The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
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epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies.
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“However, whether the epigenetic landscape of the tumor cells or T cell exhaustion is contributing to resistance is not well understood, leaving much room for further understanding of how epigenetics can lead to nonresponse to ICIs (108, 109).”
From Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance (2021) · cites this paper as [109]
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The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
Self-citationRestoring function in exhausted CD8 T cells during chronic viral infection
Barber, D. L., Wherry, E. J., Masopust, D., Zhu, B., Allison, J. P., Sharpe, A. H., Freeman, G. J., & Ahmed, R. (2005) · Nature · doi:10.1038/nature04444 · Cited by 4,057
Self-citationDefining CD8+ T cells that provide the proliferative burst after PD-1 therapy
Im, S. J., Hashimoto, M., Gerner, M. Y., Lee, J., Kissick, H. T., Burger, M. C., Shan, Q., Hale, J. S., Lee, J., Nasti, T. H., et al. (2016) · Nature · doi:10.1038/nature19330 · Cited by 2,070
Reich, M. M., Liefeld, T., Gould, J., Lerner, J., Tamayo, P., & Mesirov, J. P. (2006) · Nature Genetics · doi:10.1038/ng0506-500 · Cited by 2,053
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
Gubin, M. M., Zhang, X., Schuster, H., Caron, E., Ward, J. P., Noguchi, T., Ivanova, Y., Hundal, J., Arthur, C. D., Krebber, W.-J., et al. (2014) · Nature · doi:10.1038/nature13988 · Cited by 1,974
Utzschneider, D. T., Charmoy, M., Chennupati, V., Pousse, L., Ferreira, D. P., Calderon-Copete, S. P., Danilo, M., Alfei, F., Hofmann, M., Wieland, D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.021 · Cited by 1,095
Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection
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Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
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Metadata
- Authors
- Pauken, K. E., Sammons, M. A., Odorizzi, P. M., Manne, S., Godec, J., Khan, O., Drake, A. M., Chen, Z., Sen, D. R., Kurachi, M., Barnitz, R. A., Bartman, C., Bengsch, B., Huang, A. C., Schenkel, J. M., Vahedi, G., Haining, W. N., Berger, S. L., & Wherry, E. J.
- Affiliations
- University of Pennsylvania (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- University of Minnesota (US)
- Broad Institute (US)
- Corresponding author
- Wherry, E. John
- ORCID
- Venue
- Science
- Published
- 2016-12-02
- Volume
- 354
- Issue
- 6316
- Pages
- 1160-1165
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5484795
- OpenAlex
- W2541574334
- Cited by
- 1,348
- References
- 37
- Citations by year
- 2026: 162 · 2025: 128 · 2024: 122 · 2023: 160 · 2022: 145 · 2021: 166 · 2020: 162 · 2019: 129 · 2018: 106 · 2017: 66 · 2016: 2
- FWCI
- 54.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Robertson Foundation–Cancer Research Institute Irvington Fellowship
- American Cancer Society Postdoctoral Fellowship
- German Research Foundation Fellowship (BE5496/1-1)
- National Institutes of Health (F30DK100159, T32 2T32CA009615-26, CA78831, AI105343, AI112521, AI082630, AI115712, AI117950, AI108545)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- exhausted T cells, epigenetic stability, anti-PD-1 therapy, T cell reinvigoration, T cell exhaustion
- MeSH terms
- Animals, Female, Immunologic Memory, Immunotherapy, Mice, Inbred C57BL, Transcription, Genetic, Interleukin-7, CD8-Positive T-Lymphocytes, Cell Lineage, Epigenesis, Genetic, Mice, Gene Regulatory Networks, B7-H1 Antigen, Cellular Reprogramming
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