The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Control of neuronal synapse specification by a highly dedicated alternative splicing program
Abstract
Synapse identity through specific splicing: What are the mechanisms that create different, highly specific types of synapses? Traunmüller et al. found that the RNA-binding protein SLM2 regulated a very small number of alternative splicing decisions in mouse hippocampal neurons. Disrupting this splicing program resulted in specific defects in transsynaptic protein complexes. Glutamatergic transmission and synaptic plasticity were impaired. Genetically restoring one single alternative splicing event was enough to recover synaptic plasticity. SLM2 thus activates a highly specific alternative splicing program that controls the properties of glutamatergic synapses. Science , this issue p. 982
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The regulation of NRXN1 splicing, including the formation of aberrant splice sites by specific RBPs, is poorly understood; >100 RBPs are predicted to interact with NRXN1 mRNA in a cell-type42,43 and neuronal activity23 dependent-manner.”
From Phenotypic complexities of rare heterozygous neurexin-1 deletions (2025) · cites this paper as [23]
In the citing paper
“For example, KH-domain STAR-family RBPs regulate SS4+ in a neuronal activity dependent manner23–25, mediating trans-synaptic signaling by varying interactions among a host of post-synaptic ligands.”
From Phenotypic complexities of rare heterozygous neurexin-1 deletions (2025) · cites this paper as [23]
Citations
Cites
Nova regulates brain-specific splicing to shape the synapse
Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1610 · Cited by 509
Chih, B., Gollan, L., & Scheiffele, P. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.005 · Cited by 393
Self-citationSAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1
Iijima, T., Wu, K., Witte, H., Hanno-Iijima, Y., Glatter, T., Richard, S., & Scheiffele, P. (2011) · Cell · doi:10.1016/j.cell.2011.11.028 · Cited by 279
Self-citationEssential roles for the splicing regulator nSR100/SRRM4 during nervous system development
Quesnel-Vallières, M., Irimia, M., Cordes, S. P., & Blencowe, B. J. (2015) · Genes & Development · doi:10.1101/gad.256115.114 · Cited by 155
Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1
Iijima, T., Iijima, Y., Witte, H., & Scheiffele, P. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201310136 · Cited by 90
Self-citationEhrmann, I., Dalgliesh, C., Liu, Y., Danilenko, M., Crosier, M., Overman, L., Arthur, H. M., Lindsay, S., Clowry, G. J., Venables, J. P., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003474 · Cited by 82
Research works printed but not linked: 26
- 10.1016/j.tig.2013.04.003 · DOI · Paper page
- 10.1016/j.neuron.2015.05.004 · DOI · Paper page
- 10.1016/j.neuron.2014.09.011 · DOI
- 10.7554/eLife.01201 · DOI · Paper page
- 10.1016/j.conb.2014.02.009 · DOI
- 10.1016/j.molcel.2014.05.004 · DOI
- 10.1523/JNEUROSCI.3395-14.2014 · DOI · Paper page
- 10.1016/j.neuron.2005.08.026 · DOI · Paper page
- 10.1016/j.cell.2010.04.035 · DOI · Paper page
- 10.1111/j.1460-9568.2011.07638.x · DOI
- 10.1016/j.cell.2007.10.036 · DOI · Paper page
- 10.1126/science.1107470 · DOI
- 10.1073/pnas.1214718110 · DOI
- 10.1038/nn.2825 · DOI
- 10.1016/j.bbr.2014.08.002 · DOI
- 10.1016/j.cell.2013.05.060 · DOI
- 10.1016/S0896-6273(00)00084-2 · DOI · Paper page
- 10.1111/j.1460-9568.2007.05842.x · DOI
- 10.1038/ncomms9362 · DOI
- 10.1016/S0896-6273(01)00450-0 · DOI
- 10.7554/eLife.07794 · DOI
- 10.1021/pr300273g · DOI
- 10.1093/bioinformatics/bts635 · DOI · Paper page
- 10.1016/j.stemcr.2015.10.006 · DOI
- 10.1016/j.jhep.2012.12.025 · DOI
- 10.1371/journal.pone.0051266 · DOI
Cited by
Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits
Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2017.10.024 · Cited by 810
A cross-species proteomic map reveals neoteny of human synapse development
Wang, L., Pang, K., Zhou, L., Cebrián-Silla, A., González-Granero, S., Wang, S., Bi, Q., White, M. L., Ho, B., Li, J., et al. (2023) · Nature · doi:10.1038/s41586-023-06542-2 · Cited by 82
A cross-species proteomic map reveals neoteny of human synapse development
Wang, L., Pang, K., Zhou, L., Cebrián-Silla, A., González-Granero, S., Wang, S., Bi, Q., White, M. L., Ho, B., Li, J., et al. (2022) · doi:10.1101/2022.10.24.513541 · Cited by 82
Phenotypic complexities of rare heterozygous neurexin-1 deletions
Fernando, M. B., Fan, Y., Zhang, Y., Tokolyi, A., Murphy, A. N., Kammourh, S., Deans, P. J. M., Ghorbani, S., Onatzevitch, R., Pero, A., et al. (2025) · Nature · doi:10.1038/s41586-025-08864-9 · Cited by 30
Metadata
- Authors
- Traunmüller, L., Gomez, A. M., Nguyen, T.-M., & Scheiffele, P.
- Venue
- Science
- Published
- 2016-05-20
- Volume
- 352
- Issue
- 6288
- Pages
- 982-986
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 148
- References
- 6
- Language
- en
- Funders
- Boehringer Ingelheim Fonds
- European Molecular Biology Organization
- International PhD Program University of Basel
- Swiss National Science Foundation
- European Autism Interventions EU-AIMS
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
