NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, Hongbo, Ryu, Dongryeol, Wu, Yibo, Gariani, Karim, Wang, Xu, Luan, Peiling, D’Amico, Davide, Ropelle, Eduardo R. +5 more·2016·Science

Cited by (1,000)

Items 101–200 of 1,000

  1. Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
    Hong, Xiaotong, Isern, Joan, Campanario, Silvia, Perdiguero, Eusebio, Ramírez-Pardo, Ignacio, Segalés, Jessica, Hernansanz-Agustín, Pablo, Curtabbi, Andrea, Deryagin, Oleg, Pollán, Angela et al. · 2022 · Cell stem cell
  2. Increase in blood–brain barrier leakage in healthy, older adults
    Inge C.M. Verheggen, Joost J.A. de Jong, Martin P.J. van Boxtel, E. H. B. M. Gronenschild, Walter M. Palm, Alida Annechien Postma, Jacobus F.A. Jansen, Frans R.J. Verhey, Walter H. Backes · 2020 · GeroScience
  3. Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
    Peiling Luan, Davide D’Amico, Pénélope A. Andreux, Pirkka‐Pekka Laurila, Martin Wohlwend, Hao Li, Tanes Iamamura de Lima, Nicolas Place, Chris Rinsch, Nadège Zanou et al. · 2021 · Science Translational Medicine
  4. The multifaceted regulation of mitophagy by endogenous metabolites
    Ting Zhang, Qian Liu, Weihua Gao, Sheikh Arslan Sehgal, Hao Wu · 2021 · Autophagy
  5. Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
    Song, Ping, An, Junqing, Zou, Ming-Hui · 2020 · Cells
  6. Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age‐related disorders
    Sarika Srivastava · 2016 · Clinical and Translational Medicine
  7. Redox Control of Skeletal Muscle Regeneration
    Emméran Le Moal, Vincent Pialoux, Gaëtan Juban, Carole Groussard, Hassane Zouhal, Bénédicte Chazaud, Rémi Mounier · 2016 · Antioxidants and Redox Signaling
  8. The brain, sirtuins, and ageing
    Akiko Satoh, Shin‐ichiro Imai, Leonard Guarente · 2017 · Nature reviews. Neuroscience
  9. The Plasma NAD + Metabolome Is Dysregulated in “Normal” Aging
    James Clement, Matthew Wai Kin Wong, Anne Poljak, Perminder Singh Sachdev, Nady Braidy · 2018 · Rejuvenation Research
  10. Age-associated remodeling of T cell immunity and metabolism
    SeongJun Han, Peter Georgiev, Alison Epstein Ringel, Arlene H. Sharpe, Marcia C. Haigis · 2022 · Cell Metabolism
  11. Tomatidine Enhances Lifespan and Healthspan in C. elegans through Mitophagy Induction Via the SKN-1/Nrf2 Pathway
    Fang, Evandro F., Waltz, Tyler B., Kassahun, Henok, Lu, Qiping, Kerr, Jesse S., Morevati, Marya, Fivenson, Elayne M., Wollman, Bradley N., Marosi, Krisztina, Wilson, Mark A. et al. · 2017 · Scientific Reports
  12. Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis
    Pala, Francesca, Di Girolamo, Daniela, Mella, Sébastien, Yennek, Siham, Chatre, Laurent, Ricchetti, Miria, Tajbakhsh, Shahragim · 2018 · Journal of Cell Science
  13. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
    Dellinger, Ryan W., Santos, Santiago Roel, Morris, Mark, Evans, Mal, Alminana, Dan, Guarente, Leonard, Marcotulli, Eric · 2017 · npj Aging and Mechanisms of Disease
  14. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging
    Daniel C. Levine, Hee‐Kyung Hong, Benjamin J. Weidemann, Kathryn Moynihan Ramsey, Alison H. Affinati, Mark S. Schmidt, Jonathan Cedernaes, Chiaki Omura, Rosemary Braun, Choogon Lee et al. · 2020 · Molecular Cell
  15. NAD+ biosynthesis, aging, and disease
    Johnson, Sean, Imai, Shin–ichiro · 2018 · F1000Research
  16. The Metabolic Impact on Histone Acetylation and Transcription in Ageing
    Peleg, Shahaf, Feller, Christian, Ladurner, Andreas G., Imhof, Axel · 2016 · Trends in Biochemical Sciences
  17. Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
    Sufan Wang, Ting Wan, Mingtong Ye, Yun Qiu, Lei Pei, Rui Jiang, Nengzhi Pang, Yuanling Huang, Baoxia Liang, Wenhua Ling et al. · 2018 · Redox Biology
  18. Autophagy and Stem Cells: Self-Eating for Self-Renewal
