NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, Hongbo, Ryu, Dongryeol, Wu, Yibo, Gariani, Karim, Wang, Xu, Luan, Peiling, D’Amico, Davide, Ropelle, Eduardo R., Lutolf, Matthias P., Aebersold, Ruedi, Schoonjans, Kristina, Menzies, Keir J., Auwerx, Johan·2016·Science

DOI 10.1126/science.aaf2693

Cited by (999)

Items 301–400 of 999

Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet
Shi, Wenbiao, Hegeman, Maria A., van Dartel, Dorien A.M., Tang, Jing, Suarez, Manuel, Swarts, Hans, van der Hee, Bart, Arola, Lluis, Keijer, Jaap · 2017 · Molecular Nutrition & Food Research
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Hikosaka, Keisuke, Yaku, Keisuke, Okabe, Keisuke, Nakagawa, Takashi · 2021 · Nutritional Neuroscience
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction
Chongkui Sun, Kun Wang, Amanda J. Stock, Yi Gong, Tyler G. Demarest, Beimeng Yang, Neelam Giri, Lea A. Harrington, Blanche P. Alter, Sharon A. Savage et al. · 2020 · The EMBO Journal
The balance between NAD+ biosynthesis and consumption in ageing
Øyvind Strømland, Joseph Diab, Eugenio Ferrario, Lars Jansen Sverkeli, Mathias Ziegler · 2021 · Mechanisms of Ageing and Development
Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women
Yuichiro Fukamizu, Yoshiaki Uchida, Akari Shigekawa, Toshiya Sato, Hisayuki Kosaka, Takanobu Sakurai · 2022 · Scientific Reports
The therapeutic perspective of NAD+ precursors in age-related diseases
Tooba Iqbal, Takashi Nakagawa · 2024 · Biochemical and Biophysical Research Communications
Metabolic Syndrome and the Cellular Phase of Alzheimer's Disease
Subbiah Pugazhenthi · 2017 · Progress in molecular biology and translational science
A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging
Ha‐Neui Kim, Filipa Ponte, Aaron D. Warren, Rebecca Ring, Srividhya V. Iyer, Li Han, Maria Almeida · 2021 · npj Aging and Mechanisms of Disease
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
Kaitlin A. Freeberg, CeAnn C. Udovich, Christopher R. Martens, Douglas R. Seals, Daniel Harrison Craighead · 2023 · The Journals of Gerontology Series A
Hallmarks of stem cell aging
Thomas A. Rando, Anne Brunet, Margaret A. Goodell · 2025 · Cell stem cell
Fight to the bitter end: DNA repair and aging
Yu Chen, Anke Geng, Weina Zhang, Zhen Yu Qian, Xiaoping Wan, Ying Jiang, Zhiyong Mao · 2020 · Ageing Research Reviews
Regulation of the H+-ATP synthase by IF1: a role in mitohormesis
Pau B. Esparza‐Moltó, Cristina Nuevo‐Tapioles, Jose Manuel Cuezva · 2017 · Cellular and Molecular Life Sciences
Mitophagy in aging and longevity
Jing Guo, Wei‐Chung Chiang · 2021 · IUBMB Life
Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes
Chye Ling Tan, Toby Chin, Christina Yan Ru Tan, Holly A. Rovito, Ling Shih Quek, John E. Oblong, Sophie Bellanger · 2019 · Journal of Investigative Dermatology
The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications
