Identification and characterization of essential genes in the human genome

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Items 901–1,000 of 1,005

  1. CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines
    Daniel Josef Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, G Mohseni-Kouchesfahani, Lara Annina Haeusser, Bianca Walter, Adam Brown, Nicole S. Persky, David E. Root et al. · 2024 · Genome Medicine
  2. Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal Adenocarcinoma
    Risky Oktriani, Anna Chiara Pirona, Lili Kalmár, Ariani Syafitri Rahadian, Beiping Miao, Andrea S. Bauer, Jörg D. Hoheisel, Michael Boettcher, Haoqi Du · 2024 · Cancers
  3. scKAN: interpretable single-cell analysis for cell-type-specific gene discovery and drug repurposing via Kolmogorov-Arnold networks
    Haohuai He, Zhenchao Tang, Guanxing Chen, Fan Xu, Yao Fei Hu, Yinglan Feng, Jibin Wu, Yu‐An Huang, Zhi-An Huang, Kay Chen Tan · 2025 · Genome biology
  4. A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers
    Suman Rao, Guangyan Du, Marc A. Hafner, Kartik Subramanian, Peter Karl Sorger, Nathanael S. Gray · 2019 · Journal of Biological Chemistry
  5. mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity
    Li Guo, Yongsheng Li, Kara M. Cirillo, Robert A. Marick, Zhe Su, Xing Yin, Xu Hua, Gordon Brent Mills, Nidhi Sahni, S. Stephen Yi · 2021 · Briefings in Bioinformatics
  6. A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis
    Sipan Zhang, Junnan Wu, Xiaodong Zhu, Hui Song, Lu Ren, Qiaoli Tang, Xiaodong Xu, Chunbei Liu, Jiong Zhang, Weixin Hu et al. · 2021 · Molecular Therapy — Nucleic Acids
  7. Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response
    Hyeon Gu Kang, Haeun Hwangbo, Myung Ji Kim, Sinae Kim, Eun Ji Lee, Min Ji Park, Jae-Weon Kim, Byoung-Gie Kim, Eun-Hae Cho, Suhwan Chang et al. · 2021 · Cancer Research
  8. DISE/6mer seed toxicity-a powerful anti-cancer mechanism with implications for other diseases
    Ashley Haluck-Kangas, Monal Patel, Bidur Paudel, Aparajitha Vaidyanathan, Andrea E. Murmann, Marcus E. Peter · 2021 · Journal of Experimental & Clinical Cancer Research
  9. CRISPR Technology in Cancer Diagnosis and Treatment: Opportunities and Challenges
    Behrouz Shademan, Sepideh Masjedi, Vahidreza Karamad, Alireza Isazadeh, Fatma Söğütlü, Mohammad hosein saeedi rad, Alireza Nourazarian · 2022 · Biochemical Genetics
  10. Recombinase-mediated cassette exchange-based screening of a CRISPR/Cas9 library for enhanced recombinant protein production in human embryonic kidney cells: Improving resistance to hyperosmotic stress
    Seunghyeon Shin, Su Hyun Kim, Jong-Ho Park, Jae Seong Lee, Gyun Min Lee · 2022 · Metabolic Engineering
  11. A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains
    Vanessa R. Montoya, Trine M. Ready, Abby Felton, Sydney R. Fine, Molly OhAinle, Michael Emerman · 2023 · mBio
  12. CRISPR /Cas9 screen for genome‐wide interrogation of essential MYC ‐bound E‐boxes in cancer cells
    Marta Kazimierska, Marta Podralska, Magdalena Żurawek, Tomasz Woźniak, Marta Elżbieta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Iwona Ziółkowska‐Suchanek, Joost L. Kluiver, Anke van den Berg et al. · 2023 · Molecular Oncology
  13. Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)
    Benjamin E. Housden, Zhongchi Li, Colleen Kelley, Yuan-li Wang, Yanhui Hu, Alexander J. Valvezan, Brendan D. Manning, Norbert Perrimon · 2017 · Proceedings of the National Academy of Sciences
  14. Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
    Bo Hua, Michael Springer · 2018 · Cell Systems
