The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.
Nowell, Peter C.·1976·Science
Cited by (1,016)
Items 501–600 of 1,016
- Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastasesLurdes Torres, Franclim R. Ribeiro, Nikos Pandis, Johan A. Andersen, Sverre Heim, Manuel Rodrigues Teixeira · 2006 · Breast Cancer Research and Treatment
- Spatial genomics maps the structure, nature and evolution of cancer clonesArtem Lomakin, Jessica Svedlund, Carina Strell, Milana Gatarić, Artem Shmatko, Gleb D. Rukhovich, Jun Sung Park, Young Seok Ju, Stefan C. Dentro, Vitalii Kleshchevnikov et al. · 2022 · Nature
- The p53 gene and its role in human brain tumorsOliver Bögler, Hui Huang, Paul Kleihues, Webster K. Cavenee · 1995 · Glia
- Identification of Genetic Markers for Prostatic Cancer ProgressionJanneke C. Alers, Jenneke Rochat, Pieter-Jaap Krijtenburg, Wim C.J. Hop, Ries Kranse C, Carla Rosenberg, Hans J. Tanke, Fritz H. Schröder, Herman van Dekken · 2000 · Laboratory Investigation
- Multistep Carcinogenesis: A Chain Reaction of AneuploidizationsPETER H. DUESBERG, Ruhong Li · 2003 · Cell Cycle
- Tumor suppressor geneticsShannon R. Payne, Christopher J. Kemp · 2005 · Carcinogenesis
- Trisomy 7 in nonneoplastic cellsBertil Johansson, Sverre Heim, Nils Mandahl, Fredrik Mertens, Felix Mitelman · 1993 · Genes Chromosomes and Cancer
- Expanding the computational toolbox for mining cancer genomesLi Ding, Michael C. Wendl, Joshua F. McMichael, Benjamin J. Raphael · 2014 · Nature Reviews Genetics
- A practical guide to cancer subclonal reconstruction from DNA sequencingMaxime Tarabichi, Adriana Salcedo, Amit G. Deshwar, Máire Ní Leathlobhair, Jeff A. Wintersinger, David C. Wedge, Peter Van Loo, Quaid Morris, Paul Christopher Boutros · 2021 · Nature Methods
- Therapeutic Effects of Coumarins with Different Substitution PatternsVirginia Flores‐Morales, Ana P. Villasana-Ruíz, Idalia Garza Veloz, Samantha González Delgado, Margarita L. Martínez‐Fierro · 2023 · Molecules
- Evolution of the cancer genomePodlaha, Ondrej, Riester, Markus, De, Subhajyoti, Michor, Franziska · 2012 · Trends in Genetics
- Chromosomal instability (CIN): what it is and why it is crucial to cancer evolutionHenry H. Heng, Steven W. Bremer, Joshua B. Stevens, Steven D. Horne, Guo Liu, Batoul Y. Abdallah, Karen J. Ye, Christine J. Ye · 2013 · Cancer and Metastasis Reviews
- Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategiesWenxuan Du, Olivier Elemento · 2014 · Oncogene
- T he M olecular B iology of M ucosal F ield C ancerization of the H ead and N eckPatrick K. Ha, Joseph A. Califano · 2003 · Critical Reviews in Oral Biology & Medicine
- Tumor dedifferentiation: An important step in tumor invasionHelmut Erich Gabbert, Rudolf Wagner, Roland Moll, Claus‐Dieter Gerharz · 1985 · Clinical & Experimental Metastasis
- mTOR pathway in colorectal cancer: an updateMaria Giovanna Francipane, Eric Lagasse · 2013 · Oncotarget
- Darwinian medicine: a case for cancerMelvyn F. Greaves · 2007 · Nature reviews. Cancer
- Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?Carolyn S. Grove, George S. Vassiliou · 2014 · Disease Models & Mechanisms
- Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer InitiationSaid M. Afify, Masaharu Seno · 2019 · Cancers
- Barrett's esophagus: Cell cycle abnormalities in advancing stages of neoplastic progressionBrian J. Reid, Carissa A. Sanchez, Patricia L. Blount, Douglas S. Levine · 1993 · Gastroenterology
- How many kinds of individual are there?Bernabé Santelices · 1999 · Trends in Ecology & Evolution
