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NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
Open accessAbstract
A dietary supplement protects aging muscle: The oxidized form of cellular nicotinamide adenine dinucleotide (NAD + ) is critical for mitochondrial function, and its supplementation can lead to increased longevity. Zhang et al. found that feeding the NAD + precursor nicotinamide riboside (NR) to aging mice protected them from muscle degeneration (see the Perspective by Guarente). NR treatment enhanced muscle function and also protected mice from the loss of muscle stem cells. The treatment was similarly protective of neural and melanocyte stem cells, which may have contributed to the extended life span of the NR-treated animals. Science , this issue p. 1436 ; see also p. 1396
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“Mounting evidence supports a critical role for NAD+ in stem cell rejuvenation, including in HSCs, endothelial stem cells, muscle stem cells, and melanocyte stem cells (Das et al., 2018; Vannini et al., 2019; Zhang et al., 2016).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Zhang et al., 2016
In the citing paper
“Similarly, NR treatment of aged mice resulted in increased proliferation and increased neurogenesis in both the subventricular zone and the dentate gyrus of the hippocampus in aged mice (Zhang et al., 2016).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Zhang et al., 2016
In the citing paper
“In primary cell culture, supplementation with NR delays cellular senescence (Wiley et al., 2016), and NR treatment also reduces the senescent state in both NSCs and other stem cell types (Zhang et al., 2016).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Zhang et al., 2016
In the citing paper
“NR supplementation delayed senescence of adult NSCs in 2-year-old mice (Zhang et al., 2016), suggesting a role for a deficit in NAD+ or one or more of the enzymes it supports in neural-cell senescence.”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Zhang et al., 2016
In the citing paper
“NR administration in old mice showed a small but significant increase in lifespan (5%)198.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [198]
In the citing paper
“Treatment with NR also improved muscle stem cell functions by regulating mitochondrial metabolism in a mouse model of muscular dystrophy197,198.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [198]
In the citing paper
“In mice, NR causes a wide range of beneficial effects, including a moderate lifespan extension [202].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [202]
In the citing paper
“Additionally, nicotinamide riboside treatment in aging mice increased skeletal muscle function by preventing stem cell senescence, improved mitochondrial function, and a higher expression of genes involved in the TCA cycle and OXPHOS (266).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [266]
In the citing paper
“Reduced NAD+ levels in skeletal muscle of aged or Nampt deficient mice alter mitochondrial bioenergetics and impair muscle mass, strength and endurance49,50,52,53”
From Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities (2019) · cites this paper as [53]
In the citing paper
“the conversion of these precursors to NAD+ bypasses the rate limited enzyme NAMPT”
From Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities (2019) · cites this paper as [53]
In the citing paper
“new therapeutic strategies have emerged to restore NAD+ levels in muscle by administration of dietary NAD+ precursors such as NR or NMN46,53,54”
From Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities (2019) · cites this paper as [53]
In the citing paper
“For example, some old MuSCs become senescent, a state characterized by irreversible cell cycle arrest and secretion of cytokines and other proteins (senescence-associated secreted phenotype)39–43.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [39]
In the citing paper
“NAD precursors such as nicotinamide riboside can restore ageing defects in ISCs120, as well as in MuSCs, NSCs and melanocyte stem cells39.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [39]
In the citing paper
“The administration of NAD precursors, in particular nicotinamide riboside and nicotinamide mononucleotide, has shown benefits in terms of healthspan219 and lifespan39.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [39]
In the citing paper
“Nicotinamide riboside also has a beneficial effects on old MuSCs, NSCs and melanocyte stem cells, in part by rescuing mitochondrial function39.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [39]
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674
2016 update of the PRIDE database and its related tools
Vizcaíno, J. A., Csordás, A., del‐Toro, N., Dianes, J. A., Griss, J., Lavidas, I., Mayer, G., Pérez‐Riverol, Y., Reisinger, F., Ternent, T., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1145 · Cited by 3,466
Gillet, L. C., Navarro, P., Tate, S., Röst, H., Selevsek, N., Reiter, L., Bonner, R., & Aebersold, R. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o111.016717 · Cited by 2,877
Self-citationRejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
Self-citationSatellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994
Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648
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Yang, S., Yang, J., Hui⁃wen, Z., Deng, R., Fan, H., Zhang, J., Yang, Z., Zeng, H., Kuang, B., & Shao, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.820520 · Cited by 5
“These abnormalities in DMD mice can be partially ameliorated by administration of nutritional drugs (Zhang et al., 2016).”
