In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
Open accessAbstract
Neurogenesis and gliogenesis continue in discrete regions of the adult mammalian brain. A fundamental question remains whether cell genesis occurs from distinct lineage-restricted progenitors or from self-renewing and multipotent neural stem cells in the adult brain. Here, we developed a genetic marking strategy for lineage tracing of individual, quiescent, and nestin-expressing radial glia-like (RGL) precursors in the adult mouse dentate gyrus. Clonal analysis identified multiple modes of RGL activation, including asymmetric and symmetric self-renewal. Long-term lineage tracing in vivo revealed a significant percentage of clones that contained RGL(s), neurons, and astrocytes, indicating capacity of individual RGLs for both self-renewal and multilineage differentiation. Furthermore, conditional Pten deletion in RGLs initially promotes their activation and symmetric self-renewal but ultimately leads to terminal astrocytic differentiation and RGL depletion in the adult hippocampus. Our study identifies RGLs as self-renewing and multipotent neural stem cells and provides novel insights into in vivo properties of adult neural stem cells.
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The control of neurogenesis and self-renewal is adaptable to the ongoing cell state.
“This, on one hand suggests that the control of neurogenesis and self-renewal is adaptable to the ongoing cell state, in accordance with the proposal by Bonaguidi et al. (2011)”
From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Bonaguidi et al. (2011)
Neural progenitor cells may generate neurons and glial cells by differentiation, as well as self-renew to maintain the original pool of parent cells.
“Neural progenitor cells (NPCs) may generate cells of the neural lineage, neurons and glial cells by differentiation, as well as self-renewal in order to maintain the original pool of parent cells [159,160].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [160]
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- Authors
- Bonaguidi, M. A., Wheeler, M. A., Shapiro, J. S., Stadel, R. P., Sun, G. J., Ming, G.-L., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Ming, Guo-li
- Song, Hongjun
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 145
- Issue
- 7
- Pages
- 1142-1155
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3124562
- OpenAlex
- W2016500868
- Cited by
- 831
- References
- 53
- Citations by year
- 2026: 11 · 2025: 31 · 2024: 41 · 2023: 57 · 2022: 54 · 2021: 54 · 2020: 76 · 2019: 62 · 2018: 69 · 2017: 65 · 2016: 55 · 2015: 68 · 2014: 66 · 2013: 56 · 2012: 51
- FWCI
- 19.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 808 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Maryland Stem Cell Research Fund
- National Institutes of Health
- National Institute on Aging (AG 024984, R01AG024984)
- National Institute of General Medical Sciences (T32GM007814)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R37NS047344, R56NS047344)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD069184, HD069184)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neural stem cells, self-renewal, multilineage differentiation, clonal analysis, lineage tracing, dentate gyrus, hippocampus, PTEN deletion, astrocyte differentiation, gliogenesis, neurogenesis, nestin
- MeSH terms
- Animals, Hippocampus, Intermediate Filament Proteins, Nerve Tissue Proteins, Dentate Gyrus, Multipotent Stem Cells, Mice, Adult Stem Cells, Neurogenesis, Neural Stem Cells, Nestin
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