Isolation of New Ribozymes from a Large Pool of Random Sequences

Bartel, David P., Szostak, Jack W.·1993·Science

Cited by (901)

Items 401–500 of 901

  1. A Peptide–Nucleic Acid Replicator Origin for Life
    Bernard M. A. G. Piette, Jonathan G. Heddle · 2020 · Trends in Ecology & Evolution
  2. A Computational Study of RNA Tetraloop Thermodynamics, Including Misfolded States
    Gül H. Zerze, Pablo M. Piaggi, Pablo G. Debenedetti · 2021 · The Journal of Physical Chemistry B
  3. Introduction of point mutations into cloned genes
    Brendan P. Cormack, Irene Castaño · 2002 · Methods in enzymology on CD-ROM/Methods in enzymology
  4. HAPIscreen, a method for high-throughput aptamer identification
    Eric Dausse, Saı̈d Taouji, Laetitia Evadé, Carmelo Di Primo, Éric Chevet, Jean‐Jacques Toulmé · 2011 · Journal of Nanobiotechnology
  5. The Genotypic Landscape During In Vitro Evolution of a Catalytic RNA: Implications for Phenotypic Buffering
    Niles Lehman, Mariano Delle Donne, M L West, Thomas Gregory Dewey · 2000 · Journal of Molecular Evolution
  6. A Density-Functional Study of the Mechanism for the Diastereoselective Epoxidation of Chiral Allylic Alcohols by the Titanium Peroxy Complexes
    Meng Cui, Waldemar Adam, Jian Hua Shen, Xiao Min Luo, Xiao Jian Tan, Kai Xian Chen, Ru Yun Ji, Hua Liang Jiang · 2002 · The Journal of Organic Chemistry
  7. Generation of a catalytic module on a self-folding RNA
    Wataru Yoshioka, Yoshiya Ikawa, Luc Jaeger, Hideaki Shiraishi, Tan Inoue · 2004 · RNA
  8. A small polymerase ribozyme that can synthesize itself and its complementary strand
    Edoardo Gianni, Samantha Kwok, Christopher J. K. Wan, Kevin Goeij, Bryce E. Clifton, Enrico Sandro Colizzi, James Attwater, Philipp Holliger · 2026 · Science
  9. The Origin of Life: What Is the Question?
    Christophe Malaterre, Cyrille Jeancolas, Philippe Nghe · 2022 · Astrobiology
  10. Prelife catalysts and replicators
    Hisashi Ohtsuki, Martin A. Nowak · 2009 · Proceedings of the Royal Society B Biological Sciences
  11. In Vitro Selection for Small-Molecule-Triggered Strand Displacement and Riboswitch Activity
    Laura Martini, Adam J. Meyer, Jared W. Ellefson, John N. Milligan, Michele Forlin, Andrew D. Ellington, Sheref S. Mansy · 2015 · ACS Synthetic Biology
  12. The descent of polymerization.
    Matthew Levy, Andrew D. Ellington · 2001 · Nature Structural Biology
  13. Estimation of SELEX pool size by measurement of DNA renaturation rates
    Josephine Charlton, Drew Smith · 1999 · RNA
  14. Selection and evolution of NTP-specific aptamers
    Laure Weill · 2004 · Nucleic Acids Research
  15. Characterization of the B6.61 polymerase ribozyme accessory domain
    Wang, Qing S., Cheng, Leslie K.L., Unrau, Peter J. · 2011 · RNA
  16. On the aqueous origins of the condensation polymers of life
    Daniel E. Whitaker, Matthew W. Powner · 2024 · Nature Reviews Chemistry
  17. Functional Nucleic Acid Enzymes: Nucleic Acid-Based Catalytic Factories
    Min Yang, Yushi Xie, Longjiao Zhu, Xiangyang Li, Wentao Xu · 2024 · ACS Catalysis
  18. Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life
    Kunnev, Dimiter, Gospodinov, Anastas · 2018 · Life
  19. In Vitro Selection of Nonnatural Ribozyme-Catalyzing Porphyrin Metalation