BackgroundLoss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells
Bobadilla, M., Orbe, J., Abizanda, G., Machado, F. J. D., Vilas‐Zornoza, A., Ullate‐Agote, A., Extramiana, L., Churio, A. B., Aranguren, X. L., Cantero, G., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1128534 · Cited by 5
Guo, R., Li, Y., Song, Q., Huang, R., Ge, X., Nieto, N., Jiang, Y., & Song, Z. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00946.2024 · Cited by 5
Metabolic Alterations in HSCs during Aging and Leukemogenesis
Chiang, Y.-H., Emmrich, S., & Vannini, N. (2025) · Physiology · doi:10.1152/physiol.00054.2024 · Cited by 6
Braga, R. R., Rocha, M. B., Morelli, A. P., da Costa, R. G., Mori, M. A., da Silva, A. S. R., Pauli, J. R., Cintra, D. E., & Ropelle, E. R. (2025) · The Journal of Physiology · doi:10.1113/jp288453 · Cited by 7
Self-citationWhy Are Dithienylethene‐Linked Biscobaltocenes so Hard to Photoswitch?
Escribano, A., Steenbock, T., Stork, C., Herrmann, C., & Heck, J. (2017) · ChemPhysChem · doi:10.1002/cphc.201601146 · Cited by 5
NAMPT-Improved Mitochondrial Function Alleviates Degenerative Rotator Cuff Tendinopathy in Aged Mice
Zhang, Y., Lu, S., Yu, G., Wang, C., & Zhao, Q. (2023) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.22.00894 · Cited by 6
Nutritional Regulation of Mitochondrial Function
Vasam, G., Reid, K., Burelle, Y., & Menzies, K. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811752-1.00004-3 · Cited by 6
Self-citationEnhancing NAD+ Metabolome in Cardiovascular Diseases: Promises and Considerations
Jahan, F., & Bagchi, R. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.716989 · Cited by 5
Exploring the oncogenic impact of heteroplasmic de novo MT-ND5 truncating mutations
Wu, Y., Ye, J., & Gu, Z. (2025) · Mitochondrial Communications · doi:10.1016/j.mitoco.2025.03.001 · Cited by 4
“Similarly, NAD + replenishment has been linked to enhanced mitochondrial function, 88,89 improved cellular repair mechanisms, 90 and suppression of tumor growth in certain contexts.”
Self-citationThe emerging role of cellular senescence in amyotrophic lateral sclerosis
Tan, X., & Gao, N. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1599492 · Cited by 6
“In transgenic hSOD1 G93A mice, administration of NMN (a CD38 inhibitor) and NR (a PARP inhibitor) delays aging, promotes stem cell renewal, and extends lifespan (Zhang et al., 2016).”
NAD+ supplement molecular clusters with natural hydroxyapatite targeting for bone regeneration
Pei, J., Zhao, J., Miao, Z., Ao, S., Zhao, R., Ma, H., Wang, H., Wang, H., Liu, P., Liu, C., et al. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102863 · Cited by 4
Metabolic symphony coordinates the muscle regeneration niche
Lu, Y., Chi, Z., & Wang, D. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.07.006 · Cited by 6
Treating age‐related loss of muscle mass and function: Where should we be focusing?
Ham, D. J., Fry, C. S., Ruparelia, A. A., Ngo, S. T., & Lamon, S. (2026) · The Journal of Physiology · doi:10.1113/jp289838 · Cited by 5
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Wehkamp, L., Harris, D. M. M., Kim, N., Alsaadi, A. I., Wu, Q., Oumari, M., Taubenheim, J., Volk, V., Credidio, G., Koncina, E., et al. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag043 · Cited by 10
The Potential of Targeting APE1/Ref-1 as a Therapeutic Intervention for Duchenne Muscular Dystrophy
Lalunio, H., Stupka, N., Goodman, C. A., & Hayes, A. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0620 · Cited by 4
“…and ROS/RNS production can have detrimental effects on skeletal muscle, including muscle degeneration and necrosis, impaired regeneration, mitochondrial dysfunction, fi brosis, and diminished contractile function (Ardite et al., 2004; Ryu et al., 2016; Zhang et al., 2016; Zhou et al., 2018).”