  15. Critical cancer vulnerabilities identified by unbiased CRISPR/Cas9 screens inform on efficient cancer Immunotherapy
    Margaret A. Potts, Jackson A. McDonald, Kate D Sutherland, Marco J. Herold · 2020 · European Journal of Immunology
  16. Trypanosoma cruzi Letm1 is involved in mitochondrial Ca 2+ transport, and is essential for replication, differentiation, and host cell invasion
    Guilherme Rodrigo Reis Monteiro dos Santos, Ana Catarina Rezende Leite, Noelia Lander, Miguel Ángel Chiurillo, Aníbal Eugênio Vercesi, Roberto Docampo · 2021 · The FASEB Journal
  17. Ohnologs and SSD Paralogs Differ in Genomic and Expression Features Related to Dosage Constraints
    Zoe Vance, Aoife McLysaght · 2023 · Genome Biology and Evolution
  18. Stratifying TAD boundaries pinpoints focal genomic regions of regulation, damage, and repair
    Bijia Chen, Chao Ren, Zhangyi Ouyang, Jingxuan Xu, Kang Xu, Yaru Li, Hejiang Guo, Xuemei Bai, Mengge Tian, Xiang Xu et al. · 2024 · Briefings in Bioinformatics
  19. Unlocking biological mechanisms with integrative functional genomics approaches
    Sehee Yun, Minsoo Noh, Jivin Yu, Hyeon-Jai Kim, Chi‐chung Hui, Hunsang Lee, Joe Eun Son · 2024 · Molecules and Cells
  20. The Ptch/SPOUT1 methyltransferase deposits an m 3 U modification on 28 S rRNA for normal ribosomal function in flies and humans
    Jie Chen, Yaofu Bai, Yuantai Huang, Min Cui, Yiqing Wang, Zhenqi Gu, Xiaolong Wu, Yubin Li, Yikang S. Rong · 2024 · Science Advances
  21. Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes
    Thierry Chénard, Frédéric Guénard, Marie‐Claude Vohl, André C. Carpentier, André Tchernof, Rafaël Najmanovich · 2017 · BMC Systems Biology
  22. The essentiality of drug targets: an analysis of current literature and genomic databases
    Xiao Ji, Deepak K. Rajpal, Johannes Freudenberg · 2018 · Drug Discovery Today
  23. The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside
    Jian Gan, Su Jun Zheng, Xiao Rong Mao, Jun Feng Li · 2020 · Acta Biochimica Polonica
  24. CSC software corrects off-target mediated gRNA depletion in CRISPR-Cas9 essentiality screens
    Alexendar R. Perez, Laura Sala, Richard K. Perez, Joana Alves Vidigal · 2021 · Nature Communications
  25. Stepwise assembly of the eukaryotic translation initiation factor 2 complex
    Sven Vanselow, Lea Neumann-Arnold, Franziska Wojciech-Moock, Seufert, Wolfgang · 2022 · University of Regensburg Publication Server (University of Regensburg)
  26. Characterization of Cell Cycle-Related Competing Endogenous RNAs Using Robust Rank Aggregation as Prognostic Biomarker in Lung Adenocarcinoma
    Yifei Yang, Shiqi Zhang, Li Guo · 2022 · Frontiers in Oncology
  27. A CRISPR view on autophagy
    Jin Rui Liang, Jacob E. Corn · 2022 · Trends in Cell Biology
  28. Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens
    Alejandro Matía, Marı́a M. Lorenzo, Yolimar C. Romero-Estremera, Juana M. Sánchez-Puig, Ángel Zaballos, Rafael Blasco · 2022 · PLoS Pathogens
  29. An interactive web application for processing, correcting, and visualizing genome-wide pooled CRISPR-Cas9 screens
    Alessandro Vinceti, Riccardo Roberto De Lucia, Paolo Cremaschi, Umberto Perron, Emre Karakoç, Luca Mauri, Carlos Fernandez, Krzysztof Henryk Kluczynski, Daniel Stephen Anderson, Francesco Iorio · 2023 · Cell Reports Methods
  30. Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
    Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang, Qiu Wu, Ziyi Li, Jingxin Fu, Rongbin Zheng, Jiamin Zhang et al. · 2023 · Cancer Immunology Research
  31. acCRISPR: an activity-correction method for improving the accuracy of CRISPR screens