    Natasha C. Chang · 2020 · Frontiers in Cell and Developmental Biology
  19. The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms
    Santos, Ana L., Sinha, Sanchari, Lindner, Ariel B. · 2018 · Oxidative Medicine and Cellular Longevity
  20. Where Metabolism Meets Senescence: Focus on Endothelial Cells
    Jacopo Sabbatinelli, Francesco Prattichizzo, Fabiola Olivieri, Antonio Domenico Procopio, Maria Rita Rippo, Angelica Giuliani · 2019 · Frontiers in Physiology
  21. Age-related NAD+ decline
    Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur · 2020 · Experimental Gerontology
  22. The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells
    Yan, Wanhao, Diao, Shu, Fan, Zhipeng · 2021 · Stem Cell Research & Therapy
  23. Mitochondrial-to-nuclear communication in aging: an epigenetic perspective
    Di Zhu, Xinyu Li, Ye Tian · 2022 · Trends in Biochemical Sciences
  24. Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
    Amrita Sahu, Hikaru Mamiya, Sunita N. Shinde, Amin Cheikhi, Leabah Winter, Nam Viet Vo, Donna Beer Stolz, Vera Y. Roginskaya, Wan‐Yee Tang, Claudette M. St. Croix et al. · 2018 · Nature Communications
  25. Sirtuins and their Biological Relevance in Aging and Age-Related Diseases
    Lijun Zhao, Jianzhong Cao, Kexin Hu, Xiaodong He, Yun Dou, Tanjun Tong, Limin Han · 2020 · Aging and Disease
  26. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects
    Kiss, Tamas, Nyúl-Tóth, Ádám, Balasubramanian, Priya, Tarantini, Stefano, Ahire, Chetan, Yabluchanskiy, Andriy, Csipo, Tamas, Farkas, Eszter, Wren, Jonathan D., Garman, Lori et al. · 2020 · GeroScience
  27. Innate metabolic responses against viral infections
    Clovis Steve Palmer · 2022 · Nature Metabolism
  28. Faces of cellular senescence in skin aging
    Chin Yee Ho, Oliver Dreesen · 2021 · Mechanisms of Ageing and Development
  29. New insight into dyslipidemia‐induced cellular senescence in atherosclerosis
    Qunyan Xiang, Feng Tian, Jin Rui Xu, Xiao Du, Shilan Zhang, Ling Liu · 2022 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
  30. Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
    Yuho Kim, Matthew Triolo, David Albert Hood · 2017 · Oxidative Medicine and Cellular Longevity
  31. Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection
    Jing Xu, Charlie W. Jackson, Nathalie Khoury, Iris Escobar, Miguel A. Pérez‐Pinzón · 2018 · Frontiers in Endocrinology
  32. Oxidative stress, cellular senescence and ageing
    Akshaj Pole, Manjari Dimri, Goberdhan P. Dimri · 2016 · AIMS molecular science
  33. Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan–Kynurenine Metabolic System
    Masaru Tanaka, Ágnes Szabó, Eleonóra Spekker, Helga Polyák, Fanni Tóth, László Vécsei · 2022 · Cells
  34. The role of NAD+ metabolism and its modulation of mitochondria in aging and disease
    Khalishah Yusri, Sandra Jose, Karen S. Vermeulen, Trina Chia Min Tan, Vincenzo Sorrentino · 2025 · npj Metabolic Health and Disease
  35. Metabolic remodeling during the loss and acquisition of pluripotency
    Julie Mathieu, Hannele Ruohola‐Baker · 2017 · Development
  36. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
    Mengqi Li, Chen‐Song Zhang, Yue Zong, Jin-Wei Feng, Teng Ma, Meiqin Hu, Zhi‐Zhong Lin, Xiaotong Li, Changchuan Xie, Yaying Wu et al. · 2019 · Cell Metabolism
  37. Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm
    Jorge Oller, Enrique Gabandé‐Rodríguez, María Jesús Ruiz-Rodríguez, Gabriela Desdín-Micó, Juan Francisco Aranda, Raquel Rodrigues‐Díez, Constanza Ballesteros‐Martínez, Eva María Blanco, Raquel Roldán-Montero, Pedro Acuña et al. · 2021 · Circulation
  38. Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
    Won‐Kyu Ju, Guy A Perkins, Keun-young Kim A, Tonking Bastola, Woo-Young Choi, Soo‐Ho Choi · 2022 · Progress in Retinal and Eye Research
