Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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The future of immune checkpoint therapy

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Molecular and cellular insights into T cell exhaustion

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Restoring function in exhausted CD8 T cells during chronic viral infection

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GenePattern 2.0

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Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

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T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections

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Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection

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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

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Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

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Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade

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Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

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Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

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Immune Modulation in Cancer with Antibodies

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Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

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Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells

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The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

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Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells

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NFATc1 Regulates PD-1 Expression upon T Cell Activation

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The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

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The evolution of checkpoint blockade as a cancer therapy: what's here, what's next?

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IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

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Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation

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Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

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T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

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Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

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Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

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Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection

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IL-7/Anti-IL-7 mAb Complexes Restore T Cell Development and Induce Homeostatic T Cell Expansion without Lymphopenia

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Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection

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Immunotherapeutic effects of IL-7 during a chronic viral infection in mice

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The role of chromatin dynamics in immune cell development

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Wellington-bootstrap: differential DNase-seq footprinting identifies cell-type determining transcription factors

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Understanding the tumor immune microenvironment (TIME) for effective therapy

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A guide to cancer immunotherapy: from T cell basic science to clinical practice

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Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

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Defining trained immunity and its role in health and disease

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Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

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Abstract B104: Impact of PD-1 blockade on epigenetic and transcriptional reprogramming of exhausted T cells

Pauken, K. E., Sammons, M. A., Odorizzi, P. M., Manne, S., Godec, J., Khan, O., Sen, D. R., Kurachi, M., Barnitz, R. A., Bengsch, B., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.imm2016-b104

Exhausted T cells miss out on methylation

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LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

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Abstract IA06: Molecular basis of T cell exhaustion: Insights for immunotherapy

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Cell-Intrinsic Barriers of T Cell-Based Immunotherapy

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