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Cited by 3,130

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Microsatellite Instability in Cancer of the Proximal Colon

Thibodeau, S. N., Bren, G., Schaid, D.·1993·Science
DOI 10.1126/science.8484122
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Abstract

Colorectal tumor DNA was examined for somatic instability at (CA) n repeats on human chromosomes 5q, 15q, 17p, and 18q. Differences between tumor and normal DNA were detected in 25 of the 90 (28 percent) tumors examined. This instability appeared as either a substantial change in repeat length (often heterogeneous in nature) or a minor change (typically two base pairs). Microsatellite instability was significantly correlated with the tumor's location in the proximal colon ( P = 0.003), with increased patient survival ( P = 0.02), and, inversely, with loss of heterozygosity for chromosomes 5q, 17p, and 18q. These data suggest that some colorectal cancers may arise through a mechanism that does not necessarily involve loss of heterozygosity.

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Metadata

Authors
Thibodeau, S. N., Bren, G., & Schaid, D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-05-07
Volume
260
Issue
5109
Pages
816-819
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8484122
OpenAlex
W1995819860
Cited by
3,130
References
1
FWCI
121.00
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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