Identification and characterization of essential genes in the human genome

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Items 101–200 of 1,005

1. High-content CRISPR screening
   Christoph Bock, Paul Datlinger, Florence M. Chardon, Matthew A. Coelho, Matthew B. Dong, Keith A. Lawson, Tian Lu, Laetitia Maroc, Thomas M. Norman, Bicna Song et al. · 2022 · Nature Reviews Methods Primers
2. Functional genomics of the rapidly replicating bacterium Vibrio natriegens by CRISPRi
   Henry H. Lee, Nili Ostrov, Brandon G. Wong, Michaela A. Gold, Ahmad S. Khalil, George McDonald Church · 2019 · Nature Microbiology
3. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism
   Nora Kory, Gregory A. Wyant, Gyan Prakash, Jelmi uit de Bos, Francesca Bottanelli, Michael E. Pacold, Sze Ham Chan, Caroline A. Lewis, Tim Wang, Heather R. Keys et al. · 2018 · Science
4. To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases
   Fran Supek, Ben Lehner, Rik G.H. Lindeboom · 2020 · Trends in Genetics
5. Review of CRISPR/Cas9 sgRNA Design Tools
   Yingbo Cui, Jiaming Xu, Minxia Cheng, Xiangke Liao, Shaoliang Peng · 2018 · Interdisciplinary Sciences Computational Life Sciences
6. Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
   Saioa López, Emilia L. Lim, Stuart D. Horswell, Kerstin Haase, Ariana Huebner, Michelle Dietzen, Thanos P. Mourikis, Thomas B.K. Watkins, Andrew Rowan, Sally M. Dewhurst et al. · 2020 · Nature Genetics
7. Regulation and Function of RNA Pseudouridylation in Human Cells
   Erin K. Borchardt, Nicole M. Martínez, Wendy V. Gilbert · 2020 · Annual Review of Genetics
8. Global Genetic Networks and the Genotype-to-Phenotype Relationship
   Costanzo, Michael, Kuzmin, Elena, van Leeuwen, Jolanda, Mair, Barbara, Moffat, Jason, Boone, Charles, Andrews, Brenda · 2019 · Cell
9. Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
   Xueqian Gong, Jian Du, Stephen H. Parsons, Farhana F. Merzoug, Yue Webster, Philip W. Iversen, Li-Chun Chio, Robert Daniel Van Horn, Xi Lin, Wayne D. Blosser et al. · 2018 · Cancer Discovery
10. Human gene essentiality
    István Bartha, Julia di Iulio, J. Craig Venter, Amalio Telenti · 2017 · Nature Reviews Genetics
11. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells
    Graham Dickson and Hugh MacLeod, Danielle Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle M. Kushida, Helen Yu, Fiona J. Coutinho, Florence M.G. Cavalli et al. · 2018 · Cell Reports
12. Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy
    Papapetrou, Eirini P, Schambach, Axel · 2016 · Molecular Therapy
13. Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair
    Bruno Vaz, Marta Popović, Joseph A. Newman, John Fielden, H. Aitkenhead, Swagata Halder, Abhay Narayan Singh, Iolanda Vendrell, Román Fischer, Ignacio Torrecilla et al. · 2016 · Molecular Cell
14. Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
    Stella, Stefano, Alcón, Pablo, Montoya, Guillermo · 2017 · Nature
15. Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
    Hess, Gaelen T., Tycko, Josh, Yao, David, Bassik, Michael C. · 2017 · Molecular Cell
16. Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia
    Trinna L. Cuellar, Anna‐Maria Herzner, Xiaotian Zhang, Yogesh Goyal, Colin K. Watanabe, Brad A. Friedman, Vasantharajan Janakiraman, Steffen Durinck, Jeremy Stinson, David P. Arnott et al. · 2017 · The Journal of Cell Biology
17. Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors
    François Rousset, Lun Cui, Elise Siouve, Christophe Bécavin, Florence Depardieu, David Bikard · 2018 · PLoS Genetics
18. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation
    Scott, Daniel C., Rhee, David Y., Duda, David M., Kelsall, Ian R., Olszewski, Jennifer L., Paulo, Joao A., de Jong, Annemieke, Ovaa, Huib, Alpi, Arno F., Harper, J. Wade et al. · 2016 · Cell
19. Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