    Adithya Ramesh, Varun Trivedi, Sang Cheon Lee, Aida Tafrishi, Cory Schwartz, Amirsadra Mohseni, Mengwan Li, Stefano Lonardi, Ian R. Wheeldon · 2023 · Communications Biology
  32. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle
    Nan Song, Ling Deng, Lijie Zeng, He Li, Chunyan Liu, Ling Liu, Rong Fu · 2023 · Molecular Carcinogenesis
  33. Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency
    Qing V. Li, Bess P. Rosen, Danwei Huangfu · 2019 · WIREs Systems Biology and Medicine
  34. Protective role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP) in curcumin-induced cancer cell death
    Jambaldorj Boldbaatar, I. Ketut Gunarta, Ryusuke Suzuki, Purev Erdenebaatar, Gantulga Davaakhuu, Hirohiko Hohjoh, Katsuji Yoshioka · 2019 · Biochemical and Biophysical Research Communications
  35. A CRISPR-based method for testing the essentiality of a gene
    Yan You, Sharmila G. Ramachandra, Tian Jin · 2020 · Scientific Reports
  36. Targeting KRAS-mutant stomach/colorectal tumors by disrupting the ERK2-p53 complex
    Xiang Wang, Qing Mei Xie, Yan Ji, Jiaxin Yang, Jiayan Shen, Fangfei Peng, Yongfeng Zhang, Feng Jiang, Xiangyin Kong, Wenzhe Ma et al. · 2023 · Cell Reports
  37. Structural Mechanisms of Store-Operated and Mitochondrial Calcium Regulation: Initiation Points for Drug Discovery
    Megan Noble, Qi‐Tong Lin, Christian Sirko, Jacob A. Houpt, Matthew J. Novello, Peter B. Stathopulos · 2020 · International Journal of Molecular Sciences
  38. High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer
    Steven P. Williams, Andrew S. Barthorpe, Howard W. Lightfoot, Mathew J. Garnett, Ultan McDermott · 2017 · Scientific Data
  39. Neutrophils actively swell to potentiate rapid migration
    Tamas L Nagy, Evelyn Strickland, Orion David Weiner · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  40. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
    Sofya A. Polyanskaya, Rosamaria Y. Moreno, Bin Lu, Ruopeng Feng, Yu Yao, Seema Irani, Olaf Klingbeil, Zhaolin Yang, Yiliang Wei, Osama E. Demerdash et al. · 2022 · Cell Reports
  41. PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449
    Celimene Galiger, Meike Dahlhaus, Michael Peter Vitek, Klaus‐Michael Debatin, Christian P. Beltinger · 2022 · Frontiers in Oncology
  42. CRISPRi: a way to integrate iPSC-derived neuronal models
    Sarah N. J. Franks, Rachel Heon‐Roberts, Brent James Ryan · 2024 · Biochemical Society Transactions
  43. Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro
    Sarah Elizabeth Harris, Maria S. Alexis, Gilbert Giri, Francisco F. Cavazos, Yue Hu, Jernej Murn, Maria M. Aleman, Christopher B. Burge, Daniel Dominguez · 2024 · Nature Communications
  44. Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death
    Matthew B. Hanlon, Jason Matthew Shohet, Scot A. Wolfe · 2025 · Nature Communications
  45. Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitors
    William Y. Yang, Qianyu Guo, Songhua Quan, Zachary Rockow Chalmers, J. Brandon Parker, Mihai Ioan Truica, Mary F. Dufficy, Megan M. Kerber, Karthik Vasan, Dikshat Gopal Gupta et al. · 2025 · Science Advances
  46. Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases
    Juman Jubran, Idan Hekselman, Lena Novack, Esti Yeger‐Lotem · 2020 · Computational and Structural Biotechnology Journal
  47. A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells
    Valerie Schmieder, Neža Novak, Heena Dhiman, Nguyen Ngoc Ly, Evgenija Serafimova, Gerald Klanert, Martina Baumann, Helene Faustrup Kildegaard, Nicole Borth · 2021 · Biotechnology Reports
  48. A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites
    Päivi Pihlajamaa, Otto Kauko, Biswajyoti Sahu, Teemu Kivioja, Jussi Taipale · 2022 · Nature Biotechnology