  39. Mitochondria and aging: A role for the mitochondrial transition pore?
    Mathieu Panel, Bijan Ghaleh, Didier Morin · 2018 · Aging Cell
  40. Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload
    Ioannis Smyrnias, Stephen P. Gray, Darlington Obinnaya Okonko, Greta Jane Sawyer, Anna Zoccarato, Norman Catibog, Begoña López, Arantxa González, Susana Ravassa, Javier Dı́ez et al. · 2019 · Journal of the American College of Cardiology
  41. Regulation of aged skeletal muscle regeneration by circulating extracellular vesicles
    Amrita Sahu, Zachary J. Clemens, Sunita N. Shinde, Sruthi Sivakumar, Abish Pius, Ankit Bhatia, Silvia Picciolini, Cristiano Carlomagno, Alice Gualerzi, Marzia Bedoni et al. · 2021 · Nature Aging
  42. Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin‐resistant men
    Dollerup, Ole L., Chubanava, Sabina, Agerholm, Marianne, Søndergård, Stine D., Altıntaş, Ali, Møller, Andreas B., Høyer, Kasper F., Ringgaard, Steffen, Stødkilde‐Jørgensen, Hans, Lavery, Gareth G. et al. · 2020 · The Journal of Physiology
  43. Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia
    Membrez, Mathieu, Migliavacca, Eugenia, Christen, Stefan, Yaku, Keisuke, Trieu, Jennifer, Lee, Alaina K., Morandini, Francesco, Giner, Maria Pilar, Stiner, Jade, Makarov, Mikhail V. et al. · 2024 · Nature Metabolism
  44. Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis
    Eldad Zacksenhaus, Mariusz Shrestha, Jeff C. Liu, Ioulia Vorobieva, Philip E.D. Chung, YoungJun Ju, Uri Nir, Zhe Jiang · 2017 · Trends in cancer
  45. Long noncoding RNA SNHG12 integrates a DNA-PK–mediated DNA damage response and vascular senescence
    Stefan Haemmig, Dafeng Yang, Xinghui Sun, Debapria Das, Siavash Ghaffari, Roberto Molinaro, Lei Chen, Yihuan Deng, Dan Freeman, Norman Moullan et al. · 2020 · Science Translational Medicine
  46. NAD <sup>+</sup> supplementation rejuvenates aged gut adult stem cells
    Igarashi, Masaki, Miura, Masaomi, Williams, Eric, Jaksch, Frank, Kadowaki, Takashi, Yamauchi, Toshimasa, Guarente, Leonard · 2019 · Aging Cell
  47. Oxidative Stress in Stem Cell Aging
    Feng Chen, Yingxia Liu, Nai-Kei Wong, Jia Xiao, Kwok‐Fai So · 2017 · Cell Transplantation
  48. Skeletal muscle stem cells in comfort and stress
    Brendan Evano, Shahragim Tajbakhsh · 2018 · npj Regenerative Medicine
  49. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule
    Saikat Kumar Poddar, Ali Ehsan Sifat, Sanjana Haque, Noor Ahmed Nahid, Sabiha Chowdhury, Imtias Mehedi · 2019 · Biomolecules
  50. Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation
    Annalisa Roberti, Agustín F. Fernández, Mario F. Fraga · 2021 · Molecular Metabolism
  51. Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides
    Olivier Sallin, Luc Reymond, Corentin Gondrand, Fabio Raith, Birgit Koch, Kai Johnsson · 2018 · eLife
  52. Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment
    Tamás Kiss, Priya Balasubramanian, Marta Noa Valcarcel‐Ares, Stefano Tarantini, Andriy Yabluchanskiy, Tamás Csípő, Ágnes Lipécz, Dóra Reglődi, Xin A. Zhang, Ferenc Bari et al. · 2019 · GeroScience
  53. Why NAD + Declines during Aging: It’s Destroyed
    Schultz, Michael B., Sinclair, David A. · 2016 · Cell Metabolism
  54. Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing
    Ole Kristian Reiten, Martin Andreas Wilvang, Sarah Jayne Mitchell, Zeping Hu, Evandro Fei Fang · 2021 · Mechanisms of Ageing and Development