    Benjamin E. Housden, Matthias Muhar, Matthew P. Gemberling, Charles A. Gersbach, Didier Y. R. Stainier, Géraldine Seydoux, Stephanie Elizabeth Mohr, Johannes A. Zuber, Norbert Perrimon · 2016 · Nature Reviews Genetics
20. Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids
    Michels, Birgitta E., Mosa, Mohammed H., Streibl, Barbara I., Zhan, Tianzuo, Menche, Constantin, Abou-El-Ardat, Khalil, Darvishi, Tahmineh, Członka, Ewelina, Wagner, Sebastian, Winter, Jan et al. · 2020 · Cell Stem Cell
21. CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation
    Tuladhar, Rubina, Yeu, Yunku, Tyler Piazza, John, Tan, Zhen, Rene Clemenceau, Jean, Wu, Xiaofeng, Barrett, Quinn, Herbert, Jeremiah, Mathews, David H., Kim, James et al. · 2019 · Nature Communications
22. Biological plasticity rescues target activity in CRISPR knock outs
    Smits, Arne H., Ziebell, Frederik, Joberty, Gerard, Zinn, Nico, Mueller, William F., Clauder-Münster, Sandra, Eberhard, Dirk, Fälth Savitski, Maria, Grandi, Paola, Jakob, Petra et al. · 2019 · Nature Methods
23. A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models
    Sjoerd Opdam, Anne Richelle, Benjamin P. Kellman, Shanzhong Li, Daniel Craig Zielinski, Nathan E. Lewis · 2017 · Cell Systems
24. Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease
    Zachary M. March, Oliver D. King, James Shorter · 2016 · Brain Research
25. Open questions in the study of de novo genes: what, how and why
    Aoife McLysaght, Laurence D. Hurst · 2016 · Nature Reviews Genetics
26. Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair
    Chen, Wei, McKenna, Aaron, Schreiber, Jacob, Haeussler, Maximilian, Yin, Yi, Agarwal, Vikram, Noble, William Stafford, Shendure, Jay · 2019 · Nucleic Acids Research
27. Design and analysis of CRISPR–Cas experiments
    Ruth E. Hanna, John G. Doench · 2020 · Nature Biotechnology
28. Structural basis for the docking of mTORC1 on the lysosomal surface
    Rogala, Kacper B., Gu, Xin, Kedir, Jibril F., Abu-Remaileh, Monther, Bianchi, Laura F., Bottino, Alexia M. S., Dueholm, Rikke, Niehaus, Anna, Overwijn, Daan, Fils, Ange-Célia Priso et al. · 2019 · Science
29. MCART1/SLC25A51 is required for mitochondrial NAD transport
    Kory, Nora, uit de Bos, Jelmi, van der Rijt, Sanne, Jankovic, Nevena, Güra, Miriam, Arp, Nicholas, Pena, Izabella A., Prakash, Gyan, Chan, Sze Ham, Kunchok, Tenzin et al. · 2020 · Science Advances
30. Understudied proteins: opportunities and challenges for functional proteomics
    Georg Kustatscher, Tom Collins, Anne‐Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn Susan Lilley, Emma K. Lundberg, Edward M. Marcotte, Markus Ralser et al. · 2022 · Nature Methods
31. Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate
    Tsun-Kai Chang, David A. Lawrence, Min Lu, Jenille Tan, Jonathan M. Harnoss, Scot A. Marsters, Peter Jianrui Liu, Wendy N. Sandoval, Scott E. Martin, Avi Ashkenazi · 2018 · Molecular Cell
32. Clinical and translational advances in esophageal squamous cell carcinoma
    Zachary Wilmer Reichenbach, Mary Grace Murray, Reshu Saxena, Daniel T. Farkas, Erika G. Karassik, Alena Klochkova, Kishan Patel, Caitlin M. Tice, Timothy M. Hall, Julie Gang et al. · 2019 · Advances in cancer research
33. Integrating artificial intelligence in drug discovery and early drug development: a transformative approach
    Alberto Ocaña, Atanasio Pandiella, Cristian Privat, Iván Bravo, Miguel Angel Luengo-Oroz, Eitan Amir, Balázs Győrffy · 2025 · Biomarker Research
34. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells
    Chad M. Toledo, Yu Ding, Pia Hoellerbauer, Ryan J. Davis, Ryan Basom, Emily J. Girard, Eunjee Lee, Philip D. Corrin, Traver Hart, Hamid Bolouri et al. · 2015 · Cell Reports
35. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