  49. Applying CRISPR-Cas9 screens to dissect hematological malignancies
    Deepak Narayanan Iyer, Aaron David Schimmer, Hong Chang · 2022 · Blood Advances
  50. Recovering false negatives in CRISPR fitness screens with JLOE
    Merve Dede, Eiru Kim, Traver Hart · 2023 · Nucleic Acids Research
  51. Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA
    Byung-Sun Park, Heeju Jeon, Sung‐Gil Chi, Tackhoon Kim · 2023 · BMC Biology
  52. The evolving landscape of involvement of DTYMK enzymes in cancer
    Nadia Heydari, Mahsa Mahdizadeh, Seyyed Mehdi Jafari · 2023 · Medical Oncology
  53. Functional genomics and small molecules in mitochondrial neurodevelopmental disorders
    Daniel G. Calame, Lisa Emrick · 2024 · Neurotherapeutics
  54. A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data
    Alessandro Vinceti, Raffaele M Iannuzzi, Isabella Boyle, Lucia Trastulla, Catarina D. Campbell, Francisca Vázquez, Joshua M. Dempster, Francesco Iorio · 2024 · Genome biology
  55. Pharmacological treats for SUMO addicts
    Marco P. Licciardello, Stefan Kubicek · 2016 · Pharmacological Research
  56. Finding host targets for HIV therapy
    C. Kimberly Tsui, Amita Gupta, Michael Cory Bassik · 2017 · Nature Genetics
  57. BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis
    Aurélie Delannoy, Emmanuelle Wilhelm, Sebastian Eilebrecht, Edith Milena Alvarado-Cuevas, Arndt Benecke, Brendan Bell · 2018 · Cell Death and Disease
  58. Employing CRISPR/Cas9 genome engineering to dissect the molecular requirements for mitosis
    Kara L. McKinley · 2018 · Methods in cell biology
  59. Integrating Multifaceted Information to Predict Mycobacterium tuberculosis -Human Protein-Protein Interactions
    Jun Sun, Lingli Yang, Xi Chen, Kong De, Rong Liu · 2018 · Journal of Proteome Research
  60. A solid‐phase transfection platform for arrayed CRISPR screens
    Özdemirhan Serçin, Sabine Reither, Paris Roidos, Nadja Ballin, Spiros Palikyras, Anna Baginska, Katrin Rein, Maria Llamazares Prada, Aliaksandr A. Halavatyi, Hauke Winter et al. · 2019 · Molecular Systems Biology
  61. SeqCor: correct the effect of guide RNA sequences in clustered regularly interspaced short palindromic repeats/Cas9 screening by machine learning algorithm
    Xiaojian Liu, Yuanyuan Yang, Yan Qiu, Md. Reyad‐ul‐Ferdous, Qiurong Ding, Yi Wang · 2020 · Journal of genetics and genomics/Journal of Genetics and Genomics
  62. Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference
    S. John Liu, Max A. Horlbeck, Jonathan S. Weissman, Daniel A. Lim · 2020 · Methods in molecular biology
  63. CRISPR Screens in Toxicology Research: An Overview
    Amin Sobh, Max Russo, Chris D. Vulpe · 2021 · Current Protocols
  64. The P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation
    Corinna A. Kulicke, Erica De Zan, Zeynep Hein, Claudia González-López, Swapnil Ghanwat, Natacha Veerapen, Gurdyal Singh Besra, Paul Klenerman, John C. Christianson, Sebastian Springer et al. · 2021 · Journal of Biological Chemistry
  65. Thermofluor-Based Analysis of Protein Integrity and Ligand Interactions
    Sophia Pinz, Eva Doskocil, Wolfgang Seufert · 2022 · Methods in molecular biology
  66. Fluorescence Activated Cell Sorting (FACS) in Genome‐Wide Genetic Screening of Membrane Trafficking
    Bridget L. Menasché, Lauren Crisman, Daniel R. Gulbranson, Eric M. Davis, Haijia Yu, Jingshi Shen · 2018 · Current Protocols in Cell Biology
  67. Nanos3, a cancer-germline gene, promotes cell proliferation, migration, chemoresistance, and invasion of human glioblastoma
    Fengyu Zhang, Ruilai Liu, Cheng Liu, Haishi Zhang, Yuan Lu · 2020 · Cancer Cell International
