Isolation of New Ribozymes from a Large Pool of Random Sequences

Bartel, David P., Szostak, Jack W.·1993·Science
DOI 10.1126/science.7690155

Cited by (901)

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  2. Emergence and the experimental pursuit of the origin of life
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  3. Autocatalytic Sets and RNA Secondary Structure
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  4. Origin of Life Scenarios: between Fantastic Luck and Marvelous Fine-Tuning
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  6. RNA World
    Shotaro Ayukawa, Toshihiko Enomoto, Daisuke Kiga · 2019 · Springer eBooks
  7. Enzymes: Chemistry and biochemistry
    Jonathan Jeffery · 1995 · Birkhäuser Basel eBooks
  8. Synthetic Ribozymes and Deoxyribozymes
    Petra Burgstaller, Michael Famulok · 2003 · Organic Synthesis Set
  9. Isomorphism of Quasispecies and Percolation Models
    Luca Valandro, Benedetto Salvato, R. Caimmi, Lauro Galzigna · 2000 · Journal of Theoretical Biology
  10. Modified Nucleoside Triphosphates: Synthesis and Applications for RNA In Vitro Selection
    Th. Schoetzau, Josmar Langner, Elisabeth Moyroud, Ingo Röhl, S. Klussmann, Stefan Vonhoff · 2003 · Nucleosides Nucleotides & Nucleic Acids
  11. Assay of Random RNA Oligomerisation in Buffers with High Concentrations of Divalent Metal Ions
    Alexander V. Vlassov · 2004 · Nucleosides Nucleotides & Nucleic Acids
  12. Oligonucleotide diversity and drug discovery
    Paul P. Trotta, Bruce A. Beutel, Michael I. Sherman · 1995 · Medicinal Research Reviews
  13. Aptamers
    Subash C.B. Gopinath · 2016 · Encyclopedia of Analytical Chemistry
  14. Assembly of catalytic complexes from randomized oligonucleotides
    Xu Han, Ulrich F. Müller · 2025 · Science Advances
  15. A polymerase ribozyme increases copying fidelity through pyrophosphate-mediated RNA repair
    Alexandra D. Kent, Lucy L. Yang, Kyle H. Cole, I. Lee, Andrej Lupták · 2026 · Proceedings of the National Academy of Sciences
  16. A GTP synthase ribozyme with increased GTP turnover
    Han Xu, Zoe J. Pepper, Joshua T. Arriola, Ulrich F. Müller · 2026 · Proceedings of the National Academy of Sciences
  17. Is there a common chemical model for life in the universe?
    Steven A. Benner, Alonso Ricardo, Matthew A. Carrigan · 2010 · Cambridge University Press eBooks
  18. Introducing SELEX via a semester‐long course‐based undergraduate research experience (CURE)
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  19. Chemical Synthesis of Lipids and the Origin of Life