    David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael Cory Bassik et al. · 2018 · Nature Genetics
36. Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
    Ian C. P. Smith, Peyton Greenside, Ted E. Natoli, David L. Lahr, David Wadden, Itay Tirosh, Rajiv Narayan, David E. Root, Todd R. Golub, Aravind Subramanian et al. · 2017 · PLoS Biology
37. A CRISPR toolbox to study virus–host interactions
    Andreas S. Puschnik, Karim Majzoub, Yaw Shin Ooi, Jan E. Carette · 2017 · Nature Reviews Microbiology
38. Exploring genetic suppression interactions on a global scale
    Jolanda S. van Leeuwen, Carles Pons, Joseph C. Mellor, Takafumi N. Yamaguchi, Helena Friesen, John H. Koschwanez, Mojca Mattiazzi Ušaj, Maria Pechlaner, Mehmet Takar, Matej Ušaj et al. · 2016 · Science
39. Targeting pan-essential genes in cancer: Challenges and opportunities
    Liang Chang, Paloma A. Ruiz, Takahiro Ito, William R. Sellers · 2021 · Cancer Cell
40. Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly
    Horn-Ghetko, Daniel, Krist, David T., Prabu, J. Rajan, Baek, Kheewoong, Mulder, Monique P. C., Klügel, Maren, Scott, Daniel C., Ovaa, Huib, Kleiger, Gary, Schulman, Brenda A. · 2021 · Nature
41. Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy
    Erik S. Knudsen, Steven C. Pruitt, Pamela A. Hershberger, Agnieszka Katarzyna Witkiewicz, David W. Goodrich · 2019 · Trends in cancer
42. The whole-genome landscape of Burkitt lymphoma subtypes
    Razvan Panea, Cassandra Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann Marie Moormann, Juliana A. Otieno, John Michael Ong’echa, Cliff I. Oduor, Kristin Schroeder et al. · 2019 · Blood
43. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface
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44. Development of CRISPR-Cas systems for genome editing and beyond
    F. Zhang · 2019 · Quarterly Reviews of Biophysics
45. Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
    Farhad Hormozdiari, Steven Gazal, Bryce van de Geijn, Hilary K. Finucane, Chelsea J.‐T. Ju, Po‐Ru Loh, Armin P. Schoech, Yakir Reshef, Xuanyao Liu, Luke Jen O’Connor et al. · 2018 · Nature Genetics
46. CRISPR–Cas: a tool for cancer research and therapeutics
    Hao Yin, Wen Xue, Daniel G. Anderson · 2019 · Nature Reviews Clinical Oncology
47. Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2
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48. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance
    Anding, Allyson L., Wang, Chunxin, Chang, Tsun-Kai, Sliter, Danielle A., Powers, Christine M., Hofmann, Kay, Youle, Richard J., Baehrecke, Eric H. · 2018 · Current Biology
49. Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects
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50. New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
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51. The phenotypic landscape of essential human genes
    Funk, Luke, Su, Kuan-Chung, Ly, Jimmy, Feldman, David, Singh, Avtar, Moodie, Brittania, Blainey, Paul C., Cheeseman, Iain M. · 2022 · Cell
52. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
    Hans-Heinrich Hoffmann, Francisco J. Sánchez Rivera, William M. Schneider, Joseph M. Luna, Yadira M. Soto‐Feliciano, Alison W. Ashbrook, Jérémie Le Pen, Andrew A. Leal, Inna Ricardo-Lax, Eleftherios Michailidis et al. · 2020 · Cell Host & Microbe
53. VPS13D bridges the ER to mitochondria and peroxisomes via Miro
    Andrés Guillén-Samander, Marianna Leonzino, Michael G. Hanna, Ni Tang, Hongying Shen, Pietro V. De Camilli · 2021 · The Journal of Cell Biology
54. Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs
    Yang Zhang, Tuan M. Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G. Clohessy, Pier Paolo Pandolfi · 2021 · Genome biology
55. The ribosome-engaged landscape of alternative splicing