    Naoki Kawazoe, Naozumi Teramoto, Hisashi Ichinari, Yukio Imanishi, Yoshihiro Ito · 2001 · Biomacromolecules
  20. A versatile mechanism based reaction probe for the direct selection of biocatalysts
    Lee‐Chiang Lo, Chih‐Hung L. Lo, Kim D. Janda, Daniel B. Kassel, Frank Michael Raushel · 1996 · Bioorganic & Medicinal Chemistry Letters
  21. Nucleic acid selection as a tool for drug discovery
    Jamie M. Bacher, Andrew D. Ellington · 1998 · Drug Discovery Today
  22. Non-enzymatic, template-directed ligation of 2'-5' oligoribonucleotides. Joining of a template and a ligator strand
    H. Sawai, Shunsuke Totsuka, Kenji Yamamoto, Hiroaki Ozaki · 1998 · Nucleic Acids Research
  23. Studies on Steric and Electronic Control of 2‘−3‘ Phosphoryl Migration in 2‘-Phosphorylated Uridine Derivatives and Its Application to the Synthesis of 2‘-Phosphorylated Oligouridylates
    Mitsuo Sekine, Hiroyuki Tsuruoka, Shin Iimura, Hiroshi Kusuoku, Takeshi Wada, Kiyotaka Furusawa · 1996 · The Journal of Organic Chemistry
  24. Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage
    Tom H. Wright, Constantin Giurgiu, Wen Zhang, Aleksandar Radakovic, Derek K. O’Flaherty, Lijun Zhou, Jack W. Szostak · 2019 · Journal of the American Chemical Society
  25. Aptamer to Ribozyme: The Intrinsic Catalytic Potential of a Small RNA
    David M. Brackett, Thorsten Dieckmann · 2006 · ChemBioChem
  26. The Spliceosome and Its Metal Ions
    Samuel E. Butcher · 2011 · Royal Society of Chemistry eBooks
  27. Design, Synthesis, and Amplification of DNA Pools for In Vitro Selection
    Jack D. Pollard, Sabine D. Bell, Andrew D. Ellington · 2000 · Current Protocols in Nucleic Acid Chemistry
  28. Successive state transitions with I/O interface by molecules
    Ken Komiya, Kensaku Sakamoto, Hidetaka Gouzu, Shigeyuki Yokoyama, Masanori Arita, Akio Nishikawa, Masami Hagiya · 2001 · Lecture notes in computer science
  29. Oxytricha as a modern analog of ancient genome evolution
    Aaron David Goldman, Laura F. Landweber · 2012 · Trends in Genetics
  30. Unterschiede zwischen 4′-RNA- und 4′-DNA-Radikalen beim anaeroben und aeroben Strangbruch
    Harald Strittmatter, Adrian Dussy, Urs Schwitter, Bernd Giese · 1999 · Angewandte Chemie
  31. RNA Folding: Structure Prediction, Folding Kinetics and Ion Electrostatics
    Zhi-Jie Tan, Wenbing Zhang, Ya-Zhou Shi, Fenghua Wang · 2014 · Advances in experimental medicine and biology
  32. Structure-Guided Engineering of the Regioselectivity of RNA Ligase Ribozymes
    Jason N. Pitt, Adrian R. Ferré-D’Amaré · 2009 · Journal of the American Chemical Society
  33. A Simple Template-Dependent Ligase Ribozyme as the RNA Replicase Emerging First in the RNA World
    Wentao Ma, Chunwu Yu, Wentao Zhang, Jiming Hu · 2010 · Astrobiology
  34. The spliceosome as ribozyme hypothesis takes a second step
    Samuel E. Butcher · 2009 · Proceedings of the National Academy of Sciences
  35. Antisense oligonucleotide strategies in physiology
    Alex J. Baertschi · 1994 · Molecular and Cellular Endocrinology
  36. High-Throughput Ribozyme-Based Assays for Detection of Viral Nucleic Acids
    Karl Kossen, Narendra K. Vaish, Vasant Jadhav, Christopher Pasko, Hong Wang, ROBERT D. JENISON, James A. McSwiggen, Barry A. Polisky, Scott D. Seiwert · 2004 · Chemistry & Biology
