, Bishop, Gkoumassi, van Leeuwen, & Douglas, 2007; Pedersen, Ascher, Monroe, & Prange, 1982; Theodosis, Montagnese, Rodriguez, Vincent, & Poulain, 1986)”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Pedersen et al., 1982
In the citing paper
“However, the seminal paper demonstrating the effect of OXT on maternal behavior also showed that AVP stimulates maternal behavior, but with a longer latency of action (132).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [132]
In the citing paper
“Maternal behavior can be elicited through administration of oxytocin in virgin rats (Pedersen et al., 1982);”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Pedersen et al., 1982
In the citing paper
“For instance, in rodents, virgin rats’ behavior towards pups can switch from aggressive or apathetic to affiliative through oxytocin administration (Pedersen et al., 1982).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Pedersen et al., 1982
In the citing paper
“The importance of the oxytocin system in mammalian social behaviors including social memory, recognition and attachment has been established using a variety of animal models since 1980s.”
In the citing paper
“In highly social animals, these ancestral functions of OT have been co-opted to serve social functions, such as promoting maternal behavior (Champagne et al., 2001; Pedersen et al., 1982), fostering pair-bonding and affiliative behaviors (Cushing and Carter, 2000; Smith et al., 2010; Snowdon et al., 2010; Young and Wang, 2004), encouraging in-group bias (Dreu et al., 2010), reducing social vigil”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Pedersen et al., 1982
Citations
Cites
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Self-citationIntra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
A MODIFICATION OF THE METHOD OF DALE AND LAIDLAW FOR STANDARDIZATION OF POSTERIOR PITUITARY EXTRACT
Holton, P. (1948) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1948.tb00396.x · Cited by 242
BOHUS, B., URBAN, I., VANWIMERSMAGREIDANUS, T., & DEWIED, D. (1978) · Neuropharmacology · doi:10.1016/0028-3908(78)90107-7 · Cited by 231
Pituitary Oxytocin and Vasopressin Content of Pregnant Rats Before, During, and After Parturition
Fuchs, A., & Saito, S. (1971) · Endocrinology · doi:10.1210/endo-88-3-574 · Cited by 78
AXONAL TRANSPORT OF PROTEINS IN THE HYPOTHALAMO‐NEUROHYPOPHYSIAL SYSTEM OF THE RAT
Norströ, A., & Sjöstrand, J. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb00164.x · Cited by 70
Folley, S. J., & Knaggs, G. S. (1966) · Journal of Endocrinology · doi:10.1677/joe.0.0340197 · Cited by 68
Neurohypophyseal hormone release in the human
Cobo, E., Bernal, M. M. D., Quintero, C., & Cuadrado, E. (1968) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(68)90556-5 · Cited by 61
The release of vasopressin without oxytocin in response to haemorrhage
Beleslin, D. B., Bisset, G. W., Haldar, J., & Polak, R. L. (1967) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1967.0006 · Cited by 56
Neurohypophyseal hormone release in the human
Cobo, E., Bernal, M. M. D., Gaitán, E., & Quintero, C. (1967) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(67)90566-2 · Cited by 45
PERIPHERAL PLASMA LEVELS OF OXYTOCIN AND VASOPRESSIN IN THE MARE DURING PARTURITION
Allen, W. E., Chard, T., & Forsling, M. L. (1973) · Journal of Endocrinology · doi:10.1677/joe.0.0570175 · Cited by 44
Nickerson, K., Bonsnes, R. W., Douglas, R. G., Condliffe, P. G., & du Vigneaud, V. (1954) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(54)90261-6 · Cited by 41
CLEVERLEY, J. D., & Folley, S. J. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0460347 · Cited by 41
Cross, B., & van Dyke, H. B. (1953) · Journal of Endocrinology · doi:10.1677/joe.0.0090232 · Cited by 40
THE RESPONSE-TIME TO THE PARATHYROID HORMONE IN THE LAYING FOWL
CANDLISH, J. K., & Taylor, T. G. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0480143 · Cited by 37
SIMULTANEOUS RELEASE OF OXYTOCIN AND NEUROPHYSIN DURING PARTURITION IN THE GOAT
McNeilly, A. S., Martin, M. J., Chard, T., & Hart, I. C. (1972) · Journal of Endocrinology · doi:10.1677/joe.0.0520213 · Cited by 30
THE MILK-EJECTING ACTIVITY OF EXTRACTS OF THE POSTERIOR PITUITARY GLAND
Whittlestone, W. G. (1952) · Journal of Endocrinology · doi:10.1677/joe.0.0080089 · Cited by 27
Small, M. G. P., Gavagan, J. E., & Roberts, J. S. (1978) · Prostaglandins · doi:10.1016/s0090-6980(78)80008-2 · Cited by 18
Akaishi, T., & Negoro, H. (1979) · Endocrinologia Japonica · doi:10.1507/endocrj1954.26.725 · Cited by 11
(1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009783 · Cited by 10
Recent Trends in the Physiology of the Posterior Pituitary
Chard, T. (1971) · Current topics in experimental endocrinology · doi:10.1016/b978-0-12-153201-7.50009-0 · Cited by 5
TRANSPLACENTAL INFLUENCE OF ANDROGEN UPON OVULATORY MECHANISMS IN THE RAT
SMITH, W. N. A. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0480477 · Cited by 5
Flagged first, then by citations
Research works printed but not linked: 4
- BISSET, G.W., PEPTIDE HORMONES: 145 (1976).
- UNGER, H, NEUROSECRETION NEURO: 305 (1978).
- VALTIN, H, HDB PHYSL 4: 131 (1974).
- VANDYKE, J.B., RECENT PROGRESS IN HORMONE RESEARCH 9: 1 (1955).
Cited by
Sorted by citations
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
MAEDA, K., OHKURA, S., & Tsukamura, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012426400-7/50048-0 · Cited by 2,136
Why Does Social Exclusion Hurt? The Relationship Between Social and Physical Pain.
MacDonald, G., & Leary, M. R. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.2.202 · Cited by 1,712
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497
Adolescent Onset of the Gender Difference in Lifetime Rates of Major Depression: A Theoretical Model
Cyranowski, J. M., Frank, E., Young, E., & Shear, M. K. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.21 · Cited by 1,276
Metadata
- Authors
- Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Pedersen, Cort A.
- Venue
- Science
- Published
- 1982-05-07
- Volume
- 216
- Issue
- 4546
- Pages
- 648-650
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027523671
- Cited by
- 770
- References
- 22
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 16 · 2023: 18 · 2022: 17 · 2021: 19 · 2020: 53 · 2019: 21 · 2018: 25 · 2017: 33 · 2016: 31 · 2015: 32 · 2014: 25 · 2013: 28 · 2012: 20
- FWCI
- 27.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, maternal behavior, virgin female rats, intracerebroventricular administration, estrogen priming, ovariectomy, vasopressin, prostaglandin F2alpha, prostaglandin E2, ovarian steroids, labor, dose-response relationship
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Female, Injections, Intraventricular, Maternal Behavior, Oxytocin, Structure-Activity Relationship, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
