The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Return to quiescence of mouse neural stem cells by degradation of a proactivation protein
Open accessAbstract
Sending neural stem cells back to the garage: In the brain's hippocampus, which modulates memories and emotions, neural stem cells generate new neurons, even during adulthood. How many new neurons are generated, and when, follows from the balance between quiescence and proliferation in the pool of neural stem cells. Urbán et al. asked what signals send proliferating stem cells back into a quiescent state. They found that a key transcription factor that promotes cellular proliferation was degraded through the ubiquitinylation system. This molecular interaction regulated the return to a resting state, but one that was not quite as quiescent as the original state. Stem cells in this resting but primed state sustained the stem cell pool. Science , this issue p. 292
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Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,260
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Direct conversion of fibroblasts to functional neurons by defined factors
Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
Schepers, A. G., Snippert, H. J., Stange, D. E., van den Born, M., van Es, J. H., van de Wetering, M., & Clevers, H. (2012) · Science · doi:10.1126/science.1224676 · Cited by 1,072
Encinas, J. M., Michurina, T. V., Peunova, N., Park, J.-H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A., & Enikolopov, G. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.03.010 · Cited by 887
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell
Conti, L., Pollard, S. M., Gorba, T., Reitano, E., Toselli, M., Biella, G., Sun, Y., Sanzone, S., Ying, Q.-L., Cattaneo, E., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030283 · Cited by 870
Zhong, Q., Gao, W., Du, F., & Wang, X. (2005) · Cell · doi:10.1016/j.cell.2005.06.009 · Cited by 842
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
Bonaguidi, M. A., Wheeler, M. A., Shapiro, J. S., Stadel, R. P., Sun, G. J., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.024 · Cited by 831
Cited by
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719
Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages
Mizrak, D., Levitin, H. M., Delgado, A. C., Crotet, V., Yuan, J., Chaker, Z., Silva-Vargas, V., Sims, P. A., & Doetsch, F. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.044 · Cited by 248
Aging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186
Harris, L., Rigo, P., Stiehl, T., Gaber, Z. B., Austin, S. H. L., Masdeu, M. D. M., Edwards, A., Urbán, N., Marciniak-Czochra, A., & Guillemot, F. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.003 · Cited by 173
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Metadata
- Authors
- Urbán, N., van den Berg, D. L. C., Forget, A., Andersen, J., Demmers, J. A. A., Hunt, C., Ayrault, O., & Guillemot, F.
- Venue
- Science
- Published
- 2016-07-15
- Volume
- 353
- Issue
- 6296
- Pages
- 292-295
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2466317387
- Cited by
- 258
- References
- 37
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- green
- Funders
- Medical Research Council (MRC)
- Federation of European Biochemical Societies
- Netherlands Organisation for Scientific Research (NWO) (184.032.201)
- Fondation de France
- Wellcome Trust (106187/Z/14/Z)
- Biotechnology and Biological Sciences Research Council (BB/K005316/1)
- MRC (U117570528)
- Francis Crick Institute (BZ10089)
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- Urbán, N., van den Berg, D. L. C., Forget, A., Andersen, J., Demmers, J. A. A., Hunt, C., Ayrault, O., & Guillemot, F. (2016). Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. Science. https://doi.org/10.1126/science.aaf4802
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