  37. Template-directed chemistry and the origins of the RNA world
    Anastassia Kanavarioti · 1994 · Origins of Life and Evolution of Biospheres
  38. Targeting nucleic acid secondary structures by antisense oligonucleotides designed through in vitro selection.
    Rakesh K. Mishra, R Le Tinévez, Jean‐Jacques Toulmé · 1996 · Proceedings of the National Academy of Sciences
  39. Nucleic Acid Enzymes (Ribozymes and Deoxyribozymes): In Vitro Selection and Application
    Scott K. Silverman · 2008 · Wiley eBooks
  40. Wavelength-Selective Activation of Photocaged DNAzymes for Metal Ion Sensing in Live Cells
    Xiao Gang Xu, Lu Xiao, Chunmei Gu, Jiachen Shang, Yu Xiang · 2021 · ACS Omega
  41. Profiling Demethylase Activity Using Epigenetically Inactivated Dnazyme
    Juan Huang, Jiao Wang, Zhenkun Wu, Jianjun He, Jian‐Hui Jiang · 2022 · Biosensors and Bioelectronics
  42. Constructive Approaches for Understanding the Origin of Self-Replication and Evolution
    Norikazu Ichihashi, Tetsuya Yomo · 2016 · Life
  43. Cooperative Ligation Breaks Sequence Symmetry and Stabilizes Early Molecular Replication
    Shoichi Toyabe, Dieter Braun · 2019 · Physical Review X
  44. Turing Complete Catalytic Particle Computers
    Anthony M. L. Liekens, Chrisantha Fernando · 2007 · Lecture notes in computer science
  45. A testable genotype-phenotype map: modeling evolution of RNA molecules
    Peter M. Schuster · 2007 · Springer eBooks
  46. The RNA World and Its Evolution
    Alexander S. Spirin · 2005 · Molecular Biology
  47. A class I ligase ribozyme with reduced Mg2+ dependence: Selection, sequence analysis, and identification of functional tertiary interactions
    Sarah C. Bagby, Nicholas H. Bergman, David M Shechner, Catherine C. Yen, David P. Bartel · 2009 · RNA
  48. Substrate-Directed formation of small biocatalysts under prebiotic conditions
    E. Kochavi, Akiva Bar‐Nun, Gideon Fleminger · 1997 · Journal of Molecular Evolution
  49. Hammerhead ribozyme structure: U-turn for RNA structural biology
    Jennifer A. Doudna · 1995 · Structure
  50. An Antibody-Catalyzed Isomerization Reaction
    Tetsuo Uno, Jung Ku, James R. Prudent, Anita Huang, Peter G. Schultz · 1996 · Journal of the American Chemical Society
  51. Evolutionary Simulation Models: On Their Character, and Application to Problems Concerning the Evolution of Natural Signalling Systems
    Seth Bullock · 1997 · ePrints Soton (University of Southampton)
  52. The basic reproductive ratio of life
    Manapat, Michael L., Chen, Irene A., Nowak, Martin A. · 2010 · Journal of Theoretical Biology
  53. Salt effect on thermodynamics and kinetics of a single RNA base pair
    Yujie Wang, Taigang Liu, Ting Yu, Zhi-Jie Tan, Wenbing Zhang · 2020 · RNA
  54. The Origin of Genetic Code and Translation in the Framework of Current Concepts on the Origin of Life
    Liya G. Kondratyeva, Marina S. Dyachkova, Alexey Vladimirovich Galchenko · 2022 · Biochemistry (Moscow)
  55. An RNA aptamer that shifts the reduction potential of metabolic cofactors
    John S. Samuelian, Thomas Gremminger, Zhenwei Song, Raghav R. Poudyal, Jun Li, Yuanzhe Zhou, Seth Staller, Johan A. Carballo, Manami Roychowdhury-Saha, Shi‐Jie Chen et al. · 2022 · Nature Chemical Biology
  56. Molecular Crowding Facilitates Ribozyme-Catalyzed RNA Assembly
    Saurja DasGupta, Stephanie J. Zhang, Jack W. Szostak · 2023 · ACS Central Science
  57. The emergence of ribozymes synthesizing membrane components in RNA-based protocells
    Wentao Ma, Chunwu Yu, Wentao Zhang, Ping Zhou, Jiming Hu · 2009 · Biosystems