Yahyah Aman, Johannes Frank, Sofie Lautrup, Adrian Matysek, Zhangming Niu, Guang Yang, Liu Shi, Linda Hildegard Bergersen, Jon Storm‐Mathisen, Lene Juel Rasmussen et al. · 2019 · Mechanisms of Ageing and Development
Sarcopenia in aging, obesity, and cancer
Jennifer A. Ligibel, Kathryn H. Schmitz, Nathan A. Berger · 2020 · Translational Cancer Research
Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells
Andrey Kropotov, Veronika Kulikova, Kirill Nerinovski, Alexander P. Yakimov, Maria Svetlova, Ljudmila Solovjeva, Julia S. Sudnitsyna, Marie E. Migaud, Mikhail Khodorkovskiy, Mathias Ziegler et al. · 2021 · International Journal of Molecular Sciences
NAD(H) in mitochondrial energy transduction: implications for health and disease
Matthew A. Walker, Rong Tian · 2018 · Current Opinion in Physiology
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity
Brady, Pamlea N., Goel, Anupam, Johnson, Margaret A. · 2019 · Microbiology and Molecular Biology Reviews
CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD+/Sirt1 Signaling Pathway
Ling-Fang Wang, Qing Na Cao, Ke Wen, Yun‐Fei Xiao, Tingtao Chen, Xiao‐Hui Guan, Yu Liu, Li Zuo, Yisong Qian, Ke‐Yu Deng et al. · 2019 · Frontiers in Physiology
NAD+ Metabolism and Regulation: Lessons From Yeast
Trevor Croft, Padmaja Venkatakrishnan, Su-Ju Lin · 2020 · Biomolecules
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis
Qiangqiang Li, Jack C. Y. Cheng, Qing Yan Jiang, Wayne Lee · 2021 · Aging Cell
In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans
Cory M. Dungan, Bailey D. Peck, R. Grace Walton, Zhengyan Huang, Marcas M. Bamman, Philip A. Kern, Charlotte A. Peterson · 2020 · The FASEB Journal
DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis
Qing Tan, Xiaoqian Zhang, Shuxiang Li, Wenbin Liu, Jiaqi Yan, Siqi Wang, Feng Cui, Dan Li, Jun Li · 2023 · Free Radical Biology and Medicine
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations
Liang Yang, Zifeng Ruan, Xiaobing Lin, Hao Wang, Yanmin Xin, Haite Tang, Zhijuan Hu, Yunhao Zhou, Yi Wu, Junwei Wang et al. · 2024 · Nature Communications
Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death
Lifeng Yuan, Linhui Zhai, Lili Qian, De Huang, Yi Ding, Handan Xiang, Xiaojing Liu, J. Will Thompson, Juan Liu, Yonghan He et al. · 2018 · Cell Research
Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation
Nicolas Vignier, Maria Chatzifrangkeskou, Blanca Morales Rodríguez, Mathias Mericskay, Nathalie Mougenot, Karim Wahbi, Gisèle Bonne, Antoine Muchir · 2018 · Human Molecular Genetics
Novel Insights into the Anti-Aging Role of Mitophagy
2018 · International Review of Cell and Molecular Biology
NAD+ and NAFLD – caution, causality and careful optimism
Morten Dall, Anna S. Hassing, Jonas T. Treebak · 2021 · The Journal of Physiology
Age-Dependent Decline of NAD+—Universal Truth or Confounded Consensus?