Wang, S., Liu, M., Di, A., Jiang, X., Wu, J., Zhang, J., Liu, X., Bai, C., Su, G., Song, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052276 · Cited by 4
Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance
Zike, A. B., Abel, M., Fleck, S. A., DeWitt, E. D., & Weaver, L. N. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.05.005 · Cited by 4
Liu, Z., Sun, W., Su, Z., Cui, L., Hong, Q., Wu, D., Li, J., Yan, Y., Liang, H., Tang, S., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145449 · Cited by 4
Stem Cell Aging and Rejuvenation in the Skeletal Muscle System
Libergoli, M., & Almada, A. E. (2025) · Rejuvenation Research · doi:10.1089/rej.2025.0028 · Cited by 4
“43 The promising effects of NR supplementation were con fi rmed in a clinical trial involving 20 BMI-discordant monozygotic twin pairs.”
Aging of hematopoietic stem cells: Insight into mechanisms and consequences
Chatterjee, B., & Thakur, S. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00016-5 · Cited by 4
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis
Huang, X., Liu, B., Liang, Y., Mai, C., Ying, S., Huang, X., Chen, J., Liang, X., Hu, B., Li, W., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19505 · Cited by 4
Woo, S. H., Lee, S., Moon, S., Han, J., Seo, K.-S., Lee, H., Lee, C., & Hwang, J. H. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122342 · Cited by 4
Hennesy, H. M., Gravely, M. E., Alambarrio, D. A., Brannen, S. R., McDonald, J. J., Devane, S. A., Turner, K. K., Stelzleni, A. M., O’Quinn, T. G., & Gonzalez, J. M. (2024) · Metabolites · doi:10.3390/metabo14080424 · Cited by 4
“Canto et al. [17] and Zang et al. [18] reported that NR-dosed mice had an increased running distance by 28 and 31%, respectively.”
BackgroundLuan, T., Hu, S., Nie, W., Liu, J., Li, J., Wang, S., Zhou, J., An, N., Duan, Y., Wang, A., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.1019 · Cited by 4
Deane, C. S., Willis, C. R. G., Gallagher, I. J., Brook, M. S., Gharahdaghi, N., Wylie, L. J., Wilkinson, D. J., Smith, K. E., Atherton, P. J., & Etheridge, T. (2024) · Translational Exercise Biomedicine · doi:10.1515/teb-2024-0030 · Cited by 4
Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence
Xu, W., Li, L., Cao, Z., Ye, J., & Gu, X. (2025) · Aging and Disease · doi:10.14336/ad.2024.1188 · Cited by 5
Nesci, S., Trombetti, F., Ventrella, V., Pirini, M., & Pagliarani, A. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0209 · Cited by 4
Blum, J., Gheller, B. J. F., Hwang, S., Bender, E. L., Gheller, M. E., & Thalacker‐Mercer, A. E. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa190 · Cited by 4
Effects of in ovo injection of nicotinamide riboside on high-yield broiler myogenesis
Xu, X., Alcocer, H. M., Gravely, M. E., Jackson, A. R., & Gonzalez, J. M. (2022) · Journal of Animal Science · doi:10.1093/jas/skac203 · Cited by 4
Kahn, B., Borrelli, M. R., & Libby, T. J. (2022) · Journal of Drugs in Dermatology · doi:10.36849/jdd.6870 · Cited by 4
Biochemical Targets and Molecular Mechanism of Matrine against Aging
Sun, K., Zhang, Y., Li, Y., Yang, P., & Sun, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210098 · Cited by 4
“Previous study showed that NAD+ supplementation improved mitochondrial function and increased the lifespan in mice [32].”
