Identification and characterization of essential genes in the human genome

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.

Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950

Lethality and centrality in protein networks

Jeong, H., Mason, S., Barabási, A., & Oltvai, Z. (2001) · Nature · doi:10.1038/35075138 · Cited by 5,327

Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, O., Sanjana, N. E., Hartenian, E., Shi, X., Scott, D. A., Mikkelsen, T. S., Heckl, D., Ebert, B. L., Root, D. E., Doench, J. G., et al. (2014) · Science · doi:10.1126/science.1247005 · Cited by 5,234

Functional profiling of the Saccharomyces cerevisiae genome

Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316

BioGRID: a general repository for interaction datasets

Stark, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj109 · Cited by 3,960

BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1

Satoda, Y., Noguchi, T., Fujii, T., Taniguchi, A., Katoh, Y., & Nakayama, K. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-03-0089 · Cited by 16

Dynamic cell cycle–dependent phosphorylation modulates CENP-L–CENP-N centromere recruitment

Navarro, A. P., & Cheeseman, I. M. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-06-0239 · Cited by 17

Evolutionary adaptation revealed by comparative genome analysis of woolly mammoths and elephants

Smith, S. D., Kawash, J., Karaiskos, S., Biluck, I., & Grigoriev, A. (2017) · DNA Research · doi:10.1093/dnares/dsx007 · Cited by 18

DNA Double Strand Break Repair - Related Synthetic Lethality

Toma, M. M., Skórski, T., & Śliwiński, T. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180201114306 · Cited by 17

WINDOW consortium: A path towards increased therapy efficacy against glioblastoma

Abdul, K., Houweling, M., Svensson, F., Narayan, R. S., Cornelissen, F. M. G., Küçükosmanoğlu, A., Metzakopian, E., Watts, C., Bailey, D. S., Würdinger, T., et al. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.10.001 · Cited by 16

Discovering weak signals of emerging topics with a triple-dimensional framework

Ma, M., Mao, J., & Li, G. (2024) · Information Processing & Management · doi:10.1016/j.ipm.2024.103793 · Cited by 16

Gene editing and CRISPR-dependent homology-mediated end joining

Ruis, B. L., Bielinsky, A., & Hendrickson, E. A. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01442-z · Cited by 20

Intelligent Classification and Analysis of Essential Genes Using Quantitative Methods

Rout, R. K., Hassan, S. S., Sindhwani, S., Pandey, H. M., & Umer, S. (2020) · ACM Transactions on Multimedia Computing Communications and Applications · doi:10.1145/3343856 · Cited by 16

Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells

Pisa, R., Phua, D. Y. Z., & Kapoor, T. M. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.05.003 · Cited by 16

Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis

Xu, W., Yao, H., Wu, Z., Yan, X., Jiao, Z., Liu, Y., Zhang, M., & Wang, D. (2024) · Nature Communications · doi:10.1038/s41467-024-45585-5 · Cited by 18

RNA Binding by the m6A Methyltransferases METTL16 and METTL3

Mansfield, K. D. (2024) · Biology · doi:10.3390/biology13060391 · Cited by 18

A stable but reversible integrated surrogate reporter for assaying CRISPR/Cas9-stimulated homology-directed repair

Wen, Y., Liao, G., Pritchard, T., Zhao, T., Connelly, J. P., Pruett‐Miller, S. M., Blanc, V., Davidson, N. O., & Madison, B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.777722 · Cited by 15

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions

Simpkins, S. W., Nelson, J., Deshpande, R., Li, S. C., Piotrowski, J. S., Wilson, E. H., Gebre, A. A., Safizadeh, H., Okamoto, R., Yoshimura, M., et al. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006532 · Cited by 15

A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle

Davey, K., Wong, D., Konopacki, F. A., Kwa, E., Ly, T., Fiegler, H., & Sibley, C. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-86070-z · Cited by 19

Nucleolar localization of c‐Jun

Miyake, T., & McDermott, J. C. (2021) · FEBS Journal · doi:10.1111/febs.16187 · Cited by 16

Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease

Dahlqvist, J., Fulco, C. P., Ray, J. P., Liechti, T., de Boer, C. G., Lieb, D., Eisenhaure, T., Engreitz, J., Roederer, M., & Hacohen, N. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab372 · Cited by 15

De novo assembly and annotation of the CHOZN® GS −/− genome supports high‐throughput genome‐scale screening

Kretzmer, C., Narasimhan, R. L., Lal, R. D., Balassi, V., Ravellette, J., Manjunath, A. K. K., Koshy, J. J., Viano, M., Torre, S., Zanda, V. M., et al. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28226 · Cited by 15

mRNA export protein THOC5 as a tool for identification of target genes for cancer therapy

Tran, D. D. H., Saran, S., Koch, A., & Tamura, T. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.01.045 · Cited by 16

