Identification and characterization of essential genes in the human genome

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Items 201–300 of 1,004

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2. Genome-wide CRISPR screen for Zika virus resistance in human neural cells
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3. Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis
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5. Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
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6. Bayesian inference of negative and positive selection in human cancers
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7. The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation
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8. AKIRIN2 controls the nuclear import of proteasomes in vertebrates
   Melanie de Almeida, Matthias Hinterndorfer, Hanna L. Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak et al. · 2021 · Nature
9. Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis
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10. Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
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11. Robustness and lethality in multilayer biological molecular networks
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12. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
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13. Cancer CRISPR Screens In Vivo
    Ryan Dz-Wei Chow, Sidi Chen · 2018 · Trends in cancer
14. MYC Controls the Epstein-Barr Virus Lytic Switch
    Rui Guo, Chang Jiang, Yuchen Zhang, Apurva A. Govande, Stephen J. Trudeau, Fang Chen, Christopher J. Fry, Rishi Puri, Emma Wolinsky, Molly Schineller et al. · 2020 · Molecular Cell
15. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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16. Quantitative analysis of Y-Chromosome gene expression across 36 human tissues
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17. Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome
    Phoebe C. R. Parrish, James D. Thomas, Austin M. Gabel, Shriya Kamlapurkar, Robert K. Bradley, Alice H. Berger · 2021 · Cell Reports
18. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers
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19. Recent advances in combinatorial drug screening and synergy scoring
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20. Nested epistasis enhancer networks for robust genome regulation
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21. A Tumor Agnostic Therapeutic Strategy for Hexokinase 1–Null/Hexokinase 2–Positive Cancers
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22. Defining the role of the RSK isoforms in cancer
    Thibault Houlès, Philippe P. Roux · 2017 · Seminars in Cancer Biology
23. Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression
    Joseph Rosenbluh, Han Xu, William Harrington, Stanley Gill, Xiaoxing Wang, Francisca Vázquez, David E. Root, Aviad Tsherniak, William C. Hahn · 2017 · Nature Communications
24. The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
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25. TRAPP Complexes in Secretion and Autophagy
    Jane J. Kim, Zhanna Lipatova, Nava Segev · 2016 · Frontiers in Cell and Developmental Biology
26. Gene duplication can impart fragility, not robustness, in the yeast protein interaction network
    Guillaume Diss, Isabelle Gagnon‐Arsenault, Anne‐Marie Dion‐Côté, Hélène Vignaud, Diana Ascencio, Caroline Berger, Christian R. Landry · 2017 · Science
27. Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome
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28. Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum
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29. Validating genome-wide CRISPR-Cas9 function improves screening in the oleaginous yeast Yarrowia lipolytica
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30. Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells
    Rafaela Muniz de Queiroz, Rashna Madan, JEREMY R. CHIEN, Wagner B. Dias, Chad M Slawson · 2016 · Journal of Biological Chemistry
31. In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer
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32. Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How
    Stefan Bröer · 2020 · International Journal of Molecular Sciences
33. NuMA recruits dynein activity to microtubule minus-ends at mitosis
    Christina L. Hueschen, Samuel J. Kenny, Ke Xu, Sophie Dumont · 2017 · eLife
34. CRISPR/Cas9 library screening for drug target discovery
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35. Life or Death after a Break: What Determines the Choice?
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36. Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens
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37. Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
    Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers et al. · 2017 · Nature Communications
38. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
    Joep Beumer, Maarten H. Geurts, Mart Matthias Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart, Anna Z. Mykytyn, Tim I. Breugem, Samra Riesebosch, Debby Schipper et al. · 2021 · Nature Communications
39. Human and mouse essentiality screens as a resource for disease gene discovery
    Pilar Cacheiro, Violeta Muñoz‐Fuentes, Stephen A. Murray, Mary E. Dickinson, Maja Bućan, Lauryl M. J. Nutter, Kevin A. Peterson, Hamed Haselimashhadi, Ann Marie Flenniken, Hugh Morgan et al. · 2020 · Nature Communications
40. Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
    Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Y. Wei, Laura M. Urbanski, Naomi Currimjee, Ashton C. Berger, Galen F. Gao et al. · 2020 · Nature Communications
41. DEAD-Box RNA Helicases and Genome Stability
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42. RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and Open Questions
    Michael Hanna, Andrés Guillén-Samander, Pietro V. De Camilli · 2023 · Annual Review of Cell and Developmental Biology
43. Paralog Studies Augment Gene Discovery: DDX and DHX Genes
    Ingrid S. Paine, Jennifer Ellen Posey, Christopher M. Grochowski, Shalini N. Jhangiani, Sarah Rosenheck, Robert S. Kleyner, Taylor Marmorale, Margaret S. Yoon, Kai Wang, Reid J. Robison et al. · 2019 · The American Journal of Human Genetics
44. Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens
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45. O-GlcNAcylation and O-GlcNAc Cycling Regulate Gene Transcription: Emerging Roles in Cancer
    Matthew P. Parker, Kenneth R. Peterson, Chad M Slawson · 2021 · Cancers
46. JACKS: joint analysis of CRISPR/Cas9 knockout screens
    Felicity R. Allen, Fiona M. Behan, Anton Khodak, Francesco Iorio, Kosuke Yusa, Mathew J. Garnett, Leopold Parts · 2019 · Genome Research
47. Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
    Rui Jia, Juan S. Bonifacino · 2019 · eLife
48. Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport
    Marianna Leonzino, Karin M. Reinisch, Pietro V. De Camilli · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
49. CRISPR engineering in organoids for gene repair and disease modelling
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50. An atlas of human kinase regulation