- Principles and mechanisms of non-genetic resistance in cancerCharles C. Bell, Omer Gilan · 2019 · British Journal of Cancer
- p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail.John G. Strickler, Jianping Zheng, Q Shu, L J Burgart, S R Alberts, Darryl K. Shibata · 1994 · PubMed
- The biology of cancer metastasis and implications for therapyIsaiah J. Fidler, Charles M. Blach · 1987 · Current Problems in Surgery
- Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: Molecular bases for EGFR-targeted therapyPablo Uribe, Sergio González · 2011 · Pathology - Research and Practice
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental EvolutionBram Van den Bergh, Toon Swings, Maarten Fauvart, Jan Jacques Michiels · 2018 · Microbiology and Molecular Biology Reviews
- Generation of phenotypic diversity and progression in metastatic tumor cellsGarth L. Nicolson · 1984 · Cancer and Metastasis Reviews
- The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasisIan R. Hart, Isaiah J. Fidler · 1981 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Age-specific incidence of cancer: Phases, transitions, and biological implicationsRafael Meza, Jihyoun Jeon, Suresh H. Moolgavkar, E. Georg Luebeck · 2008 · Proceedings of the National Academy of Sciences
- How Does Multistep Tumorigenesis Really Proceed?Christine Louise Chaffer, Robert A. Weinberg · 2015 · Cancer Discovery
- The landscape of gene mutations in cirrhosis and hepatocellular carcinomaMiryam Müller, Thomas Graham Bird, Jean‐Charles Nault · 2020 · Journal of Hepatology
- Flow cytometry in assessing the clinical aggressiveness of genito-urinary neoplasmsBernhard Tribukait · 1987 · World Journal of Urology
- Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinomaSusanna L. Cooke, Charlotte K.Y. Ng, Nataliya Melnyk, María J. García, Thomas J. Hardcastle, Jillian Temple, Simon P. Langdon, David D. Huntsman, James D. Brenton · 2010 · Oncogene
- Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular AspectsRobert S. Kerbel · 1990 · Advances in cancer research
- Normal diploid human and rodent cells lack a detectable frequency of gene amplification.Thea Dorothy Tlsty · 1990 · Proceedings of the National Academy of Sciences
- Microsatellite instability: The mutator that mutates the other mutatorManuel Perucho · 1996 · Nature Medicine
- What does physics have to do with cancer?Franziska Michor, Jan Liphardt, Mauro Ferrari B, Jonathan Widom · 2011 · Nature reviews. Cancer
- The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: Implications for methylation-associated cellular processesThomas Haaf · 1995 · Pharmacology & Therapeutics
- Ataxia‐telangiectasia, cancer and the pathobiology of the ATM geneM. Stephen Meyn · 1999 · Clinical Genetics
- Prognostic significance of DNA aneuploidy and cell proliferation in rectal adenocarcinomasPhilip Quirke, Michael F. Dixon, Andrew D. Clayden, Paul Durdey, John E. D. Dyson, Norman S. Williams, Colin C. Bird · 1987 · The Journal of Pathology
- Proliferation and invasion: Plasticity in tumor cellsChong-Feng Gao, Qian Reuben Xie, Yanli Su, Julie M. Koeman, Sok Kean Khoo, Margaret F. Gustafson, Beatrice S. Knudsen, Rick V. Hay, Nariyoshi Shinomiya, George F. Vande Woude · 2005 · Proceedings of the National Academy of Sciences
- The Chromosomal Basis of CancerPETER H. DUESBERG, Ruhong Li, Alice Charlotte Fabarius, Rüediger Hehlmann · 2005 · Analytical Cellular Pathology
- Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid modelCarey, Shawn P., Starchenko, Alina, McGregor, Alexandra L., Reinhart-King, Cynthia A. · 2013 · Clinical & Experimental Metastasis
