Cited by 770Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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Oxytocin Induces Maternal Behavior in Virgin Female Rats

Pedersen, Cort A., Ascher, John A., Monroe, Yvonne L., Prange, Arthur J.·1982·Science

DOI 10.1126/science.7071605

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Abstract

Intracerebroventricular administration of oxytocin to virgin female rats that had been ovariectomized and primed with estrogen 48 hours previously induced a rapid onset of full maternal behavior. The maternal behavior persisted and its incidence was dose-related. Tocinoic acid, the ring structure of oxytocin, also rapidly induced the onset of persistent, full maternal behavior. Arginine vasopressin induced persistent maternal behavior, but this behavior had a later onset. Prostaglandin F2 alpha induced strong partial maternal behavior, which showed early onset but did not persist. Many other peptides, ovarian steroids, and prostaglandin E2 were no more effective than saline. These findings suggest that the release of oxytocin and prostaglandin F2 alpha during labor may promote maternal behavior in rats.

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Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
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Self-citation
Chapter 8 Peripartum plasticity within the hypothalamo-pituitary-adrenal axis
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Authors: Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Pedersen, Cort A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1982-05-07
Volume: 216
Issue: 4546
Pages: 648-650
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.7071605
OpenAlex: W2027523671
Cited by: 770
References: 22
Citations by year: 2026: 13 · 2025: 11 · 2024: 16 · 2023: 18 · 2022: 17 · 2021: 19 · 2020: 53 · 2019: 21 · 2018: 25 · 2017: 33 · 2016: 31 · 2015: 32 · 2014: 25 · 2013: 28 · 2012: 20
FWCI: 27.13
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin, maternal behavior, virgin female rats, intracerebroventricular administration, estrogen priming, ovariectomy, vasopressin, prostaglandin F2alpha, prostaglandin E2, ovarian steroids, labor, dose-response relationship
MeSH terms: Animals, Arginine Vasopressin, Brain, Female, Injections, Intraventricular, Maternal Behavior, Oxytocin, Structure-Activity Relationship, Rats

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Oxytocin Induces Maternal Behavior in Virgin Female Rats

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