A. Augusto Peluso, Mads V. Damgaard, Marcelo A. Mori, Jonas T. Treebak · 2021 · Nutrients
Impact of NAD+ metabolism on ovarian aging
Jinghui Liang, Feiling Huang, Zhaoqi Song, Ruiyi Tang, Peng Zhang, Rong Chen · 2023 · Immunity & Ageing
Endothelial Progenitor Cells Physiology and Metabolic Plasticity in Brain Angiogenesis and Blood-Brain Barrier Modeling
Natalia A. Malinovskaya, Yulia K. Komleva, Vladimir V. Salmin, Andrey V. Morgun, Аnton N. Shuvaev, Yu. A. Panina, Elizaveta B. Boitsova, Alla B. Salmina · 2016 · Frontiers in Physiology
Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+–Sirt1 signaling
Chenchen Pi, Yue Jin Yang, Yanan Sun, Huan Wang, Hui Sun, Mao Ma, Lin Lin, Yingai Shi, Yan Li, Yulin Li et al. · 2019 · Aging
Aerobic Exercise Training Induces the Mitonuclear Imbalance and UPRmt in the Skeletal Muscle of Aged Mice
André V. Cordeiro, Rafael S. Brícola, Renata Rosseto Braga, Luciene Lenhare, Vagner Ramon Rodrigues Silva, Chadi P. Anaruma, Carlos K. Katashima, Bárbara Crisol, Fernando Moreira Simabuco, Adelino Sánchez Ramos da Silva et al. · 2020 · The Journals of Gerontology Series A
How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span
Anne-Marie Galow, Shahaf Peleg · 2022 · Cells
Doped Graphene To Mimic the Bacterial NADH Oxidase for One-Step NAD + Supplementation in Mammals
Xi Liu, Jingkun Li, Andrea Zitolo, Meng Gao, Jun Jiang, Xiangtian Geng, Qianqian Xie, Di Wu, Huizhen Zheng, Xiaoming Cai et al. · 2023 · Journal of the American Chemical Society
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation
Dunja Petrovic, Luke Slade, Yiorgos Paikopoulos, Davide D’Andrea, Nevena Savic, Ana Stančić, Jan Lj. Miljković, Thibaut Vignane, Maria Kyriaki Drekolia, Dušan R. Mladenović et al. · 2025 · Cell Metabolism
Sarcopenia, Aging and Prospective Interventional Strategies
Tyler B. Waltz, Elayne M. Fivenson, Marya Morevati, Chuanhao Li, Kevin G. Becker, Vilhelm A. Bohr, Evandro Fei Fang · 2017 · Current Medicinal Chemistry
The mitochondria in lung fibrosis: friend or foe?
Elizabeth S. Malsin, David W. Kamp · 2018 · Translational research
Stem cells under the influence of alcohol: effects of ethanol consumption on stem/progenitor cells
Giuliana Di Rocco, Silvia Baldari, Giovambattista Pani, Gabriele Toietta · 2018 · Cellular and Molecular Life Sciences
A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome
Ran Jing, James Corbett, Jun Cai, Gyda C. Beeson, Craig Beeson, Sherine S.L. Chan, David Dimmock, Lynn Lazcares, Aron M. Geurts, John J. Lemasters et al. · 2018 · Cell Reports
Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target
Hollie B. S. Griffiths, Courtney Williams, Sarah J. King, Simon J. Allison · 2020 · Biochemical Society Transactions
Mitochondrial and Reactive Oxygen Species Signaling Coordinate Stem Cell Fate Decisions and Life Long Maintenance
Mireille Khacho, Ruth S. Slack · 2017 · Antioxidants and Redox Signaling
NAD+: A key metabolic regulator with great therapeutic potential
Ghazal Sultani, Azrah Samsudeen, Brenna Osborne, Nigel A. Turner · 2017 · Journal of Neuroendocrinology
The clock is ticking: the impact of ageing on T cell metabolism
Kylie M. Quinn, Riya Palchaudhuri, Clovis Steve Palmer, Nicole L. La Gruta · 2019 · Clinical & Translational Immunology
PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All
Lloret, Alejandro, Beal, M. Flint · 2019 · Neurochemical Research
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD + signaling