- Identification and targeting of cancer stem cellsTobias Schatton, Natasha Y. Frank, Markus H. Frank · 2009 · BioEssays
- Cancer Stem Cell Immunology: Key to Understanding Tumorigenesis and Tumor Immune Escape?Valentin S. Bruttel, Jöerg Wischhusen · 2014 · Frontiers in Immunology
- Stress-Induced Mutagenesis: Implications in Cancer and Drug ResistanceDevon M. Fitzgerald, P. J. Hastings, Susan M. Rosenberg · 2016 · Annual Review of Cancer Biology
- Aneuploidy correlated 100% with chemical transformation of Chinese hamster cellsRuhong Li, George Yerganian, PETER H. DUESBERG, Alwin Kraemer, Andreas Willer, Charlotte Rausch, Rüediger Hehlmann · 1997 · Proceedings of the National Academy of Sciences
- Genomic Instability and Tumor Progression: Mechanistic ConsiderationsKeith C. Cheng, Lawrence A. Loeb · 1992 · Advances in cancer research
- Clonal heterogeneity of small-cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis.Lars L. Vindeløv, Heine Høi Hansen, Ib Jarle Christensen, Mogens Spang‐Thomsen, Fred R. Hirsch, Mogens Hansen, Nis I. Nissen · 1980 · PubMed
- The Epigenetic Hallmarks of CancerManel Esteller, Mark A. Dawson, Cigall Kadoch, Feyruz Virgilia Rassool, Peter A. Jones, Stephen B. Baylin · 2024 · Cancer Discovery
- The biology of head and neck cancer stem cellsZhaocheng Zhang, Manoel Sant’Ana Filho, Jacques Eduardo Nor · 2011 · Oral Oncology
- Involvement of Lgl and Mahjong/VprBP in Cell CompetitionYoichiro Tamori, Carl Uli Bialucha, Aiguo Tian, Mihoko Kajita, Yi‐Chun Huang, Mark Norman, Nicholas Harrison, John Poulton, Kenzo Ivanovitch, Lena Disch et al. · 2010 · PLoS Biology
- An immersed boundary framework for modelling the growth of individual cells: An application to the early tumour developmentKatarzyna Anna Rejniak · 2007 · Journal of Theoretical Biology
- Pathogenesis of adult testicular germ cell tumorsBauke M. de Jong, J. Wolter Oosterhuis, Sérgio M.M.J. Castedo, AnneMarie Vos, Gerard J. te Meerman · 1990 · Cancer Genetics and Cytogenetics
- Molecular characterization and targeted therapeutic approaches in breast cancerAngela Toss, Massimo Cristofanilli · 2015 · Breast Cancer Research
- Reconstructing metastatic seeding patterns of human cancersJohannes G. Reiter, Alvin P. Makohon-Moore, Jeffrey M. Gerold, Ivana Božić, Krishnendu Chatterjee, Christine A. Iacobuzio–Donahue, Bert Vogelstein, Martin A. Nowak · 2017 · Nature Communications
- Abnormalities of chromosome 1p in human neuroblastoma tumors and cell linesFred Gilbert, Gloria B. Balaban, Paul S. Moorhead, Diana W. Bianchi, Harvey R. Schlesinger · 1982 · Cancer Genetics and Cytogenetics
- Tumor progression in human malignant melanoma: Five stages defined by their antigenic phenotypesBernhard Holzmann, Eva‐Bettina Bröcker, Jürgen M. Lehmann, Dirk J. Ruiter, Clemens Sorg, Gert Riethmüller, Judith P. Johnson · 1987 · International Journal of Cancer
- The origins of cancer robustness and evolvabilityTianhai Tian, Sarah Olson, James M. Whitacre, Angus Silas Harding · 2010 · Integrative Biology
- Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker DesignSalvador J. Díaz‐Cano · 2012 · International Journal of Molecular Sciences
- Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewRosalba Camicia, Hans Christian Winkler, Paul O. Hassa · 2015 · Molecular Cancer
- DNA Amplification by Breakage/Fusion/Bridge Cycles Initiated by Spontaneous Telomere Loss in a Human Cancer Cell LineAnthony W.I. Lo, Laure Sabatier, Bijan Fouladi, Géraldine Pottier, Michelle Ricoul, John P. Mumane · 2002 · Neoplasia