BackgroundKarim, M., Iqbal, T., Nawaz, A., Yaku, K., & Nakagawa, T. (2023) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.69.184 · Cited by 4
SIRT2 transgenic over‐expression does not impact lifespan in mice
Wu, L. E., Fiveash, C. E., Bentley, N. L., Kang, M., Govindaraju, H., Barbour, J. A., Wilkins, B. P., Hancock, S. E., Madawala, R. J., Das, A., et al. (2023) · Aging Cell · doi:10.1111/acel.14027 · Cited by 3
“…impact of declining NAD + levels during old age, and the beneficial effects of reversing this decline during ageing and other pathologies through treatment with exogenous NAD + metabolites (Aflatounian et al., 2022; Das et al., 2018; Rajman et al., 2018; Wu & Sinclair, 2016; Zhang et al., 2016).”
Backgroundde Médina, P. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.10.019 · Cited by 4
The Promise of a Golden Era for Exploring the Frontiers of Aging, Metabolism and Redox Biology
Zhang, J. (2020) · Frontiers in Aging · doi:10.3389/fragi.2020.610406 · Cited by 4
Saatori, S.-M., Perez, T. J., & Graham, S. M. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b02749 · Cited by 4
Restoring NAD(+) Levels with NAD(+) Intermediates, the Second Law of Thermodynamics, and Aging Delay
Poljšak, B., & Milisav, I. (2018) · Rejuvenation Research · doi:10.1089/rej.2017.2037 · Cited by 4
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Muscle Stem Cell Immunostaining
Wang, S., Zhang, B., Addicks, G. C., Zhang, H., Menzies, K. J., & Zhang, H. (2018) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.47 · Cited by 4
“Although here we discuss only PAX7 and γH2AX staining, this protocol also works well for myosin heavy chain, laminin, dystrophin, Wang et al. 9 of 12 Current Protocols in Mouse Biology and most of the other antibodies that we have tested (Zhang et al., 2016).”
BackgroundMethodSelf-citationHattori, K., Hamaguchi, T., Azuma-Suzuki, R., Higashi, S., Manji, A., & Morifuji, M. (2025) · Hearing Research · doi:10.1016/j.heares.2025.109182 · Cited by 3
Ma, Z., Cai, H., Sun, J., Du, Y., & Di, J. (2025) · Talanta · doi:10.1016/j.talanta.2025.128274 · Cited by 3
Shen, W., Zheng, M., Zhao, Y., Ni, F., & Zhu, X. (2025) · The FASEB Journal · doi:10.1096/fj.202501454rr · Cited by 3
“Grip strength was determined using a grip strength meter (Cat# DS2-5 N, PUYAN) following a previously described protocol [28].”
Protein Acetylation and NAD+ Homeostasis in Aging Muscle
Ji, L. L. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_17 · Cited by 3
The geroprotective potential of chalcones
Carmona‐Gutiérrez, D., Zimmermann, A., Kroemer, G., & Madeo, F. (2025) · Nature Communications · doi:10.1038/s41467-025-64167-7 · Cited by 4
Thiyagarajan, R., Muthaiah, R., Sreevelu, B., Treanor, O. P., Redae, Y. Z., Berman, R. N., Davis, A. L., Yellapu, N. K., Rosario, S. R., Chaves, L. D., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01959-1 · Cited by 4
Cabrera, M., Eastman, B., Ennerfelt, H. E., Alsaadi, A. I., Alexandrova, L. А., Ay, Y. A., Huang, J., Wang, Q., Blacher, E., McReynolds, M. R., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03638-6 · Cited by 3
“Previous studies have shown that repeated oral dosing is required to maintain consistent NAD ⁺ levels and elicit measurable biological effects [34, 55].”
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway
Yang, Q., Shi, Y., Li, W., Xiong, X., Chen, Q., & Zheng, M. (2025) · Biology Direct · doi:10.1186/s13062-025-00705-z · Cited by 3
“Similarly, Zhang et al. revealed that NAD + supplementation can prevent muscular dystrophy [47].”