Mustafa Nazir Okur, Evandro Fei Fang, Elayne M. Fivenson, Vinod Tiwari, Deborah L. Croteau, Vilhelm A. Bohr · 2020 · Aging Cell
Clinical Trials Targeting Aging
Johannes Leth Nielsen, Daniela Bakula, Morten Scheibye‐Knudsen · 2022 · Frontiers in Aging
Impact of Exercise and Aging on Mitochondrial Homeostasis in Skeletal Muscle: Roles of ROS and Epigenetics
Jialin Li, Zhe Wang, Can Li, Yu Song, Yan Wang, Bo Hai, Yong Zhang · 2022 · Cells
NAD+ Deficits in Age-Related Diseases and Cancer
Amanda Garrido, Nabil Djouder · 2017 · Trends in cancer
Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit+ Cardiac Progenitor Cells
Kelli Korski, Dieter A. Kubli, Bingyan J. Wang, Farid G. Khalafalla, Megan M. Monsanto, Fareheh Firouzi, Oscar Echeagaray, Tae-Yong Kim, Robert M. Adamson, Walter P. Dembitsky et al. · 2019 · Stem Cells
Infrapatellar Fat Pad Stem Cells Responsiveness to Microenvironment in Osteoarthritis: From Morphology to Function
Elena Stocco, Silvia Barbon, Monica Piccione, Elisa Belluzzi, Lucía Petrelli, Assunta Pozzuoli, Roberta Ramonda, Marco Rossato, Marta Favero, Pietro Ruggieri et al. · 2019 · Frontiers in Cell and Developmental Biology
Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance
Alexandra J. Harvey, Giuseppina Caretti, Viviana Moresi, Alessandra Renzini, Sergio Adamo · 2019 · Stem Cell Reports
Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
Pirkka‐Pekka Laurila, Martin Wohlwend, Tanes Iamamura de Lima, Peiling Luan, Sébastien Herzig, Nadège Zanou, Bárbara Crisol, Maroun S. Bou Sleiman, Eleonora Porcu, Héctor Gallart‐Ayala et al. · 2022 · Nature Aging
The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation
Borut Poljšak, Vito Kovač, Stjepan Špalj, Irina Milisav · 2023 · International Journal of Molecular Sciences
Mitochondrial regulation in stem cells
Yifei Wang, Marine Barthez, Danica Chen · 2023 · Trends in Cell Biology
Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity
Dong Zheng, Yi Zhang, Minghao Zheng, Ting Cao, Grace Wang, Lulu Zhang, Rui Ni, Joseph Brockman, Huiting Zhong, Guo‐Chang Fan et al. · 2019 · Clinical Science
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes
Zhentong Shen, Ping Liu, Qian Sun, Yizhou Li, Rabin Acharya, Xinjian Li, Chao Sun · 2021 · APOPTOSIS
Molecular pathology of rare progeroid diseases
Matthias Rieckher, George A. Garinis, Björn Schumacher · 2021 · Trends in Molecular Medicine
Emerging strategies, applications and challenges of targeting NAD+ in the clinic
Jianying Zhang, Heling Wang, Sofie Lautrup, Hilde Loge Nilsen, Jonas T. Treebak, Leiv Otto Watne, Geir Selbæk, Lindsay E. Wu, Torbjørn Omland, Eija Pirinen et al. · 2025 · Nature Aging
Nutrients, neurogenesis and brain ageing: From disease mechanisms to therapeutic opportunities
Marco Fidaleo, Virve Cavallucci, Giovambattista Pani · 2017 · Biochemical Pharmacology
Metabolism as an early predictor of DPSCs aging
Dannie Macrin, Ammar Alghadeer, Yan Ting Zhao, Jason Wayne Miklas, Abdiasis M. Hussein, Damien Detraux, Aaron Mark Robitaille, Anup Madan, Randall T. Moon, Yuliang Wang et al. · 2019 · Scientific Reports
Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome
Mustafa Nazir Okur, Beatrice Mao, Risako Kimura, Scott J. Haraczy, Tracy S. Fitzgerald, Kamren Edwards‐Hollingsworth, Jane Y. Tian, Wasif A. Osmani, Deborah L. Croteau, Matthew W. Kelley et al. · 2020 · npj Aging and Mechanisms of Disease
Satellite cell self‐renewal in endurance exercise is mediated by inhibition of mitochondrial oxygen consumption