- TP53 andMYC gene alterations independently predict poor prognosis in breast cancer patientsEls M.J.J. Berns, Jan G.M. Klijn, Marcel Smid, Iris L. van Staveren, Maxime P. Look, Wim L.J. van Putten, John A. Foekens · 1996 · Genes Chromosomes and Cancer
- Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesisRanjit S. Bindra, Peter M. Glazer · 2004 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
- Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapyStefano Fais, Giulietta Venturi, Bob Gatenby · 2014 · Cancer and Metastasis Reviews
- Ecological Therapy for Cancer: Defining Tumors Using an Ecosystem Paradigm Suggests New Opportunities for Novel Cancer TreatmentsKenneth J. Pienta, Natalie McGregor, Robert Axelrod, David E. Axelrod · 2008 · Translational Oncology
- Chromosome segregation and genomic stabilityViji M. Draviam, Stephanie Zhi-Juan Xie, Peter Karl Sorger · 2004 · Current Opinion in Genetics & Development
- Spontaneous regression of cancerRose J. Papac · 1996 · Cancer Treatment Reviews
- Heterogeneity of cancer cells from a single human colon carcinomaDaniel L. Dexter, Ellen N. Spremulli, Zuzana Fligiel, James A. Barbosa, Renee Vogel, Abby VanVoorhees, Paul Calabresi · 1981 · The American Journal of Medicine
- Therapeutic Potential and Challenges of Natural Killer Cells in Treatment of Solid TumorsAndrea Gras Navarro, Andreas T. Björklund, Martha Chekenya · 2015 · Frontiers in Immunology
- IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancersBin Zhang, Theodore G Karrison, Donald A. Rowley, Hans Wilhelm Schreiber · 2008 · Journal of Clinical Investigation
- Diagnosis and grading of dysplasia in Barrett’s oesophagusRobert Daniel Odze · 2006 · Journal of Clinical Pathology
- Cancer metastasis: A product of tumor-host interactionsEverett V. Sugarbaker · 1979 · Current Problems in Cancer
- Chapter 10 The Cancer Cell–Leukocyte Fusion Theory of MetastasisJohn M. Pawelek, Ashok K. Chakraborty · 2008 · Advances in cancer research
- Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibilityGuohze Yang, Stefan J. Scherer, Scarlet S. Shell, Kan Yang, Mimi Kim, Martin Lipkin, Raju Kucherlapati, Richard David Kolodner, Winfried Edelmann · 2004 · Cancer Cell
- NG2 proteoglycan-binding peptides target tumor neovasculature.Michael A. Burg, Renata Pasqualini, Wadih Arap, Erkki I. Ruoslahti, William B. Stallcup · 1999 · PubMed
- Clonal evolution in hematological malignancies and therapeutic implicationsDan Avi Landau, Scott L. Carter, Gad A. Getz, Catherine J. Wu · 2013 · Leukemia
- Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research.David Samuel Alberts, O. Michael Colvin, Allan H. Conney, Virginia L. Ernster, Jeff Garber, Peter Greenwald, Lorraine J. Gudas, Ki Hong Waun Ki Hong, Gary J. Kelloff, Robert A. Kramer et al. · 1999 · PubMed
- How aneuploidy affects metabolic control and causes cancerDavid Rasnick, PETER H. DUESBERG · 1999 · Biochemical Journal
- Normal stem cells and cancer stem cells: similar and differentMark J. Shackleton · 2010 · Seminars in Cancer Biology
- APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min miceCaldwell, Christine M., Green, Rebecca A., Kaplan, Kenneth B. · 2007 · The Journal of Cell Biology
- Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer MetastasisCelià-Terrassa, Toni, Jolly, Mohit Kumar · 2020 · Cold Spring Harbor Perspectives in Medicine
- DNA replication fidelity and cancerPreston, Bradley D., Albertson, Tina M., Herr, Alan J. · 2010 · Seminars in Cancer Biology