    James A. Oro · 1995 · Springer eBooks
  20. Expliquer les origines de la vie : structures et schèmes explicatifs
    Christophe Malaterre · 2008 · Noesis
  21. The role of catalytic RNA in the origin and early evolution of life on earth
    Gerald F. Joyce · 1996 · Origins of Life and Evolution of Biospheres
  22. The Old and New RNA World
    Zofia Szweykowska-Kulińska · 2014 · Acta Societatis Botanicorum Poloniae
  23. PAR-CLIP: A Genomic Technique to Dissect RNA-Protein Interactions
    Tara Dutka, Aishe A. Sarshad, Markus Hafner · 2016 · Springer eBooks
  24. Water
    Steven A. Benner · 2010 · CRC Press eBooks
  25. Energy, Information, and The Origins of Life
    Fabrizio Cleri · 2016 · Undergraduate lecture notes in physics
  26. BIOORGANIC MOLECULES IN THE COSMOS AND THE ORIGIN OF DARWINIAN MOLECULAR SYSTEMS
    Alonso Ricardo · 2004
  27. Are the different hypotheses on the emergence of life as different as they seem?
    Iris Fry · 2010 · Cambridge University Press eBooks
  28. Life: The Physical Underpinnings of Replication
    Rebecca M. Turk-MacLeod, Ulrich Gerland, Irene A. Chen · 2012 · Springer eBooks
  29. Connections Between Mathematical Models of Prebiotic Evolution and Homochirality
    Celia Blanco, Irene A. Chen · 2018 · Nucleic acids and molecular biology
  30. Beherrschung von Komplexität in der molekularen Evolution
    Peter M. Schuster · 1999 · Springer eBooks
  31. Models for the Autocatalytic Replication of RNA
    Lori Giver, Susan M. Lato, Andrew D. Ellington · 1994 · Springer eBooks
  32. [14] Strategies to express structural and catalytic RNAs in mammalian cells
    James D. Thompson · 1999 · Methods in enzymology on CD-ROM/Methods in enzymology
  33. Nucleic‐Acid‐Based Switches
    Eike Friedrichs, Friedrich Christian Simmel · 2011
  34. Evolving an Understanding of RNA Function by In Vitro Approaches
    Qing Wang, Peter J. Unrau · 2010 · Wiley eBooks
  35. Hammering out the shape of a ribozyme
    Jennifer A. Doudna · 1994 · Structure
  36. Acquisition of novel catalytic activity by the M1 RNA ribozyme: the cost of molecular adaptation
    Kyle Brubaker Cole, Robert L. Dorit · 1999 · Journal of Molecular Biology
  37. What nucleic acids cannot do: a model for information processing in protein molecules
    Koji Maekawa · 1998 · Biosystems
  38. DNA Selection and Amplification
    Dipanakar Sen · 1999 · Elsevier eBooks
  39. Expanding the space of self-reproducing ribozymes using probabilistic generative models
    Camille N. Lambert, Vaitea Opuu, Francesco Calvanese, Francesco Zamponi, Eric J. Hayden, Martin Weigt, Matteo Smerlak, Philippe Nghe · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Catalytic DNA molecules for porphyrin metallation
    Yingfu Li · 1997 · Library and Archives Canada (Government of Canada)
  41. Emergence of catalytic function in prebiotic information-coding polymers
    Alexei V. Tkachenko, Sergei Maslov · 2023 · eLife
  42. Emergence of catalytic function in prebiotic information-coding polymers
    Alexei V. Tkachenko, Sergei Maslov · 2024 · eLife
  43. A ribozyme ligase that requires a 3′ terminal phosphate on its RNA substrate
    Annyesha Biswas, Zoe Weiss, Jack W. Szostak, Saurja DasGupta · 2026 · Nature Communications
  44. Functional Analysis of Histidine‐Dependent Self‐Cleaving RNAs Obtained by In Vitro Selection
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    David W. Deamer · 2026 · Astrobiology
  46. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends
    Silke Asche, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, Zhen Peng, Avinash Vicholous Dass, Alyssa Adams et al. · 2026 · Cell Reports Physical Science
  47. Conditions Enabling the Persistence of Cooperating Synthetase, Ligase, and Mutation-Inhibitor Catalytic Polymers
    Zhen Peng, Alex M. Plum, Rahul Kartha, Emily M. Jacobson, David Baum · 2026 · Journal of Molecular Evolution
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    Julie Puyo-Fourtine, Yanan Du, Erika McCarthy, Şölen Ekesan, Darrin M. York · 2026 · Journal of the American Chemical Society
  49. Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications
    Wendy W. K. Mok, Simon A. McManus, Yingfu Li · 2014 · RNA technologies
  50. Insights into the Role of Conformational Transitions and Metal Ion Binding in RNA Catalysis from Molecular Simulations
    Tai‐Sung Lee, George M. Giambaşu, Darrin M. York · 2010 · Annual reports in computational chemistry
  51. An information-carrying and knowledge-producing molecular machine. A Monte-Carlo simulation
    Christoph Kühn · 2011 · Journal of Molecular Modeling
  52. Tethered ribozyme ligation enables detection of molecular proximity in homogeneous solutions
    Bella Katzman, Maria Vyazmensky, Olga Press, Micha Volokita, Stanislav Engel · 2014 · Biotechnology Journal
  53. DNA‐Enden: Nur ein Anfang (Nobel‐Aufsatz)
    Jack W. Szostak · 2010 · Angewandte Chemie
  54. There is no common ground between science and religion
    Antonio G. Valdecasas, Luis Boto, Ana María Correas · 2013 · Journal of Biosciences