Phablo Abreu, Alicia Juliana Kowaltowski · 2020 · Journal of Cachexia Sarcopenia and Muscle
Roles of NAD+ in Acute and Chronic Kidney Diseases
Marya Morevati, Evandro Fei Fang, Maria Lerche Mace, Mehmet Kanbay, Eva Gravesen, Anders Nordholm, Søren Egstrand, Mads Hornum · 2022 · International Journal of Molecular Sciences
Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging
Darren J. Baker, Shahaf Peleg · 2017 · Trends in Biochemical Sciences
Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem‐mass spectrometry
Keisuke Yaku, Keisuke Okabe, Takashi Nakagawa · 2018 · Biomedical Chromatography
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age‐associated insulin resistance
Maryam Gulshan, Keisuke Yaku, Keisuke Okabe, Arshad Mahmood, Tsutomu Sasaki, Masashi Yamamoto, Keisuke Hikosaka, Isao Usui, Tadahiro Kitamura, Kazuyuki Tobe et al. · 2018 · Aging Cell
In Vitro Culture Expansion Shifts the Immune Phenotype of Human Adipose-Derived Mesenchymal Stem Cells
Richard Jeske, Xuegang Yuan, Qin Fu, Bruce Alan Bunnell, Timothy M. Logan, Yan Li · 2021 · Frontiers in Immunology
Prohibitins
Takashi Tatsuta, Thomas Langer · 2017 · Current Biology
Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors
Jing She, Rui Sheng, Zheng‐Hong Qin · 2021 · Aging and Disease
Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet
Cesar L. Moreno, Charles V. Mobbs · 2016 · Molecular and Cellular Endocrinology
Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective
Sutong Xu, Xi Zhang, Chenming Liu, Qiulu Liu, Huazhen Chai, Yuping Luo, Siguang Li · 2021 · Frontiers in Cell and Developmental Biology
Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
Yuki Saito, Takako Chikenji · 2021 · Frontiers in Pharmacology
Roles of NAD + in Health and Aging
Sofie Lautrup, Yujun Hou, Evandro Fei Fang, Vilhelm A. Bohr · 2023 · Cold Spring Harbor Perspectives in Medicine
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study
Karol Mateusz Pencina, Rodrigo J. Valderrábano, Benjamin Wipper, Ariela R. Orkaby, Kieran F. Reid, Thomas W. Storer, Alexander Peter Lin, Sai K. Merugumala, Lauren A. Wilson, Nancy K. Latham et al. · 2023 · The Journal of Clinical Endocrinology & Metabolism
α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis
Roberto Pellicciari, Paride Liscio, Nicola Giacchè, Francesca Franco, Andrea Carotti, Janet Robertson, Lucia Cialabrini, Elena Katsyuba, Nadia Raffaelli, Johan H. Auwerx · 2018 · Journal of Medicinal Chemistry
The crosstalk of NAD, ROS and autophagy in cellular health and ageing
Lucia Sedlackova, Viktor I. Korolchuk · 2020 · Biogerontology
The Role of Tryptophan Metabolites in Musculoskeletal Stem Cell Aging
Jordan Marcano Anaya, Wendy Bollinger Bollag, Mark W. Hamrick, Carlos M. Isales · 2020 · International Journal of Molecular Sciences
NAD+ and cardiovascular diseases
Qiuzhen Lin, Wanyun Zuo, Yaozhong Liu, Keke Wu, Qiming Liu · 2021 · Clinica Chimica Acta
Living biobank-based cancer organoids: prospects and challenges in cancer research
Haixin Li, Hongkun Liu, Kexin Chen · 2022 · Cancer Biology and Medicine
NAD+-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer’s disease via ATF4-dependent mitochondrial UPR
Xi Xiong, Jialong Hou, Yi Zheng, Tao Jiang, Xuemiao Zhao, Jinlai Cai, Jiani Huang, Haijun He, Jiaxue Xu, Shuangjie Qian et al. · 2024 · Cell Death and Disease
Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?
Kayvan Zainabadi · 2019 · Pharmacological Research
Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?