  55. Regulation of and challenges in targeting NAD+ metabolism
    Marie E. Migaud, Mathias Ziegler, Joseph A. Baur · 2024 · Nature Reviews Molecular Cell Biology
  56. Metabolism and neurogenesis
    Marlen Knobloch, Sebastian Jessberger · 2016 · Current Opinion in Neurobiology
  57. A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor
    Judith Giroud‐Gerbetant, Magali Joffraud, Maria Pilar Giner, Angelique Cercillieux, Simona Bártová, Mikhail V. Makarov, Ruben Zapata Perez, José L. Sánchez-García, Riekelt H. Houtkooper, Marie E. Migaud et al. · 2019 · Molecular Metabolism
  58. Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments
    Ever Espino-González, Emilie Dalbram, Rémi Mounier, Julien Gondin, Jean Farup, Niels Jessen, Jonas T. Treebak · 2024 · Cell Metabolism
  59. Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence
    Park, Joon Tae, Lee, Young-Sam, Cho, Kyung A., Park, Sang Chul · 2018 · Ageing Research Reviews
  60. Proteostatic and Metabolic Control of Stemness
    Laura García‐Prat, Pedro Sousa‐Victor, Pura Muñoz‐Cánoves · 2017 · Cell stem cell
  61. Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation
    Evgenia V. Verovskaya, Paul V. Dellorusso, Emmanuelle A. Passegue · 2019 · Trends in Molecular Medicine
  62. Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
    Tamás Pándics, Dávid Major, Vince Fazekas‐Pongor, Zsófia Szarvas, Anna Péterfi, Péter Mukli, Rafał Gulej, Anna Ungvari, Mónika Fekete, Anna Tompa et al. · 2023 · GeroScience
  63. SIRT1 regulates macrophage self‐renewal
    Francesco Imperatore, Julien Maurizio, Stephanie Vargas Aguilar, Clara Jana‐Lui Busch, Jérémy Favret, Elisabeth Kowenz‐Leutz, Wilfried Cathou, Rebecca Gentek, Pierre Perrin, Achim Leutz et al. · 2017 · The EMBO Journal
  64. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
    Helena A. K. Lapatto, Minna Kuusela, Aino Heikkinen, Maheswary Muniandy, Birgitta W. van der Kolk, Swetha Gopalakrishnan, Martin Sandvik, Mark S. Schmidt, Sini Heinonen, Sina Saari et al. · 2023 · Science Advances
  65. Mouse Models to Disentangle the Hallmarks of Human Aging
    Folgueras, Alicia R., Freitas-Rodríguez, Sandra, Velasco, Gloria, López-Otín, Carlos · 2018 · Circulation Research
  66. Animal models of sarcopenia
    Christian, Courtney J., Benian, Guy M. · 2020 · Aging Cell
  67. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1
    Jeng, Mark Y., Hull, Philip A., Fei, Mingjian, Kwon, Hye-Sook, Tsou, Chia-Lin, Kasler, Herb, Ng, Che-Ping, Gordon, David E., Johnson, Jeffrey, Krogan, Nevan et al. · 2018 · Journal of Experimental Medicine
  68. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
    Rachel S. Fletcher, Joanna Ratajczak, Craig L. Doig, Lucy A. Oakey, Rebecca Callingham, Gabriela da Silva Xavier, Antje Garten, Yasir Elhassan, Philip Redpath, Marie E. Migaud et al. · 2017 · Molecular Metabolism
  69. Mechanisms and rejuvenation strategies for aged hematopoietic stem cells
    Xia Li, Xiangjun Zeng, Yulin Xu, Binsheng Wang, Yanmin Zhao, Xiaoyu Lai, Pengxu Qian, He Huang · 2020 · Journal of Hematology & Oncology
  70. Increasing ovarian NAD+ levels improve mitochondrial functions and reverse ovarian aging
    Qingling Yang, Luping Cong, Yujiao Wang, Xiaoyan Luo, Hui Li, Huan Wang, Jing Zhu, Shanjun Dai, Haixia Jin, Guidong Yao et al. · 2020 · Free Radical Biology and Medicine
