Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1
Open accessAbstract
The unique functional properties and molecular identity of neuronal cell populations rely on cell type–specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain–containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type–specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
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Slm1 and Slm2 single-null mice are viable with no apparent behavioural or anatomical defects.
“Slm1 and Slm2 single-null mice are viable with no apparent behavioural or anatomical defects84,87,98.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [84]
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Self-citation
- Authors
- Iijima, T., Iijima, Y., Witte, H., & Scheiffele, P.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Scheiffele, Peter
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2014-01-27
- Volume
- 204
- Issue
- 3
- Pages
- 331-342
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC3912522
- OpenAlex
- W2110332569
- Cited by
- 90
- References
- 49
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 15 · 2015: 7 · 2014: 4 · 2013: 2
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- edoc (University of Basel)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- alternative splicing, KH domain proteins, neuronal cell types, neurexin, synaptic adhesion molecules, conditional gene deletion, mouse brain, isoform diversity, cell type-specific gene expression
- MeSH terms
- Animals, Hippocampus, Humans, Interneurons, Nerve Tissue Proteins, Neurons, Organ Specificity, Protein Binding, RNA-Binding Proteins, Alternative Splicing, Protein Structure, Tertiary, Genes, Reporter, Mice, Knockout, Adaptor Proteins, Signal Transducing, Mice, HEK293 Cells
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