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51. Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis
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52. An intramembrane chaperone complex facilitates membrane protein biogenesis
    Patrick J. Chitwood, Ramanujan S. Hegde · 2020 · Nature
53. A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
    Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L.M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques Neefjes, Paul J. Lehner · 2020 · Nature Communications
54. Functional variomics and network perturbation: connecting genotype to phenotype in cancer
    S. Stephen Yi, Shengda Lin, Yongsheng Li, Wei Zhao, Gordon Brent Mills, Nidhi Sahni · 2017 · Nature Reviews Genetics
55. Intronic CNVs and gene expression variation in human populations
    Maria Rigau, David Juan, Alfonso Valencia, Daniel Rico · 2019 · PLoS Genetics
56. Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins
    Jiayi Lin, Jinmei Jin, Yiwen Shen, Lijun Zhang, Gang Gong, Huiting Bian, Hongzhuan Chen, Dale G. Nagle, Ye Wu, Weidong Zhang et al. · 2021 · Theranostics
57. Functional single-cell genomics of human cytomegalovirus infection
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58. Clinical considerations for the design of PROTACs in cancer
    Cristina Nieto‐Jiménez, Esther Cabañas Morafraile, Carlos Alonso‐Moreno, Alberto Ocaña · 2022 · Molecular Cancer
59. Functional Genomics via CRISPR–Cas
    Kyle M. Ford, Daniella McDonald, Prashant Mali · 2018 · Journal of Molecular Biology
60. Quantitative nucleotide resolution profiling of RNA cytidine acetylation by ac4C-seq
    Supuni Thalalla Gamage, Aldema Sas‐Chen, Schraga Schwartz, Jordan L. Meier · 2021 · Nature Protocols
61. CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer
    Shanshan Gao, Fraser Soares, Shiyan Wang, Chi Chun Wong, Huarong Chen, Zhenjie Yang, Weixin Liu, Minnie Y.Y. Go, Musaddeque Ahmed, Yong Zeng et al. · 2021 · Oncogene
62. Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data
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63. Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
    Federico Teloni, Jone Michelena, Aleksandra Lezaja, Sinan Kilic, Christina M. Ambrosi, Shruti Menon, Jana Dobrovolná, Ralph Imhof, Pavel Janščák, Tuncay Baubec et al. · 2019 · Molecular Cell
64. Deep learning in image-based phenotypic drug discovery
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65. Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments
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66. Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
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67. Functional annotation of chemical libraries across diverse biological processes
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68. A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome
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69. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
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70. CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
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71. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
    Hannah Tovell, Andrea Testa, Houjiang Zhou, Natalia Shpiro, Claire Crafter, Alessio Ciulli, Dario R. Alessi · 2019 · ACS Chemical Biology
72. OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines
    Sanathoi Gurumayum, Puzi Jiang, Xiaowen Hao, Túlio de Lima Campos, Neil David Young, Pasi K. Korhonen, Robin B. Gasser, Peer Bork, Xing‐Ming Zhao, Lijie He et al. · 2020 · Nucleic Acids Research
73. MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity
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74. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens
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75. PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens
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76. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220
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77. Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy
    Potting, Christoph, Crochemore, Christophe, Moretti, Francesca, Nigsch, Florian, Schmidt, Isabel, Manneville, Carole, Carbone, Walter, Knehr, Judith, DeJesus, Rowena, Lindeman, Alicia et al. · 2018 · Proceedings of the National Academy of Sciences
78. A CRISPR-based base-editing screen for the functional assessment of BRCA1 variants
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79. BANP opens chromatin and activates CpG-island-regulated genes
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80. Precise prediction of phase-separation key residues by machine learning
    Jun Sun, Jiale Qu, Cai Zhao, Xinyao Zhang, Xinyu Liu, Jia Wang, Chao Wei, Xinyi Liu, Mulan Wang, Pengguihang Zeng et al. · 2024 · Nature Communications
81. Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
    De Kegel, Barbara, Ryan, Colm J. · 2019 · PLOS Genetics
82. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability
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83. Patient-derived cell line, xenograft and organoid models in lung cancer therapy
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84. An affinity-directed protein missile system for targeted proteolysis
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85. Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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86. Synthetic Lethal Vulnerabilities in <i>KRAS</i>-Mutant Cancers
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87. A network of human functional gene interactions from knockout fitness screens in cancer cells
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88. Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
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89. Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation
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90. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells
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91. Highly parallel genome variant engineering with CRISPR–Cas9
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92. Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response
    Emma McCann, Jacintha N O'Sullivan, Simone Marcone · 2020 · Translational Oncology
93. A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells
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94. tRNA dynamics between the nucleus, cytoplasm and mitochondrial surface: Location, location, location
    Kunal Chatterjee, Regina Nostramo, Yao Wan, Anita K. Hopper · 2017 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
95. Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
    Samah W. Awwad, Almudena Serrano-Benítez, John Christopher Thomas, Vipul Gupta, Stephen P. Jackson · 2023 · Nature Reviews Molecular Cell Biology
96. CRISPR/Cas9 screening using unique molecular identifiers
    Bernhard Schmierer, Sandeep Kumar Botla, Jilin Zhang, Mikko M. Turunen, Teemu Kivioja, Jussi Taipale · 2017 · Molecular Systems Biology
97. Defining Human Pluripotency
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98. Alpha-satellite RNA transcripts are repressed by centromere–nucleolus associations
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99. DNA–Protein Crosslink Proteolysis Repair
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100. Minimal genome-wide human CRISPR-Cas9 library
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