CRISPR-based technology to silence the expression of IncRNAs

Phelan, J. D., & Staudt, L. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003702117 · Cited by 16

An emerging ribosomopathy affecting the skeleton due to biallelic variations in NEPRO

Narayanan, D. L., Shukla, A., Kausthubham, N., Bhavani, G. S., Shah, H. H., Mortier, G. R., & Girisha, K. M. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61267 · Cited by 15

Prioritizing genes for systematic variant effect mapping

Kuang, D., Truty, R., Weile, J., Johnson, B. A., Nykamp, K., Araya, C. L., Nussbaum, R. L., & Roth, F. P. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa1008 · Cited by 16

The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling

Torres, A. A., Macilwee, S., Rashid, A., Cox, S. E., Albarnaz, J. D., Bonjardim, C. A., & Smith, G. L. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010277 · Cited by 14

Base excision repair accessory factors in senescence avoidance and resistance to treatments

Vickridge, E., Faraco, C. C. F., & Nepveu, A. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2022.36 · Cited by 15

High-Throughput CRISPR Screening in Hematological Neoplasms

Ancos-Pintado, R., Bragado-García, I., Morales, M. L., García-Vicente, R., Arroyo-Barea, A., Rodríguez-García, A., Martínez-López, J., Linares, M., & Hernández-Sánchez, M. (2022) · Cancers · doi:10.3390/cancers14153612 · Cited by 15

Applications of Innovation Technologies for Personalized Cancer Medicine: Stem Cells and Gene-Editing Tools

Hasanzadeh, A., Ebadati, A., Dastanpour, L., Aref, A. R., Zangabad, P. S., Kalbasi, A., Dai, X., Mehta, G., Ghasemi, A., Fatahi, Y., et al. (2023) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.3c00102 · Cited by 16

Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer

Papakyriacou, I., Kutkaite, G., Bedós, M. R., Nagarajan, D., Alford, L. P., Menden, M. P., & Mao, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-47987-x · Cited by 18

Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins

Sammaibashi, S., Yamayoshi, S., & Kawaoka, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01446 · Cited by 15

In vivo Protein Evolution, Next Generation Protein Engineering Strategy: from Random Approach to Target-specific Approach

Kim, J. Y., Yoo, H., Lee, P., Lee, S., Seo, J., & Kim, B. (2019) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-018-0394-2 · Cited by 15

Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains

McNamar, R., Abu-Adas, Z., Rothblum, K. N., Knutson, B. A., & Rothblum, L. I. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009902 · Cited by 15

Towards the routine use of in silico screenings for drug discovery using metabolic modelling

Bintener, T., Pacheco, M. P., & Sauter, T. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190867 · Cited by 17

Requirement for LIM kinases in acute myeloid leukemia

Jensen, P., Carlet, M., Schlenk, R. F., Weber, A., Kress, J., Brunner, I., Slabicki, M. M., Grill, G., Weisemann, S., Cheng, Y., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0943-5 · Cited by 16

Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators

Tang, Y., Liao, S., Liu, G., Xiong, X., Liu, H., Li, F., Tan, Z., Kong, X., Yin, Y., & Tan, B. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09586-0 · Cited by 16

Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain

Reiter, K. H., Zelter, A., Janowska, M. K., Riffle, M. E., Shulman, N., MacLean, B., Tamura, K., Chambers, M., MacCoss, M. J., Davis, T. N., et al. (2022) · Structure · doi:10.1016/j.str.2022.05.017 · Cited by 15

VHL Synthetic Lethality Signatures Uncovered by Genotype-Specific CRISPR-Cas9 Screens

Sun, N., Petiwala, S. M., Lu, C., Hutti, J. E., Hu, M., Hu, M., Domanus, M. H., Mitra, D., Addo, S. N., Miller, C. P., et al. (2019) · The CRISPR Journal · doi:10.1089/crispr.2019.0018 · Cited by 15

Mitotic kinase anchoring proteins: the navigators of cell division

Fulcher, L. J., & Sapkota, G. P. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1728014 · Cited by 15

Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions

Kim, E., Novak, L. C., Lin, C., Colic, M., Bertolet, L. L., Gheorghe, V., Bristow, C. A., & Hart, T. (2022) · Genome biology · doi:10.1186/s13059-022-02712-z · Cited by 14

Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomasPreprint

Norton, J. P., Augert, A., Eastwood, E., Basom, R., Rudin, C. M., & MacPherson, D. P. (2021) · Genes & Development · doi:10.1101/gad.348316.121 · Cited by 16

Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia

Adnan Awad, S., Dufva, O., Klievink, J., Karjalainen, E., Ianevski, A., Pietarinen, P., Kim, D., Potdar, S., Wolf, M., Lotfi, K., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101521 · Cited by 14

Overexpression of VIRMA Confers Vulnerability to Breast Cancers via the m 6A-Dependent Regulation of Unfolded Protein Response