    Weatheritt, Robert J, Sterne-Weiler, Timothy, Blencowe, Benjamin J · 2016 · Nature Structural & Molecular Biology
56. Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences
    Sushant Kumar, Jonathan Warrell, Shantao Li, Patrick D. McGillivray, William U. Meyerson, Leonidas Salichos, Arif O. Harmanci, Alexander Martinez‐Fundichely, Calvin Wing Yiu Chan, Morten Muhlig Nielsen et al. · 2020 · Cell
57. SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes
    James P. Zewe, Rachel C. Wills, Sahana Sangappa, Brady D. Goulden, Gerald R. V. Hammond · 2018 · eLife
58. Long Noncoding RNAs and Repetitive Elements: Junk or Intimate Evolutionary Partners?
    Hyunmin Lee, Zhaolei Zhang, Henry M. Krause · 2019 · Trends in Genetics
59. Leveraging big data to transform target selection and drug discovery
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60. LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia
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61. Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls
    Peter Horak, Stefan Fröhling, Hanno Glimm · 2016 · ESMO Open
62. Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites
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63. Pleiotropic effects of statins: A focus on cancer
    Mazaher Ahmadi, Shayan Amiri, Stevan Pecic, Filip Machaj, Jakub Rosik, Marek Łoś, Javad Alizadeh, Reza Mahdian, Simone C. da Silva Rosa, Dedmer Schaafsma et al. · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
64. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
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65. OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines
    Wei‐Hua Chen, Guanting Lu, Xiao Chen, Xing‐Ming Zhao, Peer Bork · 2016 · Nucleic Acids Research
66. Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles
    Michlits, Georg, Jude, Julian, Hinterndorfer, Matthias, de Almeida, Melanie, Vainorius, Gintautas, Hubmann, Maria, Neumann, Tobias, Schleiffer, Alexander, Burkard, Thomas Rainer, Fellner, Michaela et al. · 2020 · Nature Methods
67. Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR)
    Stine F. Pedersen, Yasunobu Okada, Bernd Nilius · 2016 · Pflügers Archiv - European Journal of Physiology
68. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
    Liying Chen, Gabriela Alexe, Neekesh V. Dharia, Linda S. Ross, Amanda Balboni Iniguez, Amy Saur Conway, Emily Jue Wang, Veronica Veschi, Norris Lam, Jun Qi et al. · 2017 · Journal of Clinical Investigation
69. An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions
    Jingru Wang, Na Fang, Juan Xiong, Yuanjiao Du, Yue Cao, Wei-Ke Ji · 2021 · Nature Communications
70. A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
    Molly OhAinle, Louisa Helms, Jolien Vermeíre, Ferdinand Roesch, Daryl G. Humes, Ryan Basom, Jeffrey J. Delrow, Julie M. Overbaugh, Michael Emerman · 2018 · eLife
71. Estimating the selective effects of heterozygous protein-truncating variants from human exome data
    Christopher A. Cassa, Donate Weghorn, Daniel J. Balick, Daniel M. Jordan, David P. Nusinow, Kaitlin E. Samocha, Anne O’Donnell‐Luria, Daniel G. MacArthur, Mark J. Daly, David R. Beier et al. · 2017 · Nature Genetics
72. Predicting Cancer Drug Response using a Recommender System
    Chayaporn Suphavilai, Denis Bertrand, Niranjan Nagarajan · 2018 · Bioinformatics
73. Aurora A ligand complex
    Stephen Antonysamy, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Kenneth Weichert, S. Wasserman · 2018 · Worldwide Protein Data Bank
74. Mechanisms of tissue and cell-type specificity in heritable traits and diseases
    Idan Hekselman, Esti Yeger‐Lotem · 2020 · Nature Reviews Genetics
75. A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo
    Christopher Moore, Louis J. Papa, Matthew D. Shoulders · 2018 · Journal of the American Chemical Society
76. Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements
