Cited by 689Retinal Development and DisordersCircadian rhythm and melatoninCellular transport and secretion

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Rod Outer Segment Disk Shedding in Rat Retina: Relationship to Cyclic Lighting

LaVail, Matthew M.·1976·Science

DOI 10.1126/science.982063

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Abstract

When albino rats are reared in cyclic light, a burst of rod outer segment disk shedding occurs in the retina soon after the onset of light. The number of large packets of outer segment disks (phagosomes) in the pigment epithelium at this time is 2.5 to 5 times greater than at any other time of day or night. The subsequent degradation of large phagosomes to smaller structures within pigment epithelial cells proceeds rapidly. The burst of disk shedding follows a circadian rhythm for at least 3 days, since it occurs in continuous darkness at the same time without the onset of light.

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Authors: LaVail, M. M.
Affiliations: Boston Children's Hospital (US)
Corresponding author: LaVail, Matthew M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1976-12-03
Volume: 194
Issue: 4269
Pages: 1071-1074
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.982063
OpenAlex: W2051747007
Cited by: 689
References: 20
Citations by year: 2026: 13 · 2025: 19 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 14 · 2020: 24 · 2019: 18 · 2018: 24 · 2017: 16 · 2016: 9 · 2015: 25 · 2014: 21 · 2013: 11 · 2012: 15
FWCI: 10.66
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: phagosome, retinal pigment epithelium, circadian rhythm, albino rats, photoreceptors
MeSH terms: Animals, Circadian Rhythm, Light, Organoids, Phagocytosis, Photoreceptor Cells, Pigment Epithelium of Eye, Reserpine, Rats

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Rod Outer Segment Disk Shedding in Rat Retina: Relationship to Cyclic Lighting

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