Lee, Q., Song, R., Phan, D. A. V., Pinello, N., Tieng, J., Su, A., Halstead, J. M., Wong, A. C. H., van Geldermalsen, M., Lee, B. S. L., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04799-4 · Cited by 13

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment

Bhattacharjee, R., Jolly, L. A., Corbett, M. A., Wee, I. C., Rao, S. R., Gardner, A. E., Ritchie, T., van Hugte, E., Ciptasari, U., Piltz, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45121-5 · Cited by 15

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Jubran, J., Slutsky, R., Rozenblum, N., Rokach, L., Ben‐David, U., & Yeger‐Lotem, E. (2024) · Genome biology · doi:10.1186/s13059-024-03225-7 · Cited by 15

A next-generation dual guide CRISPR system for genetic interaction library screening

Burgold, T., Karakoç, E., Gonçalves, E., Barrio‐Hernandez, I., Dwane, L., Silva, R., Souster, E., Sharma, M., Beck, A., Koh, C. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67256-9 · Cited by 13

Why Genetic Effects of Radiation are Observed in Mice but not in Humans

Nakamura, N. (2017) · Radiation Research · doi:10.1667/rr14947.1 · Cited by 15

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Chan, K., Tong, A. H. Y., Brown, K. R., Mero, P., & Moffat, J. (2019) · Journal of Visualized Experiments · doi:10.3791/59780 · Cited by 14

A missense variant in NUF2, a component of the kinetochore NDC80 complex, causes impaired chromosome segregation and aneuploidy associated with microcephaly and short stature

Uehara, D. T., Mitsubuchi, H., & Inazawa, J. (2021) · Human Genetics · doi:10.1007/s00439-021-02273-4 · Cited by 14

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells

Wu, P.-S., Wang, C., Chen, P.-S., Hung, J., Yen, J.-H., & Wu, M. (2021) · Biomedicines · doi:10.3390/biomedicines9121907 · Cited by 14

Individual Genetic Heterogeneity

Vihinen, M. (2022) · Genes · doi:10.3390/genes13091626 · Cited by 17

Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice

Vanderkruk, B., Maeshima, N., Pasula, D. J., An, M., McDonald, C. L., Suresh, P., Luciani, D. S., Lynn, F. C., & Hoffman, B. G. (2023) · Diabetologia · doi:10.1007/s00125-023-05896-6 · Cited by 17

Multiomic analysis of cohesin reveals that ZBTB transcription factors contribute to chromatin interactions

Wang, R., Xu, Q., Wang, C., Tian, K., Wang, H., & Ji, X. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad401 · Cited by 13

Proteins with amino acid repeats constitute a rapidly evolvable and human-specific essentialome

Singh, A. K., Amar, I., Ramadasan, H., Kappagantula, K. S., & Chavali, S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112811 · Cited by 17

Functional Genomics for Cancer Research: Applications In Vivo and In Vitro

O’Loughlin, T. A., & Gilbert, L. A. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055742 · Cited by 14

TRIM52 regulates the proliferation and invasiveness of lung cancer cells via the Wnt/β‑catenin pathway

Mu, X., Li, H., Zhou, L., & Xu, W. (2019) · Oncology Reports · doi:10.3892/or.2019.7110 · Cited by 14

The perils of artificial intelligence in healthcare: Disease diagnosis and treatment

Jung, C. L. (2019) · Journal of Computational Biology and Bioinformatics Research · doi:10.5897/jcbbr2019.0122 · Cited by 14

One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines

Yeung, T. K., Lau, H. W., Ma, H. T., & Poon, R. Y. C. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-02-0051 · Cited by 14

RIOK1 kinase activity is required for cell survival irrespective ofMTAPstatus

Hörmann, A., Hopfgartner, B., Köcher, T., Corcokovic, M., Krammer, T., Reiser, C., Bader, G., Shi, J., Ehrenhöfer, K., Wöhrle, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25586 · Cited by 14

Genome-wide annotation of gene regulatory elements linked to cell fitnessPreprint

ter Weele, M., Klann, T. S., Barrera, A., Ettyreddy, A. R., Liu, S., Rickels, R. A., Bryois, J., Jiang, S. W., Adkar, S. S., Iglesias, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.08.434470 · Cited by 16

A deep catalog of protein-coding variation in 985,830 individualsPreprint

Sun, K., Bai, X., Chen, S., Bao, S., Kapoor, M., Zhang, C., Backman, J., Joseph, T., Maxwell, E. K., Mitra, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.09.539329 · Cited by 14

CRAMP1 drives linker histone expression to enable Polycomb repression

Matthews, R. E., Danac, J. M. C., Naden, E. L., Smith, L. E. F., Lestari, S., Gungi, A., Appert, A., Buttress, T., Verma, A., Sinclair, O. J., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.05.031 · Cited by 13