    Josh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa Truong, Alexandro E. Trevino et al. · 2019 · Nature Communications
77. Immunity to CRISPR Cas9 and Cas12a therapeutics
    Wei Leong Chew · 2017 · WIREs Systems Biology and Medicine
78. High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer
    Pierce, Sarah E., Granja, Jeffrey M., Greenleaf, William J. · 2021 · Nature Communications
79. R-spondins can potentiate WNT signaling without LGRs
    Andres M. Lebensohn, Rajat Rohatgi · 2018 · eLife
80. Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
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81. An ER translocon for multi-pass membrane protein biogenesis
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82. Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
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83. Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
    Gonatopoulos-Pournatzis, Thomas, Aregger, Michael, Brown, Kevin R., Farhangmehr, Shaghayegh, Braunschweig, Ulrich, Ward, Henry N., Ha, Kevin C. H., Weiss, Alexander, Billmann, Maximilian, Durbic, Tanja et al. · 2020 · Nature Biotechnology
84. CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens
    Georg Michlits, Maria Hubmann, Szu-Hsien Sam Wu, Gintautas Vainorius, Elena Budusan, Sergei Zhuk, Thomas Rainer Burkard, Maria Novatchkova, Martin Aichinger, YiQing Lü et al. · 2017 · Nature Methods
85. Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells
    Yilmaz, Atilgan, Peretz, Mordecai, Aharony, Aviram, Sagi, Ido, Benvenisty, Nissim · 2018 · Nature Cell Biology
86. CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
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87. The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
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88. Structural and functional insights into enzymes of the vitamin K cycle
    Jian‐Ke Tie, Darrel W. Stafford · 2015 · Journal of Thrombosis and Haemostasis
89. Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier
    Eiru Kim, Traver Hart · 2021 · Genome Medicine
90. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
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91. Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning
    Hans‐Hermann Wessels, Andrew Stirn, Alejandro Méndez‐Mancilla, Eric J. Kim, Sydney K. Hart, David A. Knowles, Neville E. Sanjana · 2023 · Nature Biotechnology
92. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
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93. RNA methyltransferase METTL16 : Targets and function
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94. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
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95. MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation
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96. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival
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97. Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma
    Masao Nakagawa, Arthur L. Shaffer, Michele Ceribelli, Meili Zhang, George W. Wright, Da Wei Huang, Wenming Xiao, John I. Powell, Michael N. Petrus, Yibin Yang et al. · 2018 · Cancer Cell
98. CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
    Judd F. Hultquist, Joseph B Hiatt, Kathrin Schumann, Michael McGregor, Theodore L. Roth, Paige Haas, Jennifer A. Doudna, Alexander Marson, Nevan J. Krogan · 2018 · Nature Protocols
99. A deep catalogue of protein-coding variation in 983,578 individuals
    Sun, Kathie Y., Bai, Xiaodong, Chen, Siying, Bao, Suying, Zhang, Chuanyi, Kapoor, Manav, Backman, Joshua, Joseph, Tyler, Maxwell, Evan, Mitra, George et al. · 2024 · Nature
100. CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine
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