The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Regulation of the Human hsp70 Promoter by p53
Abstract
The tumor suppressor p53 is a nuclear phosphoprotein with characteristics of a transcription factor. It displays sequence-specific DNA binding, contains a potent transactivation domain, and has been implicated as both a transcriptional activator and a repressor. Transcription of the human hsp70 gene is stimulated by adenovirus E1a protein. This E1a transactivation of the hsp70 promoter is mediated by CCAAT binding factor (CBF). It is demonstrated here that p53 both represses transcription from the human hsp70 promoter and also interacts with CBF. Thus, the repression of the hsp70 promoter by p53 may be mediated by direct protein-protein interaction with CBF. These results suggest that protein-protein interaction between p53 and specific transcription factors may be an additional mechanism by which p53 regulates gene expression.
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“In 1993, p53 was first reported to bind to coactivators, including the TATA-box binding protein,73, 74 the CCAAT-box binding factor (NF-Y)75 and specificity protein 1 (Sp1) that binds to GC-boxes,76 and to interfere with their transactivator function.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [75]
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Cites
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Self-citation
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p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921
The cellular and molecular basis of hyperthermia
Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,714
Clinical Implications of the p53 Tumor-Suppressor Gene
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Metadata
- Authors
- Agoff, S. N., Hou, J., Linzer, D. I., & Wu, B.
- Affiliations
- Northwestern University (US)
- Venue
- Science
- Published
- 1993-01
- Volume
- 259
- Issue
- 5091
- Pages
- 84-87
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061154169
- Cited by
- 292
- References
- 54
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 6
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- p53, HSP70 gene, promoter regulation, transcriptional repression, CCAAT-binding factor, protein-protein interaction, adenovirus E1A, transcriptional activator, tumor suppressor, gene expression regulation
- MeSH terms
- Base Sequence, Cloning, Molecular, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Gene Expression Regulation, Heat-Shock Proteins, Humans, Promoter Regions, Genetic, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Chloramphenicol O-Acetyltransferase, Tumor Suppressor Protein p53, TATA Box, Adenovirus E1A Proteins, CCAAT-Enhancer-Binding Proteins
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