  68. Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
    Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth D. Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ahmad Ansari, Rachel Pooley, Piers Wilkinson et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  69. CRISPR/Cas9 genetic screens in hepatocellular carcinoma gene discovery
    Cynthia H. Chiu · 2023 · Current Research in Biotechnology
  70. Noncanonical functions of Ku may underlie essentiality in human cells
    Rachel D. Kelly, Gursimran Parmar, Laila Bayat, Matthew E. R. Maitland, Gilles Lajoie, David R. Edgell, Caroline Schild‐Poulter · 2023 · Scientific Reports
  71. Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers
    Christina M. Caragine, Victoria T. Le, Meer Mustafa, Bianca Jay Diaz, John A. Morris, Simon Müller, Alejandro Méndez‐Mancilla, Evan T. Geller, Noa Liscovitch‐Brauer, Neville E. Sanjana · 2025 · Nature Communications
  72. ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC
    Nathan L. Tran, Jiewei Jiang, Mengyao Ma, Gillian E. Gadbois, Kevin Christian Montecillo Gulay, Alyssa L. Verano, Cara R. Schiavon, Elena Rebollo, Haowen Zhou, Chun‐Teng Huang et al. · 2025 · Nature Chemical Biology
  73. Highly efficient and long-acting split-and-mix proteolysis targeting chimera based on self-assembled polylactic acid
    Meimiao Zhan, Hailing Chen, Meiling He, Chunli Song, Zi-Jun Jiao, Na Liu, Zhihong Liu, Zhanfeng Hou, Ying Chen, Zhibo Song et al. · 2025 · Nature Communications
  74. Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production
    Kimberly S. Huggler, Kyle M. Flickinger, Matthew H. Forsberg, Carlos Mellado Fritz, Gavin R. Chang, Meghan F. McGuire, Christian M. Capitini, Jason R. Cantor · 2026 · Nature Metabolism
  75. Mammalian genome writing: Unlocking new length scales for genome engineering
    Sudarshan Pinglay, John T. Atwater, Ran Brosh, Jay Shendure, Matthew T. Maurano, Jef D. Boeke · 2026 · Cell
  76. Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
    Donghwi Ko, Raili Ruonala, Alexandre Faille, Eva Hellmann, Hanna Help, Huili Liu, Ronni Nielsen, Anders Kristian Haakonsson, Nuria De Diego, Anja Paatero et al. · 2026 · Science
  77. BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance
    Oliver W. Chung, Shun Yao, Ling Wang, Fu Yang, Lauren Schier, Melissa Aldana, Christian G. Cerda-Smith, Haley M. Hutchinson, Kris C. Wood, Weijia Su et al. · 2026 · Proceedings of the National Academy of Sciences
  78. Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression
    Tatiana Cardinal, Karl‐F. Bergeron, Rodolphe Soret, Ouliana Souchkova, Christophe C. Faure, Amélina Guillon, Nicolas Pilon · 2020 · PLoS Genetics
  79. Biochemical evidence for diverse strategies in the inner kinetochore
    Grace E Hamilton, Trisha Nell Davis · 2020 · Open Biology
  80. Congenital X‐linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6
    Raffaele Renella, Katelyn E. Gagne, Ellen M. Beauchamp, Jonathan Fogel, Aleksej Perlov, Mireia Sola, Thorsten M. Schlaeger, Inga Hofmann, Akiko Shimamura, Benjamin L. Ebert et al. · 2021 · American Journal of Hematology
  81. Functional Compensation of Mouse Duplicates by their Paralogs Expressed in the Same Tissues
    Agusto Luzuriaga-Neira, Krishnamurthy Subramanian, David Alvarez‐Ponce · 2022 · Genome Biology and Evolution
  82. PICKLES v3: the updated database of pooled in vitro CRISPR knockout library essentiality screens
    Lance C. Novak, Juihsuan Chou, Medina Colic, Christopher Aaron Bristow, Traver Hart · 2022 · Nucleic Acids Research
  83. Optimal construction of a functional interaction network from pooled library CRISPR fitness screens