Juan Miguel Suarez-Rivero, Carmen J. Pastor‐Maldonado, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Irene Villalón-García, Marta Talaverón-Rey, Alejandra Suárez-Carrillo, Manuel Munuera-Cabeza, Diana Reche-López, Paula Cilleros-Holgado et al. · 2022 · Biomedicines
Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions
Weiyi Shen, Jiamin He, Tongyao Hou, Jianmin Si, Shujie Chen · 2022 · Aging and Disease
Cellular heterogeneity and stem cells of vascular endothelial cells in blood vessel formation and homeostasis: Insights from single-cell RNA sequencing
Taku Wakabayashi, Hisamichi Naito · 2023 · Frontiers in Cell and Developmental Biology
Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials
Enza Vernucci, Carlo Tomino, Francesca Molinari, Dolores Limongi, Michele Aventaggiato, Luigi Sansone, Marco Tafani, Matteo Antonio Russo · 2019 · Oxidative Medicine and Cellular Longevity
Mitochondrial Contributions to Hematopoietic Stem Cell Aging
Claudia Morganti, Keisuke Ito · 2021 · International Journal of Molecular Sciences
Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications
Kanako Iwasaki, Cristian Abarca, Cristina Aguayo‐Mazzucato · 2023 · Diabetes & Metabolism Journal
NAD+ Metabolism and Immune Regulation: New Approaches to Inflammatory Bowel Disease Therapies
Chaoyue Chen, Wei Yan, Meihui Tao, Yu Fu · 2023 · Antioxidants
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Shalender Bhasin, Douglas R. Seals, Marie E. Migaud, Nicolas Musi, Joseph A. Baur · 2023 · Endocrine Reviews
Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Chensong Zhang, Yang Meng, Junhong Han · 2024 · Cellular and Molecular Life Sciences
Disruption of glucose homeostasis by bacterial infection orchestrates host innate immunity through NAD+/NADH balance
Jingjing Tang, Xiao Wang, Shukun Chen, Tianyuan Chang, Yanchao Gu, Fuhua Zhang, Jing Hou, Yi Luo, Mengyuan Li, Jianan Huang et al. · 2024 · Cell Reports
Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice
Morten Dall, Melanie Penke, Karolina Sulek, Madlen Matz‐Soja, Birgitte Holst, Antje Garten, Wieland Kieß, Jonas T. Treebak · 2018 · Molecular and Cellular Endocrinology
Regulatory Effects of NAD + Metabolic Pathways on Sirtuin Activity
Ning Zhang, Anthony A. Sauve · 2018 · Progress in molecular biology and translational science
MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway
Chenchen Pi, Cao Ma, Huan Wang, Hui Sun, Xiao Yu, Xingyu Gao, Yue Jin Yang, Yanan Sun, Haiying Zhang, Yingai Shi et al. · 2021 · Stem Cell Research & Therapy
BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells
Pei Zhu, Noah X. Hamlish, Abhishek Vijay Thakkar, Adam W. T. Steffeck, Emily Jane Rendleman, Nabiha Haleema Khan, Nathan J. Waldeck, Andrew DeVilbiss, Misty S. Martin-Sandoval, Thomas P. Mathews et al. · 2022 · Genes & Development
Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease
Anindita Bose, M. Flint Beal · 2018 · European Journal of Neuroscience
Glycine Enhances Satellite Cell Proliferation, Cell Transplantation, and Oligonucleotide Efficacy in Dystrophic Muscle
Caorui Lin, Gang Han, Hanhan Ning, Jun Song, Ning Ran, Xianfu Yi, Yiqi Seow, HaiFang Yin · 2020 · Molecular Therapy
Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy
Pirkka‐Pekka Laurila, Peiling Luan, Martin Wohlwend, Nadège Zanou, Bárbara Crisol, Tanes Iamamura de Lima, Ludger J.E. Goeminne, Héctor Gallart‐Ayala, Minho Shong, Julijana Ivanišević et al. · 2022 · Science Advances