Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Open accessAbstract
Significance Adult mammalian tissues contain stem cells that contribute to tissue homeostasis and regeneration, with potential therapeutic applications. Specialized niches regulate their fate. Here we evaluated quantitatively how the subependymal zone niche regulates neural stem cell (NSC) number in the adult mouse brain. Using knock-in reporter alleles and single-cell RNA sequencing, we show that the Wnt target Tnfrsf19/ Troy identifies both active and quiescent NSCs. Using the Ki67-iresCreER mouse model, we found that dividing stem cells have long-term self-renewal potential. We propose a model where the fate of NSCs is coupled to their density within a closed niche. Our results suggest a new mechanism for regulating adult stem cell number, which might be deregulated in brain malignancies and in aging.
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- Authors
- Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., Simons, B. D., & Clevers, H.
- Affiliations
- Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;
- University of Cambridge (GB)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-01-08
- Volume
- 115
- Issue
- 4
- Pages
- E610-E619
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5789932
- OpenAlex
- W2782793342
- Cited by
- 186
- References
- 70
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 20 · 2023: 30 · 2022: 31 · 2021: 15 · 2020: 35 · 2019: 19 · 2018: 8
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
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- Apollo
- Funders
- EC | FP7 | FP7 Ideas: European Research Council (EU/232814-StemCellMark, (ERC-AdG 294325-GeneNoiseControl)
- Skolkovo Institute of Science and Technology (Skolkovo 077 MPA)
- KWF Kankerbestrijding (KWF/PF-HUBR 2007-3956)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- neural stem cells, subventricular zone, stem cell quiescence, niche occupancy, TNFRSF19, Troy, Wnt signaling, stem cell self-renewal, adult brain, stem cell fate, brain aging, brain tumors
- MeSH terms
- Animals, Receptors, Tumor Necrosis Factor, Cell Lineage, Lateral Ventricles, Cell Proliferation, Mice, Stem Cell Niche, Neurogenesis, Neural Stem Cells, Single-Cell Analysis, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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