Cited by 304Growth Hormone and Insulin-like Growth FactorsCytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

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Dehkhoda, Farhad, Lee, Christine M. M., Medina, Johan, Brooks, Andrew J.·2018·Frontiers in Endocrinology

Abstract

The growth hormone receptor (GHR), although most well known for regulating growth, has many other important biological functions including regulating metabolism and controlling physiological processes related to the hepatobiliary, cardiovascular, renal, gastrointestinal, and reproductive systems. In addition, growth hormone signaling is an important regulator of aging and plays a significant role in cancer development. Growth hormone activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor. JAK2 activation is required for growth hormone-mediated activation of STAT1, STAT3, and STAT5, and the negative regulation of JAK-STAT signaling comprises an important step in the control of this signaling pathway. The GHR also activates the Src family kinase signaling pathway independent of JAK2. This review covers the molecular mechanisms of GHR activation and signal transduction as well as the physiological consequences of growth hormone signaling.

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Authors
Dehkhoda, F., Lee, C. M. M., Medina, J., & Brooks, A. J.
Affiliations
Translational Research Institute (AU)
Corresponding author
Brooks, Andrew J.
Venue
Frontiers in Endocrinology
Published
2018-02-13
Volume
9
Pages
35-35
ISSN
1664-2392 (ISSN-L)
OpenAlex
W2790718366
Cited by
304
References
330
Citations by year
2026: 37 · 2025: 41 · 2024: 33 · 2023: 46 · 2022: 46 · 2021: 50 · 2020: 35 · 2019: 13 · 2018: 3
FWCI
3.88
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RUNE (Research UNE) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Health and Medical Research Council (APP1084797)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
growth hormone receptor, receptor activation, JAK/STAT signaling, JAK2 activation, STAT1, STAT3, STAT5, Src family kinases, signal transduction, growth hormone physiology, aging, cancer, metabolism

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