  55. Origin and Evolution of Life: Another Study Program.
    Yuzuru Husimi · 1999 · Seibutsu Butsuri
  56. Continuous In Vitro evolution of a ribozyme ligase: A model experiment for the evolution of a biomolecule
    Michael P. Ledbetter, Tony Weiyang Hwang, Gwendolyn M. Stovall, Andrew D. Ellington · 2013 · Biochemistry and Molecular Biology Education
  57. Computational tests of a thermal cycling strategy to isolate more complex functional nucleic acid motifs from random sequence pools by in vitro selection
    Aaron Reba, Austin G. Meyer, Jeffrey E. Barrick · 2012 · Conference on Artificial Life (ALIFE)
  58. Mathematical Models of Prebiotic Replication of Informational Molecules
    Kelley Harris, Irene A. Chen · 2012 · Cellular origin and life in extreme habitats
  59. Extension of the Two Band Model
    Toyoyuki Kitamura · 2012 · Elsevier eBooks
  60. A Putative Living Fossil of the RNA World is Likely to be of Recent Origin
    Martino Rizzotti · 1996 · Springer eBooks
  61. What Are Ribozymes for? Arguing for Function Pluralism
    Christophe Malaterre · 2023 · History, philosophy and theory of the life sciences
  62. Canada's contributions to RNA research: past, present, and future perspectives
    Éric Lécuyer, Martin Sauvageau, Ute Kothe, Peter J. Unrau, Masad José Damha, Jonathan Perreault, Sherif Abou Elela, Mark A. Bayfield, Julie M. Claycomb, Michelle S. Scott · 2024 · Biochemistry and Cell Biology
  63. Origin of ribonucleotide recognition motifs through ligand mimicry at early earth
    Deepto Mozumdar, Raktim N. Roy · 2024 · RNA Biology
  64. Manipulations of Organisms and Ecosystems in Artificial Life
    Mohamed El-Zayat, Denis Mušić · 2025 · IEEE International Colloquium on Signal Processing & Its Applications (CSPA)
  65. Preparation of DNA Library and Affinity Column for the Analysis of RNA-RNA Interaction
    Bong-Rae Jo · 2006 · Journal of the Korean Chemical Society
  66. Aptamer Selection by Darwinian Evolution
    Fabien Chauveau, Carine Pestourie, Frederic Ducongè, Bertrand Tavitian · 2009 · Springer eBooks
  67. Genetic code based coding and mathematical formualation for DNA computation
    Mingjun Zhang, Maggie X. Cheng, TZYH JONG TARN · 2006 · Proceedings - IEEE International Conference on Robotics and Automation/Proceedings
  68. Origins of Life - A Biochemical Perspective
    Mihir Iyer · 2023 · International Journal of Science and Research (IJSR)
  69. Pharmacology and Emerging Clinical Application of RNA
    Sailen Barik, Vira Bitko · 2006 · Encyclopedia of Molecular Cell Biology and Molecular Medicine
  70. LUCA – letzter gemeinsamer Vorfahre allen Lebens
    Armen Y. Mulkidjanian, Dirk‐Henner Lankenau · 2011 · Wiley eBooks
  71. Selection for Catalytic Function with Nucleic Acids
    Ronald R. Breaker · 2000 · Current Protocols in Nucleic Acid Chemistry
  72. Artificial Selection: Finding Function amongst Randomized Sequences
    Ico de Zwart, Catherine Lozupone, Rob D. Knight, Amanda Birmingham, Mali Illangasekare, Vasant Jadhav, Michał Łęgiewicz, Irene H. Majerfeld, Jeremy Joseph Widmann, Michael Yarus · 2005 · Wiley eBooks
  73. Investigating a general biology
    John R. Bracht · 2003 · Complexity
  74. DNA Origami Nanorobots
    Ido Bachelet · 2014 · Encyclopedia of Molecular Cell Biology and Molecular Medicine
  75. The ability of tRNA-embedded ribozymes to prevent replication of HIV-1 in cell culture
    Jun Ohkawa, Noriko Yuyama, Shiori Koseki, Yutaka Takebe, Matthias Homann, Georg Sczakiel, Kazunari Taira · 1998