    Veronica Gheorghe, Traver Hart · 2022 · BMC Bioinformatics
  84. Exportin 1‐mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma
    Mélody Caillot, Hadjer Miloudi, Antoine Taly, Núria Profitós-Pelejà, Juliana Carvalho Santos, Marcelo Lima Ribeiro, Elsa Maître, Simon Saule, Gaël Roué, Fabrice Jardin et al. · 2023 · Molecular Oncology
  85. Optimization of Genomewide CRISPR Screens Using AsCas12a and Multi-Guide Arrays
    Sakina M. Petiwala, Apexa Modi, Tifani Anton, Erin Murphy, Sabah Kadri, Heng-Cheng Hu, Charles Lu, Michael J. Flister, Daniel Verduzco · 2023 · The CRISPR Journal
  86. Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing
    Liliya M. Kulishova, Ivan P. Vokhtantsev, D. V. Kim, Dmitry O. Zharkov · 2023 · Molecular Biology
  87. Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation
    Hunter Levis, Jacob D. Weston, Brooke Austin, Bryce Larsen, Matthew Ginley-Hidinger, Sarah E. Gullbrand, Brandon Douglas Lawrence, Robby D. Bowles · 2023 · Cytotherapy
  88. The developmental and evolutionary characteristics of transcription factor binding site clustered regions based on an explainable machine learning model
    Zhangyi Ouyang, Feng Liu, Wanying Li, Junting Wang, Bijia Chen, Yang Zheng, Yaru Li, Huan Tao, Xiang Xu, Cheng Li et al. · 2024 · Nucleic Acids Research
  89. The identification of essential cellular genes is critical for validating drug targets
    Ting Xu, Shuang Wang, Tingting Ma, Yawen Dong, Charles R. Ashby, Ge‐Fei Hao · 2024 · Drug Discovery Today
  90. Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2
    Kiruphagaran Thangaraju, Róbert Király, Máté Ágoston Demény, János András Mótyán, Mónika Fuxreiter, László Fésüs · 2017 · PLoS ONE
  91. CrossCheck: an open-source web tool for high-throughput screen data analysis
    Jamil Najafov, Ayaz Najafov · 2017 · Scientific Reports
  92. βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin
    Yul Eum Song, Daniel Cyburt, Tiffany M. Lucas, Devon A. Gregory, Terri D. Lyddon, Marc C. Johnson · 2018 · Viruses
  93. Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe
    Bastian Gastl, Kathleen Klotz‐Noack, Bertram Klinger, Sylvia Ispasanie, Krenoula Hani Fouad Salib, Johannes A. Zuber, Soulafa Mamlouk, Natalie Bublitz, Nils Blüthgen, David A. Horst et al. · 2020 · Cell Death and Disease
  94. The leucine zipper EF‐hand containing transmembrane protein‐1 EF‐hand is a tripartite calcium, temperature, and pH sensor
    Qi‐Tong Lin, Rachel Lee, Allen L. Feng, Michael Sunmin Kim, Peter B. Stathopulos · 2021 · Protein Science
  95. Genetic analysis of human RNA binding motif protein 48 (RBM48) reveals an essential role in U12-type intron splicing
    Amy E. Siebert, Jacob Corll, J Paige Gronevelt, Laurel Levine, Linzi M Hobbs, Catalina Kenney, Christopher Lowell Edward Powell, Fabia Ursula Battistuzzi, Ruth Davenport, A. Mark Settles et al. · 2022 · Genetics
  96. Essential genes: a cross-species perspective
    Pilar Cacheiro, Damian P. Smedley · 2023 · Mammalian Genome
  97. CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries
    Martin Becker, Heidi Noll‐Puchta, Diana Amend, Florian Nolte, Christiane Fuchs, Irmela Jeremias, Christian Joerg Braun · 2020 · Nucleic Acids Research
  98. In Vivo Cancer-Based Functional Genomics
    Chennan Li, Andrea L. Kasinski · 2020 · Trends in cancer
  99. Biases and Blind-Spots in Genome-Wide CRISPR Knockout Screens
    Merve Dede, Eiru Kim, Traver Hart · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  100. Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens
    Simon Lam, John Christopher Thomas, Stephen P. Jackson · 2024 · Genome Medicine