- The Cancer Stem Cell Hypothesis: Failures and PitfallsMaryam Rahman, Loic P. Deleyrolle, Vinata Vedam‐Mai, Hassan Azari, Muhammad M. Abd‐El‐Barr, Brent A. Reynolds · 2010 · Neurosurgery
- Evolutionary medicine: its scope, interest and potentialStephen C. Stearns · 2012 · Proceedings of the Royal Society B Biological Sciences
- Genetic insights into the morass of metastatic heterogeneityKent W. Hunter, Ruhul Amin, Sarah K. Deasy, Ngoc‐Han Ha, Lalage M. Wakefield · 2018 · Nature reviews. Cancer
- Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cellsNuzhat Ahmed, Ruth M. Escalona, Dilys T.H. Leung, Emily Chan, George Kannourakis · 2018 · Seminars in Cancer Biology
- A narrative review of tumor heterogeneity and challenges to tumor drug therapyLiang Wei Zhu, Minlin Jiang, Hao Wang, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu et al. · 2021 · Annals of Translational Medicine
- Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinomaLarry E. Puls, Deborah E. Powell, Paul D. DePriest, Holly H. Gallion, James E. Hunter, Richard J. Kryscio, John Rensselaer van Nagell · 1992 · Gynecologic Oncology
- Stochastic cancer progression driven by non‐clonal chromosome aberrationsHenry H. Heng, Joshua B. Stevens, Gou Liu, Steven W. Bremer, Karen J. Ye, Prem-veer Reddy, Gen Sheng Wu, Yanru Wang, Michael A. Tainsky, Christine J. Ye · 2006 · Journal of Cellular Physiology
- Evidence for Common Clonal Origin of Multifocal Lung CancersXiaoyan Wang, Mingsheng Wang, Gregory T. MacLennan, Fadi W. Abdul‐Karim, John N. Eble, Timothy D. Jones, Felix A. Olobatuyi, Rosana Eisenberg, Oscar W. Cummings, Shaobo Zhang et al. · 2009 · JNCI Journal of the National Cancer Institute
- The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to MalignancyRobert D. Loberg, Deborah Bradley, Scott A. Tomlins, Arul M. Chinnaiyan, Kenneth J. Pienta · 2007 · CA A Cancer Journal for Clinicians
- Extraskeletal Myxoid Chondrosarcoma: A Clinicopathologic, Immunohistochemical, and Ploidy Analysis of 23 CasesAndré M. Oliveira, Thomas J. Sebo, James E. McGrory, Thomas A. Gaffey, Michael G. Rock, Antonio G. Nascimento · 2000 · Modern Pathology
- Genome Stability Requires p53Eischen, Christine M. · 2016 · Cold Spring Harbor Perspectives in Medicine
- Unraveling the complexity of tyrosine kinase inhibitor–resistant populations by ultra-deep sequencing of the BCR-ABL kinase domainSimona Soverini, Caterina D. Benedittis, Kateřina Machová Poláková, Adéla Broučková, David Stephen Horner, Michele Iacono, Fausto Castagnetti, Gabriele Gugliotta, Francesca Palandri, Cristina Papayannidis et al. · 2013 · Blood
- Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic HeterogeneityTae‐Min Kim, Seung‐Hyun Jung, Chang Hyeok An, Sung Hak Lee, In-Pyo Baek, Min Sung Kim, Sung‐Won Park, Je‐Keun Rhee, Sug-Hyung Lee, Yeun‐Jun Chung · 2015 · Clinical Cancer Research
- Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchyAnkur Sharma, Elaine Yiqun Cao, Vibhor Kumar, Xiaoqian Zhang, Hui Sun Leong, Angeline M.L. Wong, Neeraja Ramakrishnan, Muhammad Hakimullah, Hui Min Vivian Teo, Fui Teen Chong et al. · 2018 · Nature Communications
- Cancer stem cell mimicry for immune evasion and therapeutic resistancePhei Er Saw, Qiang Liu, Ping‐Pui Wong, Erwei Song · 2024 · Cell stem cell
- The Cellular Basis of Tumor ProgressionGloria H. Heppner, Fred R. Miller · 1997 · International review of cytology
- Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.Chen‐Yang Shen, J.-C. Yu, Y.-L. Lo, C H Kuo, C T Yue, Yuh‐Shan Jou, Chiun‐Sheng Huang, J C Lung, Cheng-Han Wu · 2000 · PubMed