  71. NAD+ flux is maintained in aged mice despite lower tissue concentrations
    McReynolds, Melanie R., Chellappa, Karthikeyani, Chiles, Eric, Jankowski, Connor, Shen, Yihui, Chen, Li, Descamps, Hélène C., Mukherjee, Sarmistha, Bhat, Yashaswini R., Lingala, Siddharth R. et al. · 2021 · Cell Systems
  72. Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease
    Chi Fung Lee, Arianne Caudal, Lauren Abell, G. A. Nagana Gowda, Rong Tian · 2019 · Scientific Reports
  73. Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
    Xuan Sun, Benjamin Cao, Marina Naval-Sánchez, Tony A. Pham, Yu Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus et al. · 2021 · Nature Communications
  74. Aging: Molecular Pathways and Implications on the Cardiovascular System
    Arthur José Pontes Oliveira de Almeida, Thaís Pôrto Ribeiro, Isac Almeida de Medeiros · 2017 · Oxidative Medicine and Cellular Longevity
  75. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
    Masaki Igarashi, Yoshiko Nakagawa-Nagahama, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Mika Sawada, Rie Sekine, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai et al. · 2022 · npj Aging
  76. Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells
    Pura Muñoz‐Cánoves, Joana Neves, Pedro Sousa‐Victor · 2019 · FEBS Journal
  77. Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
    Qi Qu, Yan Chen, Yu Wang, Weiche Wang, Shating Long, Heng-Ye Yang, Jianfeng Wu, Mengqi Li, Xiao Tian, Xiaoyan Wei et al. · 2024 · Nature
  78. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age
    Daniel Brigger, Carsten Riether, Robin van Brummelen, Kira Irving Mosher, Alicia Shiu, Zhaoqing Ding, Noemi Bachmeier‐Zbären, Pascal Gasser, Pascal Guntern, Hanadie Yousef et al. · 2020 · Nature Metabolism
  79. 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
    David E. Harrison, Randy Strong, Peter C. Reifsnyder, Navasuja Kumar, Elizabeth Fernández, Kevin Flurkey, Martin A. Javors, Marisa Lopez‐Cruzan, Francesca Macchiarini, James F. Nelson et al. · 2021 · Aging Cell
  80. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression
    Yao Dang, Yongpan An, Jinzhao He, Boyue Huang, Jie Zhu, Miaomiao Gao, Shun Zhang, Xin Wang, Baoxue Yang, Zhengwei Xie · 2019 · Aging Cell
  81. Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6
    Yuelin Zhang, Liyan Guo, Shuo Han, Ling Chen, Cheng Li, Zhao Zhang, Yimei Hong, Xiaoxian Zhang, Xiaoya Zhou, Dan Jiang et al. · 2020 · Cell Death and Disease
  82. Nicotinamide Deficiency in Primary Open-Angle Glaucoma
    Judith Kouassi Nzoughet, Juan Manuel Chao de la Barca, Khadidja Guehlouz, Stéphanie Leruez, Laurent Coulbault, Stéphane Allouche, Cinzia Bocca, Jeanne Muller, Patrizia Amati‐Bonneau, Philippe Gohier et al. · 2019 · Investigative Ophthalmology & Visual Science
  83. SGLT2 Inhibitors as Calorie Restriction Mimetics: Insights on Longevity Pathways and Age-Related Diseases
    Caroline Wei Shan Hoong, Marvin Wei Jie Chua · 2021 · Endocrinology
  84. The autophagy–NAD axis in longevity and disease
    Niall Wilson, Tetsushi Kataura, Miriam E. Korsgen, Congxin Sun, Sovan Sarkar, Viktor I. Korolchuk · 2023 · Trends in Cell Biology
  85. The chemistry of the vitamin B3 metabolome
    Mikhail V. Makarov, Samuel A.J. Trammell, Marie E. Migaud · 2018 · Biochemical Society Transactions
  86. Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