  58. Stochastic innovation as a mechanism by which catalysts might self-assemble into chemical reaction networks
    Justin Allen Bradford, Ken A. Dill · 2007 · Proceedings of the National Academy of Sciences
  59. In Vitro Selection of Functional Nucleic Acid Sequences
    Dan Nieuwlandt · 2000 · Current Issues in Molecular Biology
  60. Targeted mutagenesis: A sniper-like diversity generator in microbial engineering
    Xiang Zheng, Xin‐Hui Xing, Chong Zhang · 2017 · Synthetic and Systems Biotechnology
  61. Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection
    Lewis A. Fraser, Andrew B. Kinghorn, Marco S. L. Tang, Yee‐Wai Cheung, Bryce Lim, Shaolin Liang, Roderick Marshall Dirkzwager, Julian A. Tanner · 2015 · Molecules
  62. Nucleic Acid Pool Preparation and Characterization
    Shawn K. Piasecki, Bradley Hall, Andrew D. Ellington · 2009 · Methods in molecular biology
  63. Experimental RNA evolution
    Laura F. Landweber · 1999 · Trends in Ecology & Evolution
  64. Intramolecular RNA replicase: Possibly the first self-replicating molecule in the RNA world
    Ma, Wentao, Yu, Chunwu · 2006 · Origins of Life and Evolution of Biospheres
  65. Variation and Selection
    Gerhard Quinkert, Holger Bang, Dietmar Reichert · 1996 · Helvetica Chimica Acta
  66. Molecular Complementarity of Proteomimetic Materials for Target‐Specific Recognition and Recognition‐Mediated Complex Functions
    Minsun Kim, Hyesung Jo, Gyoo Yeol Jung, Seung Soo Oh · 2022 · Advanced Materials
  67. Catalytic DNAzymes: derivations and functions
    Weihua Pan, Gary A. Clawson · 2008 · Expert Opinion on Biological Therapy
  68. DNA Ends: Just the Beginning (Nobel Lecture)
    Jack W. Szostak · 2010 · Angewandte Chemie International Edition
  69. Recombination During In Vitro Evolution
    Niles Lehman, Peter J. Unrau · 2005 · Journal of Molecular Evolution
  70. Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence
    Rachel Gysbers, Kha Tram, Jimmy Gu, Yingfu Li · 2015 · Scientific Reports
  71. [41] Selection of protein binding sites from random nucleic acid sequences
    T. Keith Blackwell · 1995 · Methods in enzymology on CD-ROM/Methods in enzymology
  72. Parallel Selections In Vitro Reveal a Preference for 2′–5′ RNA Ligation upon Deoxyribozyme-Mediated Opening of a 2′,3′-Cyclic Phosphate
    Daniel R. Semlow, Scott K. Silverman · 2005 · Journal of Molecular Evolution
  73. Catalysis Based on Nucleic Acid Structures
    Michael Famulok, Andreas Jenne · 1999 · Topics in current chemistry
  74. Isolierung von RNA‐Aptameren für biologische Cofaktoren durch In‐vitro‐Selektion
    Petra Burgstaller, Michael Famulok · 1994 · Angewandte Chemie
  75. Molecular Evolution of Catalysis
    Christian V. Forst · 2000 · Journal of Theoretical Biology
  76. Retraction Note to: High levels of genetic change in rodents of Chernobyl
    Robert J. Baker, Ronald A. Van Den Bussche, Amanda J. Wright, Lara E. Wiggins, Meredith Jean Hamilton, Erin P. Reat, Michael H. Smith, Michael D. Lomakin, Ronald K. Chesser · 1997 · Nature
  77. In Vitro Selection of Catalytic RNA
    Kelly Porter Williams, David P. Bartel · 1996 · Nucleic acids and molecular biology
  78. Metals Are Integral to Life as We Know It
    Daniele Rossetto, Sheref S. Mansy · 2022 · Frontiers in Cell and Developmental Biology
  79. Convergent donor and acceptor substrate utilization among kinase ribozymes
    Elisa Biondi, David G. Nickens, Samantha Warren, Dayal Saran, Donald H. Burke · 2010 · Nucleic Acids Research
  80. Coordinated control of a designed trans‐acting ligase ribozyme by a loop–receptor interaction