Precision geronutrition: personalized nutritional strategies to extend healthy lifespan
Park, S.-H., Jung, C. H., & Ahn, J. (2026) · BMB Reports · doi:10.5483/bmbrep.2025-0216 · Cited by 3
Fogle, K. J., Lindley, S., Satterfield, S. L., Amsalu, B. A., Figura, J. R., Eicher, S. L., Scherz, L. A., & Palladino, M. J. (2026) · Genes · doi:10.3390/genes17020192 · Cited by 3
Zhao, Y. (2026) · Biogerontology · doi:10.1007/s10522-026-10410-7 · Cited by 3
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Aging rate indicators and the search for anti-aging drugs
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Zhou, Z., Xu, Y., Huang, T., Zheng, J., Deng, Z., Dai, S., & Lin, S. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00773 · Cited by 3
Chinnapaka, S., Malekzadeh, H., Tirmizi, Z., Arellano, J. A., & Ejaz, A. (2023) · Pharmaceuticals · doi:10.3390/ph16081134 · Cited by 3
Демченко, Г. А., Нурмаханова, Б. А., Абдрешов, С. Н., Koibasova, L. U., Zhunussova, G., & Иманкулова, С. К. (2023) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-023-05947-3 · Cited by 3
“Bioflavo - noids of the phytocomposition stimulate antioxidant systems, thereby protecting the body from oxidative stress acting on cell mitochondria and changing the metabolic status of cells [15,16].”
BackgroundThe Roles of Caloric Restriction Mimetics in Central Nervous System Demyelination and Remyelination
Kaffe, D., Kaplanis, S. I., & Karagogeos, D. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45120596 · Cited by 4
Klinaki, E., & Ogrodnik, M. B. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111929 · Cited by 3
Maynard, C. J., Gonzalez, J. M., Haginouchi, T., Ellis, O. G., Jackson, A. R., & Owens, C. M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1397442 · Cited by 5
Verlinden, S. F. F. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1452453 · Cited by 4
Regulation of Stem Cell Function by NAD +
Feng, Y., Qiu, H., & Chen, D. (2025) · Physiology · doi:10.1152/physiol.00052.2024 · Cited by 3
Shi, Z., Zhang, X., Yang, H., Zheng, X., Niu, M., Zhang, Y., Yuan, P., Wei, W., Huang, G., Fang, R., et al. (2025) · Blood Science · doi:10.1097/bs9.0000000000000236 · Cited by 3
“6 11 A notable example is hematopoietic stem cells (HSCs), in which mitochondria are distributed unevenly during cellular division.”
Therapeutics of Stem Cell Treatment in Anti-Aging and Rejuvenation
Yeh, D.-C., & Chan, T.-M. (2018) · Stem Cell Discovery · doi:10.4236/scd.2018.82002 · Cited by 3
Морковник, А. С., Zubenko, A. A., Диваева, Л. Н., Kartsev, V. G., Бородкин, Г. С., & Klimenko, A. I. (2019) · Mendeleev Communications · doi:10.1016/j.mencom.2019.01.040 · Cited by 3
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Elphingstone, J. W., & Hamrick, M. W. (2019) · Springer eBooks · doi:10.1007/978-3-030-25890-0_1 · Cited by 3
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Huang, T. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.06.001080 · Cited by 3
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Uchiumi, F., Sato, A., Asai, M., & Tanuma, S. (2020) · AIMS molecular science · doi:10.3934/molsci.2020002 · Cited by 3
Barthez, M., Song, Z., Wang, C.-L., & Chen, D. (2020) · Current Stem Cell Reports · doi:10.1007/s40778-020-00180-4 · Cited by 3
Khan, A., Alshahrani, S., Arafah, A. M., Qamar, W., Shoaib, A., Wali, A. F., Amin, I., Alqahtani, S. S., & Rehman, M. U. (2020) · Springer eBooks · doi:10.1007/978-981-15-7305-7_2 · Cited by 3
Paro, R., Grossniklaus, U., Santoro, R., & Wutz, A. (2021) · Learning materials in biosciences · doi:10.1007/978-3-030-68670-3_9 · Cited by 4
Jiang, T., Du, Q., Huang, C., Xu, W., Guo, P., Li, W., Xie, X., Guo, Y., Liu, D., & Lin, D. (2021) · Molecules · doi:10.3390/molecules26175123 · Cited by 3
“Our work may be of benefit to the exploitation of D‐4F as a potential pharmacological agent against CM‐induced endothelial impairments and CI‐AKI.”