  76. Creation and Evolution of New Ribozymes
    David P. Bartel · 1999 · Biological Bulletin
  77. Detection of single enzyme molecules and catalytic nucleic acids using microfluidics and selection of aptamers using capillary electrophoresis-SELEX
    Jing Yang · 2014 · University of Minnesota Digital Conservancy (University of Minnesota)
  78. Guesswork and randomness (for now at least)
    John Maddox · 1994 · Nature
  79. Aptamers for proteomics
    Le, Thao Thi · 2008 · Spiral (Imperial College London)
  80. New Catalytic DNA Fluorescent and Colorimetric Sensors for On‐site and Real‐time Monitoring of Industrial and Drinking Water
    Yi Lu · 2009 · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
  81. Ligation of random oligomers leads to emergence of autocatalytic sequence network
    Patrick W. Kudella, Alexei V. Tkachenko, Sergei Maslov, Dieter Braun · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  82. Testing Evolutionary Convergence: From RNA World to Intelligence
    K. Tahir Shah · 2001
  83. RNA Catalysis and Transition State Stabilization
    James R. Prudent, Peter G. Schultz · 1996 · Nucleic acids and molecular biology
  84. Evolution of the cellular communication syste
    K. Tahir Shah · 1995 · Journal of Biological Physics
  85. Synthetic Ribozymes and Deoxyribozymes
    Petra Burgstaller, Michael Famulok · 1998
  86. Catalytic RNA
    Cassandra R. Burke, Andrej Lupták · 2012 · Encyclopedia of Life Sciences
  87. RNA
    William G. Scott · 2014 · Encyclopedia of Astrobiology
  88. SELEX
    Drew Smith · 2002 · Wiley Encyclopedia of Molecular Medicine
  89. Pathways of Early Evolution From the Perspectives of a Riboreplisome – The Ultimate RNA Machine of Life
    Nikolay E. Shirokikh · 2023 · Preprints.org
  90. Emergence of diverse ligase reactivities from a single RNA evolution experiment
    Annyesha Biswas, Saurja DasGupta · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  91. Cryo-EM of a nucleotide-polymerizing ribozyme enables its predictive improvement
    Deni Szokoli, Jason Hingey, Yuan Wu, Daniel B. Haack, Nicholas Spellmon, Boris Rudolfs, Adamo S. Mancino, Zhiheng Yu, Navtej Toor, Rhiju Das · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  92. Testing Evolutionary Convergence:
    K. Tahir Shah · 2001 · Springer eBooks
  93. Chapter 25. Translational Control of Gene Expression
    Lee Gehrke, Louane E. Hann, Roger L. Kaspar · 1994 · Annual reports in medicinal chemistry
  94. A light-harvesting catalytic DNA for thymine dimer repair
    Daniel J.‐F. Chinnapen · 2005 · Summit (Simon Fraser University)
  95. RNA Metabolism and Prebiotic Synthesis of RNA
    Geoffrey Zubay · 2000 · Elsevier eBooks
  96. Aptamer Selection against Biological Macromolecules: Proteins and Carbohydrates
    C. Stefan Voertler, Maria Milovnikova · 2005
  97. Selektion und Charakterisierung von Aptameren, spezifisch für das Virus der Infektiösen Bursitis
    Sabine Kainz · 2006
  98. Peptidyltransfer Reaction Catalyzed by the Ribosome and the Ribozyme: a Dissertation
    Lele Sun · 2003 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
  99. Parallel processing in DNA analysis
    Charles R. Cantor, Takeshi Sano, Natalia E. Broude, Cassandra L. Smith · 1995 · Lecture notes in computer science
  100. Aptamer Adaptability: Utilizing Tumor Cell Surface Heterogeneity to Self-Select Appropriate Diagnostic and Therapeutic Agents
    Miguel Garcia Schürmann, Donald S. Coffey · 1997 · Advances in molecular and cell biology