The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Rod Outer Segment Disk Shedding in Rat Retina: Relationship to Cyclic Lighting
Abstract
When albino rats are reared in cyclic light, a burst of rod outer segment disk shedding occurs in the retina soon after the onset of light. The number of large packets of outer segment disks (phagosomes) in the pigment epithelium at this time is 2.5 to 5 times greater than at any other time of day or night. The subsequent degradation of large phagosomes to smaller structures within pigment epithelial cells proceeds rapidly. The burst of disk shedding follows a circadian rhythm for at least 3 days, since it occurs in continuous darkness at the same time without the onset of light.
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In the citing paper
“LaVail (1976) first reported a greater number of phagosomes in the rat RPE after light onset.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“However, in his original paper, LaVail showed that blockage of the rat pineal gland with reserpine prevented the sudden increase in phagosome number that occurs after light onset (LaVail, 1976), suggesting some extraocular influence on circadian OS phagocytosis.”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“Most animals (including mouse, rat, cat, hamster, Xenopus laevis, goldfish, rabbit, and chick) appear to be entrained to a circadian rhythm, which is cued by the light/dark cycle and persists even when the animal is maintained in absolute darkness (LaVail, 1976; Besharse et al., 1977; Grace et al., 1996), but not in absolute light (Teirstein et al., 1980).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“due to their fresh dissection, reflect the in vivo circadian rhythm of OS phagocytosis (LaVail, 1976)”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as LaVail, 1976
In the citing paper
“POS disk phagocytosis is triggered according to a daily cycle at the beginning of the light phase (LaVail, 1976)”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as LaVail, 1976
In the citing paper
“The ingested POS phagosomes then migrate from the apical region into the cell and are degraded (Gibbs et al., 2003), mimicking events that occur in vivo (LaVail, 1976; Herman and Steinberg, 1982).”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as LaVail, 1976
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Metadata
- Authors
- LaVail, M. M.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- LaVail, Matthew M.
- Venue
- Science
- Published
- 1976-12-03
- Volume
- 194
- Issue
- 4269
- Pages
- 1071-1074
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051747007
- Cited by
- 689
- References
- 20
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 16 · 2023: 17 · 2022: 23 · 2021: 14 · 2020: 24 · 2019: 18 · 2018: 24 · 2017: 16 · 2016: 9 · 2015: 25 · 2014: 21 · 2013: 11 · 2012: 15
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- phagosome, retinal pigment epithelium, circadian rhythm, albino rats, photoreceptors
- MeSH terms
- Animals, Circadian Rhythm, Light, Organoids, Phagocytosis, Photoreceptor Cells, Pigment Epithelium of Eye, Reserpine, Rats
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