The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element
Abstract
Upon activation, B lymphocytes can change the class of the antibody they express by immunoglobulin class switch recombination. Cytokines can direct this recombination to distinct classes by the specific activation of repetitive recombinogenic DNA sequences, the switch regions. Recombination to a particular switch region (s γ 1) was abolished in mice that were altered to lack sequences that are 5′ to the s γ 1 region. This result directly implicates the functional importance of 5′ switch region flanking sequences in the control of class switch recombination. Mutant mice exhibit a selective agammaglobulinemia and may be useful in the assessment of the biological importance of immunoglobulin G1.
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Cites
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Self-citationHPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells
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Cited by
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Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,647
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Self-citationSpontaneous development of inflammatory bowel disease in T cell receptor mutant mice
Mombaerts, P., Mizoguchi, E., Grusby, M. J., Glimcher, L. H., Bhan, A. K., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)80069-q · Cited by 718
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Rickert, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1317 · Cited by 718
Metadata
- Authors
- Jung, S., Rajewsky, K., & Radbruch, A.
- Venue
- Science
- Published
- 1993-02-12
- Volume
- 259
- Issue
- 5097
- Pages
- 984-987
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067961064
- Cited by
- 337
- References
- 27
- FWCI
- 12.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
