Cited by 292Heat shock proteins researchCancer-related Molecular PathwaysGenomics and Chromatin Dynamics

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Regulation of the Human hsp70 Promoter by p53

Agoff, S. Nicholas, Hou, Jeannie, Linzer, Daniel I., Wu, Barbara·1993·Science

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Abstract

The tumor suppressor p53 is a nuclear phosphoprotein with characteristics of a transcription factor. It displays sequence-specific DNA binding, contains a potent transactivation domain, and has been implicated as both a transcriptional activator and a repressor. Transcription of the human hsp70 gene is stimulated by adenovirus E1a protein. This E1a transactivation of the hsp70 promoter is mediated by CCAAT binding factor (CBF). It is demonstrated here that p53 both represses transcription from the human hsp70 promoter and also interacts with CBF. Thus, the repression of the hsp70 promoter by p53 may be mediated by direct protein-protein interaction with CBF. These results suggest that protein-protein interaction between p53 and specific transcription factors may be an additional mechanism by which p53 regulates gene expression.

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Authors: Agoff, S. N., Hou, J., Linzer, D. I., & Wu, B.
Affiliations: Northwestern University (US)
ORCID: Agoff, S. Nicholas
Hou, Jeannie
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1993-01
Volume: 259
Issue: 5091
Pages: 84-87
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8418500
OpenAlex: W2061154169
Cited by: 292
References: 54
Citations by year: 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 6
FWCI: 13.77
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: p53, HSP70 gene, promoter regulation, transcriptional repression, CCAAT-binding factor, protein-protein interaction, adenovirus E1A, transcriptional activator, tumor suppressor, gene expression regulation
MeSH terms: Base Sequence, Cloning, Molecular, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Gene Expression Regulation, Heat-Shock Proteins, Humans, Promoter Regions, Genetic, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Chloramphenicol O-Acetyltransferase, Tumor Suppressor Protein p53, TATA Box, Adenovirus E1A Proteins, CCAAT-Enhancer-Binding Proteins

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Regulation of the Human hsp70 Promoter by p53

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