ELD1 mediates photoperiodic flowering via OsCCA1 alternative splicing and interacts with phytochrome signaling in rice

Cai, L., Hao, B., Xu, Z., Cui, S., Wu, Q., Lee, J., Hou, H., Hu, Y., Zhu, L., Wang, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60839-6 · Cited by 13

Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis

Arif, S. M., Floto, R. A., & Blundell, T. L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.857000 · Cited by 13

Mendelian gene identification through mouse embryo viability screening

Cacheiro, P., Westerberg, C. H., Mager, J., Dickinson, M. E., Nutter, L. M. J., Muñoz‐Fuentes, V., Hsu, C., den Veyver, I. B. V., Flenniken, A. M., McKerlie, C., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01118-7 · Cited by 12

Cre/ lox -Mediated CRISPRi Library Reveals Core Genome of a Type I Methanotroph Methylotuvimicrobium buryatense 5GB1C

Cheng, M., Pei, D., He, L., Fei, Q., & Yan, X. (2023) · Applied and Environmental Microbiology · doi:10.1128/aem.01883-22 · Cited by 13

The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma

Lacroix, M., Beauchemin, H., Khandanpour, C., & Möröy, T. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1148936 · Cited by 14

Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS

Zhao, Y., Wang, Y., Shi, L., McDonald‐McGinn, D. M., Crowley, T. B., McGinn, D. E., Tran, O., Miller, D., Lin, J.-R., Zackai, E. H., et al. (2023) · npj Genomic Medicine · doi:10.1038/s41525-023-00363-y · Cited by 14

Paralog dispensability shapes homozygous deletion patterns in tumor genomes

Kegel, B. D., & Ryan, C. J. (2023) · Molecular Systems Biology · doi:10.15252/msb.202311987 · Cited by 11

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

Misek, S. A., Fultineer, A., Kalfon, J., Noorbakhsh, J., Boyle, I., Roy, P., Dempster, J. M., Petronio, L., Huang, K. H., Saadat, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48957-z · Cited by 13

Sex chromosome cycle as a mechanism of stable sex determination

Hayashi, S., Abe, T., Igawa, T., Katsura, Y., Kazama, Y., & Nozawa, M. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae045 · Cited by 13

Noise robustness and metabolic load determine the principles of central dogma regulation

Lo, T. W., Choi, H. J., Huang, D., & Wiggins, P. A. (2024) · Science Advances · doi:10.1126/sciadv.ado3095 · Cited by 13

Auxiliary diagnosis of primary bone tumors based on Machine learning model

Deng, S., Huang, Y., Li, C., Qian, J., & Wang, X. (2024) · Journal of bone oncology · doi:10.1016/j.jbo.2024.100648 · Cited by 16

CRISPR-based functional genomics tools in vertebrate models

Varshney, G. K., & Burgess, S. M. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01514-0 · Cited by 18

CRISPR Libraries and Screening

Poirier, J. T. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.10.002 · Cited by 14

Mammalian haploid stem cells: establishment, engineering and applications

He, W., Chen, J., & Gao, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03069-6 · Cited by 11

Identification of DISE-inducing shRNAs by monitoring cellular responses

Patel, M., & Peter, M. E. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1383576 · Cited by 13

Biochemical investigation of rs1801282 variations in PPAR‐γ gene and its correlation with risk factors of diabetes mellitus in coronary artery disease

Rehman, K., Jabeen, K., Awan, F. R., Hussain, M., Saddique, M. A., & Akash, M. S. H. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13339 · Cited by 13

Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes

Le, T. T., Ainsworth, J., Rivera, C. P., Macartney, T., & Labib, K. P. M. (2021) · Biochemical Journal · doi:10.1042/bcj20210315 · Cited by 14

NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism

MohammadiPeyhani, H., Chiappino-Pepe, A., Haddadi, K., Hafner, J., Hadadi, N., & Vassily Hatzimanikatis, A. (2021) · eLife · doi:10.7554/elife.65543 · Cited by 12

Genetic Transformation of Apomictic Grasses: Progress and Constraints

Bellido, A. M., Canada, E. D. S., Permingeat, H. R., & Echenique, V. C. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.768393 · Cited by 13

Common computational tools for analyzing CRISPR screens

Colic, M., & Hart, T. (2021) · Emerging Topics in Life Sciences · doi:10.1042/etls20210222 · Cited by 13

A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication

Kozhukhar, N., Spadafora, D., Rodriguez, Y. A. R., & ALEXEYEV, M. F. (2022) · Cells · doi:10.3390/cells11142168 · Cited by 13

Cell cycle control of kinetochore assembly

Dong, Q., & Li, F. (2022) · Nucleus · doi:10.1080/19491034.2022.2115246 · Cited by 13

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

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Context-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation

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