    Di-Yang Sun, Wenbin Wu, Jianjin Wu, Yu Lin Shi, Jiajun Xu, Shen-Xi Ouyang, Chen Chi, Yi Shi, Qing‐Xin Ji, Jinhao Miao et al. · 2024 · Nature Communications
  87. Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
    Schüler, Svenja C., Kirkpatrick, Joanna M., Schmidt, Manuel, Santinha, Deolinda, Koch, Philipp, Di Sanzo, Simone, Cirri, Emilio, Hemberg, Martin, Ori, Alessandro, von Maltzahn, Julia · 2021 · Cell Reports
  88. Caloric Restriction Mimetics in Nutrition and Clinical Trials
    Hofer, Sebastian J., Davinelli, Sergio, Bergmann, Martina, Scapagnini, Giovanni, Madeo, Frank · 2021 · Frontiers in Nutrition
  89. NAD + supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy
    Beimeng Yang, Xiuli Dan, Yujun Hou, Jong‐Hyuk Lee, Noah Wechter, Sudarshan Krishnamurthy, Risako Kimura, Mansi Babbar, Tyler G. Demarest, Ross A. McDevitt et al. · 2021 · Aging Cell
  90. Lithocholic acid phenocopies anti-ageing effects of calorie restriction
    Qi Qu, Yan Chen, Yu Wang, Shating Long, Weiche Wang, Heng-Ye Yang, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan‐Hui Liu et al. · 2024 · Nature
  91. Geroprotectors: A Unified Concept and Screening Approaches
    Alexey Moskalev, Elizaveta Chernyagina, Anna V. Kudryavtseva, Mikhail Vyacheslavovich Shaposhnikov · 2017 · Aging and Disease
  92. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging
    Lehallier, Benoit, Shokhirev, Maxim N., Wyss‐Coray, Tony, Johnson, Adiv A. · 2020 · Aging Cell
  93. Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study
    Christina F. Dolopikou, I. A. Kourtzidis, Nikos V. Margaritelis, Ioannis S. Vrabas, Eirini Koidou, Antonios Kyparos, Anastasios A. Theodorou, Vassilis Paschalis, Michalis G. Nikolaidis · 2019 · European Journal of Nutrition
  94. Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function
    Orr, Adam L., Kim, Chaeyoung, Jimenez-Morales, David, Newton, Billy W., Johnson, Jeffrey R., Krogan, Nevan J., Swaney, Danielle L., Mahley, Robert W. · 2019 · Journal of Alzheimer's Disease
  95. Sending Out an SOS: Mitochondria as a Signaling Hub
    Iryna Bohovych, Oleh Khalimonchuk · 2016 · Frontiers in Cell and Developmental Biology
  96. Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma
    Williams, Pete A., Harder, Jeffrey M., John, Simon W.M. · 2017 · Journal of Glaucoma
  97. Aerobic and resistance exercise training reverses age‐dependent decline in NAD<sup>+</sup>salvage capacity in human skeletal muscle
    de Guia, Roldan M., Agerholm, Marianne, Nielsen, Thomas S., Consitt, Leslie A., Søgaard, Ditte, Helge, Jørn W., Larsen, Steen, Brandauer, Josef, Houmard, Joseph A., Treebak, Jonas T. · 2019 · Physiological Reports
  98. Healthy aging and muscle function are positively associated with NAD+ abundance in humans
    Janssens, Georges E., Grevendonk, Lotte, Perez, Ruben Zapata, Schomakers, Bauke V., de Vogel-van den Bosch, Johan, Geurts, Jan M. W., van Weeghel, Michel, Schrauwen, Patrick, Houtkooper, Riekelt H., Hoeks, Joris · 2022 · Nature Aging
  99. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects
    Okabe, Keisuke, Yaku, Keisuke, Uchida, Yoshiaki, Fukamizu, Yuichiro, Sato, Toshiya, Sakurai, Takanobu, Tobe, Kazuyuki, Nakagawa, Takashi · 2022 · Frontiers in Nutrition
  100. Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?
    Marwa Elamin, David N. Ruskin, Susan A. Masino, Paola Sacchetti · 2017 · Frontiers in Molecular Neuroscience