The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix
Open accessAbstract
Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to β 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1β converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.
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Cites
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Metadata
- Authors
- Boudreau, N., Sympson, C. J., Werb, Z., & Bissell, M. J.
- Venue
- Science
- Published
- 1995-02-10
- Volume
- 267
- Issue
- 5199
- Pages
- 891-893
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989963027
- Cited by
- 1,175
- References
- 1
- FWCI
- 45.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.