    Shigeyoshi Matsumura, Rei Ohmori, Hirohide Saito, Yoshiya Ikawa, Tan Inoue · 2009 · FEBS Letters
  81. Prebiotically Plausible RNA Activation Compatible with Ribozyme‐Catalyzed Ligation
    Emilie Yeonwha Song, Eddy Ivanhoe Jiménez, Huacan Lin, Kristian Kyle Le Vay, Ramanarayanan Krishnamurthy, Hannes Mutschler · 2020 · Angewandte Chemie International Edition
  82. A Complex RNA-Cleaving DNAzyme That Can Efficiently Cleave a Pyrimidine–Pyrimidine Junction
    Jeffrey C. F. Lam, Johanna B. Withers, Yingfu Li · 2010 · Journal of Molecular Biology
  83. Synthesis and Structure of Asymmetric Bis(sulfonamide) Based Copper(II) Complexes: Influence of Diastereomeric Interactions in the Solid State
    Alaganandan Nanthakumar, Joanne Miura, Sandra Diltz, Chao-Kang Lee, Gerardo Aguirre, Fernando Ortéga, Joseph W. Ziller, Patrick J. Walsh · 1999 · Inorganic Chemistry
  84. The importance of prebiotic chemistry in the RNA World
    Randall A. Hughes, Michael P. Robertson, Andrew D. Ellington, Matthew Levy · 2004 · Current Opinion in Chemical Biology
  85. Experimental evolution of complexity: in vitro emergence of intermolecular ribozyme interactions.
    Martin Michael Hanczyc, Robert L. Dorit · 1998 · Europe PMC (PubMed Central)
  86. Practical and general synthesis of 5′-adenylated RNA (5′-AppRNA)
    Scott K. Silverman · 2004 · RNA
  87. Fusion with an RNA binding domain to confer target RNA specificity to an RNase: design and engineering of Tat-RNase H that specifically recognizes and cleaves HIV-1 RNA in vitro
    Yuri F. Melekhovets · 1996 · Nucleic Acids Research
  88. In Vitro Selection of Nucleic Acid Enzymes
    Ronald R. Breaker, Marie Kurz · 1999 · Current topics in microbiology and immunology
  89. Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water
    Jyoti Singh, Benjamin Thoma, Daniel E. Whitaker, Max Satterly Webley, Yuan Yao, Matthew W. Powner · 2025 · Nature
  90. The RNA world ‘hypothesis’
    Hirohide Saito · 2022 · Nature Reviews Molecular Cell Biology
  91. Drawbacks of the ancient RNA-based life-like system under primitive earth conditions
    Kunio Kawamura · 2012 · Biochimie
  92. Motif frequency and evolutionary search times in RNA populations
    Michael Stich, Susanna C. Manrubia · 2011 · Journal of Theoretical Biology
  93. A small ribozyme with dual-site kinase activity
    Elisa Biondi, Adam W.R. Maxwell, Donald H. Burke · 2012 · Nucleic Acids Research
  94. Calcium(II)-dependent catalytic activity of the Azoarcus ribozyme: testing the limits of resolution for in vitro selection
    Aaron S. Burton, Niles Lehman · 2006 · Biochimie
  95. RETRACTED: Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display
    Alexander Litovchick, Jack W. Szostak · 2008 · Proceedings of the National Academy of Sciences · Retracted
  96. Autocatalytic replication in a CSTR and constant organization
    Robert Happel, Peter Florian Stadler · 1999 · Journal of Mathematical Biology
  97. Functional-DNA–Based Nanoscale Materials and Devices for Sensing Trace Contaminants in Water
    Daryl P. Wernette, Juewen Liu, Paul W. Bohn, Yi Lu · 2008 · MRS Bulletin
  98. Frame shuffling: a novel method for in vitro protein evolution
    Kenji Kashiwagi, Yasuhiro Isogai, Kei-ichi Nishiguchi, Kiyotaka Shiba · 2006 · Protein Engineering Design and Selection
  99. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity
    Evelyn Jabri, Thomas R. Cech · 1998 · RNA
  100. Kinetic partitioning mechanism of HDV ribozyme folding
    Jiawen Carmen Chen, Sha Gong, Yujie Wang, Wenbing Zhang · 2014 · The Journal of Chemical Physics