BackgroundInfluentialImpact of senescence on the transdifferentiation process of human hepatic progenitor-like cells
Bellanti, F., di Bello, G., Tamborra, R., Amatruda, M., Buglio, A. L., Dobrakowski, M., Kasperczyk, A., Kasperczyk, S., Serviddio, G., & Vendemiale, G. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i10.1595 · Cited by 3
Wone, B. W. M., & Swanson, D. L. (2022) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2022.866130 · Cited by 3
Dierolf, J. G., Hunter, H., Watson, A. J., & Betts, D. H. (2022) · Stem Cells and Development · doi:10.1089/scd.2021.0347 · Cited by 3
Lv, S., Shen, Q., Li, H., Chen, Q., Xie, W., Li, Y., Wang, X., & Ding, G. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1027055 · Cited by 4
Self-citationJin, E., Wei, S., Jo, Y., Nguyen, T. T., Ji, M., Paik, M., Jeong, J., Im, S. J., & Ryu, D. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0040 · Cited by 3
Self-citationBushana, P. N., Schmidt, M. A., Rempe, M. J., Sorg, B. A., & Wisor, J. P. (2023) · SLEEP Advances · doi:10.1093/sleepadvances/zpad044 · Cited by 3
“While Zhang et al. demonstrated neurogenesis using the same protocol, they do not describe any sleep-related effects [14].”
BackgroundMethodInfluentialRice, J., Lautrup, S., & Fang, E. F. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_4 · Cited by 4
Kim, S. H., Ki, S. H., Hyeong, S.-W., & Oh, S. (2025) · Nutrients · doi:10.3390/nu17030539 · Cited by 3
“Therefore, its supplementation may result in cytoprotection by increasing cellular ATP levels through improved mitochondrial function [34,35].”
Normothermic Preservation of Liver – What Does the Future Hold?
Bral, M., & Shapiro, A. M. J. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_517 · Cited by 3
Pharmacological Nicotinamide: Mechanisms Centered Around SIRT1 Activity
Hwang, E. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813939-4.00029-2 · Cited by 3
Therapeutic strategies targeting somatic stem cells: Chemical approaches
Chen, Y., & Ding, S. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115824 · Cited by 3
Sirtuins, healthspan, and longevity in mammals
Kumar, S., Giblin, W., & Lombard, D. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00005-6 · Cited by 2
The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of agingPreprint
Wolf, A. M. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/a2689 · Cited by 2
Longevity BottlenecksPreprint
Florea, M., Hamalainen, M., Seebold, P., Cheng, N., Murray, P., Colville, A., Zheng, S., Ingham, D., Kantelal, R., & Sicilia, R. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.18.553936 · Cited by 3
“While animal evidence exists for lifespan increase for both NAD and sirtuin targeted interventions, the effect sizes have been moderate or sex-specific (7, 8) (until the recent work published by Roichman et al.”
BackgroundLithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageingPreprint
Qu, Q., Chen, Y., Wang, Y., Long, S., Wang, W., Yang, H.-Y., Wu, J., Li, M., Tian, X., Wei, X., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.07.570558 · Cited by 3
Self-citationBoosting NAD+ for Anti-Aging: Mechanisms, Interventions, and OpportunitiesPreprint
Alpay, F. (2025) · ChemRxiv · doi:10.26434/chemrxiv-2025-nl80r · Cited by 4
Unveiling the Anti-Aging Potential of 3HB: Lifespan Extension and Cellular Senescence Delay
An, Y., Wang, Q., Qiao, P., Liu, J., Ma, A., Chen, Y., Yang, D., Yi, Y., Li, N., Lu, F., et al. (2025) · Nutrients · doi:10.3390/nu17101647 · Cited by 2
“…mean lifespan of mice by 30.2% from the start of the intervention, and the mean lifespan throughout the entire life cycle can be extended by 4.7% [4]; rapamycin can extend the mean lifespan throughout the entire life cycle by 7% to 16% [10,11]; dasatinib + quercetin can extend the mean lifespan…”
InfluentialSelf-citationYang, L., Jiang, Z., Sun, Q., Karako, K., Yuan, L., & Song, P. (2025) · BioScience Trends · doi:10.5582/bst.2025.01279 · Cited by 2
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging
Liu, J., Jiang, S., Shen, Y., Wang, R., Jin, Z., Cao, Y., Li, J., Liu, Y., Qi, Q., Guo, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.70295 · Cited by 3
Molecular time machines unleashed: small-molecule-driven reprogramming to reverse the senescence
Tang, C., Zhang, Z., Yang, C., Li, L., Li, J., Cheng, X., Zhou, W., Lin, Y., Zeng, L., & Zhang, L. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf069 · Cited by 2
A small molecule strategy with forskolin and p38 inhibitor for serum-free muscle stem cell expansion
Lu, H., Liu, Z., Liu, X., Pan, Y., Yan, D., Cheng, X., Zhang, L., Ding, S., Li, C., Zhou, G., et al. (2026) · npj Science of Food · doi:10.1038/s41538-026-00732-8 · Cited by 2
Vinten, K. T., Schomakers, B. V., Denis, S. W., van Weeghel, M., Jongejan, A., Ofman, R., Piersma, S. R., Jiménez, C. R., Janssens, G. E., Perez, R. Z., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202501925r · Cited by 2
Lu, J., Li, J., Liu, C., Feng, G., Yin, G., Hu, Z., Heng, D., Yu, Y., Jin, K., Wu, Y., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202504132r · Cited by 2
Self-citationATF5-mediated mitochondrial UPR inhibited RANKL in Porphyromonas gingivalis LPS-treated osteoblasts
Yang, T., Sun, W., & Lei, L. (2026) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2026.106556 · Cited by 2
Abd-El-Raouf, R., Harrison-Gleason, J., Kim, J., Wai, C. M., Yerlioglu, K. L., Ananías-Sáez, C., Ksiazek, A., Poomkudy, J. T., Araínga, M., Bose, D., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.198810 · Cited by 2
Long, F., Pan, X., He, A., Wang, X., Wei, Z., & Gao, S. Y. (2026) · Experimental Biology and Medicine · doi:10.3389/ebm.2026.10835 · Cited by 2
Self-citationMitochondria in muscle stem cell biology: gatekeepers of fate, function, and regeneration
Khacho, M., & Burelle, Y. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00027.2026 · Cited by 2
Saka, T., Hayashi, R., Yoshino, Y., Mitsui, T., Maruyama, H., Kono, H., Kawaguchi, M., Nakagawa, H., Ikari, A., & Endo, S. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112012 · Cited by 2
The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer
Finger, A., Ector, C., & Weaver, V. M. (2026) · Cancers · doi:10.3390/cancers18060925 · Cited by 2
Deng, X., McClements, D. J., Wu, C., Liu, X. Q., & Liu, F. (2026) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70408 · Cited by 2
Metadata
- Authors
- Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., Schoonjans, K., Menzies, K. J., & Auwerx, J.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- ETH Zurich (CH)
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Laboratory of Stem Cell Bioengineering, EPFL, 1015 Lausanne, Switzerland.
- University of Zurich (CH)
- University of Ottawa (CA)
- Corresponding author
- Menzies, Keir J.
- Auwerx, Johan
- ORCID
- Venue
- Science
- Published
- 2016-06-17
- Volume
- 352
- Issue
- 6292
- Pages
- 1436-1443
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2343193821
- Cited by
- 1,255
- References
- 54
- Citations by year
- 2026: 109 · 2025: 139 · 2024: 110 · 2023: 123 · 2022: 142 · 2021: 151 · 2020: 131 · 2019: 111 · 2018: 114 · 2017: 93 · 2016: 29
- FWCI
- 66.83
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- University of Ottawa
- Heart and Stroke Foundation of Canada
- NIH (R01AG043930)
- Krebsforschung Schweiz/SwissCancerLeague (KFS-3082-02-2013)
- Systems X (SySX.ch 2013/153)
- Swiss National Science Foundation (31003A-140780)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- nicotinamide riboside, muscle stem cells, mitochondrial unfolded protein response, prohibitin, mitochondrial function, aging, lifespan extension, neural stem cells, melanocyte stem cells, mdx mice, muscular dystrophy, cellular reprogramming
- MeSH terms
- Prohibitins, Animals, Disease Models, Animal, Longevity, Melanocytes, Mice, Inbred C57BL, Mitochondria, Muscular Dystrophies, NAD, Niacinamide, Pyridinium Compounds, Repressor Proteins, Cellular Senescence, Mice, Inbred mdx, Oxidative Stress, Myoblasts, Skeletal, Mice, Unfolded Protein Response, Neural Stem Cells, Cellular Reprogramming
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